FI104948B - Förfarande för framställning av salter av medetomidin för transdermalt administrering - Google Patents
Förfarande för framställning av salter av medetomidin för transdermalt administrering Download PDFInfo
- Publication number
- FI104948B FI104948B FI935351A FI935351A FI104948B FI 104948 B FI104948 B FI 104948B FI 935351 A FI935351 A FI 935351A FI 935351 A FI935351 A FI 935351A FI 104948 B FI104948 B FI 104948B
- Authority
- FI
- Finland
- Prior art keywords
- medetomidine
- salts
- skin
- drug
- base
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Claims (2)
1. Förfarande för framställning av ett sait mellan medetomidin eller en optiskt aktiv enantiomer därav och en karboxylsyra med 5-16 kolatomer, 5 vilken karboxylsyra innehäller en alifatisk kolkedja med minst 5 kolatomer, kännetecknat därav, att man blandar medetomidinbas eller en optiskt aktiv enantiomer därav med sagt karboxylsyra, och isolerar det erhällna saltet.
2. Förfarande enligt patentkravet 1,kännetecknat därav, att man framställer dekanoat av medetomidin eller en optiskt aktiv enantiomer därav. 10 * 1 · «
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9111732 | 1991-05-31 | ||
GB919111732A GB9111732D0 (en) | 1991-05-31 | 1991-05-31 | The use of certain salts of medetomidine and its optically active enantiomers to regulate the rate of transdermal administration of the drugs |
FI9200167 | 1992-05-27 | ||
PCT/FI1992/000167 WO1992021338A1 (en) | 1991-05-31 | 1992-05-27 | Medetomidine preparations for transdermal administration |
Publications (3)
Publication Number | Publication Date |
---|---|
FI935351A0 FI935351A0 (fi) | 1993-11-30 |
FI935351A FI935351A (fi) | 1993-11-30 |
FI104948B true FI104948B (sv) | 2000-05-15 |
Family
ID=10695876
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI935351A FI104948B (sv) | 1991-05-31 | 1993-11-30 | Förfarande för framställning av salter av medetomidin för transdermalt administrering |
Country Status (17)
Country | Link |
---|---|
US (1) | US5438067A (sv) |
EP (1) | EP0587819B1 (sv) |
JP (2) | JP3483881B2 (sv) |
AT (1) | ATE149090T1 (sv) |
AU (1) | AU1798192A (sv) |
CA (1) | CA2110161C (sv) |
DE (1) | DE69217658T2 (sv) |
EE (1) | EE03053B1 (sv) |
FI (1) | FI104948B (sv) |
GB (2) | GB9111732D0 (sv) |
IE (1) | IE67168B1 (sv) |
LT (1) | LT3130B (sv) |
LV (1) | LV10047B (sv) |
NO (1) | NO303818B1 (sv) |
NZ (1) | NZ242717A (sv) |
WO (1) | WO1992021338A1 (sv) |
ZA (1) | ZA923395B (sv) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5883115A (en) * | 1992-11-09 | 1999-03-16 | Pharmetrix Division Technical Chemicals & Products, Inc. | Transdermal delivery of the eutomer of a chiral drug |
GB2290964A (en) * | 1994-07-08 | 1996-01-17 | Arto Olavi Urtti | Transdermal drug delivery system |
GB9521680D0 (en) * | 1995-10-23 | 1996-01-03 | Orion Yhtymo Oy | New use of imidazole derivatives |
US5730721A (en) | 1996-01-25 | 1998-03-24 | Vesture Corporation | Medical applicator and method |
GB9614098D0 (en) | 1996-07-05 | 1996-09-04 | Orion Yhtymae Oy | Transdermal delivery of levosimendan |
IT1290255B1 (it) * | 1997-02-05 | 1998-10-22 | Wallcovering Pubblicita S R L | Supporto sagomato aderente all'epidermide per la cessione di sostanze cosmetiche o farmacologiche e metodo per la sua fabbricazione |
DE19936395C2 (de) | 1999-08-03 | 2002-07-18 | Antonia Buntz | Kosmetikpflaster und Verfahren zum Anheben der weiblichen Brust mittels eines solchen Kosmetikpflasters und seine Verwendung |
US6682757B1 (en) | 2000-11-16 | 2004-01-27 | Euro-Celtique, S.A. | Titratable dosage transdermal delivery system |
US7795263B2 (en) * | 2008-07-08 | 2010-09-14 | Wildlife Laboratories, Inc. | Pharmaceutical combination for and method of anesthetizing and immobilizing non-domesticated mammals |
CA2762107A1 (en) * | 2009-05-15 | 2010-11-18 | Recro Pharma, Inc. | Sublingual dexmedetomidine compositions and methods of use thereof |
AU2011204315A1 (en) * | 2010-01-08 | 2012-08-02 | Recro Pharma, Inc. | Topical transdermal dexmedetomidine compositions and methods of use thereof |
US20120202863A1 (en) * | 2011-02-03 | 2012-08-09 | Gerald Horn | Compositions and methods for treatment of glaucoma |
RU2692245C2 (ru) | 2011-12-11 | 2019-06-24 | Рекро Фарма, Инк. | Интраназальные композиции дексмедетомидина и способы их применения |
RU2646512C2 (ru) | 2013-10-07 | 2018-03-05 | ТЕЙКОКУ ФАРМА ЮЭсЭй, ИНК. | Устройства для трансдермальной доставки дексмедетомидина и способы их применения |
TWI629066B (zh) | 2013-10-07 | 2018-07-11 | 帝國製藥美國股份有限公司 | 使用右美托咪啶經皮組成物用於治療注意力不足過動症、焦慮及失眠的方法及組成物 |
TWI629061B (zh) * | 2013-10-07 | 2018-07-11 | 美商帝國製藥美國股份有限公司 | 包含右美托嘧啶(dexmedetomidine)經皮組成物之疼痛處理用方法及組成物 |
WO2015054063A1 (en) * | 2013-10-07 | 2015-04-16 | Teikoku Pharma Usa, Inc. | Methods and compositions for treating withdrawal syndromes using non-sedative dexmedetomidine transdermal compositions |
ES2847936T3 (es) | 2013-10-07 | 2021-08-04 | Teikoku Pharma Usa Inc | Métodos y composiciones para el suministro transdérmico de una cantidad no sedante de dexmedetomidina |
EP3087985B1 (en) | 2013-12-18 | 2018-10-17 | Maruishi Pharmaceutical Co., Ltd. | Hydrous adhesive patch |
CN111346072B (zh) * | 2018-12-21 | 2022-05-27 | 宜昌人福药业有限责任公司 | 一种透皮给药的药物组合物及其制备方法 |
MX2021012824A (es) | 2019-05-01 | 2022-10-19 | Clexio Biosciences Ltd | Métodos para tratar el prurito. |
US20220211672A1 (en) | 2019-05-01 | 2022-07-07 | Clexio Biosciences Ltd. | Methods of treating pruritus |
TWI772807B (zh) | 2019-05-27 | 2022-08-01 | 日商救急藥品工業股份有限公司 | 外用製劑 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2101114B (en) * | 1981-07-10 | 1985-05-22 | Farmos Group Ltd | Substituted imidazole derivatives and their preparation and use |
FI864570A0 (fi) * | 1986-11-11 | 1986-11-11 | Farmos Oy | Terapeutiskt anvaendbar foerening. |
GB2206880B (en) * | 1987-07-16 | 1991-04-24 | Farmos Oy | Optical isomers of an imidazole derivative |
GB2215206B (en) * | 1988-02-29 | 1991-07-03 | Farmos Oy | 4-substituted imidazole derivatives useful in perioperative care |
US5217718A (en) * | 1989-08-18 | 1993-06-08 | Cygnus Therapeutic Systems | Method and device for administering dexmedetomidine transdermally |
US5124157A (en) * | 1989-08-18 | 1992-06-23 | Cygnus Therapeutic Systems | Method and device for administering dexmedetomidine transdermally |
US5304569A (en) * | 1989-11-13 | 1994-04-19 | Orion-Yhtyma Oy | Compositions and their use in lowering intraocular pressure |
-
1991
- 1991-05-31 GB GB919111732A patent/GB9111732D0/en active Pending
-
1992
- 1992-05-11 ZA ZA923395A patent/ZA923395B/xx unknown
- 1992-05-13 NZ NZ242717A patent/NZ242717A/en not_active IP Right Cessation
- 1992-05-22 GB GB9211033A patent/GB2256367B/en not_active Expired - Fee Related
- 1992-05-27 CA CA002110161A patent/CA2110161C/en not_active Expired - Lifetime
- 1992-05-27 EP EP92917469A patent/EP0587819B1/en not_active Expired - Lifetime
- 1992-05-27 WO PCT/FI1992/000167 patent/WO1992021338A1/en active IP Right Grant
- 1992-05-27 AT AT92917469T patent/ATE149090T1/de not_active IP Right Cessation
- 1992-05-27 JP JP51014392A patent/JP3483881B2/ja not_active Expired - Fee Related
- 1992-05-27 DE DE69217658T patent/DE69217658T2/de not_active Expired - Fee Related
- 1992-05-27 AU AU17981/92A patent/AU1798192A/en not_active Abandoned
- 1992-05-28 LV LVP-92-18A patent/LV10047B/en unknown
- 1992-05-29 LT LTIP112A patent/LT3130B/lt not_active IP Right Cessation
- 1992-07-01 IE IE921937A patent/IE67168B1/en not_active IP Right Cessation
-
1993
- 1993-11-12 US US08/146,201 patent/US5438067A/en not_active Expired - Fee Related
- 1993-11-29 NO NO934323A patent/NO303818B1/no unknown
- 1993-11-30 FI FI935351A patent/FI104948B/sv not_active IP Right Cessation
-
1994
- 1994-10-18 EE EE9400270A patent/EE03053B1/xx not_active IP Right Cessation
-
2003
- 2003-06-20 JP JP2003175781A patent/JP2003327531A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
CA2110161A1 (en) | 1992-12-10 |
ZA923395B (en) | 1993-03-31 |
LTIP112A (en) | 1994-07-15 |
AU1798192A (en) | 1993-01-08 |
DE69217658D1 (de) | 1997-04-03 |
JP3483881B2 (ja) | 2004-01-06 |
GB9211033D0 (en) | 1992-07-08 |
NO934323L (no) | 1993-11-29 |
NO303818B1 (no) | 1998-09-07 |
EP0587819B1 (en) | 1997-02-26 |
JP2003327531A (ja) | 2003-11-19 |
GB2256367A (en) | 1992-12-09 |
JPH06507888A (ja) | 1994-09-08 |
NO934323D0 (no) | 1993-11-29 |
US5438067A (en) | 1995-08-01 |
DE69217658T2 (de) | 1997-07-03 |
IE921937A1 (en) | 1992-12-02 |
CA2110161C (en) | 2004-08-03 |
LT3130B (en) | 1994-12-25 |
NZ242717A (en) | 1994-03-25 |
ATE149090T1 (de) | 1997-03-15 |
EE03053B1 (et) | 1997-12-15 |
LV10047B (en) | 1995-02-20 |
GB9111732D0 (en) | 1991-07-24 |
FI935351A0 (fi) | 1993-11-30 |
LV10047A (lv) | 1994-05-10 |
WO1992021338A1 (en) | 1992-12-10 |
FI935351A (fi) | 1993-11-30 |
EP0587819A1 (en) | 1994-03-23 |
IE67168B1 (en) | 1996-03-06 |
GB2256367B (en) | 1995-03-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MA | Patent expired |