FI104554B - Förfarande för framsällning av nya terapeutiskt användbara karbamoyl-1-(pyridinylalkyl)-1H-indol- och indolinderivat - Google Patents
Förfarande för framsällning av nya terapeutiskt användbara karbamoyl-1-(pyridinylalkyl)-1H-indol- och indolinderivat Download PDFInfo
- Publication number
- FI104554B FI104554B FI913801A FI913801A FI104554B FI 104554 B FI104554 B FI 104554B FI 913801 A FI913801 A FI 913801A FI 913801 A FI913801 A FI 913801A FI 104554 B FI104554 B FI 104554B
- Authority
- FI
- Finland
- Prior art keywords
- indol
- formula
- loweralkyl
- hydrogen
- pyridinylmethyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Psychiatry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Claims (4)
1. Förfarande för framställning av nya terapeu-tiskt användbara karbamoyl-1-(pyridinylalkyl)-lH-indol-5 och -indolinderivat med formeln I och farmaceutiskt godtagbara syraadditionssalter, geometriska och optiska isomerer och racemiska blandningar därav, rO 15 i vilken formel Ri är väte eller lägre alkyl; R4 är lägre alkyl eller fenylmetyl; och den streckade Iinjen betecknar en eventuell bind- 20 ning, kännetecknat därav, att en förening med formeln |Γ~!Ι 25 chra ^ (IV) u 3 N 30 där Ri betecknar samma som ovan, omsätts med ett isocyanat med formeln r4-n=c=o • · 18 104554 där R4 betecknar samma som ovan, i närvaro av en bas i ett lämpligt lösningsmedel. f
2. Förfarande enligt patentkrav 1, k ä n n e - , 5 tecknat därav, att isocyanatet är metylisocyanat, butylisocyanat eller fenylmetylisocyanat.
3. Förfarande enligt patentkrav 1, känne-tecknat därav, att basen är kaliumkarbonat och lös-ningsmedlet är tetrahydrofuran. 10
4. Förfarande enligt patentkrav 1, känne tecknat därav, att man framställer 1-(4-pyridinylmetyl)-lH-indol-5-ylmetylkarbamat, 1-(4-pyridinylmetyl)-lH-indol-5-ylbutylkarbamat eller en hydroklorid därav, 15 1-(4-pyridinylmetyl)-lH-indol-5-ylfenylmetylkar- bamat, 1—[1— (4-pyridinylbutyl) ]-lH-indol-5-ylmetylkarba- mat, eller 1-[1- (4-pyridinylbutyl) ]-lH-indol-5-ylfenylmetyl-20 karbamat. > i • t • ^ ψ • 4 •
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56672490A | 1990-08-13 | 1990-08-13 | |
| US56672490 | 1990-08-13 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI913801A0 FI913801A0 (fi) | 1991-08-09 |
| FI913801A FI913801A (fi) | 1992-02-14 |
| FI104554B true FI104554B (sv) | 2000-02-29 |
Family
ID=24264113
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI913801A FI104554B (sv) | 1990-08-13 | 1991-08-09 | Förfarande för framsällning av nya terapeutiskt användbara karbamoyl-1-(pyridinylalkyl)-1H-indol- och indolinderivat |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP0471298B1 (sv) |
| JP (1) | JPH0670034B2 (sv) |
| KR (1) | KR100215156B1 (sv) |
| AT (1) | ATE129710T1 (sv) |
| AU (1) | AU638158B2 (sv) |
| CA (1) | CA2048931C (sv) |
| CZ (1) | CZ284753B6 (sv) |
| DE (1) | DE69114210T2 (sv) |
| DK (1) | DK0471298T3 (sv) |
| ES (1) | ES2079532T3 (sv) |
| FI (1) | FI104554B (sv) |
| GR (1) | GR3018068T3 (sv) |
| HU (1) | HUT58723A (sv) |
| IE (1) | IE69968B1 (sv) |
| IL (1) | IL99167A (sv) |
| MX (1) | MX9100640A (sv) |
| NO (1) | NO178372C (sv) |
| NZ (1) | NZ239327A (sv) |
| PT (1) | PT98646B (sv) |
| ZA (1) | ZA916340B (sv) |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE787444A (fr) * | 1971-08-13 | 1973-02-12 | Hoffmann La Roche | Composes polycycliques |
| GB2102795A (en) * | 1981-07-31 | 1983-02-09 | Pfizer Ltd | Indole derivatives |
| FR2591595B1 (fr) * | 1985-12-13 | 1988-09-09 | Roussel Uclaf | Nouveaux derives du 4-morpholinyl 1h-indole, leurs sels, procede de preparation, application a titre de medicaments, compositions les renfermant, et intermediaires |
| DE3809155A1 (de) * | 1988-03-18 | 1989-09-28 | Bayer Ag | 1,3,4,5-tetrahydrobenz-(c,d)-indole |
| DK0471296T3 (da) * | 1990-08-13 | 1996-03-11 | Hoechst Roussel Pharma | 1-(Pyridinylalkyl)-1H-indoler, -indoliner og beslægtede analoge |
-
1991
- 1991-08-08 DK DK91113336.1T patent/DK0471298T3/da active
- 1991-08-08 ES ES91113336T patent/ES2079532T3/es not_active Expired - Lifetime
- 1991-08-08 DE DE69114210T patent/DE69114210T2/de not_active Expired - Fee Related
- 1991-08-08 AT AT91113336T patent/ATE129710T1/de not_active IP Right Cessation
- 1991-08-08 EP EP91113336A patent/EP0471298B1/en not_active Expired - Lifetime
- 1991-08-09 FI FI913801A patent/FI104554B/sv not_active IP Right Cessation
- 1991-08-09 NZ NZ23932791A patent/NZ239327A/en unknown
- 1991-08-12 CZ CS912490A patent/CZ284753B6/cs not_active IP Right Cessation
- 1991-08-12 JP JP3201712A patent/JPH0670034B2/ja not_active Expired - Lifetime
- 1991-08-12 CA CA002048931A patent/CA2048931C/en not_active Expired - Fee Related
- 1991-08-12 MX MX9100640A patent/MX9100640A/es not_active IP Right Cessation
- 1991-08-12 HU HU912675A patent/HUT58723A/hu unknown
- 1991-08-12 NO NO913141A patent/NO178372C/no unknown
- 1991-08-12 KR KR1019910013848A patent/KR100215156B1/ko not_active IP Right Cessation
- 1991-08-12 IL IL9916791A patent/IL99167A/en unknown
- 1991-08-12 ZA ZA916340A patent/ZA916340B/xx unknown
- 1991-08-12 AU AU81766/91A patent/AU638158B2/en not_active Expired - Fee Related
- 1991-08-12 IE IE285291A patent/IE69968B1/en not_active IP Right Cessation
- 1991-08-12 PT PT98646A patent/PT98646B/pt not_active IP Right Cessation
-
1995
- 1995-11-10 GR GR950403169T patent/GR3018068T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NZ239327A (en) | 1994-07-26 |
| KR100215156B1 (ko) | 1999-08-16 |
| PT98646A (pt) | 1992-06-30 |
| JPH05125075A (ja) | 1993-05-21 |
| ZA916340B (en) | 1992-04-29 |
| NO913141L (no) | 1992-02-14 |
| DK0471298T3 (da) | 1996-03-04 |
| IE912852A1 (en) | 1992-02-26 |
| CA2048931A1 (en) | 1992-02-14 |
| HUT58723A (en) | 1992-03-30 |
| FI913801A0 (fi) | 1991-08-09 |
| EP0471298A1 (en) | 1992-02-19 |
| ES2079532T3 (es) | 1996-01-16 |
| CS249091A3 (en) | 1992-03-18 |
| HU912675D0 (en) | 1992-01-28 |
| DE69114210D1 (de) | 1995-12-07 |
| NO178372C (no) | 1996-03-13 |
| EP0471298B1 (en) | 1995-11-02 |
| GR3018068T3 (en) | 1996-02-29 |
| DE69114210T2 (de) | 1996-05-02 |
| KR920004378A (ko) | 1992-03-27 |
| CZ284753B6 (cs) | 1999-02-17 |
| JPH0670034B2 (ja) | 1994-09-07 |
| AU638158B2 (en) | 1993-06-17 |
| FI913801A (fi) | 1992-02-14 |
| IL99167A0 (en) | 1992-07-15 |
| IE69968B1 (en) | 1996-10-16 |
| AU8176691A (en) | 1992-02-20 |
| MX9100640A (es) | 1992-04-01 |
| NO178372B (no) | 1995-12-04 |
| PT98646B (pt) | 1999-01-29 |
| NO913141D0 (no) | 1991-08-12 |
| IL99167A (en) | 1995-05-26 |
| ATE129710T1 (de) | 1995-11-15 |
| CA2048931C (en) | 2001-10-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GB | Transfer or assigment of application |
Owner name: HOECHST MARION ROUSSEL, INC. |
|
| MA | Patent expired |