FI104178B1 - 17-spirofuran-3'-ylideenisteroidit - Google Patents

17-spirofuran-3'-ylideenisteroidit

Info

Publication number
FI104178B1
FI104178B1 FI925790A FI925790A FI104178B1 FI 104178 B1 FI104178 B1 FI 104178B1 FI 925790 A FI925790 A FI 925790A FI 925790 A FI925790 A FI 925790A FI 104178 B1 FI104178 B1 FI 104178B1
Authority
FI
Finland
Prior art keywords
lower alkyl
hydrogen
spirofuran
ylidensteroider
acyl
Prior art date
Application number
FI925790A
Other languages
English (en)
Swedish (sv)
Other versions
FI104178B (fi
FI925790A (fi
FI925790A0 (fi
Inventor
Johannes Antonius Mar Hamersma
Everardus Otto Maria Orlemans
Johannes Bernardus Ma Rewinkel
Original Assignee
Akzo Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nv filed Critical Akzo Nv
Publication of FI925790A0 publication Critical patent/FI925790A0/fi
Publication of FI925790A publication Critical patent/FI925790A/fi
Application granted granted Critical
Publication of FI104178B publication Critical patent/FI104178B/fi
Publication of FI104178B1 publication Critical patent/FI104178B1/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/36—Antigestagens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)
FI925790A 1991-12-20 1992-12-18 17-spirofuran-3'-ylideenisteroidit FI104178B1 (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP91203366 1991-12-20
EP91203366 1991-12-20

Publications (4)

Publication Number Publication Date
FI925790A0 FI925790A0 (fi) 1992-12-18
FI925790A FI925790A (fi) 1993-06-21
FI104178B FI104178B (fi) 1999-11-30
FI104178B1 true FI104178B1 (fi) 1999-11-30

Family

ID=8208088

Family Applications (1)

Application Number Title Priority Date Filing Date
FI925790A FI104178B1 (fi) 1991-12-20 1992-12-18 17-spirofuran-3'-ylideenisteroidit

Country Status (17)

Country Link
US (1) US5292878A (fi)
EP (1) EP0549041B1 (fi)
JP (1) JP3462515B2 (fi)
KR (1) KR100287513B1 (fi)
AT (1) ATE128983T1 (fi)
AU (1) AU655858B2 (fi)
CA (1) CA2084431C (fi)
DE (1) DE69205405T2 (fi)
DK (1) DK0549041T3 (fi)
ES (1) ES2081040T3 (fi)
FI (1) FI104178B1 (fi)
GR (1) GR3018630T3 (fi)
HK (1) HK1002033A1 (fi)
MX (1) MX9207394A (fi)
NO (1) NO302525B1 (fi)
NZ (1) NZ245520A (fi)
ZA (1) ZA929315B (fi)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2100514C (en) * 1992-07-29 2005-03-29 Johannes A. M. Hamersma 17-spiromethylene steroids
JP2001523639A (ja) * 1997-11-14 2001-11-27 アクゾ・ノベル・エヌ・ベー プロゲストゲン−抗プロゲストゲンレジメン
US6020328A (en) * 1998-03-06 2000-02-01 Research Triangle Institute 20-keto-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
CA2330611A1 (en) 1998-05-22 1999-12-02 The Board Of Trustees Of The Leland Stanford Junior University Bifunctional molecules and therapies based thereon
US5962444A (en) * 1998-05-29 1999-10-05 Research Triangle Institute 17β-nitro-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
US6262042B1 (en) * 1998-05-29 2001-07-17 Research Triangle Institute 17β-amino and hydroxylamino-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
NZ514895A (en) * 1999-04-29 2004-06-25 Akzo Nobel Nv Use of the anti-progestagen ORG 33245 administrated intermittently with a daily dosage of a progestagen in combined therapy
US6043235A (en) * 1999-07-21 2000-03-28 Research Triangle Institute 11β-aryl-17, 17-spirothiolane-substituted steroids
US7426602B2 (en) * 2004-01-08 2008-09-16 Topside Research, Llc Switch for bus optimization
TW200531977A (en) 2004-03-25 2005-10-01 Akzo Nobel Nv Progesterone receptor modulators
EP1889198B1 (en) 2005-04-28 2014-11-26 Proteus Digital Health, Inc. Pharma-informatics system
JP2009508494A (ja) 2005-09-16 2009-03-05 ラプトール ファーマシューティカル インコーポレイテッド Ｃｒを含むタンパク質に対して特異的な受容体−結合タンパク質（ｒａｐ）変異体を含む組成物およびその使用
SI1989218T1 (sl) * 2006-02-17 2010-04-30 Janssen Pharmaceutica Nv 17- fosforjevi steroidni derivati, koristni kot progesteronski receptorski modulatorji
PT1989217E (pt) 2006-02-17 2012-08-30 Janssen Pharmaceutica Nv Derivados esteróides de 11-fósforo úteis como moduladores de receptor de progesterona
CA2673128C (en) 2006-10-24 2018-07-03 Repros Therapeutics Inc. Compositions and methods for suppressing endometrial proliferation
TWI539953B (zh) 2008-04-28 2016-07-01 瑞波若斯治療學公司 用於治療乳癌之組成物和方法
DK3395372T3 (da) 2009-02-20 2022-04-19 Enhanx Biopharm Inc System til afgivelse af glutathion-baseret medikament
US8673968B2 (en) * 2009-04-06 2014-03-18 Evestra, Inc. Progesterone antagonists
EP2427178B1 (en) 2009-05-06 2023-01-04 Laboratory Skin Care, Inc. Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
CN101926806A (zh) * 2009-06-24 2010-12-29 天津金耀集团有限公司 一种17磷类雌甾化合物在制备紧急避孕药物中的应用
CN102906103A (zh) 2010-03-22 2013-01-30 利普生物药剂公司 用于抗孕酮的非毒性递送的组合物和方法
WO2011157443A1 (en) 2010-06-17 2011-12-22 N.V. Organon (11b,17a)-11-(4-(2-11c-acetyl)phenyl)-17,23-epoxy-19,24-dinorchola-4,9,20-trien-3-one
US9096641B2 (en) 2013-06-05 2015-08-04 Evestra, Inc. Imidazolyl progesterone antagonists

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0116974B1 (de) * 1983-02-18 1986-10-29 Schering Aktiengesellschaft 11-Beta-Aryl-Estradiene, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Präparate
FR2596395B1 (fr) * 1986-03-26 1989-05-26 Roussel Uclaf Nouveaux steroides comportant un cycle spirannique en position 17, leur procede de preparation, leur application comme medicaments et les compositions les renfermant
EP0254341B1 (en) * 1986-07-23 1990-01-03 Akzo N.V. Novel 18-phenyloestrane derivatives
IE60780B1 (en) * 1987-01-23 1994-08-10 Akzo Nv New 11-aryl steroid derivatives
EP0289073B1 (en) * 1987-04-24 1991-11-27 Akzo N.V. Novel 11-aryloestrane and 11-arylpregnane derivatives
ES2053714T3 (es) * 1987-12-12 1994-08-01 Akzo Nv Proceso para la preparacion de 11-arilesteroides.

Also Published As

Publication number Publication date
DK0549041T3 (da) 1996-01-29
NZ245520A (en) 1995-02-24
NO924857D0 (no) 1992-12-15
NO924857L (no) 1993-06-21
HK1002033A1 (en) 1998-07-24
FI104178B (fi) 1999-11-30
CA2084431C (en) 2003-04-08
ES2081040T3 (es) 1996-02-16
US5292878A (en) 1994-03-08
KR100287513B1 (ko) 2001-05-02
ZA929315B (en) 1993-05-24
EP0549041B1 (en) 1995-10-11
MX9207394A (es) 1993-07-30
CA2084431A1 (en) 1993-06-21
AU3009392A (en) 1993-06-24
AU655858B2 (en) 1995-01-12
DE69205405T2 (de) 1996-05-09
FI925790A (fi) 1993-06-21
NO302525B1 (no) 1998-03-16
GR3018630T3 (en) 1996-04-30
DE69205405D1 (de) 1995-11-16
EP0549041A1 (en) 1993-06-30
JPH05255380A (ja) 1993-10-05
FI925790A0 (fi) 1992-12-18
ATE128983T1 (de) 1995-10-15
JP3462515B2 (ja) 2003-11-05

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