FI104178B1 - 17-spirofuran-3'ylidensteroider - Google Patents

17-spirofuran-3'ylidensteroider

Info

Publication number
FI104178B1
FI104178B1 FI925790A FI925790A FI104178B1 FI 104178 B1 FI104178 B1 FI 104178B1 FI 925790 A FI925790 A FI 925790A FI 925790 A FI925790 A FI 925790A FI 104178 B1 FI104178 B1 FI 104178B1
Authority
FI
Finland
Prior art keywords
lower alkyl
hydrogen
spirofuran
ylidensteroider
acyl
Prior art date
Application number
FI925790A
Other languages
English (en)
Finnish (fi)
Other versions
FI104178B (sv
FI925790A (fi
FI925790A0 (fi
Inventor
Johannes Antonius Mar Hamersma
Everardus Otto Maria Orlemans
Johannes Bernardus Ma Rewinkel
Original Assignee
Akzo Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nv filed Critical Akzo Nv
Publication of FI925790A0 publication Critical patent/FI925790A0/fi
Publication of FI925790A publication Critical patent/FI925790A/fi
Application granted granted Critical
Publication of FI104178B publication Critical patent/FI104178B/sv
Publication of FI104178B1 publication Critical patent/FI104178B1/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/36—Antigestagens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
FI925790A 1991-12-20 1992-12-18 17-spirofuran-3'ylidensteroider FI104178B1 (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP91203366 1991-12-20
EP91203366 1991-12-20

Publications (4)

Publication Number Publication Date
FI925790A0 FI925790A0 (fi) 1992-12-18
FI925790A FI925790A (fi) 1993-06-21
FI104178B FI104178B (sv) 1999-11-30
FI104178B1 true FI104178B1 (sv) 1999-11-30

Family

ID=8208088

Family Applications (1)

Application Number Title Priority Date Filing Date
FI925790A FI104178B1 (sv) 1991-12-20 1992-12-18 17-spirofuran-3'ylidensteroider

Country Status (17)

Country Link
US (1) US5292878A (sv)
EP (1) EP0549041B1 (sv)
JP (1) JP3462515B2 (sv)
KR (1) KR100287513B1 (sv)
AT (1) ATE128983T1 (sv)
AU (1) AU655858B2 (sv)
CA (1) CA2084431C (sv)
DE (1) DE69205405T2 (sv)
DK (1) DK0549041T3 (sv)
ES (1) ES2081040T3 (sv)
FI (1) FI104178B1 (sv)
GR (1) GR3018630T3 (sv)
HK (1) HK1002033A1 (sv)
MX (1) MX9207394A (sv)
NO (1) NO302525B1 (sv)
NZ (1) NZ245520A (sv)
ZA (1) ZA929315B (sv)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2100514C (en) * 1992-07-29 2005-03-29 Johannes A. M. Hamersma 17-spiromethylene steroids
NZ504351A (en) * 1997-11-14 2002-10-25 Akzo Nobel Nv Contraceptive kit comprising progestogen and anti-progestogen and use in treating bleeding induced by a progestogen-only contraceptive regimen
US6020328A (en) * 1998-03-06 2000-02-01 Research Triangle Institute 20-keto-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
ATE473759T1 (de) 1998-05-22 2010-07-15 Univ Leland Stanford Junior Bifunktionelle moleküle sowie darauf basierende therapien.
US6262042B1 (en) 1998-05-29 2001-07-17 Research Triangle Institute 17β-amino and hydroxylamino-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
US5962444A (en) * 1998-05-29 1999-10-05 Research Triangle Institute 17β-nitro-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
EP1178807B1 (en) * 1999-04-29 2004-09-29 Akzo Nobel N.V. Use of org 33245 in combined intermittent hormone therapy and contraception
US6043235A (en) * 1999-07-21 2000-03-28 Research Triangle Institute 11β-aryl-17, 17-spirothiolane-substituted steroids
US7426602B2 (en) * 2004-01-08 2008-09-16 Topside Research, Llc Switch for bus optimization
TW200531977A (en) 2004-03-25 2005-10-01 Akzo Nobel Nv Progesterone receptor modulators
CN103259027A (zh) 2005-04-28 2013-08-21 普罗透斯数字保健公司 药物信息系统
JP2009508494A (ja) 2005-09-16 2009-03-05 ラプトール ファーマシューティカル インコーポレイテッド Ｃｒを含むタンパク質に対して特異的な受容体−結合タンパク質（ｒａｐ）変異体を含む組成物およびその使用
AU2007217094A1 (en) * 2006-02-17 2007-08-30 Janssen Pharmaceutica N.V. 11-phosphorous steroid derivatives useful as progesterone receptor modulators
DK1989218T3 (da) * 2006-02-17 2010-04-26 Janssen Pharmaceutica Nv 17-phosphor-steroidderivater, der er anvendelige som progesteronreceptormodulatorer
EP3693376A1 (en) 2006-10-24 2020-08-12 Allergan Pharmaceuticals International Limited Compositions for suppressing endometrial proliferation
TWI539953B (zh) 2008-04-28 2016-07-01 瑞波若斯治療學公司 用於治療乳癌之組成物和方法
PT2398500T (pt) 2009-02-20 2019-06-14 2 Bbb Medicines B V Sistema de entrega de medicamentos à base de glutationas
US8673968B2 (en) * 2009-04-06 2014-03-18 Evestra, Inc. Progesterone antagonists
TWI556839B (zh) 2009-05-06 2016-11-11 研究室護膚股份有限公司 包含活性劑－磷酸鈣粒子複合物之皮膚遞送組成物及其使用方法
CN101926806A (zh) * 2009-06-24 2010-12-29 天津金耀集团有限公司 一种17磷类雌甾化合物在制备紧急避孕药物中的应用
EP2550288A1 (en) 2010-03-22 2013-01-30 Repros Therapeutics Inc. Compositions and methods for non-toxic delivery of antiprogestins
US20130272956A1 (en) * 2010-06-17 2013-10-17 Franciscus Theodorus Leonardus Brands (11beta, 17alpha)-11-(4-(2-11C-ACETYL)PHENYL)-17,23-EPOXY-19,24-DINORCHOLA-4,9,20-TRIEN-3-ONE
US9096641B2 (en) 2013-06-05 2015-08-04 Evestra, Inc. Imidazolyl progesterone antagonists

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3461090D1 (en) * 1983-02-18 1986-12-04 Schering Ag 11-beta-aryl-estradienes, process for their preparation and pharmaceutical compositions containing them
FR2596395B1 (fr) * 1986-03-26 1989-05-26 Roussel Uclaf Nouveaux steroides comportant un cycle spirannique en position 17, leur procede de preparation, leur application comme medicaments et les compositions les renfermant
DE3761308D1 (de) * 1986-07-23 1990-02-08 Akzo Nv 18-phenylestrane-derivate.
IE60780B1 (en) * 1987-01-23 1994-08-10 Akzo Nv New 11-aryl steroid derivatives
DE3866410D1 (de) * 1987-04-24 1992-01-09 Akzo Nv 11-arylestranderivate und 11-arylpregnanderivate.
ES2053714T3 (es) * 1987-12-12 1994-08-01 Akzo Nv Proceso para la preparacion de 11-arilesteroides.

Also Published As

Publication number Publication date
EP0549041B1 (en) 1995-10-11
FI104178B (sv) 1999-11-30
NZ245520A (en) 1995-02-24
CA2084431A1 (en) 1993-06-21
HK1002033A1 (en) 1998-07-24
KR100287513B1 (ko) 2001-05-02
ES2081040T3 (es) 1996-02-16
GR3018630T3 (en) 1996-04-30
CA2084431C (en) 2003-04-08
ZA929315B (en) 1993-05-24
FI925790A (fi) 1993-06-21
EP0549041A1 (en) 1993-06-30
JP3462515B2 (ja) 2003-11-05
JPH05255380A (ja) 1993-10-05
NO924857D0 (no) 1992-12-15
AU655858B2 (en) 1995-01-12
MX9207394A (es) 1993-07-30
NO302525B1 (no) 1998-03-16
DE69205405D1 (de) 1995-11-16
ATE128983T1 (de) 1995-10-15
DK0549041T3 (da) 1996-01-29
FI925790A0 (fi) 1992-12-18
DE69205405T2 (de) 1996-05-09
NO924857L (no) 1993-06-21
AU3009392A (en) 1993-06-24
US5292878A (en) 1994-03-08

Similar Documents

Publication Publication Date Title
FI104178B1 (sv) 17-spirofuran-3'ylidensteroider
DE69416306D1 (de) Sphingoglycolipid und verwendung davon
BR1100621A (pt) Compostos
FI955108A (sv) Steroider som innehåller en 17-spirometylenlakton- eller -laktolgrupp
NO940777D0 (no) Anvendelse av et pregnanderivat
DE69717895D1 (de) Diagnostisches Mittel zur Glykostoffwechselfunktion
ZA907639B (en) Benzanilides
FI823458A0 (fi) Substituerade tiazolidinylestrar av mineralsyror
FR2501676B1 (sv)
ATE72445T1 (de) 4'-epi-4'-aminoanthracycline.
ES2068407T3 (es) Tratamiento de apneas durante el sueño con derivados de azapirona.
IL117497A0 (en) 17-Difluoromethylene estratriene derivatives and pharmaceutical compositions containing the same
ATE73136T1 (de) Verfahren zur herstellung von 6alpha, 9alphadifluor-11beta, 17alpha-dihydroxy-16alpha-methyl4-pregnen-3,20-dion und dessen derivate.
ES463228A1 (es) Procedimiento para preparar quinolinonas
ATE116655T1 (de) 2-acyloxy-4-morpholinyl-anthracyclin.
FI812777L (fi) Foerfarande foer framstaellning av nya cardenolid-bis-digitoxosider
DE69615814D1 (de) Uch-15-verbindungen

Legal Events

Date Code Title Description
PC Transfer of assignment of patent

Owner name: N.V. ORGANON

Free format text: N.V. ORGANON