ES463228A1 - Procedimiento para preparar quinolinonas - Google Patents

Procedimiento para preparar quinolinonas

Info

Publication number
ES463228A1
ES463228A1 ES463228A ES463228A ES463228A1 ES 463228 A1 ES463228 A1 ES 463228A1 ES 463228 A ES463228 A ES 463228A ES 463228 A ES463228 A ES 463228A ES 463228 A1 ES463228 A1 ES 463228A1
Authority
ES
Spain
Prior art keywords
treatment
quinolin
pyrrolo
ones
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES463228A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of ES463228A1 publication Critical patent/ES463228A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Procedimiento para preparar quinolinonas, de fórmula I, **(Fórmula)** En la fórmula I, R1 como grupo alquilo, preferentemente significa el grupo metilo. R1 significa preferentemente hidrógeno o metilo. R2 significa preferentemente cloro o el grupo CF3. R3 significa preferentemente hidrógeno. Particularmente ventajosos son los compuestos 1,2,3,4- tetrahidro-5-trifluorometil-9H-pirrolo[3,4-b] quinolin-9-ona y 7-cloro-1,2,3,4-tetrahidro-4-metil-9H-pirrolo[3,4-b]quinolin- 9-ona.
ES463228A 1976-10-15 1977-10-14 Procedimiento para preparar quinolinonas Expired ES463228A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1308676A CH625521A5 (es) 1976-10-15 1976-10-15

Publications (1)

Publication Number Publication Date
ES463228A1 true ES463228A1 (es) 1979-01-01

Family

ID=4389164

Family Applications (1)

Application Number Title Priority Date Filing Date
ES463228A Expired ES463228A1 (es) 1976-10-15 1977-10-14 Procedimiento para preparar quinolinonas

Country Status (21)

Country Link
US (1) US4235907A (es)
JP (1) JPS5384994A (es)
AT (1) AT367421B (es)
AU (1) AU514226B2 (es)
BE (1) BE859709A (es)
CA (1) CA1104136A (es)
CH (1) CH625521A5 (es)
DE (1) DE2744772A1 (es)
DK (1) DK143802C (es)
ES (1) ES463228A1 (es)
FI (1) FI61313C (es)
FR (1) FR2367765A1 (es)
GB (1) GB1589396A (es)
IE (1) IE46161B1 (es)
IL (1) IL53120A (es)
NL (1) NL7711125A (es)
NZ (1) NZ185419A (es)
PH (1) PH14888A (es)
PT (1) PT67154B (es)
SE (1) SE7711185L (es)
ZA (1) ZA776138B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA72611C2 (uk) 2000-05-17 2005-03-15 Орто-Макнейл Фармацевтикал, Інк. Похідні заміщеного піролопіридинону, корисні як інгібітори фосфодіестерази
ATE368040T1 (de) 2001-11-14 2007-08-15 Ortho Mcneil Pharmaceutical Co Substituierte tetrazyklische pyprolochinolonderivate als phosphodiesterase- inhibitoren
US6800625B2 (en) * 2002-06-19 2004-10-05 Janssen Pharmaceutica N.V. Substituted 2,4-dihydro-pyrrolo[3,4-b]quinolin-9-one derivatives useful as phosphodiesterase inhibitors
CL2008003573A1 (es) * 2008-11-28 2011-02-18 Univ Talca Metodo de sintesis enantioselectiva de intermediarios de beta-carbolina del tipo pirrolo-quinolonas por hidrogenacion con auxiliares quirales de cloroformiato.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2023514A1 (de) * 1970-05-14 1971-12-02 Badische Anilin- & Soda-Fabrik Ag, 6700 Ludwigshafen Verfahren zur Herstellung von 5,6-gamma-Pyridonderivaten
DE2343549A1 (de) * 1973-08-29 1975-03-13 Thiemann Chem Pharm Fab 4-hydroxychinolinverbindungen und solche verbindungen enthaltende arzneimittel
DE2521544A1 (de) 1975-05-15 1976-12-02 Thomae Gmbh Dr K Neue chinoline

Also Published As

Publication number Publication date
IE46161L (en) 1978-04-15
PT67154B (en) 1979-06-07
FR2367765A1 (fr) 1978-05-12
FI61313B (fi) 1982-03-31
FR2367765B1 (es) 1980-04-18
SE7711185L (sv) 1978-04-16
PH14888A (en) 1982-01-08
DK143802B (da) 1981-10-12
IE46161B1 (en) 1983-03-09
ATA736777A (de) 1981-11-15
AU2965977A (en) 1979-04-26
DK443477A (da) 1978-04-16
CH625521A5 (es) 1981-09-30
PT67154A (en) 1977-11-01
AU514226B2 (en) 1981-01-29
AT367421B (de) 1982-07-12
JPS5384994A (en) 1978-07-26
DK143802C (da) 1982-03-29
CA1104136A (en) 1981-06-30
IL53120A (en) 1980-06-30
FI61313C (fi) 1982-07-12
IL53120A0 (en) 1977-12-30
US4235907A (en) 1980-11-25
DE2744772A1 (de) 1978-04-20
FI772955A (fi) 1978-04-16
NZ185419A (en) 1980-08-26
GB1589396A (en) 1981-05-13
ZA776138B (en) 1979-05-30
BE859709A (fr) 1978-04-13
NL7711125A (nl) 1978-04-18

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