FI103971B - Menetelmä terapeuttisesti käyttökelpoisten pyrrolo- ja pyrido£2,3-d|pyrimidinonijohdannaisten valmistamiseksi - Google Patents

Menetelmä terapeuttisesti käyttökelpoisten pyrrolo- ja pyrido£2,3-d|pyrimidinonijohdannaisten valmistamiseksi Download PDF

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Publication number
FI103971B
FI103971B FI924397A FI924397A FI103971B FI 103971 B FI103971 B FI 103971B FI 924397 A FI924397 A FI 924397A FI 924397 A FI924397 A FI 924397A FI 103971 B FI103971 B FI 103971B
Authority
FI
Finland
Prior art keywords
formula
methyl
compound
pyrido
mixture
Prior art date
Application number
FI924397A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI103971B1 (fi
FI924397A0 (fi
FI924397L (fi
Inventor
John Watson Ellingboe
Madelene Nikaido
Jehan Franroz Bagli
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/782,025 external-priority patent/US5149699A/en
Priority claimed from GB9207560A external-priority patent/GB2265899A/en
Priority claimed from US07/901,485 external-priority patent/US5256654A/en
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of FI924397A0 publication Critical patent/FI924397A0/fi
Publication of FI924397L publication Critical patent/FI924397L/fi
Application granted granted Critical
Publication of FI103971B1 publication Critical patent/FI103971B1/fi
Publication of FI103971B publication Critical patent/FI103971B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
FI924397A 1991-10-24 1992-09-30 Menetelmä terapeuttisesti käyttökelpoisten pyrrolo- ja pyrido£2,3-d|pyrimidinonijohdannaisten valmistamiseksi FI103971B (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US78202591 1991-10-24
US07/782,025 US5149699A (en) 1991-10-24 1991-10-24 Substituted pyridopyrimidines useful as antgiotensin II antagonists
GB9207560A GB2265899A (en) 1992-04-07 1992-04-07 Substituted pyrimidines
GB9207560 1992-04-07
US90148592 1992-06-25
US07/901,485 US5256654A (en) 1991-10-24 1992-06-25 Substituted pyrrolopyrimidines, azepinopyrimidines and pyridopyrimidines useful as angiotensin II antagonists

Publications (4)

Publication Number Publication Date
FI924397A0 FI924397A0 (fi) 1992-09-30
FI924397L FI924397L (fi) 1993-04-25
FI103971B1 FI103971B1 (fi) 1999-10-29
FI103971B true FI103971B (fi) 1999-10-29

Family

ID=27266132

Family Applications (1)

Application Number Title Priority Date Filing Date
FI924397A FI103971B (fi) 1991-10-24 1992-09-30 Menetelmä terapeuttisesti käyttökelpoisten pyrrolo- ja pyrido£2,3-d|pyrimidinonijohdannaisten valmistamiseksi

Country Status (21)

Country Link
EP (1) EP0539086B1 (en:Method)
JP (1) JP3240192B2 (en:Method)
KR (1) KR100286624B1 (en:Method)
CN (2) CN1039324C (en:Method)
AT (1) ATE161537T1 (en:Method)
AU (1) AU653635B2 (en:Method)
CA (1) CA2080705C (en:Method)
DE (1) DE69223734T2 (en:Method)
DK (1) DK0539086T3 (en:Method)
ES (1) ES2111617T3 (en:Method)
FI (1) FI103971B (en:Method)
GR (1) GR3025926T3 (en:Method)
HK (1) HK1003031A1 (en:Method)
HU (2) HU218786B (en:Method)
IL (1) IL103436A (en:Method)
LV (1) LV12047B (en:Method)
NO (1) NO301275B1 (en:Method)
SG (1) SG47626A1 (en:Method)
SK (1) SK280292B6 (en:Method)
TW (1) TW226375B (en:Method)
UA (1) UA27748C2 (en:Method)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69233208T2 (de) * 1991-11-18 2004-07-08 E.I. Du Pont De Nemours And Co., Wilmington Tetrazolylphenylborsäureintermediate zur synthese von aii rezeptor antagonisten
DE69415706T2 (de) * 1993-03-24 1999-05-20 American Home Products Corp., Madison, N.J. Substituierte Pyridopyrimidine als Antihypertensiva
DE69507887T2 (de) * 1994-09-20 1999-06-17 Wakunaga Seiyaku K.K., Osaka Verfahren zur herstellung von n-biphenylmethylthiadiazolin derivaten oder deren salzen sowie dafür benötigte zwischen verbindungen
IT1292437B1 (it) * 1997-06-30 1999-02-08 Zambon Spa Processo di orto-metallazione utile per la sintesi di 1 - tetrazol- 5-il) benzeni 2-sostituiti
US6638937B2 (en) 1998-07-06 2003-10-28 Bristol-Myers Squibb Co. Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
AR033390A1 (es) 2000-08-22 2003-12-17 Novartis Ag Una composicion farmaceutica que comprende un antagonista del receptor at1 y un potenciador de la secrecion de insulina, el uso de dicha composicion para la fabricacion de un medicamento y un kit de partes
US8168616B1 (en) 2000-11-17 2012-05-01 Novartis Ag Combination comprising a renin inhibitor and an angiotensin receptor inhibitor for hypertension
US7732162B2 (en) 2003-05-05 2010-06-08 Probiodrug Ag Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
GB0327839D0 (en) 2003-12-01 2003-12-31 Novartis Ag Organic compounds
GB0402262D0 (en) 2004-02-02 2004-03-10 Novartis Ag Process for the manufacture of organic compounds
KR20070006774A (ko) 2004-03-17 2007-01-11 노파르티스 아게 치료에서 레닌 억제제의 용도
CA2580862A1 (en) 2004-10-08 2006-04-20 Novartis Ag Use of renin inhibitors for the prevention or treatment of diastolic dysfunction or diastolic heart failure
EP1749828A1 (en) 2005-08-04 2007-02-07 Farmaprojects S.L. Process for preparing an angiotensin II receptor antagonist
ZA200905537B (en) 2007-03-01 2010-10-27 Probiodrug Ag New use of glutaminyl cyclase inhibitors
JP5667440B2 (ja) 2007-04-18 2015-02-12 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤としてのチオ尿素誘導体
AU2008261102B2 (en) 2007-06-04 2013-11-28 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8034782B2 (en) 2008-07-16 2011-10-11 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
RS54459B1 (sr) * 2007-06-07 2016-06-30 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Derivati 5beta, 14beta androstana korisni za lečenje bolesti nastalih iz fibroze organa
CA2930674A1 (en) 2008-06-04 2009-12-10 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
PL2475428T3 (pl) 2009-09-11 2015-12-31 Probiodrug Ag Pochodne heterocykliczne jako inhibitory cyklazy glutaminowej
ES2586231T3 (es) 2010-03-03 2016-10-13 Probiodrug Ag Inhibidores de glutaminil ciclasa
EA022420B1 (ru) 2010-03-10 2015-12-30 Пробиодруг Аг Гетероциклические ингибиторы глутаминилциклазы (qc, ec 2.3.2.5)
JP5945532B2 (ja) 2010-04-21 2016-07-05 プロビオドルグ エージー グルタミニルシクラーゼの阻害剤としてのベンゾイミダゾール誘導体
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
WO2012123563A1 (en) 2011-03-16 2012-09-20 Probiodrug Ag Benz imidazole derivatives as inhibitors of glutaminyl cyclase
US20130158080A1 (en) 2011-12-15 2013-06-20 Takeda Pharmaceuticals U.S.A., Inc. Methods for treating hypertension in black patients
EP2968439A2 (en) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
AU2014235215A1 (en) 2013-03-15 2015-10-01 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
CN113388007A (zh) 2013-06-05 2021-09-14 博士医疗爱尔兰有限公司 鸟苷酸环化酶c的超纯激动剂、制备和使用所述激动剂的方法
PL3461819T3 (pl) 2017-09-29 2020-11-30 Probiodrug Ag Inhibitory cyklazy glutaminylowej

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0407342A3 (en) * 1989-07-06 1991-07-10 Ciba-Geigy Ag Pyrimidine derivatives
US5100897A (en) * 1989-08-28 1992-03-31 Merck & Co., Inc. Substituted pyrimidinones as angiotensin ii antagonists
EP0415886A3 (en) * 1989-08-30 1991-10-23 Ciba-Geigy Ag Aza compounds
WO1991011999A1 (en) * 1990-02-13 1991-08-22 Merck & Co., Inc. Angiotensin ii antagonists incorporating a substituted benzyl element
IL100917A0 (en) 1991-02-16 1992-11-15 Fisons Plc Pyridinone and pyrimidinone derivatives,their preparation and pharmaceutical compositions containing them
US5149699A (en) * 1991-10-24 1992-09-22 American Home Products Corporation Substituted pyridopyrimidines useful as antgiotensin II antagonists

Also Published As

Publication number Publication date
CA2080705A1 (en) 1993-04-25
JP3240192B2 (ja) 2001-12-17
EP0539086B1 (en) 1997-12-29
SK322192A3 (en) 1999-11-08
IL103436A (en) 1996-03-31
AU2607992A (en) 1993-04-29
SG47626A1 (en) 1998-04-17
HU218786B (hu) 2000-12-28
LV12047A (lv) 1998-05-20
CN1039324C (zh) 1998-07-29
NO924121L (no) 1993-04-26
NO924121D0 (no) 1992-10-23
AU653635B2 (en) 1994-10-06
FI103971B1 (fi) 1999-10-29
DK0539086T3 (da) 1998-02-02
TW226375B (en:Method) 1994-07-11
DE69223734D1 (de) 1998-02-05
KR100286624B1 (ko) 2001-05-02
ATE161537T1 (de) 1998-01-15
DE69223734T2 (de) 1998-04-16
FI924397A0 (fi) 1992-09-30
IL103436A0 (en) 1993-03-15
CN1072682A (zh) 1993-06-02
CN1175414A (zh) 1998-03-11
HU9203161D0 (en) 1992-12-28
ES2111617T3 (es) 1998-03-16
EP0539086A2 (en) 1993-04-28
NO301275B1 (no) 1997-10-06
HUT62893A (en) 1993-06-28
LV12047B (en) 1998-08-20
GR3025926T3 (en) 1998-04-30
CA2080705C (en) 2002-12-03
EP0539086A3 (en) 1993-06-16
HK1003031A1 (en) 1998-09-30
SK280292B6 (sk) 1999-11-08
JPH05222039A (ja) 1993-08-31
UA27748C2 (uk) 2000-10-16
KR930007949A (ko) 1993-05-20
FI924397L (fi) 1993-04-25
HU211915A9 (en) 1996-01-29

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MA Patent expired