FI103112B1 - Menetelmä proteolyyttisen entsyymin inhibiittoreina käyttökelpoisten 2-sakkarinyylimetyyliaryylikarboksylaattien valmistamiseksi - Google Patents
Menetelmä proteolyyttisen entsyymin inhibiittoreina käyttökelpoisten 2-sakkarinyylimetyyliaryylikarboksylaattien valmistamiseksiInfo
- Publication number
- FI103112B1 FI103112B1 FI915163A FI915163A FI103112B1 FI 103112 B1 FI103112 B1 FI 103112B1 FI 915163 A FI915163 A FI 915163A FI 915163 A FI915163 A FI 915163A FI 103112 B1 FI103112 B1 FI 103112B1
- Authority
- FI
- Finland
- Prior art keywords
- inhibitors
- preparation
- proteolytic enzyme
- carboxylates useful
- saccharinylmethylaryl
- Prior art date
Links
- 102000035195 Peptidases Human genes 0.000 title 1
- 108091005804 Peptidases Proteins 0.000 title 1
- 150000007942 carboxylates Chemical class 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
- C07D275/03—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
- C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
- C07F9/6539—Five-membered rings
- C07F9/6541—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI944968A FI944968L (fi) | 1990-11-01 | 1991-11-01 | Menetelmä sakkariinijohdannaisten valmistamiseksi |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60806890A | 1990-11-01 | 1990-11-01 | |
| US60806890 | 1990-11-01 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI915163A0 FI915163A0 (fi) | 1991-11-01 |
| FI915163A7 FI915163A7 (fi) | 1992-05-02 |
| FI103112B FI103112B (fi) | 1999-04-30 |
| FI103112B1 true FI103112B1 (fi) | 1999-04-30 |
Family
ID=24434891
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI915163A FI103112B1 (fi) | 1990-11-01 | 1991-11-01 | Menetelmä proteolyyttisen entsyymin inhibiittoreina käyttökelpoisten 2-sakkarinyylimetyyliaryylikarboksylaattien valmistamiseksi |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0483928A1 (show.php) |
| JP (1) | JPH04273866A (show.php) |
| KR (1) | KR920009807A (show.php) |
| AU (1) | AU642537B2 (show.php) |
| CA (1) | CA2054653A1 (show.php) |
| FI (1) | FI103112B1 (show.php) |
| HU (2) | HUT63399A (show.php) |
| IE (1) | IE913827A1 (show.php) |
| IL (1) | IL99913A (show.php) |
| MX (1) | MX9101861A (show.php) |
| MY (1) | MY131053A (show.php) |
| NO (1) | NO300373B1 (show.php) |
| NZ (1) | NZ240444A (show.php) |
| PT (1) | PT99411B (show.php) |
| RU (1) | RU2114843C1 (show.php) |
| SG (1) | SG69977A1 (show.php) |
| TW (1) | TW221294B (show.php) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR0183397B1 (ko) * | 1989-05-04 | 1999-05-01 | 존 엠. 스피나토 | 단백질 분해 효소 저해제로서 유용한 사카린 유도체들 및 그의 제조방법 |
| US5306818A (en) * | 1990-11-01 | 1994-04-26 | Sterling Winthrop Inc. | Tetrahydro 2-saccharinylmerthyl aryl carboxylates |
| US5512589A (en) * | 1990-11-01 | 1996-04-30 | Sterling Winthrop Inc. | 2-saccharinylmethyl aryl carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof |
| AU656027B2 (en) * | 1991-11-15 | 1995-01-19 | Sanofi | Saccharin derivative proteolytic enzime inhibitors |
| AU668694B2 (en) * | 1991-12-19 | 1996-05-16 | Sanofi-Synthelabo | Saccharin derivative proteolytic enzyme inhibitors |
| US5378720A (en) * | 1991-12-19 | 1995-01-03 | Sterling Winthrop Inc. | Saccharin derivative proteolytic enzyme inhibitors |
| US5187173A (en) * | 1991-12-27 | 1993-02-16 | Sterling Winthrop Inc. | 2-saccharinylmethyl and 4,5,6,7-tetrahydro-2-saccharinylmethyl phosphates, phosphonates and phosphinates useful as proteolytic enzyme inhibitors and compositions and method of use thereof |
| US5296496A (en) * | 1991-12-27 | 1994-03-22 | Sterling Winthrop Inc. | 2-saccharinylmethyl phosphates, phosphonates and phosphinates useful as proteolytic enzyme inhibitors and compositions and method of use thereof |
| TW226016B (show.php) * | 1991-12-30 | 1994-07-01 | Sterling Winthrop Inc | |
| AU653279B2 (en) * | 1991-12-30 | 1994-09-22 | Sanofi | Novel 2-saccharinylmethyl heterocyclic carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof |
| US5684195A (en) * | 1994-07-14 | 1997-11-04 | G. D. Searle & Co. | Method of preparing sulfmonamides from sulfones |
| DE4427996A1 (de) * | 1994-08-08 | 1996-02-15 | Basf Ag | Verfahren zur Herstellung von Saccharincarbonsäuren und -carbonsäureestern |
| DE19533643A1 (de) * | 1995-09-12 | 1997-03-13 | Nycomed Arzneimittel Gmbh | Neue cyclische Derivate von Benzolsulfonamiden |
| MY147790A (en) * | 2005-04-28 | 2013-01-31 | Takeda Pharmaceutical | Stable emulsion composition |
| JP6239458B2 (ja) * | 2014-07-22 | 2017-11-29 | 日本曹達株式会社 | ２−（ベンジルスルフィニル）−１−シクロアルケン−１−カルボン酸エステルの製造方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4276298A (en) * | 1978-03-24 | 1981-06-30 | Merck & Co., Inc. | 2-Aryl-1,2-benzisothiazolinone-1,1-dioxides and their use as selective protease inhibitors |
| DE3617976A1 (de) * | 1986-05-28 | 1988-01-14 | Alter Sa | 1,4-dihydropyridin, verfahren zu dessen herstellung und dessen verwendung in antithrombotischen medikamenten |
| US4783473A (en) * | 1987-09-02 | 1988-11-08 | E. R. Squibb & Sons, Inc. | Geminally substituted cyclic ether carboxylic acids, derivatives thereof, compositions containing same and method of use |
| KR0183397B1 (ko) * | 1989-05-04 | 1999-05-01 | 존 엠. 스피나토 | 단백질 분해 효소 저해제로서 유용한 사카린 유도체들 및 그의 제조방법 |
-
1991
- 1991-10-24 AU AU86083/91A patent/AU642537B2/en not_active Ceased
- 1991-10-30 SG SG1996007579A patent/SG69977A1/en unknown
- 1991-10-30 MX MX9101861A patent/MX9101861A/es not_active IP Right Cessation
- 1991-10-30 EP EP91202809A patent/EP0483928A1/en not_active Withdrawn
- 1991-10-31 PT PT99411A patent/PT99411B/pt not_active IP Right Cessation
- 1991-10-31 HU HU913430A patent/HUT63399A/hu unknown
- 1991-10-31 IL IL9991391A patent/IL99913A/en not_active IP Right Cessation
- 1991-10-31 CA CA002054653A patent/CA2054653A1/en not_active Abandoned
- 1991-11-01 NZ NZ240444A patent/NZ240444A/en unknown
- 1991-11-01 KR KR1019910019381A patent/KR920009807A/ko not_active Ceased
- 1991-11-01 RU SU5010338A patent/RU2114843C1/ru active
- 1991-11-01 NO NO914288A patent/NO300373B1/no unknown
- 1991-11-01 IE IE382791A patent/IE913827A1/en not_active Application Discontinuation
- 1991-11-01 FI FI915163A patent/FI103112B1/fi active
- 1991-11-01 MY MYPI91002030A patent/MY131053A/en unknown
- 1991-11-01 JP JP3288080A patent/JPH04273866A/ja active Pending
- 1991-11-04 TW TW080108649A patent/TW221294B/zh active
-
1995
- 1995-06-29 HU HU95P/P00542P patent/HU211929A9/hu unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HU913430D0 (en) | 1992-01-28 |
| SG69977A1 (en) | 2000-01-25 |
| RU2114843C1 (ru) | 1998-07-10 |
| PT99411B (pt) | 1999-04-30 |
| FI103112B (fi) | 1999-04-30 |
| KR920009807A (ko) | 1992-06-25 |
| MY131053A (en) | 2007-07-31 |
| HUT63399A (en) | 1993-08-30 |
| JPH04273866A (ja) | 1992-09-30 |
| TW221294B (show.php) | 1994-02-21 |
| PT99411A (pt) | 1992-10-30 |
| IE913827A1 (en) | 1992-05-22 |
| EP0483928A1 (en) | 1992-05-06 |
| NO300373B1 (no) | 1997-05-20 |
| AU8608391A (en) | 1992-05-07 |
| IL99913A0 (en) | 1992-08-18 |
| NO914288L (no) | 1992-05-04 |
| NO914288D0 (no) | 1991-11-01 |
| MX9101861A (es) | 1992-07-08 |
| FI915163A0 (fi) | 1991-11-01 |
| HU211929A9 (en) | 1996-01-29 |
| AU642537B2 (en) | 1993-10-21 |
| FI915163A7 (fi) | 1992-05-02 |
| NZ240444A (en) | 1994-06-27 |
| CA2054653A1 (en) | 1992-05-02 |
| IL99913A (en) | 1996-11-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GB | Transfer or assigment of application |
Owner name: SANOFI |