FI102844B1 - Menetelmä valmistaa parannettu terapeuttisesti aktiivinen kudosplasminogeenin aktivaattori - Google Patents

Menetelmä valmistaa parannettu terapeuttisesti aktiivinen kudosplasminogeenin aktivaattori

Info

Publication number
FI102844B1
FI102844B1 FI902066A FI902066A FI102844B1 FI 102844 B1 FI102844 B1 FI 102844B1 FI 902066 A FI902066 A FI 902066A FI 902066 A FI902066 A FI 902066A FI 102844 B1 FI102844 B1 FI 102844B1
Authority
FI
Finland
Prior art keywords
preparation
therapeutically active
tissue plasminogen
improved
active activator
Prior art date
Application number
FI902066A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI102844B (fi
FI902066A0 (fi
Inventor
Yasushi Kawauchi
Toshiyuki Takemoto
Makoto Takayama
Masami Yokota
Masao Kato
Kimio Katsuta
Hiroshi Gushima
Original Assignee
Yamanouchi Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharma Co Ltd filed Critical Yamanouchi Pharma Co Ltd
Publication of FI902066A0 publication Critical patent/FI902066A0/fi
Application granted granted Critical
Publication of FI102844B publication Critical patent/FI102844B/fi
Publication of FI102844B1 publication Critical patent/FI102844B1/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Graft Or Block Polymers (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • External Artificial Organs (AREA)
  • Pens And Brushes (AREA)
  • Fixed Capacitors And Capacitor Manufacturing Machines (AREA)
FI902066A 1987-10-29 1990-04-25 Menetelmä valmistaa parannettu terapeuttisesti aktiivinen kudosplasminogeenin aktivaattori FI102844B1 (fi)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
JP27477087 1987-10-29
JP27477087 1987-10-29
JP32078587 1987-12-18
JP32078587 1987-12-18
JP7012688 1988-03-23
JP7012688 1988-03-23
JP18935188 1988-07-27
JP18935188 1988-07-27
JP8801098 1988-10-28
PCT/JP1988/001098 WO1989003874A1 (en) 1987-10-29 1988-10-28 Novel polypeptide compounds

Publications (3)

Publication Number Publication Date
FI902066A0 FI902066A0 (fi) 1990-04-25
FI102844B FI102844B (fi) 1999-02-26
FI102844B1 true FI102844B1 (fi) 1999-02-26

Family

ID=27465213

Family Applications (1)

Application Number Title Priority Date Filing Date
FI902066A FI102844B1 (fi) 1987-10-29 1990-04-25 Menetelmä valmistaa parannettu terapeuttisesti aktiivinen kudosplasminogeenin aktivaattori

Country Status (10)

Country Link
US (2) US5556621A (ja)
JP (1) JP2534332B2 (ja)
KR (1) KR970005046B1 (ja)
AT (1) ATE125294T1 (ja)
DE (1) DE3854195T2 (ja)
DK (1) DK104390A (ja)
FI (1) FI102844B1 (ja)
HU (2) HU217100B (ja)
NO (1) NO301174B1 (ja)
WO (1) WO1989003874A1 (ja)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2007364A1 (en) * 1989-01-17 1990-07-17 David J. Livingston Gene sequences encoding modified residues situated in the protease domain of tpa
CA2278823A1 (en) 1997-01-29 1998-07-30 Joe M. Mccord Plasminogen activator as an anti-inflammatory agent
KR100613531B1 (ko) 1997-09-22 2006-08-16 도시오 미야타 멕신 단백질

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4753879A (en) * 1984-08-27 1988-06-28 Biogen N.V. Modified tissue plasminogen activators
US5073494A (en) * 1985-04-22 1991-12-17 Genentech, Inc. Human tissue plasminogen activator substituted at position 275 or at positions 275 and 277
EP0199574B1 (en) * 1985-04-22 1991-10-23 Genentech, Inc. Human tissue plasminogen activator mutants, methods and intermediates therefor, and compositions using such mutants
NZ217331A (en) * 1985-08-26 1989-05-29 Lilly Co Eli Tissue plasminogen activator derivatives and genetically engineered product
KR880700856A (ko) * 1985-12-20 1988-04-12 로버어트 에이 아미테이지 조직 플라스미노겐 활성화인자(tpa)상사체
DK43387A (da) * 1986-01-29 1987-07-30 Beecham Group Plc Fibrinolytisk enzym
PT84588B (en) * 1986-04-02 1989-05-09 Beecham Group Plc Process for preparing a fibrinolytic enzyme
DE3886755T3 (de) * 1987-06-30 2005-12-08 Genentech, Inc., South San Francisco Verfahren zur behandlung von gefässkrankheiten.
US4935237A (en) * 1988-03-21 1990-06-19 Genentech, Inc. Processes for the preparation of t-PA mutants
US5094953A (en) * 1988-03-21 1992-03-10 Genentech, Inc. Human tissue plasminogen activator variants
US5037646A (en) * 1988-04-29 1991-08-06 Genentech, Inc. Processes for the treatment of vascular disease
JP2793462B2 (ja) * 1993-02-23 1998-09-03 山陽特殊製鋼株式会社 超耐食Ｎｉ基合金

Also Published As

Publication number Publication date
DE3854195T2 (de) 1995-12-21
JP2534332B2 (ja) 1996-09-11
WO1989003874A1 (en) 1989-05-05
DK104390D0 (da) 1990-04-27
US5739012A (en) 1998-04-14
HU211335A9 (en) 1995-11-28
KR890701732A (ko) 1989-12-21
NO301174B1 (no) 1997-09-22
NO901920L (no) 1990-04-27
HUT58811A (en) 1992-03-30
HU217100B (hu) 1999-11-29
ATE125294T1 (de) 1995-08-15
DE3854195D1 (de) 1995-08-24
HU886304D0 (en) 1991-11-28
KR970005046B1 (ko) 1997-04-11
FI102844B (fi) 1999-02-26
NO901920D0 (no) 1990-04-27
JPH02167076A (ja) 1990-06-27
FI902066A0 (fi) 1990-04-25
US5556621A (en) 1996-09-17
DK104390A (da) 1990-06-21

Similar Documents

Publication Publication Date Title
CA1158551A (en) Plasminogen preparations
EP0217379A3 (en) Thrombolytic composition and a process for production thereof
ZA909854B (en) Proteins and nucleic acids
FI925787A (fi) Proteolytiska enzymers sackarinderivatinhibitorer
ES8101385A1 (es) Un procedimiento para la preparacion de un derivado de una enzima fibrinolitica
NO880774L (no) Fremgangsmaate for fremstilling av terapeutisk akive mettede fettsyreamider.
EP0278696A3 (en) An arg-serpin human plasminogen activator inhibitor designated pai-2
ES8800601A1 (es) Un procedimiento para preparar una formulacion farmaceutica liofilizada de activador de plasminogeno de tejidro (t-pa)
DK167738B1 (da) Fremgangsmaade til fremstilling af en oploesning med hoej specifik rumfangsaktivitet af et protein med vaevs-plasminogenaktivator(t-pa)-aktivitet, oploesning der indeholder protein med t-pa-aktivitet, og anvendelsen af oploesningen inden for human- og veterinaermedicinen
SE8701921L (sv) Ny farmaceutisk anvendning
ATE108206T1 (de) Gewebe-plasminogenaktivator.
NO954778L (no) Ekspresjon av urokinase plasminogen aktivator inhibitorer
GB1533205A (en) Plasmin fractions and complexes thereof
FI102844B1 (fi) Menetelmä valmistaa parannettu terapeuttisesti aktiivinen kudosplasminogeenin aktivaattori
ES8501438A1 (es) Un procedimiento para preparar un derivado del complejo activador de plasminogeno humano-estreptoquinasa.
Sherry Thrombolytic therapy in acute myocardial infarction: a perspective
DE3888619D1 (de) Modifizierter Gewebeplasminogenaktivator.
EP0326013A3 (en) Novel proteins derived from human alpha2-plasmin inhibitor or proteins similar thereto
EP0386240A4 (en) Novel polypeptide compounds
Fräki et al. Human skin proteases
Heimburger The mechanism of action of sstreptokinase.
DE3685416D1 (de) Mittel aus einem plasmin-inhibitor und einem plasminogen-aktivator zur behandlung von thrombosen.
RU95115761A (ru) 4-(n,n,n-триметиламино)-циннамоильные производные фибринолитических ферментов в качестве пролонгированного тромболитического средства и способ их получения

Legal Events

Date Code Title Description
MM Patent lapsed

Owner name: YAMANOUCHI PHARMACEUTICAL CO., LTD.