DK104390A - Vaevs-plasminogen aktivatorforbindelse, dna, der koder herfor, udtrykkelsesvektor indeholdende dette dna, vaertsceller transformeret med udtrykkelsesvektoren, fremgangsmaade til fremstilling af aktivatoren og farmaceutisk praeparat indeholdende denne - Google Patents
Vaevs-plasminogen aktivatorforbindelse, dna, der koder herfor, udtrykkelsesvektor indeholdende dette dna, vaertsceller transformeret med udtrykkelsesvektoren, fremgangsmaade til fremstilling af aktivatoren og farmaceutisk praeparat indeholdende denne Download PDFInfo
- Publication number
- DK104390A DK104390A DK104390A DK104390A DK104390A DK 104390 A DK104390 A DK 104390A DK 104390 A DK104390 A DK 104390A DK 104390 A DK104390 A DK 104390A DK 104390 A DK104390 A DK 104390A
- Authority
- DK
- Denmark
- Prior art keywords
- prepared
- expression vector
- dna
- vaevs
- processed
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Graft Or Block Polymers (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Adhesives Or Adhesive Processes (AREA)
- External Artificial Organs (AREA)
- Pens And Brushes (AREA)
- Fixed Capacitors And Capacitor Manufacturing Machines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP27477087 | 1987-10-29 | ||
JP32078587 | 1987-12-18 | ||
JP7012688 | 1988-03-23 | ||
JP18935188 | 1988-07-27 | ||
PCT/JP1988/001098 WO1989003874A1 (en) | 1987-10-29 | 1988-10-28 | Novel polypeptide compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
DK104390D0 DK104390D0 (da) | 1990-04-27 |
DK104390A true DK104390A (da) | 1990-06-21 |
Family
ID=27465213
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK104390A DK104390A (da) | 1987-10-29 | 1990-04-27 | Vaevs-plasminogen aktivatorforbindelse, dna, der koder herfor, udtrykkelsesvektor indeholdende dette dna, vaertsceller transformeret med udtrykkelsesvektoren, fremgangsmaade til fremstilling af aktivatoren og farmaceutisk praeparat indeholdende denne |
Country Status (10)
Country | Link |
---|---|
US (2) | US5556621A (ja) |
JP (1) | JP2534332B2 (ja) |
KR (1) | KR970005046B1 (ja) |
AT (1) | ATE125294T1 (ja) |
DE (1) | DE3854195T2 (ja) |
DK (1) | DK104390A (ja) |
FI (1) | FI102844B1 (ja) |
HU (2) | HU217100B (ja) |
NO (1) | NO301174B1 (ja) |
WO (1) | WO1989003874A1 (ja) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2007364A1 (en) * | 1989-01-17 | 1990-07-17 | David J. Livingston | Gene sequences encoding modified residues situated in the protease domain of tpa |
US6497877B1 (en) | 1997-01-29 | 2002-12-24 | University Technology Corporation | Plasminogen activator as an anti-inflammatory agent |
CA2303762A1 (en) | 1997-09-22 | 1999-04-01 | Toshio Miyata | Megsin protein |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4753879A (en) * | 1984-08-27 | 1988-06-28 | Biogen N.V. | Modified tissue plasminogen activators |
ATE68825T1 (de) * | 1985-04-22 | 1991-11-15 | Genentech Inc | Plasminogenaktivator-mutante des menschlichen gewebes, verfahren und zwischenprodukte dafuer und diese mutante verwendende zusammensetzungen. |
US5073494A (en) * | 1985-04-22 | 1991-12-17 | Genentech, Inc. | Human tissue plasminogen activator substituted at position 275 or at positions 275 and 277 |
NZ217331A (en) * | 1985-08-26 | 1989-05-29 | Lilly Co Eli | Tissue plasminogen activator derivatives and genetically engineered product |
KR950000303B1 (ko) * | 1985-12-20 | 1995-01-13 | 디 엎죤 캄파니 | 조직 플라스미노겐 활성화 인자(tpa) 상사체를 제조하는 방법 |
DK43387A (da) * | 1986-01-29 | 1987-07-30 | Beecham Group Plc | Fibrinolytisk enzym |
AU7090887A (en) * | 1986-04-02 | 1987-10-08 | Beecham Group Plc | Plasminogen activators modified in first kringle domain |
JPH02504102A (ja) * | 1987-06-30 | 1990-11-29 | ジェネンテク,インコーポレイテッド | 血管障害治療のための改良法 |
US4935237A (en) * | 1988-03-21 | 1990-06-19 | Genentech, Inc. | Processes for the preparation of t-PA mutants |
US5094953A (en) * | 1988-03-21 | 1992-03-10 | Genentech, Inc. | Human tissue plasminogen activator variants |
US5037646A (en) * | 1988-04-29 | 1991-08-06 | Genentech, Inc. | Processes for the treatment of vascular disease |
JP2793462B2 (ja) * | 1993-02-23 | 1998-09-03 | 山陽特殊製鋼株式会社 | 超耐食Ni基合金 |
-
1988
- 1988-10-28 WO PCT/JP1988/001098 patent/WO1989003874A1/ja active IP Right Grant
- 1988-10-28 HU HU886304A patent/HU217100B/hu not_active IP Right Cessation
- 1988-10-28 JP JP63272020A patent/JP2534332B2/ja not_active Expired - Lifetime
- 1988-10-28 KR KR1019890701197A patent/KR970005046B1/ko not_active IP Right Cessation
- 1988-10-28 AT AT88909384T patent/ATE125294T1/de not_active IP Right Cessation
- 1988-10-28 DE DE3854195T patent/DE3854195T2/de not_active Expired - Lifetime
-
1990
- 1990-04-25 FI FI902066A patent/FI102844B1/fi not_active IP Right Cessation
- 1990-04-27 DK DK104390A patent/DK104390A/da not_active Application Discontinuation
- 1990-04-27 NO NO901920A patent/NO301174B1/no not_active IP Right Cessation
-
1994
- 1994-05-04 US US08/237,249 patent/US5556621A/en not_active Expired - Fee Related
-
1995
- 1995-06-30 HU HU95P/P00671P patent/HU211335A9/hu unknown
-
1996
- 1996-09-10 US US08/712,999 patent/US5739012A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
KR970005046B1 (ko) | 1997-04-11 |
DE3854195T2 (de) | 1995-12-21 |
HU211335A9 (en) | 1995-11-28 |
FI102844B (fi) | 1999-02-26 |
HU886304D0 (en) | 1991-11-28 |
DE3854195D1 (de) | 1995-08-24 |
FI902066A0 (fi) | 1990-04-25 |
US5556621A (en) | 1996-09-17 |
JP2534332B2 (ja) | 1996-09-11 |
NO301174B1 (no) | 1997-09-22 |
FI102844B1 (fi) | 1999-02-26 |
HUT58811A (en) | 1992-03-30 |
KR890701732A (ko) | 1989-12-21 |
WO1989003874A1 (en) | 1989-05-05 |
DK104390D0 (da) | 1990-04-27 |
HU217100B (hu) | 1999-11-29 |
NO901920D0 (no) | 1990-04-27 |
ATE125294T1 (de) | 1995-08-15 |
US5739012A (en) | 1998-04-14 |
NO901920L (no) | 1990-04-27 |
JPH02167076A (ja) | 1990-06-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
AHB | Application shelved due to non-payment |