FI102066B1 - Menetelmä farmakologisesti aktiivisen 2,5,6,7-tetranor-4,8-inter-m-fenyleeni-PGI2-johdannaisen valmistamiseksi sekä välituote - Google Patents

Menetelmä farmakologisesti aktiivisen 2,5,6,7-tetranor-4,8-inter-m-fenyleeni-PGI2-johdannaisen valmistamiseksi sekä välituote

Info

Publication number
FI102066B1
FI102066B1 FI892949A FI892949A FI102066B1 FI 102066 B1 FI102066 B1 FI 102066B1 FI 892949 A FI892949 A FI 892949A FI 892949 A FI892949 A FI 892949A FI 102066 B1 FI102066 B1 FI 102066B1
Authority
FI
Finland
Prior art keywords
tetranor
inter
preparation
pharmacologically active
phenylene pgi2
Prior art date
Application number
FI892949A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI102066B (fi
FI892949A (fi
FI892949A0 (fi
Inventor
Kiyotaka Ohno
Toshiya Takahashi
Atsushi Ohtake
Hisanori Wakita
Shintaro Nishio
Original Assignee
Toray Industries
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries filed Critical Toray Industries
Publication of FI892949A publication Critical patent/FI892949A/fi
Publication of FI892949A0 publication Critical patent/FI892949A0/fi
Application granted granted Critical
Publication of FI102066B publication Critical patent/FI102066B/fi
Publication of FI102066B1 publication Critical patent/FI102066B1/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
FI892949A 1987-10-16 1989-06-15 Menetelmä farmakologisesti aktiivisen 2,5,6,7-tetranor-4,8-inter-m-fenyleeni-PGI2-johdannaisen valmistamiseksi sekä välituote FI102066B1 (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP26202187 1987-10-16
JP26202187 1987-10-16
JP8801048 1988-10-14
PCT/JP1988/001048 WO1989003387A1 (fr) 1987-10-16 1988-10-14 DERIVES DE 2,5,6,7-TETRANOR-4,8-INTER-m-PHENYLENE-PGI2, LEUR PROCEDE DE PREPARATION ET LEUR UTILISATION

Publications (4)

Publication Number Publication Date
FI892949A FI892949A (fi) 1989-06-15
FI892949A0 FI892949A0 (fi) 1989-06-15
FI102066B FI102066B (fi) 1998-10-15
FI102066B1 true FI102066B1 (fi) 1998-10-15

Family

ID=17369918

Family Applications (1)

Application Number Title Priority Date Filing Date
FI892949A FI102066B1 (fi) 1987-10-16 1989-06-15 Menetelmä farmakologisesti aktiivisen 2,5,6,7-tetranor-4,8-inter-m-fenyleeni-PGI2-johdannaisen valmistamiseksi sekä välituote

Country Status (8)

Country Link
US (1) US5401768A (fr)
EP (1) EP0365678B1 (fr)
KR (1) KR960016541B1 (fr)
DE (1) DE3886936T2 (fr)
DK (1) DK296289A (fr)
FI (1) FI102066B1 (fr)
NO (1) NO174668C (fr)
WO (1) WO1989003387A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5589615A (en) * 1988-10-14 1996-12-31 Plant Genetic Systems N.V. Process for the production of transgenic plants with increased nutritional value via the expression of modified 2S storage albumins
KR960016542B1 (ko) * 1989-03-14 1996-12-14 토레이 가부시기가이샤 2,5,6,7-테트라놀-4,8-인터-m-페닐렌 PGI₂유도체, 이것의 제조 방법 및 이를 함유하는 약제
US5403867A (en) * 1992-02-07 1995-04-04 Kaken Pharmaceutical Co., Ltd. Preparation for treating wounds or hemorrhoids
ES2171742T3 (es) * 1995-11-14 2002-09-16 Toray Industries Agente reductor de la presion ocular.
CA2303343C (fr) * 1997-09-16 2011-01-04 Toray Industries, Inc. Inhibiteur de la production de chemokine c-c
EP0970697A4 (fr) * 1997-09-17 2001-02-21 Toray Industries Agent de maturation cervical
EP1044972A4 (fr) * 1998-10-23 2003-03-12 Toray Industries DERIVE PGI2 DE 5,6,7-TRINOR-4,8-INTER-m-PHENYLENE ET MEDICAMENTS CONTENANT LEDIT DERIVE
ATE306256T1 (de) 1999-08-05 2005-10-15 Teijin Ltd Mittel zur besserung der neuropathie, die als wirkstoff stickstoffhaltige verbindungen enthalten
WO2014015247A1 (fr) 2012-07-19 2014-01-23 Cayman Chemical Company, Inc. Composés de difluorolactame comme agonistes sélectifs du récepteur ep4, destinés à être utilisés dans le traitement de maladies et d'affections médiées par ep4

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5732277A (en) * 1980-08-05 1982-02-20 Toray Ind Inc 5,6,7-trinor-4,8-inter-m-phenylene pgi2 derivative
JPS57144276A (en) * 1981-03-03 1982-09-06 Toray Ind Inc 5,6,7-trinor-4,8-inter-m-phenylene pgi2 derivative
US4880939A (en) * 1986-12-11 1989-11-14 Toray Industries 2,5,6,7-tetranor-18,18,19,19-tetradehydro-4,8-inter-m-phenylene PGI2 derivatives
IL81215A (en) * 1987-01-09 1990-11-29 Israel Defence Two axis rate gyroscope

Also Published As

Publication number Publication date
NO174668B (no) 1994-03-07
KR960016541B1 (en) 1996-12-14
FI102066B (fi) 1998-10-15
DE3886936T2 (de) 1994-04-28
EP0365678A4 (fr) 1990-02-20
EP0365678A1 (fr) 1990-05-02
FI892949A (fi) 1989-06-15
DK296289A (da) 1989-08-01
FI892949A0 (fi) 1989-06-15
DK296289D0 (da) 1989-06-15
WO1989003387A1 (fr) 1989-04-20
US5401768A (en) 1995-03-28
NO892499D0 (no) 1989-06-15
DE3886936D1 (de) 1994-02-17
NO174668C (no) 1994-06-15
NO892499L (no) 1989-08-16
KR890701576A (ko) 1989-12-21
EP0365678B1 (fr) 1994-01-05

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Legal Events

Date Code Title Description
MM Patent lapsed

Owner name: TORAY INDUSTRIES, INC.