FI101378B1 - Funktionalisoituja kelatoivia polyamiineja ja niiden rodiumkomplekseja sekä menetelmä rodiumkompleksien valmistamiseksi - Google Patents
Funktionalisoituja kelatoivia polyamiineja ja niiden rodiumkomplekseja sekä menetelmä rodiumkompleksien valmistamiseksiInfo
- Publication number
- FI101378B1 FI101378B1 FI883046A FI883046A FI101378B1 FI 101378 B1 FI101378 B1 FI 101378B1 FI 883046 A FI883046 A FI 883046A FI 883046 A FI883046 A FI 883046A FI 101378 B1 FI101378 B1 FI 101378B1
- Authority
- FI
- Finland
- Prior art keywords
- rhodium complexes
- preparation
- rhodium
- complexes
- functionalized chelating
- Prior art date
Links
- 150000003283 rhodium Chemical class 0.000 title abstract 3
- 229920000768 polyamine Polymers 0.000 title abstract 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 abstract 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 abstract 1
- 229910052703 rhodium Inorganic materials 0.000 abstract 1
- 239000010948 rhodium Substances 0.000 abstract 1
- MHOVAHRLVXNVSD-UHFFFAOYSA-N rhodium atom Chemical compound [Rh] MHOVAHRLVXNVSD-UHFFFAOYSA-N 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C263/00—Preparation of derivatives of isocyanic acid
- C07C263/10—Preparation of derivatives of isocyanic acid by reaction of amines with carbonyl halides, e.g. with phosgene
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6887—Antibody-chelate conjugates using chelates for therapeutic purposes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0073—Rhodium compounds
- C07F15/008—Rhodium compounds without a metal-carbon linkage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Inorganic Compounds Of Heavy Metals (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/065,739 US4994560A (en) | 1987-06-24 | 1987-06-24 | Functionalized polyamine chelants and radioactive rhodium complexes thereof for conjugation to antibodies |
US6573987 | 1987-06-24 |
Publications (4)
Publication Number | Publication Date |
---|---|
FI883046A0 FI883046A0 (fi) | 1988-06-23 |
FI883046A FI883046A (fi) | 1988-12-25 |
FI101378B FI101378B (fi) | 1998-06-15 |
FI101378B1 true FI101378B1 (fi) | 1998-06-15 |
Family
ID=22064774
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI883046A FI101378B1 (fi) | 1987-06-24 | 1988-06-23 | Funktionalisoituja kelatoivia polyamiineja ja niiden rodiumkomplekseja sekä menetelmä rodiumkompleksien valmistamiseksi |
Country Status (19)
Country | Link |
---|---|
US (2) | US4994560A (fr) |
EP (1) | EP0296522B1 (fr) |
JP (1) | JP2728437B2 (fr) |
KR (1) | KR970011005B1 (fr) |
CN (1) | CN1022839C (fr) |
AT (1) | ATE143364T1 (fr) |
CA (1) | CA1341349C (fr) |
DE (1) | DE3855564T2 (fr) |
DK (1) | DK343288A (fr) |
ES (1) | ES2091746T3 (fr) |
FI (1) | FI101378B1 (fr) |
GR (1) | GR3021537T3 (fr) |
HK (1) | HK1006168A1 (fr) |
HU (1) | HU201333B (fr) |
IL (1) | IL86835A (fr) |
NO (1) | NO178928C (fr) |
NZ (1) | NZ225070A (fr) |
PT (1) | PT87802B (fr) |
ZA (1) | ZA884545B (fr) |
Families Citing this family (105)
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DE353450T1 (de) * | 1988-06-24 | 1990-09-06 | The Dow Chemical Co., Midland, Mich. | Macrocyclische bifunktionelle chelatbildner, komplexe davon und ihre konjugierten antikoerper. |
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BR8907282A (pt) * | 1988-12-23 | 1991-03-12 | Dow Chemical Co | Processo para preparar complexos de metal funcionalizados com isotiocianato |
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CN110818795B (zh) | 2020-01-10 | 2020-04-24 | 上海复宏汉霖生物技术股份有限公司 | 抗tigit抗体和使用方法 |
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DE2803528C2 (de) * | 1977-03-09 | 1984-10-18 | Tabushi, Iwao, Kyoto | Schwermetallionen-Adsorbens und dessen Verwendung zum Adsorbieren von Schwermetallionen |
US4622420A (en) * | 1980-03-18 | 1986-11-11 | The Regents Of The University Of California | Chelating agents and method |
US4454106A (en) * | 1982-06-07 | 1984-06-12 | Gansow Otto A | Use of metal chelate conjugated monoclonal antibodies |
US4479930A (en) * | 1982-07-26 | 1984-10-30 | Trustees Of The University Of Massachusetts | Amines coupled wth dicyclic dianhydrides capable of being radiolabeled product |
US4615876A (en) * | 1983-04-25 | 1986-10-07 | Curators Of The University Of Missouri | Macrocyclic complexes of technetium-99m for use as diagnostic radionuclides |
US4678667A (en) * | 1985-07-02 | 1987-07-07 | 501 Regents of the University of California | Macrocyclic bifunctional chelating agents |
US4885363A (en) * | 1987-04-24 | 1989-12-05 | E. R. Squibb & Sons, Inc. | 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs |
GB8603537D0 (en) * | 1986-02-13 | 1986-03-19 | Parker D | Conjugate compound |
US5057302A (en) * | 1987-02-13 | 1991-10-15 | Abbott Laboratories | Bifunctional chelating agents |
US5006643A (en) * | 1987-06-24 | 1991-04-09 | The Dow Chemical Company | Process for preparing isothiocyanato functionalized metal complexes |
-
1987
- 1987-06-24 US US07/065,739 patent/US4994560A/en not_active Expired - Fee Related
-
1988
- 1988-06-15 CA CA000569508A patent/CA1341349C/fr not_active Expired - Fee Related
- 1988-06-17 NZ NZ225070A patent/NZ225070A/xx unknown
- 1988-06-20 EP EP88109799A patent/EP0296522B1/fr not_active Expired - Lifetime
- 1988-06-20 DE DE3855564T patent/DE3855564T2/de not_active Expired - Fee Related
- 1988-06-20 AT AT88109799T patent/ATE143364T1/de not_active IP Right Cessation
- 1988-06-20 ES ES88109799T patent/ES2091746T3/es not_active Expired - Lifetime
- 1988-06-22 DK DK343288A patent/DK343288A/da not_active Application Discontinuation
- 1988-06-22 IL IL8683588A patent/IL86835A/en not_active IP Right Cessation
- 1988-06-23 PT PT87802A patent/PT87802B/pt not_active IP Right Cessation
- 1988-06-23 HU HU883188A patent/HU201333B/hu not_active IP Right Cessation
- 1988-06-23 FI FI883046A patent/FI101378B1/fi not_active IP Right Cessation
- 1988-06-23 NO NO882784A patent/NO178928C/no not_active IP Right Cessation
- 1988-06-24 JP JP63155058A patent/JP2728437B2/ja not_active Expired - Fee Related
- 1988-06-24 CN CN88104543A patent/CN1022839C/zh not_active Expired - Fee Related
- 1988-06-24 ZA ZA884545A patent/ZA884545B/xx unknown
- 1988-06-24 KR KR1019880007673A patent/KR970011005B1/ko not_active IP Right Cessation
-
1990
- 1990-11-28 US US07/619,153 patent/US5284644A/en not_active Expired - Lifetime
-
1996
- 1996-11-06 GR GR960402911T patent/GR3021537T3/el unknown
-
1998
- 1998-06-13 HK HK98105268A patent/HK1006168A1/xx not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM | Patent lapsed |
Owner name: THE DOW CHEMICAL COMPANY |