ES8802487A1 - Un procedimiento para la preparacion de derivados de fenetanolamina - Google Patents

Un procedimiento para la preparacion de derivados de fenetanolamina

Info

Publication number
ES8802487A1
ES8802487A1 ES557414A ES557414A ES8802487A1 ES 8802487 A1 ES8802487 A1 ES 8802487A1 ES 557414 A ES557414 A ES 557414A ES 557414 A ES557414 A ES 557414A ES 8802487 A1 ES8802487 A1 ES 8802487A1
Authority
ES
Spain
Prior art keywords
compounds
image
general formula
hydrogen atom
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES557414A
Other languages
English (en)
Other versions
ES557414A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of ES8802487A1 publication Critical patent/ES8802487A1/es
Publication of ES557414A0 publication Critical patent/ES557414A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

LOS DERIVADOS DE FENETANOLAMINA (I), DONDE R ES HIDROGENO O ALQUILO C1-3 DE CADENA LINEAL Y N ES 1 O 3; SE OBTIENEN POR REACCION DE UN COMPUESTO (II) CON UNA AMINA (V), DONDE R6 ES UN GRUPO TIPO (III) O (IV), R2, R3, R4 Y R5 SON HIDROGENO O UN GRUPO PROTECTOR Y X ES UN GRUPO FACILMENTE DESPLAZABLE, EN PRESENCIA O NO DE UN DISOLVENTE COMO ETANOL O CLOROFORMO Y DE UNA BASE, COMO CARBONATO E HIDROXIDO SODICO, O EXCESO DE AMINA (V), CON ELIMINACION DE LOS GRUPOS PROTECTORES PRESENTES. PRESENTAN ACTIVIDAD CARDIOTONICA Y VASODILATADORA POR LO QUE SON APLICABLES EN EL TRATAMIENTO DE LA INSUFICIENCIA CARDIACA, SHOCK CARDIOGENICO O ISQUEMIA CARDIACA. *FORMULA+
ES557414A 1984-08-09 1987-02-16 Un procedimiento para la preparacion de derivados de fenetanolamina Expired ES8802487A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB848420303A GB8420303D0 (en) 1984-08-09 1984-08-09 Chemical compounds

Publications (2)

Publication Number Publication Date
ES8802487A1 true ES8802487A1 (es) 1988-07-01
ES557414A0 ES557414A0 (es) 1988-07-01

Family

ID=10565130

Family Applications (5)

Application Number Title Priority Date Filing Date
ES546010A Expired ES8703829A1 (es) 1984-08-09 1985-08-08 Un procedimiento para la preparacion de derivados de fenetanolamina.
ES552097A Expired ES8801783A1 (es) 1984-08-09 1986-02-17 Un procedimiento para la preparacion de derivados de fenetanolamina
ES557414A Expired ES8802487A1 (es) 1984-08-09 1987-02-16 Un procedimiento para la preparacion de derivados de fenetanolamina
ES557415A Expired ES8802488A1 (es) 1984-08-09 1987-02-16 Un procedimiento para la preparacion de derivados de fenetanolamina
ES557416A Expired ES8801784A1 (es) 1984-08-09 1987-02-16 Un procedimiento para la preparacion de derivados de fenetanolamina

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES546010A Expired ES8703829A1 (es) 1984-08-09 1985-08-08 Un procedimiento para la preparacion de derivados de fenetanolamina.
ES552097A Expired ES8801783A1 (es) 1984-08-09 1986-02-17 Un procedimiento para la preparacion de derivados de fenetanolamina

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES557415A Expired ES8802488A1 (es) 1984-08-09 1987-02-16 Un procedimiento para la preparacion de derivados de fenetanolamina
ES557416A Expired ES8801784A1 (es) 1984-08-09 1987-02-16 Un procedimiento para la preparacion de derivados de fenetanolamina

Country Status (24)

Country Link
JP (1) JPS6183154A (es)
KR (1) KR860001783A (es)
AU (1) AU4590885A (es)
BE (1) BE903041A (es)
CH (1) CH667870A5 (es)
DE (1) DE3528700A1 (es)
DK (1) DK364185A (es)
ES (5) ES8703829A1 (es)
FI (1) FI853057L (es)
FR (1) FR2568874B1 (es)
GB (2) GB8420303D0 (es)
GR (1) GR851949B (es)
HU (1) HU196171B (es)
IL (1) IL76062A (es)
IT (1) IT1184685B (es)
LU (1) LU86038A1 (es)
MY (1) MY102187A (es)
NL (1) NL8502212A (es)
NO (1) NO853151L (es)
NZ (1) NZ213055A (es)
PH (1) PH21664A (es)
PT (1) PT80936B (es)
SE (1) SE8503763L (es)
ZA (1) ZA856021B (es)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1165845A (fr) * 1955-05-28 1958-10-29 Philips Nv Amines secondaires portant des substituants et leur préparation
EP0021636B1 (en) * 1979-06-16 1982-12-01 Beecham Group Plc Secondary amines, their preparation and use in pharmaceutical compositions

Also Published As

Publication number Publication date
ES8801783A1 (es) 1988-02-16
ZA856021B (en) 1986-05-28
BE903041A (fr) 1986-02-10
FI853057L (fi) 1986-02-10
ES552097A0 (es) 1988-02-16
ES557414A0 (es) 1988-07-01
IL76062A0 (en) 1985-12-31
ES8801784A1 (es) 1988-02-16
FR2568874A1 (fr) 1986-02-14
SE8503763L (sv) 1986-02-10
DK364185D0 (da) 1985-08-09
GB2162845A (en) 1986-02-12
GB2162845B (en) 1988-06-08
ES557415A0 (es) 1988-07-01
LU86038A1 (fr) 1986-09-11
DE3528700A1 (de) 1986-03-06
SE8503763D0 (sv) 1985-08-09
IL76062A (en) 1989-07-31
GR851949B (es) 1985-12-11
ES8802488A1 (es) 1988-07-01
FI853057A0 (fi) 1985-08-09
ES546010A0 (es) 1987-03-01
GB8420303D0 (en) 1984-09-12
NO853151L (no) 1986-02-10
GB8520111D0 (en) 1985-09-18
ES8703829A1 (es) 1987-03-01
HUT39149A (en) 1986-08-28
JPS6183154A (ja) 1986-04-26
PH21664A (en) 1988-01-13
DK364185A (da) 1986-02-10
NZ213055A (en) 1988-11-29
KR860001783A (ko) 1986-03-22
CH667870A5 (fr) 1988-11-15
PT80936A (en) 1985-09-01
NL8502212A (nl) 1986-03-03
ES557416A0 (es) 1988-02-16
FR2568874B1 (fr) 1988-09-09
MY102187A (en) 1992-04-30
PT80936B (en) 1987-06-02
AU4590885A (en) 1986-02-13
IT8548467A0 (it) 1985-08-09
IT1184685B (it) 1987-10-28
HU196171B (en) 1988-10-28

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