ES8802455A1 - Procedimiento para la preparacion de derivados de pirido-benzo-tiacina - Google Patents
Procedimiento para la preparacion de derivados de pirido-benzo-tiacinaInfo
- Publication number
- ES8802455A1 ES8802455A1 ES557331A ES557331A ES8802455A1 ES 8802455 A1 ES8802455 A1 ES 8802455A1 ES 557331 A ES557331 A ES 557331A ES 557331 A ES557331 A ES 557331A ES 8802455 A1 ES8802455 A1 ES 8802455A1
- Authority
- ES
- Spain
- Prior art keywords
- treat
- product
- fluoro
- chlorine
- benzothiazine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/16—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Luminescent Compositions (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
- Dental Preparations (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
LOS DERIVADOS DE LA PIRIDO-BENZOTIACINA (I), DONDE N ES 0, 1 O 2 E Y ES CL O F; SE OBTIENEN MEDIANTE LAS SIGUIENTES ETAPAS: A) TRATAR EL 3-CLORO (O FLUORO)-4-FLUOROANILINA CON TIACIANATO POTASICO Y BROMO, LUEGO B) TRATAR CON NAOH EL PRODUCTO DE A) PARA OBTENER EL DISULFURO, DESPUES C) TRATAR CON MONOCLOROACETATO SODICO Y SUBSIGUIENTEMENTE CON LIA1H4 EN THF EL PRODUCTO DE B) PARA OBTENER LA 7-FLUORO-8-CLORO (O FLUORO)-3,4-DIHIDRO-2H-1,4-BENZOTIACINA (II), A PARTIR DE LA CUAL SE OBTIENE EL PRODUCTO (I) POR: D) CIERRE DEL ANILLO AL TRATAR CON ETOXIMETILENMALONATO DE ETILO, ENTRE 80 Y 160GC Y ACIDO POLIFOSFORICO, E) HIROLIZAR Y OXIDAR A SULFOXIDO CON PEROXIDO DE HIDROGENO Y F) SUSTITUCION NUCLEOFILA CON AMINA TIPO PIPERACINA, EN DISOLVENTE APROTICO POLAR, ENTRE 70 Y 160GC CON REDUCCION FINAL A TIOETER. APLICABLES COMO ANTIBACTERIANOS Y PARTICULARMENTE COMO DESINFECTANTES DEL TRACTO URINARIO. *FORMULA*
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT19790/84A IT1173374B (it) | 1984-02-24 | 1984-02-24 | Derivati pirido-benzotiazinici ad elevata attivita' antimicrobica |
Publications (2)
Publication Number | Publication Date |
---|---|
ES557331A0 ES557331A0 (es) | 1988-06-16 |
ES8802455A1 true ES8802455A1 (es) | 1988-06-16 |
Family
ID=11161233
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES541170A Expired ES8801923A1 (es) | 1984-02-24 | 1985-02-23 | Procedimiento para la preparacion de derivados de pirido- benzotiacina |
ES557332A Expired ES8802456A1 (es) | 1984-02-24 | 1987-01-16 | Procedimiento para la preparacion de derivados de pirido-benzo-tiacina |
ES557331A Expired ES8802455A1 (es) | 1984-02-24 | 1987-01-16 | Procedimiento para la preparacion de derivados de pirido-benzo-tiacina |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES541170A Expired ES8801923A1 (es) | 1984-02-24 | 1985-02-23 | Procedimiento para la preparacion de derivados de pirido- benzotiacina |
ES557332A Expired ES8802456A1 (es) | 1984-02-24 | 1987-01-16 | Procedimiento para la preparacion de derivados de pirido-benzo-tiacina |
Country Status (22)
Country | Link |
---|---|
US (2) | US4668784A (es) |
EP (1) | EP0165375B1 (es) |
JP (2) | JPS60208987A (es) |
KR (1) | KR880000024B1 (es) |
AT (1) | ATE57532T1 (es) |
AU (1) | AU573780B2 (es) |
CA (1) | CA1340554C (es) |
DE (1) | DE3580124D1 (es) |
DK (1) | DK81885A (es) |
EG (1) | EG17585A (es) |
ES (3) | ES8801923A1 (es) |
FI (1) | FI83327C (es) |
GR (1) | GR850482B (es) |
IE (1) | IE57974B1 (es) |
IT (1) | IT1173374B (es) |
MX (5) | MX172473B (es) |
NO (1) | NO171163C (es) |
NZ (1) | NZ211224A (es) |
PH (2) | PH22239A (es) |
PT (1) | PT80003B (es) |
YU (1) | YU43401B (es) |
ZA (1) | ZA851379B (es) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2358580A1 (fr) * | 1976-07-16 | 1978-02-10 | Comet | Perfectionnements aux cages pour ecrous prisonniers et aux appareils et procedes pour fabriquer de telles cages |
IT1196429B (it) * | 1986-07-01 | 1988-11-16 | Mediolanum Farmaceutici Srl | Processo per la preparazione di pirido benzotiazine ad attivita' antibatterica e loro sali con acidi solfonici |
IT1197841B (it) * | 1986-10-14 | 1988-12-06 | Mediolanum Farmaceutici Srl | Derivati pirido-benzotiazinici ad attivita' antibatterica ed a lunga durata di azione |
IT1222833B (it) * | 1987-10-06 | 1990-09-12 | Mediolanum Farmaceutici Srl | Derivati pirido benzotiazinici dotati di elevata attivita' antibatterica e di elevata biodisponibilita' tissutale |
US4840525A (en) * | 1987-12-09 | 1989-06-20 | Unistrut International Corp. | Fastener restrainer for framing system |
DE3906365A1 (de) * | 1988-07-15 | 1990-01-18 | Bayer Ag | 7-(1-pyrrolidinyl)-3-chinolon- und -naphthyridoncarbonsaeure-derivate, verfahren sowie substituierte (oxa)diazabicyclooctane und -nonane als zwischenprodukte zu ihrer herstellung, und sie enthaltende antibakterielle mittel und futterzusatzstoffe |
US5308843A (en) * | 1990-09-11 | 1994-05-03 | Sterling Drug Inc. | Method of inhibiting mammalian topoisomerase II and malignant cell growth in mammals, with substituted (S)-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4 ]-benzoxazine(and-benzothiazine)-6-carboxylic acids |
IT1248011B (it) * | 1991-06-07 | 1995-01-05 | Mediolanum Farmaceutici Spa | Procedimento per la preparazione dell'acido 9-fluoro-10- (4-metil-1-piperazinil)-7-oxo-2,3-diidro-7h-pirido (1,2,3-de) (1,4)benzotiadin-6-carbossilico cloridrato. |
US5532239A (en) * | 1993-08-02 | 1996-07-02 | Assistance Publique - Hopitaux De Paris | Therapeutic application of fluoroquinolone derivatives |
IT1270834B (it) * | 1993-10-27 | 1997-05-13 | Archimica Spa | Disolfuro chinolico |
US6326391B1 (en) | 1998-12-04 | 2001-12-04 | Influx, Inc. | Inhibitors of multidrug transporters |
US6262072B1 (en) | 1999-10-12 | 2001-07-17 | Yung Shin Pharmaceutical Industrial Co. Ltd. | Orally administered antimicrobial pharmaceutical formulations of ciprofloxacin |
SE9904108D0 (sv) * | 1999-11-15 | 1999-11-15 | New Pharma Research Ab | Nya föreningar |
KR100440192B1 (ko) * | 2001-11-22 | 2004-07-12 | 이수화학 주식회사 | 광학 활성 퀴놀론카르복실산 유도체의 제조방법 |
US6957105B2 (en) * | 2002-03-26 | 2005-10-18 | Cardiac Pacemakers, Inc. | Method and apparatus for detecting oscillations in cardiac rhythm with electrogram signals |
US7973022B2 (en) * | 2006-02-17 | 2011-07-05 | Idexx Laboratories, Inc. | Fluoroquinolone carboxylic acid salt compositions |
US20070196398A1 (en) * | 2006-02-17 | 2007-08-23 | Murthy Yerramilli V S | Fluoroquinolone fatty acid salt compositions |
US20070197548A1 (en) * | 2006-02-17 | 2007-08-23 | Murthy Yerramilli V S | Fluoroquinolone compositions |
WO2013076590A1 (en) * | 2011-11-23 | 2013-05-30 | Oxygen Healthcare Research Pvt. Ltd | Benzothiazine compounds as h3 receptor ligands |
DE102013101756A1 (de) | 2012-11-30 | 2014-06-05 | Hamberger Industriewerke Gmbh | Verbindung und Verriegelungselement |
DE102013108538A1 (de) | 2013-08-07 | 2015-02-12 | Hamberger Industriewerke Gmbh | Verbindung und Verriegelungselement |
DE102013108539A1 (de) | 2013-08-07 | 2015-02-12 | Hamberger Industriewerke Gmbh | Verbindung und Verriegelungselement |
DE102015106035A1 (de) | 2014-07-31 | 2016-02-04 | Hamberger Industriewerke Gmbh | Verbindung für plattenförmige Bauelemente und Feder |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS57203085A (en) * | 1981-06-09 | 1982-12-13 | Dai Ichi Seiyaku Co Ltd | 1,8-cyclic substituted quinoline derivative |
JPS5976091A (ja) * | 1982-10-22 | 1984-04-28 | Otsuka Pharmaceut Co Ltd | ピリド〔1,2,3−de〕〔1,4〕ベンゾチアジン誘導体 |
-
1984
- 1984-02-24 IT IT19790/84A patent/IT1173374B/it active Protection Beyond IP Right Term
-
1985
- 1985-02-21 IE IE432/85A patent/IE57974B1/en not_active IP Right Cessation
- 1985-02-21 DE DE8585101881T patent/DE3580124D1/de not_active Expired - Fee Related
- 1985-02-21 AT AT85101881T patent/ATE57532T1/de not_active IP Right Cessation
- 1985-02-21 EP EP85101881A patent/EP0165375B1/en not_active Expired - Lifetime
- 1985-02-22 DK DK81885A patent/DK81885A/da not_active Application Discontinuation
- 1985-02-22 FI FI850741A patent/FI83327C/fi not_active IP Right Cessation
- 1985-02-22 NO NO850710A patent/NO171163C/no unknown
- 1985-02-22 CA CA000474952A patent/CA1340554C/en not_active Expired - Fee Related
- 1985-02-22 PT PT80003A patent/PT80003B/pt not_active IP Right Cessation
- 1985-02-22 ZA ZA851379A patent/ZA851379B/xx unknown
- 1985-02-23 KR KR8501180A patent/KR880000024B1/ko not_active IP Right Cessation
- 1985-02-23 ES ES541170A patent/ES8801923A1/es not_active Expired
- 1985-02-24 EG EG115/85A patent/EG17585A/xx active
- 1985-02-25 MX MX013422A patent/MX172473B/es unknown
- 1985-02-25 MX MX5776A patent/MX162343A/es unknown
- 1985-02-25 JP JP60036261A patent/JPS60208987A/ja active Granted
- 1985-02-25 MX MX013420A patent/MX172472B/es unknown
- 1985-02-25 YU YU290/85A patent/YU43401B/xx unknown
- 1985-02-25 PH PH31907A patent/PH22239A/en unknown
- 1985-02-25 MX MX013421A patent/MX173934B/es unknown
- 1985-02-25 AU AU39142/85A patent/AU573780B2/en not_active Ceased
- 1985-02-25 NZ NZ211224A patent/NZ211224A/en unknown
- 1985-02-26 GR GR850482A patent/GR850482B/el not_active IP Right Cessation
- 1985-08-13 US US06/765,154 patent/US4668784A/en not_active Expired - Lifetime
-
1986
- 1986-10-24 US US06/922,712 patent/US4684647A/en not_active Expired - Lifetime
-
1987
- 1987-01-16 ES ES557332A patent/ES8802456A1/es not_active Expired
- 1987-01-16 ES ES557331A patent/ES8802455A1/es not_active Expired
- 1987-08-05 PH PH35622A patent/PH23882A/en unknown
-
1989
- 1989-11-29 JP JP1307826A patent/JPH0327389A/ja active Granted
-
1992
- 1992-06-26 MX MX9203608A patent/MX9203608A/es unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20040407 |