AU3914285A - Pyrido-benzothiazine derivatives - Google Patents

Pyrido-benzothiazine derivatives

Info

Publication number
AU3914285A
AU3914285A AU39142/85A AU3914285A AU3914285A AU 3914285 A AU3914285 A AU 3914285A AU 39142/85 A AU39142/85 A AU 39142/85A AU 3914285 A AU3914285 A AU 3914285A AU 3914285 A AU3914285 A AU 3914285A
Authority
AU
Australia
Prior art keywords
pyrido
chem
general formula
processes
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU39142/85A
Other versions
AU573780B2 (en
Inventor
Arnaldo Fravolini
Giuseppe Mascellani
Patrizia Terni
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mediolanum Farmaceutici SpA
Original Assignee
Mediolanum Farmaceutici SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mediolanum Farmaceutici SpA filed Critical Mediolanum Farmaceutici SpA
Publication of AU3914285A publication Critical patent/AU3914285A/en
Application granted granted Critical
Publication of AU573780B2 publication Critical patent/AU573780B2/en
Assigned to MEDIOLANUM FARMACEUTICI S.P.A. reassignment MEDIOLANUM FARMACEUTICI S.P.A. Request to Amend Deed and Register Assignors: MEDIOLANUM FARMACEUTICI S.R.L.
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/16—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring

Abstract

Pyridobenzothiazine derivatives with high antimicrobial activity having the following general formula: <CHEM> wherein R is H or CH3; n is 0 or 1 or 2 and Y is Cl or F, <CHEM> wherein R<1> is a C1-C6 alkyl or a C2-C6 alkenyl, or an arylalkyl, arylalkylcarbonyl, alkylcarbonyl, alkyloxycarbonyl, possibly substituted with halogens or hydroxy groups. <??>The present invention relates also to the processes for obtaining the compounds having the general formula (I). Such processes consist in synthesis routes using as starting products 3-chloro-4-fluoraniline, or 2,3,4-trifluoronitrobenzene.
AU39142/85A 1984-02-24 1985-02-25 Pyrido-benzothiazine derivatives Ceased AU573780B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT19790/84 1984-02-24
IT19790/84A IT1173374B (en) 1984-02-24 1984-02-24 PYRID-BENZOTHIAZINIC DERIVATIVES WITH HIGH ANTIMICROBIAL ACTIVITY

Publications (2)

Publication Number Publication Date
AU3914285A true AU3914285A (en) 1985-09-05
AU573780B2 AU573780B2 (en) 1988-06-23

Family

ID=11161233

Family Applications (1)

Application Number Title Priority Date Filing Date
AU39142/85A Ceased AU573780B2 (en) 1984-02-24 1985-02-25 Pyrido-benzothiazine derivatives

Country Status (22)

Country Link
US (2) US4668784A (en)
EP (1) EP0165375B1 (en)
JP (2) JPS60208987A (en)
KR (1) KR880000024B1 (en)
AT (1) ATE57532T1 (en)
AU (1) AU573780B2 (en)
CA (1) CA1340554C (en)
DE (1) DE3580124D1 (en)
DK (1) DK81885A (en)
EG (1) EG17585A (en)
ES (3) ES8801923A1 (en)
FI (1) FI83327C (en)
GR (1) GR850482B (en)
IE (1) IE57974B1 (en)
IT (1) IT1173374B (en)
MX (5) MX173934B (en)
NO (1) NO171163C (en)
NZ (1) NZ211224A (en)
PH (2) PH22239A (en)
PT (1) PT80003B (en)
YU (1) YU43401B (en)
ZA (1) ZA851379B (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2358580A1 (en) * 1976-07-16 1978-02-10 Comet IMPROVEMENTS TO CAGES FOR PRISONER NUTS AND TO APPARATUS AND METHODS FOR MANUFACTURING SUCH CAGES
IT1196429B (en) * 1986-07-01 1988-11-16 Mediolanum Farmaceutici Srl PROCESS FOR THE PREPARATION OF PYRID BENZOTIAZINS FOR ANTIBACTERIAL ACTIVITY AND THEIR SALTS WITH SULPHONIC ACIDS
IT1197841B (en) * 1986-10-14 1988-12-06 Mediolanum Farmaceutici Srl PYRID-BENZOTHIAZINIC DERIVATIVES WITH ANTIBACTERIAL ACTIVITY AND LONG LIFE
IT1222833B (en) * 1987-10-06 1990-09-12 Mediolanum Farmaceutici Srl PYROID BENZOTHIAZINIC DERIVATIVES EQUIPPED WITH HIGH ANTIBACTERIAL ACTIVITY AND HIGH TISSUE BIO AVAILABILITY
US4840525A (en) * 1987-12-09 1989-06-20 Unistrut International Corp. Fastener restrainer for framing system
DE3906365A1 (en) * 1988-07-15 1990-01-18 Bayer Ag 7- (1-PYRROLIDINYL) -3-CHINOLONE AND NAPHTHYRIDONE CARBOXYLIC ACID DERIVATIVES, METHOD AND SUBSTITUTED (OXA) DIAZABICYCLOOCTANES AND NONANESE AS INTERMEDIATE PRODUCTS, AND ANTIBACTERIAL AGENTS AND FOOD ADDITIVES CONTAINING THEM
US5308843A (en) * 1990-09-11 1994-05-03 Sterling Drug Inc. Method of inhibiting mammalian topoisomerase II and malignant cell growth in mammals, with substituted (S)-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4 ]-benzoxazine(and-benzothiazine)-6-carboxylic acids
IT1248011B (en) * 1991-06-07 1995-01-05 Mediolanum Farmaceutici Spa PROCEDURE FOR THE PREPARATION OF 9-FLUORO-10- (4-METHYL-1-PIPERAZINYL) -7-OXO-2,3-DIHYDRO-7H-PYRID (1,2,3-DE) acid (1,4) BENZOTIADIN-6-CARBOXYL HYDROCHLORIDE.
US5532239A (en) * 1993-08-02 1996-07-02 Assistance Publique - Hopitaux De Paris Therapeutic application of fluoroquinolone derivatives
IT1270834B (en) * 1993-10-27 1997-05-13 Archimica Spa DISINFURO QUINOLICO
WO2000032196A2 (en) 1998-12-04 2000-06-08 Influx, Inc. Inhibitors of multidrug transporters
US6262072B1 (en) 1999-10-12 2001-07-17 Yung Shin Pharmaceutical Industrial Co. Ltd. Orally administered antimicrobial pharmaceutical formulations of ciprofloxacin
SE9904108D0 (en) * 1999-11-15 1999-11-15 New Pharma Research Ab New compounds
KR100440192B1 (en) * 2001-11-22 2004-07-12 이수화학 주식회사 Method of preparing optical active quinolonecarboxylic acid derivatives
US6957105B2 (en) * 2002-03-26 2005-10-18 Cardiac Pacemakers, Inc. Method and apparatus for detecting oscillations in cardiac rhythm with electrogram signals
US20070197548A1 (en) * 2006-02-17 2007-08-23 Murthy Yerramilli V S Fluoroquinolone compositions
US7973022B2 (en) * 2006-02-17 2011-07-05 Idexx Laboratories, Inc. Fluoroquinolone carboxylic acid salt compositions
US20070196398A1 (en) * 2006-02-17 2007-08-23 Murthy Yerramilli V S Fluoroquinolone fatty acid salt compositions
WO2013076590A1 (en) * 2011-11-23 2013-05-30 Oxygen Healthcare Research Pvt. Ltd Benzothiazine compounds as h3 receptor ligands
DE102013101756A1 (en) 2012-11-30 2014-06-05 Hamberger Industriewerke Gmbh Connector e.g. glueless connector, for e.g. floor element for flooring applications, has structural element moved to latch position in which locking lip of locking element is non-positively or positively locked in direction
DE102013108539A1 (en) 2013-08-07 2015-02-12 Hamberger Industriewerke Gmbh Connection and locking element
DE102013108538A1 (en) 2013-08-07 2015-02-12 Hamberger Industriewerke Gmbh Connection and locking element
DE102015106035A1 (en) 2014-07-31 2016-02-04 Hamberger Industriewerke Gmbh Connection for plate-shaped components and spring

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57203085A (en) * 1981-06-09 1982-12-13 Dai Ichi Seiyaku Co Ltd 1,8-cyclic substituted quinoline derivative
JPS5976091A (en) * 1982-10-22 1984-04-28 Otsuka Pharmaceut Co Ltd Pyrido (1,2,3-de)(1,4)benzothiazine derivative

Also Published As

Publication number Publication date
FI850741L (en) 1985-08-25
IE57974B1 (en) 1993-06-02
DE3580124D1 (en) 1990-11-22
DK81885A (en) 1985-08-25
FI83327B (en) 1991-03-15
US4684647A (en) 1987-08-04
ES8802456A1 (en) 1988-06-16
ES557331A0 (en) 1988-06-16
YU43401B (en) 1989-06-30
MX162343A (en) 1991-04-26
DK81885D0 (en) 1985-02-22
IT8419790A0 (en) 1984-02-24
EP0165375A2 (en) 1985-12-27
NO850710L (en) 1985-08-26
FI83327C (en) 1991-06-25
ZA851379B (en) 1985-10-30
FI850741A0 (en) 1985-02-22
JPH0259153B2 (en) 1990-12-11
MX172472B (en) 1993-12-17
EP0165375A3 (en) 1986-10-08
JPH0327389A (en) 1991-02-05
NZ211224A (en) 1992-03-26
JPS60208987A (en) 1985-10-21
IE850432L (en) 1985-08-24
MX9203608A (en) 1992-07-01
EP0165375B1 (en) 1990-10-17
CA1340554C (en) 1999-05-25
NO171163B (en) 1992-10-26
ES8802455A1 (en) 1988-06-16
AU573780B2 (en) 1988-06-23
KR850006426A (en) 1985-10-05
KR880000024B1 (en) 1988-02-15
ES557332A0 (en) 1988-06-16
PT80003B (en) 1987-06-17
US4668784A (en) 1987-05-26
YU29085A (en) 1987-12-31
MX172473B (en) 1993-12-17
PT80003A (en) 1985-03-01
GR850482B (en) 1985-06-26
ATE57532T1 (en) 1990-11-15
ES541170A0 (en) 1988-03-01
ES8801923A1 (en) 1988-03-01
IT1173374B (en) 1987-06-24
PH22239A (en) 1988-07-01
JPH0413326B2 (en) 1992-03-09
EG17585A (en) 1993-08-30
PH23882A (en) 1989-12-18
NO171163C (en) 1993-02-03
MX173934B (en) 1994-04-11

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