ES8802393A1 - Procedimiento para preparar un analogo polipeptido inhibidorde renina - Google Patents

Procedimiento para preparar un analogo polipeptido inhibidorde renina

Info

Publication number
ES8802393A1
ES8802393A1 ES544296A ES544296A ES8802393A1 ES 8802393 A1 ES8802393 A1 ES 8802393A1 ES 544296 A ES544296 A ES 544296A ES 544296 A ES544296 A ES 544296A ES 8802393 A1 ES8802393 A1 ES 8802393A1
Authority
ES
Spain
Prior art keywords
lipophilic
aromatic
analogue
amino acid
analogues
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES544296A
Other languages
English (en)
Other versions
ES544296A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hassle AB
Original Assignee
Hassle AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB838322414A external-priority patent/GB8322414D0/en
Application filed by Hassle AB filed Critical Hassle AB
Publication of ES8802393A1 publication Critical patent/ES8802393A1/es
Publication of ES544296A0 publication Critical patent/ES544296A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/14—Angiotensins: Related peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Vascular Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

LOS POLIPEPTIDOS INHIBIDORES DE LA RENINA (I), SE OBTIENE HACIENDO REACCIONAR X-A-W CON DOS O MAS RESIDUOS PHE, HIS, B Y Z INDIVIDUALMENTE O COMO UNIDADES PRESINTETIZADAS, DONDE NO EXCLUSIVAMENTE, X ES UN GRUPO N-PROTECTOR, COMO ACETILO O PIRALOILO, A ES UN GRUPO (II) QUE TIENE UN ENLACE ISOSTERO HIDROXI, B RESIDUO AMINOACILO LIPOFILICO COMO VAL, LEU O ILE, Z RESIDUO AMINOACILO AROMATICO COMO TYR, PHE, HIS Y W -OH O ESTER PROTEGIDO. DE APLICACION COMO AGENTE DE DIAGNOSTICO Y TRATAMIENTO DE LA RENINA QUE PROVOCA HIPERTENSION.
ES544296A 1983-02-07 1985-06-17 Procedimiento para preparar un analogo polipeptido inhibidorde renina Expired ES8802393A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46954083A 1983-02-07 1983-02-07
GB838322414A GB8322414D0 (en) 1983-08-19 1983-08-19 Renin inhibitors

Publications (2)

Publication Number Publication Date
ES8802393A1 true ES8802393A1 (es) 1988-05-16
ES544296A0 ES544296A0 (es) 1988-05-16

Family

ID=26286781

Family Applications (4)

Application Number Title Priority Date Filing Date
ES529523A Expired ES8602847A1 (es) 1983-02-07 1984-02-07 Procedimiento para preparar un analogo polipeptido inhibidor de renina
ES544297A Expired ES8604111A1 (es) 1983-02-07 1985-06-17 Procedimiento para preparar el compuesto 3-amino-3-deoxi-es-tanina
ES544296A Expired ES8802393A1 (es) 1983-02-07 1985-06-17 Procedimiento para preparar un analogo polipeptido inhibidorde renina
ES544295A Expired ES8802129A1 (es) 1983-02-07 1985-06-17 Procedimiento para preparar un analogo polipeptido inhibidorde resina

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES529523A Expired ES8602847A1 (es) 1983-02-07 1984-02-07 Procedimiento para preparar un analogo polipeptido inhibidor de renina
ES544297A Expired ES8604111A1 (es) 1983-02-07 1985-06-17 Procedimiento para preparar el compuesto 3-amino-3-deoxi-es-tanina

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES544295A Expired ES8802129A1 (es) 1983-02-07 1985-06-17 Procedimiento para preparar un analogo polipeptido inhibidorde resina

Country Status (8)

Country Link
EP (2) EP0118223A1 (es)
AU (2) AU573735B2 (es)
DK (1) DK478684D0 (es)
ES (4) ES8602847A1 (es)
FI (1) FI843837L (es)
MY (1) MY102058A (es)
NO (1) NO843975L (es)
WO (1) WO1984003044A1 (es)

Families Citing this family (103)

* Cited by examiner, † Cited by third party
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EP0144290A3 (de) * 1983-12-01 1987-05-27 Ciba-Geigy Ag Substituierte Aethylendiaminderivate
JPS60163899A (ja) * 1984-02-03 1985-08-26 Sankyo Co Ltd レニン阻害ペプチド類
CA1254699A (en) * 1984-03-12 1989-05-23 Jasjit S. Bindra Renin inhibitors containing statine or derivatives thereof
US4636491A (en) * 1984-03-27 1987-01-13 Merck & Co., Inc. Renin inhibitory peptides having improved solubility
US4661473A (en) * 1984-03-27 1987-04-28 Merck & Co., Inc. Renin inhibitors containing peptide isosteres
US4663310A (en) * 1984-04-04 1987-05-05 Merck & Co., Inc. Renin inhibitors containing 2-substituted statine
DE3418491A1 (de) * 1984-05-18 1985-11-21 Merck Patent Gmbh, 6100 Darmstadt Diaminosaeurederivate
EP0163237A3 (en) * 1984-05-29 1988-04-27 Merck & Co. Inc. Di- and tri-peptidal renin inhibitors
US4880781A (en) * 1984-08-06 1989-11-14 The Upjohn Company Renin inhibitory peptides containing an N-alkyl-histidine moiety
EP0486478A3 (en) * 1984-08-06 1992-08-12 The Upjohn Company Renin-inhibiting peptides
DE3438545A1 (de) * 1984-10-20 1986-04-24 Merck Patent Gmbh, 6100 Darmstadt Peptide
US4616088A (en) * 1984-10-29 1986-10-07 E. R. Squibb & Sons, Inc. Amino acid ester and amide renin inhibitor
US4727060A (en) * 1984-11-13 1988-02-23 Ciba-Geigy Corporation Novel 5-amino-4-hydroxyvaleryl derivatives
US4629724A (en) * 1984-12-03 1986-12-16 E. R. Squibb & Sons, Inc. Amino acid ester and amide renin inhibitors
DE3512128A1 (de) * 1985-04-03 1986-10-09 Merck Patent Gmbh, 6100 Darmstadt Peptide
US4882420A (en) * 1985-04-19 1989-11-21 The Upjohn Company Dihalo-statine substituted renin inhibitors
EP0218688B1 (en) 1985-04-19 1990-09-12 The Upjohn Company Dihalo-statine substituted renin inhibitors
US4777286A (en) * 1985-06-18 1988-10-11 The Upjohn Company Certain aryl or hetero-hydroxamic acid esters useful as renin inhibitors
CA1290097C (en) * 1985-07-24 1991-10-01 Merck & Co., Inc. Peptide enzyme inhibitors
US4599198A (en) * 1985-08-02 1986-07-08 Pfizer Inc. Intermediates in polypeptide synthesis
US4729985A (en) * 1985-08-09 1988-03-08 Pfizer Inc. Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues
US4992562A (en) * 1985-08-09 1991-02-12 Pfizer Inc. Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues
US4749781A (en) * 1985-11-12 1988-06-07 E. R. Squibb & Sons, Inc. Aminocarbonyl renin inhibitors
JPS63501364A (ja) * 1985-11-15 1988-05-26 ジ・アップジョン・カンパニ− Ｓ−アリ−ル−ｄ−またはｌ−またはｄｌ−システイニル、３−（アリ−ルチオ）乳酸または３−（アリ−ルチオ）アルキル基を含有する新規レニン阻害ポリペプチド同族体
US4894437A (en) * 1985-11-15 1990-01-16 The Upjohn Company Novel renin inhibiting polypeptide analogs containing S-aryl-D- or L- or DL-cysteinyl, 3-(arylthio)lactic acid or 3-(arylthio)alkyl moieties
DE3540495A1 (de) * 1985-11-15 1987-05-21 Merck Patent Gmbh Aminosaeurederivate
KR870005013A (ko) * 1985-11-29 1987-06-04 가와무라 요시부미 레닌-억제 올리고펩티드, 그의 제조방법 및 용도
CA1297631C (en) * 1985-12-23 1992-03-17 Sesha I. Natarajan Ureido renin inhibitors
US4757050A (en) * 1985-12-23 1988-07-12 E. R. Squibb Sons, Inc. Ureido renin inhibitors
DE3601248A1 (de) * 1986-01-17 1987-07-23 Hoechst Ag Substituierte 4-amino-3-hydroxybuttersaeure-derivate, verfahren zu deren herstellung, diese enthaltende mittel und ihre verwendung
FI870474A (fi) * 1986-02-07 1987-08-08 Ciba Geigy Ag Med svavelhaltiga grupper substituerade 5-amino-4-hydroxivalerylderivat.
US4705846A (en) * 1986-03-27 1987-11-10 The Upjohn Company Novel renin inhibiting peptides having a gamma lactam pseudo dipeptide insert
US4999186A (en) * 1986-06-27 1991-03-12 The Procter & Gamble Company Novel sunscreen agents, sunscreen compositions and methods for preventing sunburn
DE3626130A1 (de) * 1986-08-01 1988-02-11 Merck Patent Gmbh Aminosaeurederivate
US4743585A (en) * 1986-11-21 1988-05-10 Warner-Lambert Company Renin inhibitors
DE3640535A1 (de) * 1986-11-27 1988-06-01 Merck Patent Gmbh Peptide
SE8605573D0 (sv) * 1986-12-29 1986-12-29 Haessle Ab Novel compounds
US5032577A (en) * 1986-12-31 1991-07-16 Abbott Laboratories Peptidylaminodiols
US4804743A (en) * 1987-01-29 1989-02-14 Warner-Lambert Copmany Proline-containing renin inhibitors
US4863905A (en) * 1987-02-04 1989-09-05 Warner-Lambert Company Renin inhibitors II
US4758584A (en) * 1987-02-05 1988-07-19 Ciba-Geigy Corporation Antihypertensive 5-amino-4-hydroxyvaleryl derivatives substituted by sulphur-containing groups
EP0366669A1 (en) * 1987-06-29 1990-05-09 The Upjohn Company Malic acid derivative containing renin inhibiting peptides
US5055466A (en) * 1987-11-23 1991-10-08 E. R. Squibb & Sons, Inc. N-morpholino derivatives and their use as anti-hypertensive agents
GB8728561D0 (en) * 1987-12-07 1988-01-13 Glaxo Group Ltd Chemical compounds
GB8728560D0 (en) * 1987-12-07 1988-01-13 Glaxo Group Ltd Chemical compounds
GB2212158A (en) * 1987-12-15 1989-07-19 Sandoz Ltd Trialkylsilymethyl-substituted peptides; renin inhibitors
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EP0374097A3 (de) * 1988-12-15 1991-06-12 Ciba-Geigy Ag Verwendung von Peptidisosteren als retrovirale Proteasehemmer
US5126326A (en) * 1989-06-06 1992-06-30 Bio-Mega, Inc. Enzyme inhibiting peptide derivatives
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US5475013A (en) * 1990-11-19 1995-12-12 Monsanto Company Retroviral protease inhibitors
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US5278326A (en) * 1991-03-18 1994-01-11 Warner-Lambert Company Substituted beta-ketoamide ACAT inhibitors
US5643878A (en) * 1991-09-12 1997-07-01 Ciba-Geigy Corporation 5-amino-4-hydroxyhexanoic acid derivatives
TW217410B (es) * 1992-04-01 1993-12-11 Ciba Geigy
ATE199545T1 (de) 1992-05-21 2001-03-15 Monsanto Co Inhibitoren retroviraler proteasen
US6743929B1 (en) 1992-08-25 2004-06-01 G. D. Searle & Co. Sulfonylalkanoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
US5968942A (en) 1992-08-25 1999-10-19 G. D. Searle & Co. α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
US6022994A (en) 1992-08-25 2000-02-08 G. D. Searle &. Co. Succinoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
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JP4091654B2 (ja) * 1992-08-25 2008-05-28 ジー．ディー．サール、リミテッド、ライアビリティ、カンパニー レトロウイルスプロテアーゼ阻害剤として有用なスルホニルアルカノイルアミノヒドロキシエチルアミノスルホンアミド
CA2142998C (en) * 1992-08-25 2008-01-29 Michael L. Vazquez N-(alkanoylamino-2-hydroxypropyl)-sulfonamides useful as retroviral protease inhibitors
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CA1245217A (en) * 1981-12-10 1988-11-22 Joshua S. Boger Renin inhibitory peptides having phe su13 xx deletion
IT1212508B (it) * 1981-12-22 1989-11-22 Anic Spa Analoghi retro - invertiti dei penta - ed esapeptidi c - terminali della sostanza p. utili come vasodilatatori
IT1190891B (it) * 1982-06-24 1988-02-24 Anic Spa Metodo per la sintesi in fase solida di polipeptidi retroinvertiti

Also Published As

Publication number Publication date
FI843837A0 (fi) 1984-09-28
ES529523A0 (es) 1985-12-01
WO1984003044A1 (en) 1984-08-16
ES544296A0 (es) 1988-05-16
ES8602847A1 (es) 1985-12-01
EP0316965A2 (en) 1989-05-24
MY102058A (en) 1992-03-31
AU1516788A (en) 1988-09-08
NO843975L (no) 1984-10-02
AU2494484A (en) 1984-08-30
EP0118223A1 (en) 1984-09-12
EP0316965A3 (en) 1989-08-09
ES544297A0 (es) 1986-01-16
ES8802129A1 (es) 1988-04-01
ES544295A0 (es) 1988-04-01
FI843837L (fi) 1984-09-28
AU573735B2 (en) 1988-06-23
DK478684A (da) 1984-10-05
DK478684D0 (da) 1984-10-05
ES8604111A1 (es) 1986-01-16

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