ES8604111A1 - Procedimiento para preparar el compuesto 3-amino-3-deoxi-es-tanina - Google Patents

Procedimiento para preparar el compuesto 3-amino-3-deoxi-es-tanina

Info

Publication number
ES8604111A1
ES8604111A1 ES544297A ES544297A ES8604111A1 ES 8604111 A1 ES8604111 A1 ES 8604111A1 ES 544297 A ES544297 A ES 544297A ES 544297 A ES544297 A ES 544297A ES 8604111 A1 ES8604111 A1 ES 8604111A1
Authority
ES
Spain
Prior art keywords
lipophilic
aromatic
analogue
amino acid
analogues
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES544297A
Other languages
English (en)
Other versions
ES544297A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ferring AB
Original Assignee
Ferring AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB838322414A external-priority patent/GB8322414D0/en
Application filed by Ferring AB filed Critical Ferring AB
Publication of ES544297A0 publication Critical patent/ES544297A0/es
Publication of ES8604111A1 publication Critical patent/ES8604111A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/14—Angiotensins: Related peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Vascular Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

PROCEDIMIENTO PARA OBTENER ANALOGOS HEXAPEPTIDOS O ANALOGOS INFERIORES.COMPRENDE: A) ALQUILAR LA BROMOHIDRINA O HALOCETONA DE FORMULA (II) CON UN DERIVADO DE METAL ALCALINO DE ACIDO CARBOXILICO DE FORMULA (III) Y CON UN DERIVADO DE METAL ALCALINO DE EPSTER MALONICO DE FORMULA (IV), PARA OBTENER EL INTERMEDIARIO DE FORMULA (V) EN FORMA PROTEGIDA; Y B) DESPROTEGER AL INTERMEDIARIO (V) PARA OBTENER EL ISOSTERO O HEXAPEPTIDO DE FORMULA (I). SIENDO: R14 Y R15 UNA CADENA LATERAL AMINOACIDO Y LOS GRUPOS NH2 Y OH ESTAN PROTEGIDOS Y R16 ES UN GRUPO ESTERIFICANTE O UN HALURO. SE UTILIZAN COMO ANTIHIPERTENSORES.
ES544297A 1983-02-07 1985-06-17 Procedimiento para preparar el compuesto 3-amino-3-deoxi-es-tanina Expired ES8604111A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46954083A 1983-02-07 1983-02-07
GB838322414A GB8322414D0 (en) 1983-08-19 1983-08-19 Renin inhibitors

Publications (2)

Publication Number Publication Date
ES544297A0 ES544297A0 (es) 1986-01-16
ES8604111A1 true ES8604111A1 (es) 1986-01-16

Family

ID=26286781

Family Applications (4)

Application Number Title Priority Date Filing Date
ES529523A Granted ES529523A0 (es) 1983-02-07 1984-02-07 Procedimiento para preparar un analogo polipeptido inhibidor de renina
ES544295A Expired ES8802129A1 (es) 1983-02-07 1985-06-17 Procedimiento para preparar un analogo polipeptido inhibidorde resina
ES544296A Expired ES8802393A1 (es) 1983-02-07 1985-06-17 Procedimiento para preparar un analogo polipeptido inhibidorde renina
ES544297A Expired ES8604111A1 (es) 1983-02-07 1985-06-17 Procedimiento para preparar el compuesto 3-amino-3-deoxi-es-tanina

Family Applications Before (3)

Application Number Title Priority Date Filing Date
ES529523A Granted ES529523A0 (es) 1983-02-07 1984-02-07 Procedimiento para preparar un analogo polipeptido inhibidor de renina
ES544295A Expired ES8802129A1 (es) 1983-02-07 1985-06-17 Procedimiento para preparar un analogo polipeptido inhibidorde resina
ES544296A Expired ES8802393A1 (es) 1983-02-07 1985-06-17 Procedimiento para preparar un analogo polipeptido inhibidorde renina

Country Status (8)

Country Link
EP (2) EP0316965A3 (es)
AU (2) AU573735B2 (es)
DK (1) DK478684A (es)
ES (4) ES529523A0 (es)
FI (1) FI843837L (es)
MY (1) MY102058A (es)
NO (1) NO843975L (es)
WO (1) WO1984003044A1 (es)

Families Citing this family (103)

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JPS60163899A (ja) * 1984-02-03 1985-08-26 Sankyo Co Ltd レニン阻害ペプチド類
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US4661473A (en) * 1984-03-27 1987-04-28 Merck & Co., Inc. Renin inhibitors containing peptide isosteres
US4663310A (en) * 1984-04-04 1987-05-05 Merck & Co., Inc. Renin inhibitors containing 2-substituted statine
DE3418491A1 (de) * 1984-05-18 1985-11-21 Merck Patent Gmbh, 6100 Darmstadt Diaminosaeurederivate
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US4880781A (en) * 1984-08-06 1989-11-14 The Upjohn Company Renin inhibitory peptides containing an N-alkyl-histidine moiety
EP0173481A3 (en) * 1984-08-06 1988-12-21 The Upjohn Company Peptides
DE3438545A1 (de) * 1984-10-20 1986-04-24 Merck Patent Gmbh, 6100 Darmstadt Peptide
US4616088A (en) * 1984-10-29 1986-10-07 E. R. Squibb & Sons, Inc. Amino acid ester and amide renin inhibitor
US4727060A (en) * 1984-11-13 1988-02-23 Ciba-Geigy Corporation Novel 5-amino-4-hydroxyvaleryl derivatives
US4629724A (en) * 1984-12-03 1986-12-16 E. R. Squibb & Sons, Inc. Amino acid ester and amide renin inhibitors
DE3512128A1 (de) * 1985-04-03 1986-10-09 Merck Patent Gmbh, 6100 Darmstadt Peptide
US4882420A (en) * 1985-04-19 1989-11-21 The Upjohn Company Dihalo-statine substituted renin inhibitors
DE3674131D1 (de) 1985-04-19 1990-10-18 Upjohn Co Substituierte dihalo-statin-reninhemmungsmittel.
US4777286A (en) * 1985-06-18 1988-10-11 The Upjohn Company Certain aryl or hetero-hydroxamic acid esters useful as renin inhibitors
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US4729985A (en) * 1985-08-09 1988-03-08 Pfizer Inc. Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues
US4992562A (en) * 1985-08-09 1991-02-12 Pfizer Inc. Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues
US4749781A (en) * 1985-11-12 1988-06-07 E. R. Squibb & Sons, Inc. Aminocarbonyl renin inhibitors
US4894437A (en) * 1985-11-15 1990-01-16 The Upjohn Company Novel renin inhibiting polypeptide analogs containing S-aryl-D- or L- or DL-cysteinyl, 3-(arylthio)lactic acid or 3-(arylthio)alkyl moieties
DE3540495A1 (de) * 1985-11-15 1987-05-21 Merck Patent Gmbh Aminosaeurederivate
EP0245361A1 (en) * 1985-11-15 1987-11-19 The Upjohn Company Novel renin inhibiting polypeptide analogs containing s-aryl-d- or l- or dl-cysteinyl, 3-(arylthio)lactic acid or 3-(arylthio)alkyl moieties
KR870005013A (ko) * 1985-11-29 1987-06-04 가와무라 요시부미 레닌-억제 올리고펩티드, 그의 제조방법 및 용도
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US4705846A (en) * 1986-03-27 1987-11-10 The Upjohn Company Novel renin inhibiting peptides having a gamma lactam pseudo dipeptide insert
US4999186A (en) * 1986-06-27 1991-03-12 The Procter & Gamble Company Novel sunscreen agents, sunscreen compositions and methods for preventing sunburn
DE3626130A1 (de) * 1986-08-01 1988-02-11 Merck Patent Gmbh Aminosaeurederivate
US4743585A (en) * 1986-11-21 1988-05-10 Warner-Lambert Company Renin inhibitors
DE3640535A1 (de) * 1986-11-27 1988-06-01 Merck Patent Gmbh Peptide
SE8605573D0 (sv) * 1986-12-29 1986-12-29 Haessle Ab Novel compounds
US5032577A (en) * 1986-12-31 1991-07-16 Abbott Laboratories Peptidylaminodiols
US4804743A (en) * 1987-01-29 1989-02-14 Warner-Lambert Copmany Proline-containing renin inhibitors
US4863905A (en) * 1987-02-04 1989-09-05 Warner-Lambert Company Renin inhibitors II
US4758584A (en) * 1987-02-05 1988-07-19 Ciba-Geigy Corporation Antihypertensive 5-amino-4-hydroxyvaleryl derivatives substituted by sulphur-containing groups
JPH02504143A (ja) * 1987-06-29 1990-11-29 ジ・アップジョン・カンパニー リンゴ酸誘導体含有レニン抑制ペプチド
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US5643878A (en) * 1991-09-12 1997-07-01 Ciba-Geigy Corporation 5-amino-4-hydroxyhexanoic acid derivatives
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KR100296461B1 (ko) * 1992-08-25 2001-11-14 죤 에이치. 뷰센 레트로바이러스프로테아제저해제로서유용한n-(알카노일아미노-2-히드록시프로필)-술폰아미드
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Also Published As

Publication number Publication date
ES8802393A1 (es) 1988-05-16
EP0316965A3 (en) 1989-08-09
ES8602847A1 (es) 1985-12-01
ES544295A0 (es) 1988-04-01
FI843837A0 (fi) 1984-09-28
MY102058A (en) 1992-03-31
AU1516788A (en) 1988-09-08
ES8802129A1 (es) 1988-04-01
WO1984003044A1 (en) 1984-08-16
DK478684D0 (da) 1984-10-05
ES544297A0 (es) 1986-01-16
DK478684A (da) 1984-10-05
FI843837L (fi) 1984-09-28
EP0316965A2 (en) 1989-05-24
ES529523A0 (es) 1985-12-01
NO843975L (no) 1984-10-02
AU573735B2 (en) 1988-06-23
ES544296A0 (es) 1988-05-16
AU2494484A (en) 1984-08-30
EP0118223A1 (en) 1984-09-12

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Effective date: 19960401