ES8802206A1 - Procedimiento para la preparacion de microparticulas que permiten la liberacion prolongada de una substancia biologicameente activa. - Google Patents

Procedimiento para la preparacion de microparticulas que permiten la liberacion prolongada de una substancia biologicameente activa.

Info

Publication number
ES8802206A1
ES8802206A1 ES554821A ES554821A ES8802206A1 ES 8802206 A1 ES8802206 A1 ES 8802206A1 ES 554821 A ES554821 A ES 554821A ES 554821 A ES554821 A ES 554821A ES 8802206 A1 ES8802206 A1 ES 8802206A1
Authority
ES
Spain
Prior art keywords
microparticles
biologically active
extrusion
preparation
compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES554821A
Other languages
English (en)
Other versions
ES554821A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc Sante SA
Original Assignee
Rhone Poulenc Sante SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Sante SA filed Critical Rhone Poulenc Sante SA
Publication of ES8802206A1 publication Critical patent/ES8802206A1/es
Publication of ES554821A0 publication Critical patent/ES554821A0/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Peptides Or Proteins (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE MICROCAPSULAS QUE PERMITEN LA LIBERACION PROLONGADA DE UNA SUSTANCIA BIOLOGICAMENTE ACTIVA EN EL QUE SE PREPARA UN GRANULADO HOMOGENEO CONSTITUIDO POR 5 A 40% EN PESO DE CETOPROFENO COMO SUSTANCIA ACTIVA, UNO O VARIOS POLIMEROS COMPATIBLES Y DE 10 A 40% EN PESO DE LA COMPOSICION DE UNA MEZCLA DE AL MENOS DOS EXCIPIENTES LIPIDICOS UNO DE LOS CUALES POSEE LA PROPIEDAD DE DISOLVER O DE GELIFICAR EL O LOS POLIMEROS Y EL OTRO POSEE PROPIEDADES LUBRIFICANTES O DE UN EXCIPIENTE LIPIDICO QUE POSEA A LA VEZ LA PROPIEDAD DE DISOLVER O DE GELIFICAR EL O LOS POLIMEROS Y PROPIEDADES LUBRIFICANTES Y EVENTUALMENTE UNO O VARIOS ADITIVOS ELEGIDOS DE ENTRE LOS DILUYENTES Y LOS AGENTES ANTIESTATICOS. EL GRANULADO SE EXTRUYE A TEMPERATURA TAL QUE EL EXCIPIENTE LIPIDICO ESTE FUNDIDO PARCIALMENTE PARA DAR UNA MASA PLASTICA QUE SE RESOLIDIFIQUE DESPUES DE LA EXTRUSION. TIENE APLICACION EN LA INDUSTRIA FARMACEUTICA.
ES554821A 1985-05-09 1986-05-09 Procedimiento para la preparacion de microparticulas que permiten la liberacion prolongada de una substancia biologicameente activa. Expired ES8802206A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8507013A FR2581541B1 (fr) 1985-05-09 1985-05-09 Nouvelles compositions pharmaceutiques permettant la liberation prolongee d'un principe actif et leur procede de preparation

Publications (2)

Publication Number Publication Date
ES8802206A1 true ES8802206A1 (es) 1988-04-16
ES554821A0 ES554821A0 (es) 1988-04-16

Family

ID=9319093

Family Applications (1)

Application Number Title Priority Date Filing Date
ES554821A Expired ES8802206A1 (es) 1985-05-09 1986-05-09 Procedimiento para la preparacion de microparticulas que permiten la liberacion prolongada de una substancia biologicameente activa.

Country Status (14)

Country Link
EP (1) EP0204596B1 (es)
JP (1) JPS61260029A (es)
KR (1) KR860008774A (es)
AT (1) ATE45283T1 (es)
AU (1) AU579012B2 (es)
CA (1) CA1266841A (es)
DE (1) DE3664867D1 (es)
DK (1) DK217286A (es)
ES (1) ES8802206A1 (es)
FI (1) FI861923A (es)
FR (1) FR2581541B1 (es)
MA (1) MA20670A1 (es)
NZ (1) NZ216082A (es)
ZA (1) ZA863431B (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2061394A1 (es) * 1993-02-05 1994-12-01 Robert S A Lab Procedimiento de fabricacion de un granulado de citrato potasico con cesion retardada.

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL81419A0 (en) * 1986-01-30 1987-08-31 Syntex Inc Long acting sustained release pharmaceutical compositions containing dihydropyridines and their preparation
US5198226A (en) * 1986-01-30 1993-03-30 Syntex (U.S.A.) Inc. Long acting nicardipine hydrochloride formulation
US4940556A (en) * 1986-01-30 1990-07-10 Syntex (U.S.A.) Inc. Method of preparing long acting formulation
SE457326B (sv) * 1986-02-14 1988-12-19 Lejus Medical Ab Foerfarande foer framstaellning av en snabbt soenderfallande kaerna innehaallande bl a mikrokristallin cellulosa
DE3612212A1 (de) * 1986-04-11 1987-10-15 Basf Ag Verfahren zur herstellung von festen pharmazeutischen formen
NL8701335A (nl) * 1986-06-21 1988-01-18 Sandoz Ag Orale farmaceutische preparaten.
FR2634376B1 (fr) 1988-07-21 1992-04-17 Farmalyoc Nouvelle forme unitaire, solide et poreuse comprenant des microparticules et/ou des nanoparticules, ainsi que sa preparation
FR2663818B1 (fr) * 1990-06-29 1993-07-09 Rhone Poulenc Nutrition Animale Procede de preparation de granules de principes actifs par extrusion.
DE4021678C2 (de) * 1990-07-07 1994-07-07 Merz & Co Gmbh & Co Verfahren zur Herstellung klein dimensionierter Formkörper mit hohem Etofibrat-Gehalt und kontrollierter Wirkstoff-Freisetzung, deren Verwendung und daraus bestehende oral verabreichbare Applikationsformen
DE4031881C2 (de) * 1990-10-08 1994-02-24 Sanol Arznei Schwarz Gmbh Lösungsmittelfreie, oral zu verabreichende pharmazeutische Zubereitung mit verzögerter Wirkstoffreisetzung und Verfahren zu deren Herstellung
WO1993007859A1 (en) * 1991-10-23 1993-04-29 Warner-Lambert Company Novel pharmaceutical pellets and process for their production
ES2086229T3 (es) * 1992-05-22 1996-06-16 Goedecke Ag Procedimiento para la obtencion de preparados medicinales de accion retardada.
US5700410A (en) * 1992-10-16 1997-12-23 Nippon Shinyaku Co., Ltd. Method of manufacturing wax matrices
US5843347A (en) * 1993-03-23 1998-12-01 Laboratoire L. Lafon Extrusion and freeze-drying method for preparing particles containing an active ingredient
FR2702968B1 (fr) * 1993-03-23 1995-06-23 Lafon Labor Procédé de préparation de particules renfermant un ingrédient actif par extrusion et lyophilisation .
BE1006990A5 (nl) * 1993-04-22 1995-02-07 Univ Gent Werkwijze en samenstelling om een aktief bestanddeel in een vaste toedieningsvorm te brengen.
FR2710500B1 (fr) * 1993-09-27 1995-12-01 Virbac Laboratoires Composition et système à administration orale pour animaux, leur procédé de préparation et leurs applications.
DE4422881A1 (de) * 1993-10-25 1995-04-27 Bayer Ag Kolloidal dispergierbare Wirkstoff-Formulierungen
PT744941E (pt) * 1994-02-16 2003-10-31 Abbott Lab Processo para preparar formulacoes farmaceuticas de particulas finas
DE4413350A1 (de) * 1994-04-18 1995-10-19 Basf Ag Retard-Matrixpellets und Verfahren zu ihrer Herstellung
GB9422154D0 (en) * 1994-11-03 1994-12-21 Euro Celtique Sa Pharmaceutical compositions and method of producing the same
US5965161A (en) * 1994-11-04 1999-10-12 Euro-Celtique, S.A. Extruded multi-particulates
DE29502547U1 (de) * 1995-02-16 1995-03-30 Röhm GmbH, 64293 Darmstadt Thermoplastisches Überzugs- und Bindemittel für Arzneiformen
DE19531277A1 (de) * 1995-08-25 1997-02-27 Basf Ag Verwendung von Lipiden als Hilfsmittel bei der Herstellung von festen Arzneiformen nach dem Schmelzextrusionsverfahren
DE19539363A1 (de) * 1995-10-23 1997-04-24 Basf Ag Verfahren zur Herstellung von festen Arzneiformen
GB2344520A (en) * 1998-12-08 2000-06-14 Phares Pharm Res Nv Pharmaceutical carriers comprising lipids and polymers
DE10029201A1 (de) 2000-06-19 2001-12-20 Basf Ag Verfahren zur Herstellung fester oraler Darreichungsformen mit retardierender Wirkstoffreisetzung
US6733709B2 (en) 2000-08-03 2004-05-11 The Procter & Gamble Company Methods and apparatus for producing granular compositions
WO2018140941A1 (en) * 2017-01-30 2018-08-02 Case Western Reserve University Polymer constructs for controlled release of guest agents

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3146167A (en) * 1961-10-05 1964-08-25 Smith Kline French Lab Method of preparing sustained release pellets and products thereof
US3247065A (en) * 1963-10-14 1966-04-19 Hoffmann La Roche Free-flowing coated ascorbic acid
US3965256A (en) * 1972-05-16 1976-06-22 Synergistics Slow release pharmaceutical compositions
DE3024416C2 (de) * 1980-06-28 1982-04-15 Gödecke AG, 1000 Berlin Verfahren zur Herstellung von Arzneimitteln mit retardierter Wirkstoff-Freisetzung
FR2515035A1 (fr) * 1981-10-26 1983-04-29 Rhone Poulenc Sante Nouvelle forme galenique solide pour administration par voie orale et son procede de fabrication
IT1200217B (it) * 1986-09-30 1989-01-05 Valducci Roberto Membrana per uso farmaceutico ed industriale

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2061394A1 (es) * 1993-02-05 1994-12-01 Robert S A Lab Procedimiento de fabricacion de un granulado de citrato potasico con cesion retardada.

Also Published As

Publication number Publication date
EP0204596A1 (fr) 1986-12-10
ATE45283T1 (de) 1989-08-15
AU5722486A (en) 1986-11-13
AU579012B2 (en) 1988-11-10
FI861923A (fi) 1986-11-10
CA1266841A (fr) 1990-03-20
FR2581541A1 (fr) 1986-11-14
ZA863431B (en) 1986-12-30
FI861923A0 (fi) 1986-05-08
JPS61260029A (ja) 1986-11-18
DE3664867D1 (en) 1989-09-14
ES554821A0 (es) 1988-04-16
DK217286A (da) 1986-11-10
DK217286D0 (da) 1986-05-09
NZ216082A (en) 1989-01-06
KR860008774A (ko) 1986-12-18
MA20670A1 (fr) 1986-12-31
EP0204596B1 (fr) 1989-08-09
FR2581541B1 (fr) 1988-05-20

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Legal Events

Date Code Title Description
MM4A Patent lapsed

Effective date: 19960506