ES8801664A1 - Un procedimiento para la preparacion de derivados de acidos griseolicos. - Google Patents

Un procedimiento para la preparacion de derivados de acidos griseolicos.

Info

Publication number
ES8801664A1
ES8801664A1 ES557558A ES557558A ES8801664A1 ES 8801664 A1 ES8801664 A1 ES 8801664A1 ES 557558 A ES557558 A ES 557558A ES 557558 A ES557558 A ES 557558A ES 8801664 A1 ES8801664 A1 ES 8801664A1
Authority
ES
Spain
Prior art keywords
griseolic acid
acid derivatives
preparation
griseolic
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES557558A
Other languages
English (en)
Other versions
ES557558A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Publication of ES557558A0 publication Critical patent/ES557558A0/es
Publication of ES8801664A1 publication Critical patent/ES8801664A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE ACIDOS GRISEOLICOS, DE FORMULA (I). COMPRENDE LA REACCION DE OXIDACION DE UN COMPUESTO DE FORMULA (II), POR TRATAMIENTO CON UN PEROXIDO, EN PRESENCIA DE UN DISOLVENTE ALCOHOLICO, A UNA TEMPERATURA COMPRENDIDA ENTRE 0JC Y 60JC, PARA OBTENER UN COMPUESTO DE FORMULA (I), EN LA QUE R29 REPRESENTA HIDROGENO O HIDROXI, R5 Y R6 SON HIDROGENO O JUNTOS REPRESENTAN UN ENLACE C-C, Y R31, R32 Y A-A PUEDEN SER VARIOS RADICALES. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO INHIBIDORES DE FOSFODIESTERASAS.
ES557558A 1985-04-19 1987-05-21 Un procedimiento para la preparacion de derivados de acidos griseolicos. Expired ES8801664A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP8213285 1985-04-19
JP9198985 1985-04-27
JP9198785 1985-04-27

Publications (2)

Publication Number Publication Date
ES557558A0 ES557558A0 (es) 1988-02-16
ES8801664A1 true ES8801664A1 (es) 1988-02-16

Family

ID=27303820

Family Applications (4)

Application Number Title Priority Date Filing Date
ES554178A Expired ES8802054A1 (es) 1985-04-19 1986-04-19 Un procedimiento para la preparacion de derivados de acidos griseolicos.
ES557558A Expired ES8801664A1 (es) 1985-04-19 1987-05-21 Un procedimiento para la preparacion de derivados de acidos griseolicos.
ES557560A Expired ES8801666A1 (es) 1985-04-19 1987-05-21 Un procedimiento para la prepracion de derivados de acidos griseolicos.
ES557559A Expired ES8801665A1 (es) 1985-04-19 1987-05-21 Un procedimiento para la preparacion de derivados de acidos griseolicos.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES554178A Expired ES8802054A1 (es) 1985-04-19 1986-04-19 Un procedimiento para la preparacion de derivados de acidos griseolicos.

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES557560A Expired ES8801666A1 (es) 1985-04-19 1987-05-21 Un procedimiento para la prepracion de derivados de acidos griseolicos.
ES557559A Expired ES8801665A1 (es) 1985-04-19 1987-05-21 Un procedimiento para la preparacion de derivados de acidos griseolicos.

Country Status (11)

Country Link
US (5) US5498819A (es)
EP (1) EP0214708B1 (es)
KR (1) KR930007385B1 (es)
AT (2) ATE129501T1 (es)
CA (1) CA1267409A (es)
DE (3) DE3667470D1 (es)
DK (1) DK167878B1 (es)
ES (4) ES8802054A1 (es)
FI (1) FI94133C (es)
HK (2) HK1005739A1 (es)
NO (1) NO169901C (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0319316A3 (en) * 1987-12-02 1990-11-28 Sankyo Company Limited Griseolic acid monoesters, their preparation and use
US5091431A (en) * 1988-02-08 1992-02-25 Schering Corporation Phosphodiesterase inhibitors
US4971972A (en) * 1989-03-23 1990-11-20 Schering Corporation Phosphodiesterase inhibitors having an optionally substituted purine derivative portion and a benzo- or cyclopenta-furan portion
JPH04112889A (ja) * 1990-09-04 1992-04-14 Kyowa Hakko Kogyo Co Ltd Ｋｓ―５０５誘導体
US5866702A (en) * 1996-08-02 1999-02-02 Cv Therapeutics, Incorporation Purine inhibitors of cyclin dependent kinase 2
CA2238283C (en) * 1997-05-30 2002-08-20 Cell Pathways, Inc. Method for identifying compounds for inhibition of neoplastic lesions, pharmaceutical compositions from such compounds and uses of such compounds and compositions for treating neoplastic lesions
US6558787B1 (en) * 1999-12-27 2003-05-06 Kodak Polychrome Graphics Llc Relation to manufacture of masks and electronic parts
EP1312363A1 (en) * 2001-09-28 2003-05-21 Pfizer Products Inc. Methods of treatment and kits comprising a growth hormone secretagogue
US7342884B2 (en) * 2002-03-13 2008-03-11 Harmonic, Inc. Method and apparatus for one directional communications in bidirectional communications channel
US20040043014A1 (en) * 2002-08-30 2004-03-04 Hiroyoshi Moriyama Platelet aggregation inhibitor and supplement food effective for inhibiting platelet aggregation
WO2005018563A2 (en) * 2003-08-22 2005-03-03 Pharmacia Corporation Compositions of a cyclooxygenase-2 selective inhibitor and a phosphodiesterase inhibitor for the treatment of ischemic mediated central nervous system disorders or injury
GB0601951D0 (en) 2006-01-31 2006-03-15 Novartis Ag Organic compounds
WO2011081915A2 (en) * 2009-12-15 2011-07-07 Cebix Inc. Methods for treating erectile dysfunction in patients with insulin-dependent diabetes
CN105636967B (zh) 2013-08-12 2018-09-28 沙特基础工业公司 用于烯烃聚合的催化剂体系

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4035370A (en) * 1971-11-03 1977-07-12 Richter Gedeon Vegyeszeti Gyar Rt. Alkaloid esters
US4167565A (en) * 1976-11-08 1979-09-11 Abbott Laboratories Adenosine-5'-carboxamides and method of use
JPS5668695A (en) * 1979-11-10 1981-06-09 Sankyo Co Ltd Enzyme inhibitor griseolic acid and its preparation
US4803271A (en) * 1982-02-01 1989-02-07 Syntex (U.S.A.) Inc. Process for preparing guanine derivatives
US4783532A (en) * 1983-10-28 1988-11-08 Sankyo Company Limited Process for preparing griseolic acid derivatives
JPS6094992A (ja) * 1983-10-28 1985-05-28 Sankyo Co Ltd グリゼオ−ル酸誘導体
JPS60246396A (ja) * 1984-05-22 1985-12-06 Sankyo Co Ltd 酵素阻害物質ジヒドロデスオキシグリゼオ−ル酸及びその塩類
US4788190A (en) * 1986-12-24 1988-11-29 Schering Corporation 2,4,4-tri- and 2,2,4,4-tetra substituted-1,3-dioxolane antifungal, antiallergy compounds
US5091431A (en) * 1988-02-08 1992-02-25 Schering Corporation Phosphodiesterase inhibitors
US4966912A (en) * 1989-09-29 1990-10-30 Uniroyal Chemical Company, Inc. Fungicidal 3-imino-1,4-oxathiins
JPH0559085A (ja) * 1990-12-27 1993-03-09 Nippon Kayaku Co Ltd イミダゾール塩基を有するオキセタノシン誘導体
JPH0639472B2 (ja) * 1991-12-21 1994-05-25 メルシャン株式会社 アゾール誘導体

Also Published As

Publication number Publication date
DK167878B1 (da) 1993-12-27
DE3650429D1 (de) 1995-11-30
DK179586A (da) 1986-10-20
CA1267409A (en) 1990-04-03
FI94133B (fi) 1995-04-13
US5760042A (en) 1998-06-02
NO169901C (no) 1992-08-19
KR930007385B1 (ko) 1993-08-09
EP0214708A3 (en) 1987-08-26
FI861655A (fi) 1986-10-20
NO169901B (no) 1992-05-11
ES557559A0 (es) 1988-02-16
DE3650429T2 (de) 1996-06-13
EP0214708B1 (en) 1989-12-13
DE3650297D1 (de) 1995-05-18
EP0214708A2 (en) 1987-03-18
FI861655A0 (fi) 1986-04-18
ES557558A0 (es) 1988-02-16
DE3650297T2 (de) 1996-01-25
DE3667470D1 (de) 1990-01-18
ES557560A0 (es) 1988-02-16
ATE121097T1 (de) 1995-04-15
ATE129501T1 (de) 1995-11-15
ES554178A0 (es) 1988-03-16
ES8801665A1 (es) 1988-02-16
FI94133C (fi) 1995-07-25
ES8801666A1 (es) 1988-02-16
HK1005739A1 (en) 1999-01-22
US5532369A (en) 1996-07-02
US5556975A (en) 1996-09-17
ES8802054A1 (es) 1988-03-16
US5616600A (en) 1997-04-01
NO861533L (no) 1986-11-21
US5498819A (en) 1996-03-12
HK1005738A1 (en) 1999-01-22
DK179586D0 (da) 1986-04-18
KR860008206A (ko) 1986-11-14

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