ES8801263A1 - Procedimiento para la preparacion de derivados de 10 l-metoxi-6-metilergolina y sus sales de adicion de acidos - Google Patents
Procedimiento para la preparacion de derivados de 10 l-metoxi-6-metilergolina y sus sales de adicion de acidosInfo
- Publication number
- ES8801263A1 ES8801263A1 ES556358A ES556358A ES8801263A1 ES 8801263 A1 ES8801263 A1 ES 8801263A1 ES 556358 A ES556358 A ES 556358A ES 556358 A ES556358 A ES 556358A ES 8801263 A1 ES8801263 A1 ES 8801263A1
- Authority
- ES
- Spain
- Prior art keywords
- methylergoline
- metoxi
- derivatives
- procedure
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000002253 acid Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 150000007513 acids Chemical class 0.000 title 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 2
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical group ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- YSEXMKHXIOCEJA-FVFQAYNVSA-N Nicergoline Chemical compound C([C@@H]1C[C@]2([C@H](N(C)C1)CC=1C3=C2C=CC=C3N(C)C=1)OC)OC(=O)C1=CN=CC(Br)=C1 YSEXMKHXIOCEJA-FVFQAYNVSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical group II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 229960003642 nicergoline Drugs 0.000 abstract 1
- 239000000810 peripheral vasodilating agent Substances 0.000 abstract 1
- 229960002116 peripheral vasodilator Drugs 0.000 abstract 1
- 230000005855 radiation Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU852446A HU193781B (en) | 1985-06-21 | 1985-06-21 | Process for producing 10alpha-methoxy-6-methylergoline derivatives and acid additional salts thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8801263A1 true ES8801263A1 (es) | 1988-01-01 |
| ES556358A0 ES556358A0 (es) | 1988-01-01 |
Family
ID=10959396
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES556358A Expired ES8801263A1 (es) | 1985-06-21 | 1986-06-20 | Procedimiento para la preparacion de derivados de 10 l-metoxi-6-metilergolina y sus sales de adicion de acidos |
Country Status (14)
| Country | Link |
|---|---|
| BE (1) | BE904956A (cs) |
| CS (1) | CS255876B2 (cs) |
| DD (1) | DD246110A5 (cs) |
| DE (1) | DE3620487A1 (cs) |
| DK (1) | DK291986A (cs) |
| ES (1) | ES8801263A1 (cs) |
| FR (1) | FR2583755B1 (cs) |
| GB (1) | GB2177090B (cs) |
| GR (1) | GR861619B (cs) |
| HU (1) | HU193781B (cs) |
| IT (1) | IT1190135B (cs) |
| LU (1) | LU86486A1 (cs) |
| NL (1) | NL8601584A (cs) |
| PT (1) | PT82807B (cs) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU196598B (en) * | 1986-04-25 | 1988-12-28 | Richter Gedeon Vegyeszet | Process for producing 1- and/or 8-substituted 2-halogenated ergoline derivatives and pharmaceutics comprising such compounds |
| GB9603226D0 (en) * | 1996-02-15 | 1996-04-17 | Pharmacia Spa | Heterocyclyl-ergoline derivatives |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1094965B (it) * | 1978-04-05 | 1985-08-10 | Corvi Mora E | Procedimento di preparazione di derivati del lisergolo |
| HU193782B (en) * | 1985-06-21 | 1987-11-30 | Richter Gedeon Vegyeszet | Process for producing 2-halogeno-nicergoline derivatives and acid additional salts thereof |
-
1985
- 1985-06-21 HU HU852446A patent/HU193781B/hu not_active IP Right Cessation
-
1986
- 1986-06-19 BE BE0/216805A patent/BE904956A/fr not_active IP Right Cessation
- 1986-06-19 NL NL8601584A patent/NL8601584A/nl not_active Application Discontinuation
- 1986-06-19 FR FR868608869A patent/FR2583755B1/fr not_active Expired - Lifetime
- 1986-06-19 IT IT20854/86A patent/IT1190135B/it active
- 1986-06-19 DE DE19863620487 patent/DE3620487A1/de not_active Withdrawn
- 1986-06-20 ES ES556358A patent/ES8801263A1/es not_active Expired
- 1986-06-20 PT PT82807A patent/PT82807B/pt not_active IP Right Cessation
- 1986-06-20 DD DD86291508A patent/DD246110A5/de not_active IP Right Cessation
- 1986-06-20 LU LU86486A patent/LU86486A1/de unknown
- 1986-06-20 CS CS864585A patent/CS255876B2/cs unknown
- 1986-06-20 GR GR861619A patent/GR861619B/el unknown
- 1986-06-20 GB GB8615121A patent/GB2177090B/en not_active Expired
- 1986-06-20 DK DK291986A patent/DK291986A/da not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| GB2177090A (en) | 1987-01-14 |
| HU193781B (en) | 1987-11-30 |
| PT82807B (pt) | 1988-04-21 |
| GR861619B (en) | 1986-10-21 |
| FR2583755A1 (fr) | 1986-12-26 |
| LU86486A1 (de) | 1986-12-02 |
| HUT41023A (en) | 1987-03-30 |
| PT82807A (en) | 1986-07-01 |
| GB2177090B (en) | 1989-07-12 |
| FR2583755B1 (fr) | 1990-06-22 |
| DD246110A5 (de) | 1987-05-27 |
| DE3620487A1 (de) | 1987-01-02 |
| ES556358A0 (es) | 1988-01-01 |
| IT8620854A1 (it) | 1987-12-19 |
| DK291986D0 (da) | 1986-06-20 |
| DK291986A (da) | 1986-12-22 |
| BE904956A (fr) | 1986-12-19 |
| IT8620854A0 (it) | 1986-06-19 |
| NL8601584A (nl) | 1987-01-16 |
| GB8615121D0 (en) | 1986-07-23 |
| IT1190135B (it) | 1988-02-10 |
| CS255876B2 (en) | 1988-03-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19970303 |