ES8800668A1 - Un procedimiento para preparar en forma solida la sal disodica del acido 9-etil-6,9-dihidro-4,6-dioxo-10 propil-4-h pirano (3,2-g)quinolein -2,8-dicarboxilico. - Google Patents

Un procedimiento para preparar en forma solida la sal disodica del acido 9-etil-6,9-dihidro-4,6-dioxo-10 propil-4-h pirano (3,2-g)quinolein -2,8-dicarboxilico.

Info

Publication number
ES8800668A1
ES8800668A1 ES542184A ES542184A ES8800668A1 ES 8800668 A1 ES8800668 A1 ES 8800668A1 ES 542184 A ES542184 A ES 542184A ES 542184 A ES542184 A ES 542184A ES 8800668 A1 ES8800668 A1 ES 8800668A1
Authority
ES
Spain
Prior art keywords
formulations
nedocromil sodium
forms
novels
new forms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES542184A
Other languages
English (en)
Other versions
ES542184A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fisons Ltd
Original Assignee
Fisons Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB848409705A external-priority patent/GB8409705D0/en
Priority claimed from GB848423634A external-priority patent/GB8423634D0/en
Application filed by Fisons Ltd filed Critical Fisons Ltd
Publication of ES8800668A1 publication Critical patent/ES8800668A1/es
Publication of ES542184A0 publication Critical patent/ES542184A0/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR EN ESTADO SOLIDO LA SAL DISODICA DEL ACIDO 9-ETIL-6,9-DIHIDRO-4,6-DIOXO-10-PROPIL-4H-PIRANO (3,2-G)QUINOLEIN-2,8-DICARBOXILICO. COMPRENDE: A) CALENTAR UNA SOLUCION ACUOSA DE NEDOCRONIL-SODIO A PH ENTRE 5,0 Y 7,5 A UNA TEMPERATURA ENTRE 55 Y 85JC; B) MEZCLAR LA SOLUCION ACUOSA DE NEDOCRONIL-SODIO CON UN DISOLVENTE DE PRECIPITACION MISCIBLE EN AGUA, DURANTE 20 MINUTOS; C) AGITAR LA MEZCLA Y D) ENFRIAR LA MEZCLA ENTRE 25 Y 40JC Y DURANTE 1 A 5 HORAS, PARA OBTENER LA SAL DISODICA DEL ACIDO 9-ETIL-6,9-DIHIDRO-4,6-DIOXO-10-PROPIL-4H-PIRANO(3,2-G)QUINOLEIN-2,8-DICARBOXILICO O NEDOCRONIL-SODIO EN ESTADO SOLIDO QUE TIENE UNA LECTURA EN EL AMARILLO LOVIBOND POR DEBAJO DE 1,0 CUANDO CONTIENE UN 10% DE AGUA, PRESENTA UNA FORMA DE AGUJAS QUE TIENE UNA ANCHURA DE 1,5 A 3,5 MICRAS Y TIENE UNA INFLEXION DE 3.599 CMC EN EL ESPECTRO INFRARROJO. EL DISOLVENTE DE PRECIPITACION SE ELIGE ENTRE METIL-ETIL-CETONA Y ALCANOLES DE C 2 A 6. SE UTILIZA POR INHALACION PARA EL TRATAMIENTO DE OBSTRUCCION DE LAS VIAS RESPIRATORIAS (ASMA O SINUSITIS ALERGICA).
ES542184A 1984-04-13 1985-04-12 Un procedimiento para preparar en forma solida la sal disodica del acido 9-etil-6,9-dihidro-4,6-dioxo-10 propil-4-h pirano (3,2-g)quinolein -2,8-dicarboxilico. Expired ES8800668A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB848409705A GB8409705D0 (en) 1984-04-13 1984-04-13 Pharmaceutical formulation
GB848423634A GB8423634D0 (en) 1984-09-19 1984-09-19 Pharmaceutical formulation

Publications (2)

Publication Number Publication Date
ES8800668A1 true ES8800668A1 (es) 1987-11-16
ES542184A0 ES542184A0 (es) 1987-11-16

Family

ID=26287614

Family Applications (1)

Application Number Title Priority Date Filing Date
ES542184A Expired ES8800668A1 (es) 1984-04-13 1985-04-12 Un procedimiento para preparar en forma solida la sal disodica del acido 9-etil-6,9-dihidro-4,6-dioxo-10 propil-4-h pirano (3,2-g)quinolein -2,8-dicarboxilico.

Country Status (22)

Country Link
US (2) US4760072A (es)
EP (1) EP0162556B1 (es)
JP (2) JPH0613519B2 (es)
AU (1) AU584329B2 (es)
BE (1) BE902185A (es)
CA (1) CA1257201A (es)
CH (1) CH667271A5 (es)
DE (1) DE3584580D1 (es)
DK (1) DK174429B1 (es)
ES (1) ES8800668A1 (es)
FI (1) FI90942C (es)
FR (1) FR2563105B1 (es)
GB (1) GB2157291B (es)
GR (1) GR850916B (es)
IE (1) IE57653B1 (es)
IL (1) IL74883A (es)
LU (1) LU85850A1 (es)
MY (1) MY100428A (es)
NO (1) NO172542C (es)
NZ (1) NZ211771A (es)
PT (1) PT80275B (es)
SA (1) SA94150322B1 (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260306A (en) * 1981-07-24 1993-11-09 Fisons Plc Inhalation pharmaceuticals
EP0150966B1 (en) * 1984-01-26 1989-07-12 FISONS plc Benzopyran derivatives, compositions containing them and processes for their preparation
GB2187953B (en) * 1986-03-15 1989-11-15 Fisons Plc Pharmaceutical formulation
USRE38628E1 (en) * 1986-12-23 2004-10-19 Fisons Plc Pharmaceutical compositions
DE3787274T2 (de) * 1986-12-23 1994-01-27 Fisons Plc Pharmazeutische Präparate, die eine wässerige Lösung eines Pyranoquinolins enthalten.
GB8704089D0 (en) * 1987-02-21 1987-03-25 Fisons Plc Method of treatment
GB8704773D0 (en) * 1987-02-28 1987-04-01 Fisons Plc Compounds
EP0294914A3 (en) * 1987-03-17 1990-10-10 FISONS plc Nedocromil for the treatment of dermatological disorders
GB8712251D0 (en) * 1987-05-23 1987-07-01 Fisons Plc Formulation
GB8727590D0 (en) * 1987-11-25 1987-12-31 Fisons Plc Formulation
GB8820267D0 (en) * 1988-08-26 1988-09-28 Fisons Plc Pharmaceutical formulation
GB8820398D0 (en) * 1988-08-27 1988-09-28 Fisons Plc Pharmaceutical formulation
US5248493A (en) * 1988-08-27 1993-09-28 Fisons Plc Pharmaceutical composition
US5198221A (en) * 1989-05-17 1993-03-30 Fisons Plc Pharmaceutical composition
GB8911259D0 (en) * 1989-05-17 1989-07-05 Fisons Plc Inhalation medicament
US5195287A (en) * 1990-03-19 1993-03-23 Bemis Manufacturing Company Panel and method of making the same
US6140348A (en) * 1997-09-19 2000-10-31 Auburn University Treating/preventing heart failure via inhibition of mast cell degranulation
US5952353A (en) * 1997-09-19 1999-09-14 Auburn University Treating/preventing heart failure via inhibition of mast cell degranulation
GB9806462D0 (en) * 1998-03-26 1998-05-27 Glaxo Group Ltd Improved compositions for inhalation
WO2002015883A1 (en) * 2000-08-21 2002-02-28 Aeropharm Technology Incorporated A method of stabilizing a dry powder pharmaceutical formulation
US20050026880A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a cromone for treatment of asthma or chronic obstructive pulmonary disease
KR100550556B1 (ko) * 2003-11-11 2006-02-10 엘지전자 주식회사 에어컨의 중앙제어 시스템 및 그 동작방법
US9132116B2 (en) * 2004-08-02 2015-09-15 Willowcroft Pharm Inc. Mast cell stabilizers to prevent or treat laminitis
FR2898284B1 (fr) * 2006-03-10 2009-06-05 Inst Francais Du Petrole Procede de desacidification d'un gaz par solution absorbante avec regeneration fractionnee par chauffage.
CN101657402B (zh) * 2007-04-12 2014-05-14 陶氏环球技术公司 用于在二氯代醇回收期间减少重质副产物形成的方法和设备

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL54614A (en) * 1977-05-04 1983-07-31 Fisons Ltd Dihydrodioxo-pyranoquinoline dicarboxylic acid derivatives,their production and pharmaceutical compositions containing them
ZA782473B (en) * 1977-05-04 1979-04-25 Fisons Ltd Benzo pyrano-quinolinones
FR2440371A1 (fr) * 1978-10-31 1980-05-30 Fisons Ltd Nouveaux composes azotes heterocycliques, des compositions pharmaceutiques en contenant et des procedes pour les preparer
ZM8479A1 (en) * 1978-10-31 1980-09-22 Fisons Ltd Compounds
EP0150966B1 (en) * 1984-01-26 1989-07-12 FISONS plc Benzopyran derivatives, compositions containing them and processes for their preparation

Also Published As

Publication number Publication date
FR2563105A1 (fr) 1985-10-25
BE902185A (fr) 1985-07-31
DK160985A (da) 1985-10-14
JPH0798749B2 (ja) 1995-10-25
US4760072A (en) 1988-07-26
NO172542C (no) 1993-08-04
FI90942B (fi) 1994-01-14
NZ211771A (en) 1988-10-28
CH667271A5 (fr) 1988-09-30
FR2563105B1 (fr) 1987-02-13
PT80275B (pt) 1987-10-20
JPS60231680A (ja) 1985-11-18
NO851475L (no) 1985-10-14
CA1257201A (en) 1989-07-11
AU4094285A (en) 1985-10-17
FI851463A0 (fi) 1985-04-12
GB2157291B (en) 1988-08-10
FI851463L (fi) 1985-10-14
GB8508782D0 (en) 1985-05-09
PT80275A (en) 1985-05-01
IL74883A (en) 1990-08-31
US4918078A (en) 1990-04-17
IE57653B1 (en) 1993-02-10
DE3584580D1 (de) 1991-12-12
NO172542B (no) 1993-04-26
ES542184A0 (es) 1987-11-16
GB2157291A (en) 1985-10-23
MY100428A (en) 1990-09-29
JPH06227981A (ja) 1994-08-16
EP0162556A1 (en) 1985-11-27
DK174429B1 (da) 2003-03-03
GR850916B (es) 1985-11-25
JPH0613519B2 (ja) 1994-02-23
SA94150322B1 (ar) 2004-08-31
AU584329B2 (en) 1989-05-25
DK160985D0 (da) 1985-04-10
IE850938L (en) 1985-10-13
FI90942C (fi) 1994-04-25
LU85850A1 (fr) 1985-12-16
EP0162556B1 (en) 1991-11-06

Similar Documents

Publication Publication Date Title
ES8800668A1 (es) Un procedimiento para preparar en forma solida la sal disodica del acido 9-etil-6,9-dihidro-4,6-dioxo-10 propil-4-h pirano (3,2-g)quinolein -2,8-dicarboxilico.
OA09868A (en) Non-chorofluorocarbon aerosol formulation.
HUT39739A (en) Process for production of derivatives of 13,3-milbemycin and medical preparatives containing thereof
HUT37410A (en) Process for the production of benzothiazole- and benzothiophene-derivatives, as well as of therapeutic preparations containing them as agent
IL72928A (en) Bronchodilating pharmaceutical compositions containing 5,6-dialkoxybenzothiophene-2-carboxylic acid
DE3480053D1 (en) A kit or device and method for administering gangliosides and derivatives thereof of inhalation and pharmaceutical compositions suitable therefor
ATE70180T1 (de) Aerosolmittel zur nasenverstaeubung von vitamin b 12.
ES8607271A1 (es) Amidinohidrazonas
EP0136569A3 (en) Isoflavone derivatives, their production and use
DE3361609D1 (en) New n-((2-oxo-1-pyrrolidinyl)acetyl)piperazines, the methods of producing such new compounds and their salts as well as pharmaceutical preparations for therapeutic use containing these compounds or salts
ES8707734A1 (es) Procedimiento para la obtencion de cefalosporinas
ES8802612A1 (es) Procedimiento para preparar derivados de benzisoselenazolilo
HUT40568A (en) Process for production of medical preparatives containing ketityphen and xantin-derivatives against asthma
EP0253650A3 (en) Improvements relating to benzothiophene derivatives
DE3063196D1 (en) Derivatives of 2-substituted-6-phenyl-3(2h)pyridazinone, their production and pharmaceutical compositions containing them
HU904877D0 (en) Process for the production of plant extracts with medicative effect on the respiratory organs
AU569041B2 (en) Production of synthesis gas and subsequent treatment of the gas
ES8606375A1 (es) Un procedimiento para preparar un derivado de aminoprpilaminobleomicina

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20070820