ES8609296A1 - Un procedimiento para la preparacion de un compuesto - Google Patents

Un procedimiento para la preparacion de un compuesto

Info

Publication number
ES8609296A1
ES8609296A1 ES499079A ES499079A ES8609296A1 ES 8609296 A1 ES8609296 A1 ES 8609296A1 ES 499079 A ES499079 A ES 499079A ES 499079 A ES499079 A ES 499079A ES 8609296 A1 ES8609296 A1 ES 8609296A1
Authority
ES
Spain
Prior art keywords
hydroxy
methyl
lower alkyl
same
hydroxy acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES499079A
Other languages
English (en)
Spanish (es)
Other versions
ES499079A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27494171&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES8609296(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/175,232 external-priority patent/US4293496A/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES8609296A1 publication Critical patent/ES8609296A1/es
Publication of ES499079A0 publication Critical patent/ES499079A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ES499079A 1980-02-04 1981-02-03 Un procedimiento para la preparacion de un compuesto Granted ES499079A0 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US11805180A 1980-02-04 1980-02-04
US11804980A 1980-02-04 1980-02-04
US17546080A 1980-08-05 1980-08-05
US06/175,232 US4293496A (en) 1980-02-04 1980-08-05 6(R)-[2-(8-Hydroxy-2,6-dimethylpolyhydronaphthyl-1)-ethyl]-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-ones

Publications (2)

Publication Number Publication Date
ES8609296A1 true ES8609296A1 (es) 1985-10-16
ES499079A0 ES499079A0 (es) 1985-10-16

Family

ID=27494171

Family Applications (1)

Application Number Title Priority Date Filing Date
ES499079A Granted ES499079A0 (es) 1980-02-04 1981-02-03 Un procedimiento para la preparacion de un compuesto

Country Status (22)

Country Link
EP (1) EP0033538B1 (OSRAM)
AU (1) AU548996B2 (OSRAM)
CA (1) CA1199322A (OSRAM)
CY (1) CY1404A (OSRAM)
DD (1) DD155989A5 (OSRAM)
DE (1) DE3173042D1 (OSRAM)
DK (1) DK157292C (OSRAM)
ES (1) ES499079A0 (OSRAM)
FI (1) FI78082C (OSRAM)
GR (1) GR74798B (OSRAM)
HK (1) HK16488A (OSRAM)
IE (1) IE51478B1 (OSRAM)
IL (1) IL62044A (OSRAM)
MA (1) MA19054A1 (OSRAM)
MY (1) MY8700745A (OSRAM)
NL (1) NL930009I2 (OSRAM)
NO (2) NO154229C (OSRAM)
NZ (1) NZ196172A (OSRAM)
PT (1) PT72441B (OSRAM)
RO (1) RO82367B (OSRAM)
SG (1) SG61087G (OSRAM)
YU (1) YU28181A (OSRAM)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0692381B2 (ja) * 1980-03-31 1994-11-16 三共株式会社 Ｍｂ−５３０ａ誘導体
US4343814A (en) * 1980-11-17 1982-08-10 Merck & Co., Inc. Hypocholesterolemic fermentation products
US4432996A (en) * 1980-11-17 1984-02-21 Merck & Co., Inc. Hypocholesterolemic fermentation products and process of preparation
EP0094443A1 (en) * 1982-05-17 1983-11-23 Merck & Co. Inc. 6(R)-(2-(8(S) (2,2-dimethylbutyryloxy)-2(S),6(S)-dimethyl-1,2,3,4,4a(S),5,6,7,8,8a(S)-decahydronaphthyl-1(S))ethyl)-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one, process for preparing and pharmaceutical composition containing the same
US4503072A (en) * 1982-12-22 1985-03-05 Merck & Co., Inc. Antihypercholesterolemic compounds
GR81711B (OSRAM) * 1983-01-24 1984-12-12 Sandoz Ag
DE3481190D1 (de) * 1983-10-11 1990-03-08 Merck & Co Inc Verfahren zur herstellung von 6(r)-(2-(8(s)(2,2-dimethylbutyryloxy)-2(s),6(s)-dimethyl-1,2,3,4,4a(s),5,6,7,8,8a(s)-decahydronaphthyl-1(s))ethyl)-4(r)-hydroxy-3,4,5,6-tetrahydro-2h-pyran-2-on.
DE3480923D1 (de) * 1983-10-11 1990-02-08 Merck & Co Inc Verfahren zur c-methylierung von 2-methylbutyraten.
US4668699A (en) * 1985-08-05 1987-05-26 Merck & Co., Inc. Novel HMG-CoA reductase inhibitors
US4833258A (en) * 1987-02-17 1989-05-23 Merck & Co., Inc. Intermediates useful in the preparation of HMG-COA reductase inhibitors
US4997848A (en) 1987-10-27 1991-03-05 Sankyo Company, Limited Octahydronaphthalene oxime derivatives for cholesterol synthesis inhibition
US5021451A (en) * 1988-11-14 1991-06-04 Hoffman-La Roche Inc. Method for inhibiting hyperproliferative diseases
GB8915280D0 (en) * 1989-07-04 1989-08-23 British Bio Technology Compounds
US5110825A (en) * 1989-12-28 1992-05-05 Shionogi & Co., Ltd. Benzofuran derivative
GB9100174D0 (en) * 1991-01-04 1991-02-20 British Bio Technology Compounds
NZ250609A (en) * 1992-12-28 1995-07-26 Sankyo Co Hexahydronaphthalene esters and ring closed lactones; preparation and medicaments
US6642268B2 (en) 1994-09-13 2003-11-04 G.D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors
US6268392B1 (en) 1994-09-13 2001-07-31 G. D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors
AU706628B2 (en) * 1995-07-03 1999-06-17 Sankyo Company Limited Treatment of arteriosclerosis and xanthoma
EA000954B1 (ru) * 1995-12-06 2000-08-28 Балканфарма - Разград Ад Способ получения ловастатина
CA2185961A1 (en) 1996-09-19 1998-03-20 K.S. Keshava Murthy Process for producing simvastatin
US6083497A (en) 1997-11-05 2000-07-04 Geltex Pharmaceuticals, Inc. Method for treating hypercholesterolemia with unsubstituted polydiallylamine polymers
SI9800057A (sl) * 1998-02-26 1999-08-31 Krka, Tovarna Zdravil, D.D. Postopek za pripravo simvastatina in njegovih derivatov
CA2240983A1 (en) 1998-06-18 1999-12-18 Yong Tao Process to manufacture simvastatin and intermediates
EP1340510A1 (en) 1998-12-23 2003-09-03 G.D. Searle LLC. Combinations of cholesteryl ester transfer protein inhibitors and bile acid sequestering agents for cardiovascular indications
NZ512536A (en) 1998-12-23 2003-11-28 G Combinations of ileal bile acid transport inhibitors and cholesteryl ester transfer protein inhibitors for cardiovascular indications
PT1140190E (pt) 1998-12-23 2003-02-28 Searle Llc Combinacoes de inibidores do transporte ileal dos acidos biliares e agentes sequestrantes dos acidos biliares usadas para problemas cardiovasculares
EP1340508A1 (en) 1998-12-23 2003-09-03 G.D. Searle LLC. Combinations of cholesteryl ester transfer protein inhibitors and nicotinic acid derivatives for cardiovascular indications
DE69907960T2 (de) 1998-12-23 2004-02-26 G.D. Searle Llc, Chicago Kombinationen von ileumgallensäuretransports inhibitoren und fibronsäure derivaten für kardiovaskuläre indikationen
AU776664B2 (en) 1998-12-23 2004-09-16 G.D. Searle Llc Combinations of cholesteryl ester transfer protein inhibitors and fibric acid derivatives for cardiovascular indications
WO2000038722A1 (en) 1998-12-23 2000-07-06 G.D. Searle & Co. COMBINATIONS OF CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS AND HMG CoA REDUCTASE INHIBITORS FOR CARDIOVASCULAR INDICATIONS
US6794544B2 (en) 2000-03-10 2004-09-21 Pharmacia Corporation Method for the preparation of tetrahydrobenzothiepines
ES2329974T3 (es) * 2000-09-07 2009-12-03 Kaneka Corporation Metodos para la cristalizacion de acidos hidroxicarboxilicos.
BR0213501A (pt) 2001-11-02 2004-08-24 Searle Llc Compostos de benzotiepina mono- e di-fluorada como inibidores de transporte de ácido biliar co-dependente de sódio apical (asbt) e captação de taurocolato
CA2471639A1 (en) 2002-01-17 2003-07-31 Pharmacia Corporation Novel alkyl/aryl hydroxy or keto thiepines.
SI21187A (sl) 2002-03-26 2003-10-31 Krka, Tovarna Zdravil D.D., Novo Mesto Postopek za pripravo 4-oksitetrahidropiran-2-onov
KR20040092790A (ko) * 2003-04-29 2004-11-04 씨제이 주식회사 심바스타틴 중간체 제조방법
EP1741427A1 (en) 2005-07-06 2007-01-10 KRKA, D.D., Novo Mesto Pharmaceutical composition comprising simvastatin and ezetimibe
UA106422C2 (uk) 2006-07-05 2014-08-26 Такеда Гмбх КОМБІНОВАНЕ ЗАСТОСУВАННЯ ІНГІБІТОРА PDE4 ТА ІНГІБІТОРА HMG-CоA-РЕДУКТАЗИ ДЛЯ ПРОФІЛАКТИКИ АБО ЗЦІЛЮВАЛЬНОГО ЛІКУВАННЯ ЗАПАЛЬНОГО ЗАХВОРЮВАННЯ ЛЕГЕНІВ
WO2009013764A2 (en) * 2007-07-24 2009-01-29 Jubilant Organosys Limited Process for producing 6(r)-[2-(8'(s)-2 ',2 '-dimethylbutyryloxy-2'(s),6'(r)-dimethyl-1,2,6,7', 8',8a'(r)- hexahydronaphthyl-l'(s))ethyl]-4(r)-hydroxy-3,4,5,6- tetrahydro-2h-pyran-2-one
JOP20080381B1 (ar) 2007-08-23 2023-03-28 Amgen Inc بروتينات مرتبطة بمولدات مضادات تتفاعل مع بروبروتين كونفيرتاز سيتيليزين ككسين من النوع 9 (pcsk9)
ES2330184B1 (es) 2008-06-03 2010-07-05 Neuron Biopharma, S.A. Uso de estatinas como anticonvulsivantes, antiepilepticos y neuroprotectores.
ES2343049B1 (es) 2008-10-15 2011-06-10 Neuron Biopharma, S.A. Biosintesis de derivados de monacolina j.
EP2204170A1 (en) 2008-12-01 2010-07-07 LEK Pharmaceuticals D.D. Pharmaceutical composition comprising ezetimibe and simvastatin
EP2327682A1 (en) 2009-10-29 2011-06-01 KRKA, D.D., Novo Mesto Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates
WO2010069593A1 (en) 2008-12-19 2010-06-24 Krka, D. D., Novo Mesto Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates
EP2216016A1 (en) 2009-02-06 2010-08-11 LEK Pharmaceuticals d.d. Process for the preparation of a pharmaceutical composition comprising ezetimibe
EP2241561A1 (en) * 2009-04-16 2010-10-20 Neuron Biopharma, S.A. Neuroprotective, hypocholesterolemic and antiepileptic compound
WO2011002424A2 (en) 2009-07-02 2011-01-06 Bilgic Mahmut Solubility and stability enchancing pharmaceutical formulation
AR079336A1 (es) 2009-12-11 2012-01-18 Irm Llc Antagonistas de la pro-proteina convertasa-subtilisina/quexina tipo 9 (pcsk9)
EP2368543A1 (en) 2010-03-25 2011-09-28 KRKA, tovarna zdravil, d.d., Novo mesto Method of preparing a granulated pharmaceutical composition comprising simvastatin and/or ezetimibe
ES2380473B1 (es) * 2010-10-13 2013-02-19 Neuron Biopharma, S.A. Compuesto neuroprotector, hipocolesterolémico, antiinflamatorio y antiepiléptico.
CA2865796A1 (en) 2011-12-29 2013-07-04 Trustees Of Tufts College Functionalization of biomaterials to control regeneration and inflammation responses
CA2875096A1 (en) 2012-06-15 2013-12-19 Genentech, Inc. Anti-pcsk9 antibodies, formulations, dosing, and methods of use

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5612114B2 (OSRAM) * 1974-06-07 1981-03-18
US4049495A (en) 1974-06-07 1977-09-20 Sankyo Company Limited Physiologically active substances and fermentative process for producing the same
US4137322A (en) 1976-11-02 1979-01-30 Sankyo Company Limited ML-236B carboxylic acid derivatives and their use as antihyperlipemic agents
JPS6026094B2 (ja) 1978-07-04 1985-06-21 三共株式会社 テトラヒドロｍｌ↓−２３６ｂおよびその誘導体並びにそれを有効成分とする高脂血症治療剤
JPS5925599B2 (ja) * 1979-02-20 1984-06-19 三共株式会社 新生理活性物質モナコリンｋおよびその製造法
IL60219A (en) * 1979-06-15 1985-05-31 Merck & Co Inc Hypocholesteremic fermentation products of the hmg-coa reductase inhibitor type,their preparation and pharmaceutical compositions containing them
US4231938A (en) 1979-06-15 1980-11-04 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation
PT72394B (en) 1980-02-04 1982-09-06 Merck & Co Inc Process for preparing dihydro and tetrahydromevinoline hypocholesterolimics

Also Published As

Publication number Publication date
RO82367B (ro) 1984-02-28
MA19054A1 (fr) 1981-10-01
NO154229B (no) 1986-05-05
DK157292C (da) 1990-05-07
CY1404A (en) 1988-04-22
EP0033538B1 (en) 1985-11-27
FI810287L (fi) 1981-08-05
NL930009I2 (nl) 1993-09-16
NO1994001I1 (no) 1994-07-01
HK16488A (en) 1988-03-11
SG61087G (en) 1987-10-23
EP0033538A2 (en) 1981-08-12
RO82367A (ro) 1984-02-21
FI78082C (fi) 1989-06-12
YU28181A (en) 1983-10-31
DK46181A (da) 1981-08-05
IE810204L (en) 1981-08-04
NO810358L (no) 1981-08-05
DD155989A5 (de) 1982-07-21
NZ196172A (en) 1985-01-31
GR74798B (OSRAM) 1984-07-12
DK157292B (da) 1989-12-04
EP0033538A3 (en) 1982-02-24
NL930009I1 (nl) 1993-04-01
PT72441B (pt) 1984-08-01
AU6657381A (en) 1981-08-13
MY8700745A (en) 1987-12-31
AU548996B2 (en) 1986-01-09
PT72441A (pt) 1981-03-01
IE51478B1 (en) 1987-01-07
IL62044A (en) 1987-03-31
FI78082B (fi) 1989-02-28
DE3173042D1 (en) 1986-01-09
ES499079A0 (es) 1985-10-16
CA1199322A (en) 1986-01-14
NO154229C (no) 1986-08-13
IL62044A0 (en) 1981-03-31

Similar Documents

Publication Publication Date Title
ES8609296A1 (es) Un procedimiento para la preparacion de un compuesto
US7674921B2 (en) Internal 1,15-lactones of fluprostenol and related prostaglandin F2α analogs and their use in the treatment of glaucoma and intraocular hypertension
US8389748B2 (en) Method for preparing prostaglandin derivative
US5773654A (en) 7-(5-substituted cyclopentyl) and (5-substituted cyclopentenyl) heptyl alcohols, heptylamines and heptanoic acid amides, and method of lowering intraocular pressure in the eye of a mammal by administration of these compounds
US5476872A (en) 1,11-diesters of prostaglandin-F2α having a polar ester group at C-1
AU653240B2 (en) Ocular hypotensive 2-decarboxyl-2-acylthioalkyl prostaglandin derivatives
US4087435A (en) 8-Aza-9-dioxothiaprostanoic acids
AU2001233286A1 (en) Internal 1,15-lactones of fluprostenol and related prostaglandin F2alpha analogs and their use in the treatment of glaucoma and intraocular hypertension
US4346228A (en) Novel 11-oxoprostaglandin derivatives
US4118584A (en) 9-Deoxy-9-methylene-16-phenyl-PGF compounds
US4771071A (en) Antihypercholesterolemic compounds
US5650523A (en) Process for the desilylation of a 4-silyloxy-tetrahydro-pyran-2-one
US6506929B1 (en) Process to manufacture simvastatin and intermediates
EP0113881A1 (en) Antihypercholesterolemic compounds
ES8308358A1 (es) Un procedimiento para la preparacion de una serie de nuevos derivados del compuesto ml-236b
FR2515642A1 (fr) Nouvelles (11r)-11-deoxy-11-alkyl-6-oxo-prostaglandines et compositions pharmaceutiques les contenant
US4916162A (en) Antihypercholesterolemic compounds
US4182759A (en) Arylalkyl and aryloxyalkyl phosphonates and use as antiviral agents
CH630898A5 (de) Verfahren zur herstellung neuer prostaglandin-analoga mit dreifachbindung zwischen c-13 und c-14.
KR880001561A (ko) 유효한 치료성을 갖는 신규 8-(저급알킬)비시클로[4.2.0] 옥탄 유도체
DE2542686A1 (de) 2a,2b-dihomo-15-methyl- und -15- aethyl-pgf-und pge-verbindungen und verfahren zu deren herstellung
US4017534A (en) 16-Fluoro-11-deoxy-13-dihydro-prostaglandin
US4124706A (en) Esters of bis-(hydroxyalkylthio)-alkanes
KR800000314B1 (ko) 프로스타글란딘류 유사체의 제조방법
US5149835A (en) Substituted mevalonolactones, and methods for stereoselective preparation thereof and desmethyl homologues thereof

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20050726