ES8607926A1 - Procedimiento para preparar nuevas pirrolidinonas substitui-das - Google Patents

Procedimiento para preparar nuevas pirrolidinonas substitui-das

Info

Publication number
ES8607926A1
ES8607926A1 ES543592A ES543592A ES8607926A1 ES 8607926 A1 ES8607926 A1 ES 8607926A1 ES 543592 A ES543592 A ES 543592A ES 543592 A ES543592 A ES 543592A ES 8607926 A1 ES8607926 A1 ES 8607926A1
Authority
ES
Spain
Prior art keywords
group
carbon atoms
alkyl group
substituted
chained
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES543592A
Other languages
English (en)
Spanish (es)
Other versions
ES543592A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim GmbH
Original Assignee
Boehringer Ingelheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim GmbH filed Critical Boehringer Ingelheim GmbH
Publication of ES8607926A1 publication Critical patent/ES8607926A1/es
Publication of ES543592A0 publication Critical patent/ES543592A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ES543592A 1984-05-30 1985-05-29 Procedimiento para preparar nuevas pirrolidinonas substitui-das Expired ES8607926A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843420193 DE3420193A1 (de) 1984-05-30 1984-05-30 Neue substituierte pyrrolidinone, verfahren zu ihrer herstellung und arzneimittel

Publications (2)

Publication Number Publication Date
ES8607926A1 true ES8607926A1 (es) 1986-06-01
ES543592A0 ES543592A0 (es) 1986-06-01

Family

ID=6237240

Family Applications (4)

Application Number Title Priority Date Filing Date
ES543592A Expired ES8607926A1 (es) 1984-05-30 1985-05-29 Procedimiento para preparar nuevas pirrolidinonas substitui-das
ES552410A Expired ES8707927A1 (es) 1984-05-30 1986-02-26 Procedimiento para preparar nuevas pirrolidinonas substituidas
ES552411A Expired ES8707928A1 (es) 1984-05-30 1986-02-26 Procedimiento para preparar nuevas pirrolidinonas substituidas
ES552409A Expired ES8801200A1 (es) 1984-05-30 1986-02-26 Procedimiento para preparar nuevas pirrolidinonas substituidas

Family Applications After (3)

Application Number Title Priority Date Filing Date
ES552410A Expired ES8707927A1 (es) 1984-05-30 1986-02-26 Procedimiento para preparar nuevas pirrolidinonas substituidas
ES552411A Expired ES8707928A1 (es) 1984-05-30 1986-02-26 Procedimiento para preparar nuevas pirrolidinonas substituidas
ES552409A Expired ES8801200A1 (es) 1984-05-30 1986-02-26 Procedimiento para preparar nuevas pirrolidinonas substituidas

Country Status (22)

Country Link
US (4) US4670456A (en, 2012)
EP (1) EP0163260B1 (en, 2012)
JP (1) JPS6168A (en, 2012)
KR (1) KR850008343A (en, 2012)
AT (1) ATE36151T1 (en, 2012)
AU (1) AU581438B2 (en, 2012)
CA (1) CA1255664A (en, 2012)
CS (1) CS261883B2 (en, 2012)
DD (1) DD235256A5 (en, 2012)
DE (2) DE3420193A1 (en, 2012)
DK (1) DK239685A (en, 2012)
ES (4) ES8607926A1 (en, 2012)
FI (1) FI78462C (en, 2012)
GR (1) GR851306B (en, 2012)
HU (1) HU193393B (en, 2012)
IL (1) IL75339A (en, 2012)
NO (1) NO852133L (en, 2012)
NZ (1) NZ212241A (en, 2012)
PL (1) PL144921B1 (en, 2012)
PT (1) PT80545B (en, 2012)
SU (1) SU1360583A3 (en, 2012)
ZA (1) ZA854072B (en, 2012)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3336024A1 (de) * 1983-10-04 1985-04-18 Boehringer Ingelheim KG, 6507 Ingelheim 4-amino-l-benzyl-pyrrolidinone und ihre saeureadditionssalze, verfahren zu ihrer herstellung und arzneimittel
FR2597100A1 (fr) * 1986-01-21 1987-10-16 Nippon Shinyaku Co Ltd Derives du pyroglutamide
US4960776A (en) * 1987-01-28 1990-10-02 A. H. Robins Company, Inc. 4-aryl-N-(alkylaminoalkyl, heterocyclicamino and heterocyclicamino)alkyl)-1-piperazinecarboxamides
CA1305148C (en) * 1987-08-19 1992-07-14 Hiromu Matsumura Carbamoylpyrrolidone derivatives and drugs for senile dementia
US4833139A (en) * 1988-01-25 1989-05-23 Hoechst-Roussel Pharmaceuticals, Inc. Enhancing cholinergic activity with 5-substituted 1-[4-(1-pyrrolidinyl)-2-butynyl]-2-pyrrolidinones and related compounds
ES2043943T3 (es) * 1988-05-20 1994-01-01 Zambon Spa Procedimiento para la preparacion de compuestos con actividad analgesica central.
JPH02137427A (ja) * 1988-11-18 1990-05-25 Du Pont Opt Electron Kk 光電気的接続装置及び光コンセント
US4981974A (en) * 1989-05-08 1991-01-01 Gaf Chemicals Corporation Polymerizable pyrrolidonyl oxazoline monomers
TW448172B (en) * 1996-03-08 2001-08-01 Pharmacia & Upjohn Co Llc Novel hydroxamic acid derivatives useful for the treatment of diseases related to connective tissue degradation
TWI294778B (en) * 2002-03-13 2008-03-21 Smithkline Beecham Corp Peptide deformylase inhibitors
PT2383271E (pt) * 2006-03-13 2013-10-10 Kyorin Seiyaku Kk Aminoquinolonas como inibidores de gsk-3
CN101855228B (zh) * 2007-09-11 2012-10-24 杏林制药株式会社 作为gsk-3抑制剂的氰基氨基喹诺酮和四唑并氨基喹诺酮
AU2008333173A1 (en) * 2007-12-05 2009-06-11 Astrazeneca Ab Piperazines as anti-obesity agents
CN102015668A (zh) 2007-12-05 2011-04-13 阿斯利康(瑞典)有限公司 用作瘦蛋白受体调节剂的哌嗪衍生物及其用途
US20110275670A1 (en) * 2008-06-04 2011-11-10 Emma Chapman New Compounds VII
MX2011009414A (es) * 2009-03-11 2011-10-19 Kyorin Seiyaku Kk 7-cicloalquiloaminoquinolonas como inhibidores de gsk-3.

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2838914A (en) * 1957-07-03 1958-06-17 Olin Mathieson Isonicotinic acid hydrazide derivatives
GB1039113A (en) * 1964-08-06 1966-08-17 Ucb Sa New n-substituted lactams
GB1309692A (en) * 1970-02-13 1973-03-14 Ucb Sa N-substituted lactams
JPS4924916B1 (en, 2012) * 1970-08-14 1974-06-26
FR2387218A1 (fr) * 1977-04-15 1978-11-10 Ile De France Nouveaux n-(1'-ethyl 2'-oxo 5'-pyrrolidinyl methyl) benzamides, leurs procedes de preparation et leur application comme modificateurs du comportement
CU21107A3 (es) * 1978-02-10 1988-02-01 Hoffmann La Roche Pyrrolidines derivatives
DE3326724A1 (de) * 1983-07-25 1985-02-07 Boehringer Ingelheim KG, 6507 Ingelheim In 1-stellung substituierte 4-hydroxymethyl-pyrrolidinone, verfahren zu ihrer herstellung, pharmazeutische zusammensetzungen und zwischenprodukte
DE3336024A1 (de) * 1983-10-04 1985-04-18 Boehringer Ingelheim KG, 6507 Ingelheim 4-amino-l-benzyl-pyrrolidinone und ihre saeureadditionssalze, verfahren zu ihrer herstellung und arzneimittel
GB8412358D0 (en) * 1984-05-15 1984-06-20 Ucb Sa Pharmaceutical composition
US4670436A (en) * 1986-08-29 1987-06-02 Mcneilab, Inc. Hypoglycemic 5-substituted pyrrolidinylidene compounds, compositions and use

Also Published As

Publication number Publication date
FI852130L (fi) 1985-12-01
DD235256A5 (de) 1986-04-30
EP0163260B1 (de) 1988-08-03
PL144921B1 (en) 1988-07-30
FI78462C (fi) 1989-08-10
ES8707928A1 (es) 1987-09-01
AU581438B2 (en) 1989-02-23
US4891378A (en) 1990-01-02
IL75339A0 (en) 1985-09-29
CS385485A2 (en) 1988-06-15
GR851306B (en, 2012) 1985-11-25
PT80545B (de) 1987-04-06
DE3420193A1 (de) 1985-12-05
ES552409A0 (es) 1987-12-16
US4762832A (en) 1988-08-09
HUT37751A (en) 1986-02-28
DK239685A (da) 1985-12-01
AU4317085A (en) 1985-12-05
PL253668A1 (en) 1986-05-20
NO852133L (no) 1985-12-02
JPS6168A (ja) 1986-01-06
HU193393B (en) 1987-09-28
DE3564105D1 (en) 1988-09-08
ES552410A0 (es) 1987-09-01
ES543592A0 (es) 1986-06-01
JPH0517904B2 (en, 2012) 1993-03-10
PT80545A (de) 1985-06-01
CS261883B2 (en) 1989-02-10
US4857528A (en) 1989-08-15
SU1360583A3 (ru) 1987-12-15
DK239685D0 (da) 1985-05-29
IL75339A (en) 1988-07-31
ES8801200A1 (es) 1987-12-16
FI78462B (fi) 1989-04-28
EP0163260A1 (de) 1985-12-04
CA1255664A (en) 1989-06-13
ES8707927A1 (es) 1987-09-01
ES552411A0 (es) 1987-09-01
ZA854072B (en) 1987-02-25
US4670456A (en) 1987-06-02
ATE36151T1 (de) 1988-08-15
NZ212241A (en) 1989-07-27
FI852130A0 (fi) 1985-05-29
KR850008343A (ko) 1985-12-16

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