ES8607756A1 - Un procedimiento para la preparacion de hidrocloruro de van-comicina - Google Patents
Un procedimiento para la preparacion de hidrocloruro de van-comicinaInfo
- Publication number
- ES8607756A1 ES8607756A1 ES548042A ES548042A ES8607756A1 ES 8607756 A1 ES8607756 A1 ES 8607756A1 ES 548042 A ES548042 A ES 548042A ES 548042 A ES548042 A ES 548042A ES 8607756 A1 ES8607756 A1 ES 8607756A1
- Authority
- ES
- Spain
- Prior art keywords
- vancomycin
- product
- purification improvement
- vancomycin purification
- improvement
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 108010059993 Vancomycin Proteins 0.000 title abstract 5
- 229960003165 vancomycin Drugs 0.000 title abstract 5
- MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 title abstract 5
- 238000000746 purification Methods 0.000 title 1
- MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 title 1
- MYPYJXKWCTUITO-LYRMYLQWSA-O vancomycin(1+) Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C([O-])=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)[NH2+]C)[C@H]1C[C@](C)([NH3+])[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-O 0.000 abstract 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 abstract 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000001177 diphosphate Substances 0.000 abstract 1
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 abstract 1
- 235000011180 diphosphates Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
- C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Cephalosporin Compounds (AREA)
- Pyrane Compounds (AREA)
- Compounds Of Unknown Constitution (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
Abstract
PROCEDIMIENTO MODIFICADO PARA AISLAR Y PURIFICAR A LA VANCOMICINA. COMPRENDE: A) FILTRAR EL CALDO DE VANCOMICINA A UN PH ENTRE 0 A 10 EN PRESENCIA DE CELITE O SIMILARES PARA SEPARAR A LAS IMPUREZAS SOLIDAS Y AL MICELIO DE FERMENTACION; B) TRATAR AL FILTRADO CON UNA RESINA CAMBIADORA DE ION, COMO UNA RESINA CATIONICA SODICA DE POLIESTIRENO-DIVINILBENCENO POCO ENTRECRUZADO, PARA ABSORBER A LA VANCOMICINA EN LA RESINA; C) ELUIR A LA VANCOMICINA DE LA RESINA CON AGUA; D) DILUIR A LA VANCOMICINA DE (C) CON UNA SOLUCION ACUOSA ALCALINA DE PH ENTRE 9,0 Y 11,0; E) NEUTRALIZAR AL ELUATO ALCALINO DE LA RESINA; F) TRATAR AL ELUATO NEUTRALIZADO CON UNA RESINA COMERCIAL DIAION HP-20 O SIMILAR; G) ELUIR A LA RESINA CARGADA CON UNA SOLUCION ACUOSA DE ETANOL O ISOPROPANOL AL 3-30% EN VOLUMEN; H) CONCENTRAR AL ELUATO DE (G) HASTA OBTENER DE 250 A 285 MG DE VANCOMICINA POR MILILITRO DE SOLUCION; I) ACIDULAR AL ELUATO DE (H) CON UNA SOLUCION DE ACIDO FOSFORICO A UN PH DE 2,0; Y J) ENFRIAR LA SOLUCION ACUOSA ACIDA ENTRE 0 Y 20JC, PARA PRECIPITAR AL DIFOSFATO DE VANCOMICINA EN FORMA CRISTALINA QUE SE PURIFICA CON ALCOHOL O RESINA. SE UTILIZA COMO AGENTE ANTIBACTERIANO CONTRA CEPAS DE MICROORGANISMOS GRAM-(B) COMO STREPTOCOCCI O CLORHIDIUM DIFFICILE.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56030083A | 1983-12-12 | 1983-12-12 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES548042A0 ES548042A0 (es) | 1986-06-01 |
| ES8607756A1 true ES8607756A1 (es) | 1986-06-01 |
Family
ID=24237197
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES538423A Expired ES8606409A1 (es) | 1983-12-12 | 1984-12-07 | Un procedimiento para aislar vancomicina de una solucion acuosa |
| ES548042A Expired ES8607756A1 (es) | 1983-12-12 | 1985-10-18 | Un procedimiento para la preparacion de hidrocloruro de van-comicina |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES538423A Expired ES8606409A1 (es) | 1983-12-12 | 1984-12-07 | Un procedimiento para aislar vancomicina de una solucion acuosa |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP0145484B1 (es) |
| JP (1) | JPH0689038B2 (es) |
| KR (1) | KR870000550B1 (es) |
| AT (1) | ATE41015T1 (es) |
| AU (1) | AU575887B2 (es) |
| CA (1) | CA1245639A (es) |
| DE (1) | DE3476886D1 (es) |
| DK (1) | DK164914C (es) |
| EG (1) | EG16899A (es) |
| ES (2) | ES8606409A1 (es) |
| FI (1) | FI844801L (es) |
| GB (1) | GB2151234B (es) |
| GR (1) | GR81191B (es) |
| HU (1) | HU194914B (es) |
| IE (1) | IE57674B1 (es) |
| IL (1) | IL73746A (es) |
| NZ (1) | NZ210470A (es) |
| PH (1) | PH20269A (es) |
| PL (1) | PL250763A1 (es) |
| PT (1) | PT79634B (es) |
| ZA (1) | ZA849516B (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4736031A (en) * | 1985-06-10 | 1988-04-05 | Takeda Chemical Industries, Ltd. | 2-(piperazinylalkyl)-1-benzothiepin, 1-benzoxepin, and 1,5-benzodioxepin derivatives |
| GB8600952D0 (en) * | 1986-01-16 | 1986-02-19 | Glaxo Group Ltd | Antibiotic production |
| US4874843A (en) * | 1987-12-03 | 1989-10-17 | Eli Lilly And Company | Chromatographic purification process |
| CA1320312C (en) * | 1987-12-28 | 1993-07-13 | Harold Raymond Catt | Improved vancomycin precipitation process |
| US5037652A (en) * | 1987-12-28 | 1991-08-06 | Eli Lilly And Company | Vancomycin precipitation process |
| US5258495A (en) * | 1990-07-10 | 1993-11-02 | Abbott Laboratories | Process for making vancomycin HC1 |
| US5149784A (en) * | 1990-07-10 | 1992-09-22 | Abbott Laboratories | Process for making vancomycin |
| US5574135A (en) * | 1990-07-10 | 1996-11-12 | Abbott Laboratories | Process for making vancomycin |
| US5235037A (en) * | 1991-08-15 | 1993-08-10 | American Cyanamid Company | Vancomycin precipitation process |
| KR19980039737A (ko) * | 1996-11-28 | 1998-08-17 | 손경식 | 반코마이신의 결정화방법 |
| SI21924A (sl) * | 2004-12-07 | 2006-06-30 | Lek Farmacevtska Druzba D.D. | Cist vankomicin hidroklorid |
| EP1798237A1 (en) * | 2005-12-16 | 2007-06-20 | Pharmatex Italia Srl | Process for the purification of macrolide antibiotics |
| EP2097440A4 (en) * | 2006-12-22 | 2010-09-08 | Targanta Therapeutics Inc | ANTIBIOTICS BASED ON GLYCOPEPTIDES AND LIPOGLYCOPEPTIDES PHOSPHONES AND THEIR USES IN THE PREVENTION AND TREATMENT OF BONE AND JOINT INFECTIONS |
| JP2011153119A (ja) * | 2010-01-27 | 2011-08-11 | Mylan Seiyaku Ltd | バンコマイシンまたはその塩を含有する錠剤 |
| CN104672310A (zh) * | 2013-11-27 | 2015-06-03 | 北大医药重庆大新药业股份有限公司 | 一种盐酸万古霉素的制备方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3067099A (en) * | 1955-09-16 | 1962-12-04 | Lilly Co Eli | Vancomycin and method for its preparation |
| US4667024A (en) * | 1983-07-13 | 1987-05-19 | Smithkline Beckman Corporation | Process for the preparation of purified vancomycin class antibiotics |
-
1984
- 1984-12-05 CA CA000469358A patent/CA1245639A/en not_active Expired
- 1984-12-05 FI FI844801A patent/FI844801L/fi not_active Application Discontinuation
- 1984-12-05 GR GR81191A patent/GR81191B/el unknown
- 1984-12-05 IL IL73746A patent/IL73746A/xx not_active IP Right Cessation
- 1984-12-05 JP JP59258386A patent/JPH0689038B2/ja not_active Expired - Lifetime
- 1984-12-06 PT PT79634A patent/PT79634B/pt unknown
- 1984-12-06 ZA ZA849516A patent/ZA849516B/xx unknown
- 1984-12-06 PH PH31539A patent/PH20269A/en unknown
- 1984-12-06 NZ NZ210470A patent/NZ210470A/en unknown
- 1984-12-06 PL PL25076384A patent/PL250763A1/xx unknown
- 1984-12-07 ES ES538423A patent/ES8606409A1/es not_active Expired
- 1984-12-10 DK DK589484A patent/DK164914C/da not_active IP Right Cessation
- 1984-12-11 GB GB08431231A patent/GB2151234B/en not_active Expired
- 1984-12-11 EG EG759/84A patent/EG16899A/xx active
- 1984-12-11 HU HU844603A patent/HU194914B/hu unknown
- 1984-12-11 IE IE3179/84A patent/IE57674B1/en not_active IP Right Cessation
- 1984-12-11 AU AU36480/84A patent/AU575887B2/en not_active Expired
- 1984-12-11 EP EP84308610A patent/EP0145484B1/en not_active Expired
- 1984-12-11 AT AT84308610T patent/ATE41015T1/de not_active IP Right Cessation
- 1984-12-11 DE DE8484308610T patent/DE3476886D1/de not_active Expired
- 1984-12-12 KR KR1019840007851A patent/KR870000550B1/ko not_active IP Right Cessation
-
1985
- 1985-10-18 ES ES548042A patent/ES8607756A1/es not_active Expired
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20051217 |