ES8607300A1 - Acidos 1,7-diamino-1,4-dihidro-4-oxo-3-(aza) quinolincarbo- xilicos - Google Patents
Acidos 1,7-diamino-1,4-dihidro-4-oxo-3-(aza) quinolincarbo- xilicosInfo
- Publication number
- ES8607300A1 ES8607300A1 ES541192A ES541192A ES8607300A1 ES 8607300 A1 ES8607300 A1 ES 8607300A1 ES 541192 A ES541192 A ES 541192A ES 541192 A ES541192 A ES 541192A ES 8607300 A1 ES8607300 A1 ES 8607300A1
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- group
- alkyl
- radical
- hydroxyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/58—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems with hetero atoms directly attached to the ring nitrogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Quinoline Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE ACIDOS 1,7-DIAMINO-1,4-DIHIDRO-4-OXO-3-(AZA)-QUINOLINCARBOXILICOS Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE A, X, R2 Y R3 PUEDEN SER VARIOS TIPOS DE RADICALES; Y R5 Y R6 REPRESENTAN HIDROGENO O ALQUILO C1-4. CONSISTE EN LA REACCION DE SUSTITUCION DE UN ACIDO 1-AMINOQUINOLONCARBOXILICO, DE FORMULA (II), CON UNA AMINA DE FORMULA R2NHR3, EN LAS QUE Y REPRESENTA CLORO O FLUOR Y LOS DEMAS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EN UN DILUYENTE, EN PRESENCIA DE UN ACEPTADO DE ACIDO, A UNA TEMPERATURA COMPRENDIDA ENTRE 0JC Y 200JC. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE ENFERMEDADES BACTERIANAS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19843409922 DE3409922A1 (de) | 1984-03-17 | 1984-03-17 | 1,7-diamino-1,4-dihydro-4-oxo-3-(aza)chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie ihre verwendung bei der bekaempfung bakterieller erkrankungen |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8607300A1 true ES8607300A1 (es) | 1986-05-16 |
ES541192A0 ES541192A0 (es) | 1986-05-16 |
Family
ID=6230867
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES541192A Expired ES8607300A1 (es) | 1984-03-17 | 1985-03-12 | Acidos 1,7-diamino-1,4-dihidro-4-oxo-3-(aza) quinolincarbo- xilicos |
Country Status (7)
Country | Link |
---|---|
US (2) | US4666920A (es) |
EP (1) | EP0155587B1 (es) |
JP (1) | JPH064590B2 (es) |
KR (1) | KR910006635B1 (es) |
AT (1) | ATE34985T1 (es) |
DE (2) | DE3409922A1 (es) |
ES (1) | ES8607300A1 (es) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4806541A (en) * | 1985-09-24 | 1989-02-21 | Hoffmann-La Roche Inc. | Quinoline derivatives |
JPS62228063A (ja) * | 1985-12-27 | 1987-10-06 | Sankyo Co Ltd | キノリンカルボン酸誘導体 |
EP0259804B1 (de) * | 1986-09-12 | 1993-11-18 | F. Hoffmann-La Roche Ag | Pyrido [3,2,1-ij]-1,3,4-benzoxadiazinderivate, Verfahren zu deren Herstellung, entsprechende pharmazeutische Präparate und im Verfahren verwendbare Zwischenprodukte |
US4864023A (en) * | 1986-09-12 | 1989-09-05 | Hoffmann-La Roche Inc. | Pyrido(3,2,1-IJ)-1,3,4-benzoxadiazine derivatives |
US4889857A (en) * | 1987-10-12 | 1989-12-26 | Yoshitomi Pharmaceutical Industries, Ltd. | Quinolonecarboxylic acid compounds and pharmaceutical use thereof |
US5173484A (en) * | 1988-02-05 | 1992-12-22 | Bayer Aktiengesellschaft | Quinolone- and naphthyridone carboxylic acid derivatives, process for their production, antibacterial compositions and feed additives containing them |
US5336768A (en) * | 1988-05-24 | 1994-08-09 | Hoffmann-La Roche Inc. | Antibacterial cephalosporin compounds |
CS273349B2 (en) * | 1988-03-31 | 1991-03-12 | Hoffmann La Roche | Method of cephalosporin's new derivatives production |
US5262417A (en) * | 1988-12-06 | 1993-11-16 | The Upjohn Company | Antibacterial quinolone compounds |
DE3918544A1 (de) * | 1989-06-07 | 1990-12-13 | Bayer Ag | Verfahren zur herstellung von 7-(3-amino- sowie 3-amino-methyl-1-pyrrolidinyl)-3-chinolon- carbonsaeuren sowie -naphthyridoncarbonsaeuren |
US5159077A (en) * | 1989-07-21 | 1992-10-27 | Hoffmann-La Roche Inc. | Penam antibacterial compounds |
US5162523A (en) * | 1989-07-21 | 1992-11-10 | Hoffmann-La Roche Inc. | Cephalosporin antibacterial compounds |
US4992449A (en) * | 1990-02-01 | 1991-02-12 | American Cyanamid Company | 7-(substituted)cycloalkylamino-1-(substituted)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids |
DE4019023A1 (de) * | 1990-06-14 | 1991-12-19 | Bayer Ag | Verfahren zur herstellung von chinolincarbonsaeuren |
WO1994017074A1 (en) * | 1993-01-23 | 1994-08-04 | Pfizer Inc. | Process for the manufacture of a tricyclic compound |
JPH072783A (ja) * | 1993-11-26 | 1995-01-06 | Sankyo Co Ltd | キノリンカルボン酸誘導体の製造中間体 |
JPH08208617A (ja) * | 1995-11-02 | 1996-08-13 | Sankyo Co Ltd | キノリンカルボン酸誘導体の製造中間体 |
EP2332916A3 (en) | 2009-11-19 | 2011-08-03 | Krka Tovarna Zdravil, D.D., Novo Mesto | A process for a preparation of marbofloxacin and intermediate thereof |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2808070A1 (de) * | 1978-02-24 | 1979-08-30 | Bayer Ag | Verfahren zur herstellung von 4-pyridon-3-carbonsaeuren und/oder deren derivaten |
AR223983A1 (es) * | 1978-08-25 | 1981-10-15 | Dainippon Pharmaceutical Co | Un procedimiento para-preparar derivados de acido 6-halogeno-4-oxo-7-(1-piperazinil)-1,8-naftiridin-3-carboxilico |
JPS5540656A (en) * | 1978-09-19 | 1980-03-22 | Kyorin Pharmaceut Co Ltd | Substituted quinoline-carboxylic acid derivative |
JPS5649382A (en) * | 1979-09-28 | 1981-05-02 | Dainippon Pharmaceut Co Ltd | 6-fluoro-7-cyclic amino-1,8-naphthylidine derivative and its salt |
SE440354B (sv) * | 1981-02-19 | 1985-07-29 | Kyorin Seiyaku Kk | Kinolinkarboxylsyraderivat |
JPS57145862A (en) * | 1981-03-06 | 1982-09-09 | Kyorin Pharmaceut Co Ltd | Quinolinecarboxylic acid derivative |
US4499091A (en) * | 1982-03-31 | 1985-02-12 | Sterling Drug Inc. | 1-Amino (or substituted amino)-1,4-dihydro-4-oxo-6-fluoro-7-heterylquinoline-3-carboxylic acids and their use as antibacterial agents |
EP0090424B1 (en) * | 1982-03-31 | 1986-05-28 | Sterling Drug Inc. | New quinolone compounds and preparation thereof |
JPS59128383A (ja) * | 1982-12-29 | 1984-07-24 | Kanebo Ltd | 新規キノリンカルボン酸誘導体および該化合物を有効成分とする抗菌剤 |
DE3318145A1 (de) * | 1983-05-18 | 1984-11-22 | Bayer Ag, 5090 Leverkusen | 7-amino-1-cyclopropyl-6,8-difluor-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
-
1984
- 1984-03-17 DE DE19843409922 patent/DE3409922A1/de not_active Withdrawn
-
1985
- 1985-03-05 EP EP85102447A patent/EP0155587B1/de not_active Expired
- 1985-03-05 DE DE8585102447T patent/DE3563210D1/de not_active Expired
- 1985-03-05 AT AT85102447T patent/ATE34985T1/de not_active IP Right Cessation
- 1985-03-12 ES ES541192A patent/ES8607300A1/es not_active Expired
- 1985-03-13 JP JP60048443A patent/JPH064590B2/ja not_active Expired - Fee Related
- 1985-03-15 US US06/712,490 patent/US4666920A/en not_active Expired - Lifetime
- 1985-03-16 KR KR1019850001705A patent/KR910006635B1/ko not_active IP Right Cessation
-
1986
- 1986-08-22 US US06/899,458 patent/US4753925A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ATE34985T1 (de) | 1988-06-15 |
KR910006635B1 (ko) | 1991-08-29 |
JPS60204765A (ja) | 1985-10-16 |
US4666920A (en) | 1987-05-19 |
US4753925A (en) | 1988-06-28 |
JPH064590B2 (ja) | 1994-01-19 |
KR850006400A (ko) | 1985-10-05 |
EP0155587A1 (de) | 1985-09-25 |
ES541192A0 (es) | 1986-05-16 |
EP0155587B1 (de) | 1988-06-08 |
DE3563210D1 (en) | 1988-07-14 |
DE3409922A1 (de) | 1985-09-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES8607300A1 (es) | Acidos 1,7-diamino-1,4-dihidro-4-oxo-3-(aza) quinolincarbo- xilicos | |
DE69133455D1 (de) | Zwischenprodukte zur Herstellung von Camptothecin und Analogen | |
FR2619111B1 (fr) | Derives de (piperidinyl-4)methyl-2 tetrahydro-1,2,3,4 9h-pyrido (3,4-b) indole, leur preparation et leur application en therapeutique | |
GR1000155B (el) | ΜΕΘΟΔΟΣ ΠΑΡΑΣΚΕΥΗΣ ΝΕΩΝ ΠΑΡΑΓΩΓΩΝ ΤΗΣ ΑΜΙΝΟ ΤΕΤΡΑΥΔΡΟ-5,6,7,8 ΝΑΦΘΟ[2,3b] ΦΟΥΡΑΝΗΣ. | |
TW340115B (en) | Triazine derivatives and pharmaceutical composition for hepatitis the invention relates to triazine derivatives and pharmaceutical composition for hepatitis | |
FI894061A0 (fi) | Menetelmä lääkeaineina käyttökelpoisten , -disubstituoitujen N-sykloalkyylialkyylibentsyyliamiinien valmistamiseksi ja niiden synteesivälituotteita | |
NZ217398A (en) | Angiotensin-converting enzyme(ace)inhibitor and pharmaceutical composition | |
ES8406193A1 (es) | Procedimiento para la preparacion de nuevas 1,4-dihidropiridinas sustituidas | |
MX9605366A (es) | Derivados de amidina biciclicos como inhibidores de la oxido nitrico sintetasa. | |
ES8305755A1 (es) | Procedimiento para preparar derivados de pirimidona. | |
MY113427A (en) | Anti-neurodegeneratively active 10-aminoaliphatyl- dibenz [b,f] oxepines | |
DK492288A (da) | Amidforbindelser, farmaceutisk praeparat indeholdende samme samt fremgangsmaade til fremstilling af forbindelserne | |
TW333532B (en) | Benzopyrans | |
ES2012736A6 (es) | Procedimiento para la preparacion de derivados triciclicos de 3-oxopropanonitrilo. | |
AU554959B2 (en) | Triazolo(4,3-a) quinazolin-5-ones | |
NZ322227A (en) | Amidine and isothiourea derivatives as inhibitors of nitric oxide synthase | |
AU1099788A (en) | 5-(3-alkyl-5-tert. butyl-4-hydroxyphenyl)-2-amino-6H-1,3,4- thia-diazines, a process for the preparation thereof, medicaments containing same, and the use thereof | |
JPS6470412A (en) | Medicinal composition | |
ES8401456A1 (es) | Procedimiento para la preparacion de 2-aminometilfenoles. | |
ES8504768A1 (es) | Un procedimiento para preparar derivados de pirimidona | |
JO1274B1 (en) | Pyridine derivatives | |
ES8604853A1 (es) | Un metodo para la preparacion de un derivado de acetileno. | |
MY100938A (en) | Arylkylimidazole derivatives. | |
ES8304956A1 (es) | Un procedimiento para preparar nuevos derivados de 1,4-benzotiazina. | |
DK470888D0 (da) | Imidazobenzodiazepinderivater, deres fresmtilling samt laegemidler med indholdd deraf |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20060220 |