ES8606361A1 - Un procedimiento para la preparacion de nuevos derivados de cefalosporina. - Google Patents

Un procedimiento para la preparacion de nuevos derivados de cefalosporina.

Info

Publication number
ES8606361A1
ES8606361A1 ES549498A ES549498A ES8606361A1 ES 8606361 A1 ES8606361 A1 ES 8606361A1 ES 549498 A ES549498 A ES 549498A ES 549498 A ES549498 A ES 549498A ES 8606361 A1 ES8606361 A1 ES 8606361A1
Authority
ES
Spain
Prior art keywords
novel cephalosporin
cephalosporin derivatives
organisms
gram
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES549498A
Other languages
English (en)
Other versions
ES549498A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Meiji Seika Kaisha Ltd
Original Assignee
Meiji Seika Kaisha Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP59033747A external-priority patent/JPS60178890A/ja
Priority claimed from JP59071414A external-priority patent/JPS60215690A/ja
Priority claimed from JP59138206A external-priority patent/JPS6117589A/ja
Priority claimed from JP59254517A external-priority patent/JPS61134390A/ja
Application filed by Meiji Seika Kaisha Ltd filed Critical Meiji Seika Kaisha Ltd
Publication of ES549498A0 publication Critical patent/ES549498A0/es
Publication of ES8606361A1 publication Critical patent/ES8606361A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/68—One oxygen atom attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO DE OBTENCION DE DERIVADOS DE CEFALOSPORINA Y SUS SALES DE FORMULA (I), DONDE Y ES UN GRUPO ALQUILO O ALQUENILO DE CADENA LINEAL O RAMIFICADA O CICLOALCANOMETILO DE 3 A 6 ATOMOS DE C, SIENDO CADA GRUPO OPCIONALMENTE SUSTITUIDO POR ATOMOS O GRUPOS SELECCIONADOS; Y Z ES UN GRUPO PIRIDINIOTIOALQUILO. CONSISTE EN SOMETER A ACILACION UN COMPUESTO DE FORMULA (II), DONDE Z TIENE EL SIGNIFICADO ANTERIOR, R10 ES HIDROGENO O UN GRUPO PROTECTOR DEL GRUPO CARBOXILO Y Q ES 0 O 1, CON UN COMPUESTO DE FORMULA (III)EN EL QUE R9 ES UN GRUPO PROTECTOR DEL GRUPO AMINO E YK ES ALQUILO, ALQUENILO LINEAL O RAMIFICADO O CICLOALCANOMETILO DE 3 A 6 ATOMOS DE C, SIENDO CADA GRUPO OPCIONALMENTE SUSTITUIDO. ALTERNATIVAMENTE LA ACILACION PUEDE PRODUCIRSE CON UN DERIVADO REACTIVO DEL ACIDO CARBOXILICO. LA REACCION SE REALIZA A TEMPERATURA COMPRENDIDA ENTRE C30 Y 40JC, CON UNA DURACION DE 30 MINUTOS A 10 H. DE APLICACION FARMACOLOGICA POR SU ACTIVIDAD ANTIBACTERIANA FRENTE A ORGANISMOS GRAM (B) Y GRAM (C).
ES549498A 1984-02-23 1985-12-02 Un procedimiento para la preparacion de nuevos derivados de cefalosporina. Expired ES8606361A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP59033747A JPS60178890A (ja) 1984-02-23 1984-02-23 新規セフアロスポリン誘導体およびその製造法
JP59071414A JPS60215690A (ja) 1984-04-09 1984-04-09 セフアロスポリン化合物及びそれを有効成分とする抗菌剤
JP59138206A JPS6117589A (ja) 1984-07-03 1984-07-03 新規セフアロスポリン誘導体及びその製造法
JP59254517A JPS61134390A (ja) 1984-12-01 1984-12-01 新規セフアロスポリン化合物及びそれを含む抗菌剤

Publications (2)

Publication Number Publication Date
ES549498A0 ES549498A0 (es) 1986-04-16
ES8606361A1 true ES8606361A1 (es) 1986-04-16

Family

ID=27459829

Family Applications (2)

Application Number Title Priority Date Filing Date
ES540664A Expired ES8606360A1 (es) 1984-02-23 1985-02-22 Un derivado de cefalosporina.
ES549498A Expired ES8606361A1 (es) 1984-02-23 1985-12-02 Un procedimiento para la preparacion de nuevos derivados de cefalosporina.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES540664A Expired ES8606360A1 (es) 1984-02-23 1985-02-22 Un derivado de cefalosporina.

Country Status (6)

Country Link
US (1) US4785090A (es)
EP (1) EP0153709B1 (es)
KR (1) KR920004820B1 (es)
CA (1) CA1276013C (es)
DE (1) DE3583751D1 (es)
ES (2) ES8606360A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK500285A (da) * 1984-11-02 1986-05-03 Glaxo Group Ltd Cephalosporinantibiotika
JPH064645B2 (ja) * 1985-11-27 1994-01-19 明治製菓株式会社 新規セフアロスポリン誘導体およびそれを含む抗菌剤
DE3782260T2 (de) * 1986-03-20 1993-05-06 Banyu Pharma Co Ltd Cephalosporinverbindungen, verfahren zu ihrer herstellung und antibakterielle mittel.
US4880797A (en) * 1986-03-20 1989-11-14 Banyu Pharmaceutical Co., Ltd. Cephalosporin derivatives and antibacterial agents
US5084453A (en) * 1986-04-14 1992-01-28 Banyu Pharmaceutical Co., Ltd. 1-carboxy-1-vinyloxyimino aminothiazole cephalosporin derivatives
US5147871A (en) * 1986-07-03 1992-09-15 Hoffmann La-Roche, Inc. Anti-bacterial cephalosporin compounds
JPS63154622A (ja) * 1986-12-18 1988-06-27 Meiji Seika Kaisha Ltd セフアロスポリン誘導体を有効成分とする哺乳動物用抗菌剤
NZ227470A (en) * 1987-12-28 1991-06-25 Hoffmann La Roche Acyl derivatives of substituted cephem compounds; pharmaceutical compositions and methods for preparation and treatment
US5134138A (en) * 1989-07-18 1992-07-28 Shionogi & Co., Ltd. Phenacylpyridiniothiocephalosporins
US5162523A (en) * 1989-07-21 1992-11-10 Hoffmann-La Roche Inc. Cephalosporin antibacterial compounds
US5159077A (en) * 1989-07-21 1992-10-27 Hoffmann-La Roche Inc. Penam antibacterial compounds
GB9006728D0 (en) * 1990-03-26 1990-05-23 Beecham Group Plc Novel compounds
DE69033952T2 (de) * 1989-09-04 2002-11-28 Pfizer Antibakterielle Cephalosporin-Derivate
MY106991A (en) * 1989-09-04 1995-08-30 Pfizer Novel cephalosporin derivatives or compounds
US5143910A (en) * 1989-09-07 1992-09-01 Shionogi & Co., Ltd. Piperaziniocephalosporins
KR100194942B1 (ko) * 1992-01-23 1999-06-15 이명환 신규세팔로스포린유도체

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2716677C2 (de) * 1977-04-15 1985-10-10 Hoechst Ag, 6230 Frankfurt Cephemderivate und Verfahren zu ihrer Herstellung
AR231986A1 (es) * 1978-05-26 1985-04-30 Glaxo Group Ltd Procedimiento para preparar antibioticos de cefalosporina
ES486026A1 (es) * 1978-11-17 1980-09-01 Glaxo Group Ltd Un procedimiento para la preparacion de antibioticos de ce- falosporina
GR75487B (es) * 1981-06-22 1984-07-23 Fujisawa Pharmaceutical Co
FR2516515A1 (fr) * 1981-11-16 1983-05-20 Sanofi Sa Nouveaux derives de pyridinium thiomethyl cephalosporines, procede pour leur preparation et compositions pharmaceutiques les contenant

Also Published As

Publication number Publication date
KR850006421A (ko) 1985-10-05
EP0153709A3 (en) 1986-06-25
US4785090A (en) 1988-11-15
EP0153709A2 (en) 1985-09-04
ES549498A0 (es) 1986-04-16
CA1276013C (en) 1990-11-06
ES540664A0 (es) 1986-04-16
DE3583751D1 (de) 1991-09-19
EP0153709B1 (en) 1991-08-14
ES8606360A1 (es) 1986-04-16
KR920004820B1 (ko) 1992-06-18

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