ES8606286A1 - Procedimiento para preparar nuevos derivados de benzazocinona y de benzazoninona - Google Patents

Procedimiento para preparar nuevos derivados de benzazocinona y de benzazoninona

Info

Publication number
ES8606286A1
ES8606286A1 ES529593A ES529593A ES8606286A1 ES 8606286 A1 ES8606286 A1 ES 8606286A1 ES 529593 A ES529593 A ES 529593A ES 529593 A ES529593 A ES 529593A ES 8606286 A1 ES8606286 A1 ES 8606286A1
Authority
ES
Spain
Prior art keywords
benzazocinone
derivatives
formula
procedure
benzazoninone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES529593A
Other languages
English (en)
Spanish (es)
Other versions
ES529593A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES8606286A1 publication Critical patent/ES8606286A1/es
Publication of ES529593A0 publication Critical patent/ES529593A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ES529593A 1983-02-10 1984-02-09 Procedimiento para preparar nuevos derivados de benzazocinona y de benzazoninona Expired ES8606286A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/465,696 US4470988A (en) 1983-02-10 1983-02-10 Benzazocinone and benzazoninone derivatives, and their pharmaceutical use

Publications (2)

Publication Number Publication Date
ES8606286A1 true ES8606286A1 (es) 1986-04-01
ES529593A0 ES529593A0 (es) 1986-04-01

Family

ID=23848809

Family Applications (2)

Application Number Title Priority Date Filing Date
ES529593A Expired ES8606286A1 (es) 1983-02-10 1984-02-09 Procedimiento para preparar nuevos derivados de benzazocinona y de benzazoninona
ES544051A Expired ES8700240A1 (es) 1983-02-10 1985-06-11 Procedimiento para preparar nuevos derivados de benzazocino-na y de benzaconinona

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES544051A Expired ES8700240A1 (es) 1983-02-10 1985-06-11 Procedimiento para preparar nuevos derivados de benzazocino-na y de benzaconinona

Country Status (20)

Country Link
US (1) US4470988A (OSRAM)
EP (1) EP0119161B1 (OSRAM)
JP (1) JPS59172474A (OSRAM)
KR (1) KR840007872A (OSRAM)
AT (1) ATE44279T1 (OSRAM)
AU (1) AU2443184A (OSRAM)
CA (1) CA1218989A (OSRAM)
DD (1) DD216717A5 (OSRAM)
DE (1) DE3478810D1 (OSRAM)
DK (1) DK58084A (OSRAM)
ES (2) ES8606286A1 (OSRAM)
FI (1) FI840463A7 (OSRAM)
GR (1) GR81766B (OSRAM)
HU (1) HU193671B (OSRAM)
IE (1) IE56816B1 (OSRAM)
IL (1) IL70882A0 (OSRAM)
NO (1) NO840486L (OSRAM)
NZ (1) NZ207090A (OSRAM)
PT (1) PT78064B (OSRAM)
ZA (1) ZA84959B (OSRAM)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4873235A (en) * 1982-06-01 1989-10-10 Merck & Co., Inc. Benzofused lactams as antihypertensives
US4537885A (en) * 1983-02-10 1985-08-27 Ciba Geigy Corporation Certain benzazocinone and benzazoninone derivatives
EP0166357A3 (en) * 1984-06-26 1988-10-26 Merck & Co. Inc. Benzofused lactams and pharmaceutical compositions containing them
DE3586445T2 (de) * 1984-06-26 1993-01-14 Merck & Co Inc Kondensierte benzo-laktam-verbindungen und deren pharmazeutische zusammensetzungen.
US4692522A (en) * 1985-04-01 1987-09-08 Merck & Co., Inc. Benzofused lactams useful as cholecystokinin antagonists
US4785089A (en) * 1985-06-13 1988-11-15 Ciba-Geigy Corporation Novel sulfonic acid esters and their preparation
DE3704661A1 (de) * 1987-02-14 1988-08-25 Hoechst Ag Annelierte azepinon- und azocinon-derivate, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung, sowie zwischenprodukte bei ihrer herstellung
US5145864A (en) * 1987-09-15 1992-09-08 Alcoholism And Drug Addiction Research Foundation Reduction of voluntary alcohol consumption by treatment with angiotensin converting enzyme inhibitors
US5110813A (en) * 1987-09-15 1992-05-05 Alcoholism And Drug Addiction Research Foundation Reduction of voluntary alcohol consumption by treatment with angiotensin converting enzyme inhibitors
US5428031A (en) * 1991-12-03 1995-06-27 Merck & Co., Inc. Methods of treating cardiac arrhythmia
US5552397A (en) * 1992-05-18 1996-09-03 E. R. Squibb & Sons, Inc. Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase
RU2124503C1 (ru) 1992-05-18 1999-01-10 И.Р.Сквибб энд Санз, Инк. Гетероциклические азотсодержащие производные карбоновой кислоты, способ их получения и фармацевтическая композиция
US5654294A (en) * 1993-05-13 1997-08-05 Bristol-Myers Squibb Spiro lactam dual action inhibitors
ES2162907T3 (es) * 1993-11-22 2002-01-16 Merck & Co Inc 3-acilaminobenzacepinas.
DE69513295T2 (de) * 1994-08-18 2000-06-08 Merck & Co., Inc. 2,3-dihydro-1-(2,2,2-trifluorethyl)-2-oxo-5-phenyl-1h-1,4-benzodiazepine
US5587375A (en) * 1995-02-17 1996-12-24 Bristol-Myers Squibb Company Azepinone compounds useful in the inhibition of ACE and NEP
US5877313A (en) * 1995-05-17 1999-03-02 Bristol-Myers Squibb Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP
US5691331A (en) * 1995-06-07 1997-11-25 Merck & Co., Inc. N-(2,4-Dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3yl) -3- amides
US5631251A (en) * 1995-06-07 1997-05-20 Merck & Co., Inc. 5-cyclopropyl-1,4 benzodiazepine-2-ones
US5635504A (en) * 1995-06-07 1997-06-03 Bristol-Myers Squibb Co. Diazepine containing dual action inhibitors
US5726171A (en) * 1995-06-07 1998-03-10 Merck & Co Inc N-(1-alkyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo B! 1,4!diazepin-3yl)-acetamides
DE69626981T2 (de) * 1995-06-07 2003-12-18 Merck & Co., Inc. N-(2-oxo-2,3,4,5-tetrahydro-1h-1,5-benzodiazepin-3-yl)-3-amide
US5700797A (en) * 1995-06-07 1997-12-23 Merck & Co, Inc. N-(2,4-dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl)-3-amides
US5650408A (en) * 1995-06-07 1997-07-22 Karanewsky; Donald S. Thiazolo benzazepine containing dual action inhibitors
EP2544765A1 (en) 2010-03-11 2013-01-16 Merck Patent GmbH Fibers in therapy and cosmetics
EP4497745A1 (en) * 2022-03-23 2025-01-29 Zhejiang Huahai Pharmaceutical Co., Ltd. Method for purifying levetiracetam intermediate

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3395150A (en) * 1965-02-26 1968-07-30 Squibb & Sons Inc Benzothiazepine carboxamides and derivatives thereof
GB1191963A (en) * 1968-02-07 1970-05-13 Ucb Sa Heterocyclic Compounds
GB1183442A (OSRAM) * 1968-02-23 1970-03-04
LU79008A1 (de) * 1978-02-03 1979-09-06 Byk Gulden Lomberg Chem Fab W-(n-alkyl-n-benzoyl-amino)-phenylalkansaeuren,ihre verwendung und herstellung sowie sie enthaltende arzneimittel
GR74635B (OSRAM) * 1980-08-18 1984-06-29 Merck & Co Inc
GR74625B (OSRAM) * 1980-08-18 1984-06-29 Merck & Co Inc
IL63540A0 (en) * 1980-08-18 1981-11-30 Merck & Co Inc Substituted enantholactam derivatives as antihypertensives
US4410520A (en) * 1981-11-09 1983-10-18 Ciba-Geigy Corporation 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids
DE3373469D1 (en) * 1982-09-30 1987-10-15 Merck & Co Inc 1-n-alkylcarboxy-benzofused lactams useful as antihypertensive agents

Also Published As

Publication number Publication date
ZA84959B (en) 1984-09-26
NZ207090A (en) 1985-10-11
DE3478810D1 (en) 1989-08-03
ES8700240A1 (es) 1986-09-16
AU2443184A (en) 1984-08-16
NO840486L (no) 1984-08-13
IE840301L (en) 1984-08-10
FI840463A0 (fi) 1984-02-06
HU193671B (en) 1987-11-30
JPH0449545B2 (OSRAM) 1992-08-11
JPS59172474A (ja) 1984-09-29
PT78064B (en) 1986-06-02
FI840463A7 (fi) 1984-08-11
US4470988A (en) 1984-09-11
EP0119161A2 (de) 1984-09-19
KR840007872A (ko) 1984-12-11
DK58084A (da) 1984-08-11
EP0119161A3 (en) 1986-06-11
DK58084D0 (da) 1984-02-09
ATE44279T1 (de) 1989-07-15
ES544051A0 (es) 1986-09-16
CA1218989A (en) 1987-03-10
PT78064A (en) 1984-03-01
IL70882A0 (en) 1984-05-31
EP0119161B1 (de) 1989-06-28
IE56816B1 (en) 1991-12-18
ES529593A0 (es) 1986-04-01
GR81766B (OSRAM) 1984-12-12
DD216717A5 (de) 1984-12-19

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970401