ES8606286A1 - Procedimiento para preparar nuevos derivados de benzazocinona y de benzazoninona - Google Patents

Procedimiento para preparar nuevos derivados de benzazocinona y de benzazoninona

Info

Publication number
ES8606286A1
ES8606286A1 ES529593A ES529593A ES8606286A1 ES 8606286 A1 ES8606286 A1 ES 8606286A1 ES 529593 A ES529593 A ES 529593A ES 529593 A ES529593 A ES 529593A ES 8606286 A1 ES8606286 A1 ES 8606286A1
Authority
ES
Spain
Prior art keywords
derivatives
compounds
benzazoninone
benzazocinone
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES529593A
Other languages
English (en)
Other versions
ES529593A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES8606286A1 publication Critical patent/ES8606286A1/es
Publication of ES529593A0 publication Critical patent/ES529593A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Cosmetics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR NUEVOS DERIVADOS DE BENZAZOCINONA Y DE BENZACONINONA. CONSISTE EN INTRODUCIR R4 EN EL COMPUESTO DE FORMULA (II) POR ALQUILACION CON UN COMPUESTO DE FORMULA (III A) ENTRE 0JC Y LA TEMPERATURA DE EBULLICION DE LOS REACCIONANTES, EN UN ALCANO INFERIOR CLORADO COMO DISOLVENTE, EN PRESENCIA DE UN AGENTE REDUCTOR TAL COMO UN BICARBONATO, CARBONATO O HIDROXIDO DE METAL ALCALINO, PARA OBTENER UN COMPUESTO DE FORMULA (I). SIENDO: RA Y RB, RESTOS DE FORMULA (IV) Y (V); R0, CARBOXI; R1, H, ALQUILO INFERIOR, Y OTROS; R2 Y R5, H O ALQUILO INFERIOR; R3 Y R4, JUNTOS, ALQUILENDOXI INFERIOR; X, OXO, DOS ATOMOS DE H, Y OTROS; Y M 2 O 3. SE UTILIZA EN FARMACOLOGIA PARA EL TRATAMIENTO DE ENFERMEDADES QUE RESPONDEN A LA INHIBICION DEL ENZIMA QUE TRANSFORMA ANGIOTESINA.
ES529593A 1983-02-10 1984-02-09 Procedimiento para preparar nuevos derivados de benzazocinona y de benzazoninona Expired ES8606286A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/465,696 US4470988A (en) 1983-02-10 1983-02-10 Benzazocinone and benzazoninone derivatives, and their pharmaceutical use

Publications (2)

Publication Number Publication Date
ES8606286A1 true ES8606286A1 (es) 1986-04-01
ES529593A0 ES529593A0 (es) 1986-04-01

Family

ID=23848809

Family Applications (2)

Application Number Title Priority Date Filing Date
ES529593A Expired ES8606286A1 (es) 1983-02-10 1984-02-09 Procedimiento para preparar nuevos derivados de benzazocinona y de benzazoninona
ES544051A Expired ES8700240A1 (es) 1983-02-10 1985-06-11 Procedimiento para preparar nuevos derivados de benzazocino-na y de benzaconinona

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES544051A Expired ES8700240A1 (es) 1983-02-10 1985-06-11 Procedimiento para preparar nuevos derivados de benzazocino-na y de benzaconinona

Country Status (20)

Country Link
US (1) US4470988A (es)
EP (1) EP0119161B1 (es)
JP (1) JPS59172474A (es)
KR (1) KR840007872A (es)
AT (1) ATE44279T1 (es)
AU (1) AU2443184A (es)
CA (1) CA1218989A (es)
DD (1) DD216717A5 (es)
DE (1) DE3478810D1 (es)
DK (1) DK58084A (es)
ES (2) ES8606286A1 (es)
FI (1) FI840463A (es)
GR (1) GR81766B (es)
HU (1) HU193671B (es)
IE (1) IE56816B1 (es)
IL (1) IL70882A0 (es)
NO (1) NO840486L (es)
NZ (1) NZ207090A (es)
PT (1) PT78064B (es)
ZA (1) ZA84959B (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4873235A (en) * 1982-06-01 1989-10-10 Merck & Co., Inc. Benzofused lactams as antihypertensives
US4537885A (en) * 1983-02-10 1985-08-27 Ciba Geigy Corporation Certain benzazocinone and benzazoninone derivatives
DE3586445T2 (de) * 1984-06-26 1993-01-14 Merck & Co Inc Kondensierte benzo-laktam-verbindungen und deren pharmazeutische zusammensetzungen.
EP0166357A3 (en) * 1984-06-26 1988-10-26 Merck & Co. Inc. Benzofused lactams and pharmaceutical compositions containing them
US4692522A (en) * 1985-04-01 1987-09-08 Merck & Co., Inc. Benzofused lactams useful as cholecystokinin antagonists
US4785089A (en) * 1985-06-13 1988-11-15 Ciba-Geigy Corporation Novel sulfonic acid esters and their preparation
DE3704661A1 (de) * 1987-02-14 1988-08-25 Hoechst Ag Annelierte azepinon- und azocinon-derivate, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung, sowie zwischenprodukte bei ihrer herstellung
US5110813A (en) * 1987-09-15 1992-05-05 Alcoholism And Drug Addiction Research Foundation Reduction of voluntary alcohol consumption by treatment with angiotensin converting enzyme inhibitors
US5145864A (en) * 1987-09-15 1992-09-08 Alcoholism And Drug Addiction Research Foundation Reduction of voluntary alcohol consumption by treatment with angiotensin converting enzyme inhibitors
US5428031A (en) * 1991-12-03 1995-06-27 Merck & Co., Inc. Methods of treating cardiac arrhythmia
US5552397A (en) * 1992-05-18 1996-09-03 E. R. Squibb & Sons, Inc. Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase
RU2124503C1 (ru) 1992-05-18 1999-01-10 И.Р.Сквибб энд Санз, Инк. Гетероциклические азотсодержащие производные карбоновой кислоты, способ их получения и фармацевтическая композиция
US5654294A (en) * 1993-05-13 1997-08-05 Bristol-Myers Squibb Spiro lactam dual action inhibitors
DE69428546T2 (de) * 1993-11-22 2002-04-11 Merck & Co Inc 3-acylaminobenzazepine
EP0776208B1 (en) * 1994-08-18 1999-11-10 Merck & Co. Inc. 2,3-dihydro-1-(2,2,2-trifluoroethyl)-2-oxo-5-phenyl-1h-1,4-benzodiazepines
US5587375A (en) * 1995-02-17 1996-12-24 Bristol-Myers Squibb Company Azepinone compounds useful in the inhibition of ACE and NEP
US5877313A (en) 1995-05-17 1999-03-02 Bristol-Myers Squibb Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP
US5726171A (en) * 1995-06-07 1998-03-10 Merck & Co Inc N-(1-alkyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo B! 1,4!diazepin-3yl)-acetamides
JPH11506760A (ja) * 1995-06-07 1999-06-15 メルク エンド カンパニー インコーポレーテッド 新規なｎ−（２，４−ジオキソ−２，３，４，５−テトラヒドロ−１ｈ−１，５−ベンゾジアゼピン−３イル）−３−アミド
US5691331A (en) * 1995-06-07 1997-11-25 Merck & Co., Inc. N-(2,4-Dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3yl) -3- amides
US5650408A (en) * 1995-06-07 1997-07-22 Karanewsky; Donald S. Thiazolo benzazepine containing dual action inhibitors
US5635504A (en) * 1995-06-07 1997-06-03 Bristol-Myers Squibb Co. Diazepine containing dual action inhibitors
US5700797A (en) * 1995-06-07 1997-12-23 Merck & Co, Inc. N-(2,4-dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl)-3-amides
US5631251A (en) * 1995-06-07 1997-05-20 Merck & Co., Inc. 5-cyclopropyl-1,4 benzodiazepine-2-ones
JP6246468B2 (ja) 2010-03-11 2017-12-13 メルク パテント ゲーエムベーハー 治療および化粧品におけるファイバー
WO2023178538A1 (zh) * 2022-03-23 2023-09-28 浙江华海药业股份有限公司 一种纯化左乙拉西坦中间体的方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3395150A (en) * 1965-02-26 1968-07-30 Squibb & Sons Inc Benzothiazepine carboxamides and derivatives thereof
GB1191963A (en) * 1968-02-07 1970-05-13 Ucb Sa Heterocyclic Compounds
GB1183442A (es) * 1968-02-23 1970-03-04
LU79008A1 (de) * 1978-02-03 1979-09-06 Byk Gulden Lomberg Chem Fab W-(n-alkyl-n-benzoyl-amino)-phenylalkansaeuren,ihre verwendung und herstellung sowie sie enthaltende arzneimittel
IL63540A0 (en) * 1980-08-18 1981-11-30 Merck & Co Inc Substituted enantholactam derivatives as antihypertensives
GR74635B (es) * 1980-08-18 1984-06-29 Merck & Co Inc
PT73522B (en) * 1980-08-18 1983-07-14 Merck & Co Inc Process for preparing substituted caprylolactam derivatives as antihypertensives
US4410520A (en) * 1981-11-09 1983-10-18 Ciba-Geigy Corporation 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids
DE3373469D1 (en) * 1982-09-30 1987-10-15 Merck & Co Inc 1-n-alkylcarboxy-benzofused lactams useful as antihypertensive agents

Also Published As

Publication number Publication date
PT78064A (en) 1984-03-01
NO840486L (no) 1984-08-13
CA1218989A (en) 1987-03-10
IE56816B1 (en) 1991-12-18
DK58084D0 (da) 1984-02-09
PT78064B (en) 1986-06-02
FI840463A0 (fi) 1984-02-06
DK58084A (da) 1984-08-11
JPH0449545B2 (es) 1992-08-11
JPS59172474A (ja) 1984-09-29
IL70882A0 (en) 1984-05-31
GR81766B (es) 1984-12-12
DE3478810D1 (en) 1989-08-03
ATE44279T1 (de) 1989-07-15
IE840301L (en) 1984-08-10
ES8700240A1 (es) 1986-09-16
ES529593A0 (es) 1986-04-01
ES544051A0 (es) 1986-09-16
EP0119161B1 (de) 1989-06-28
KR840007872A (ko) 1984-12-11
AU2443184A (en) 1984-08-16
ZA84959B (en) 1984-09-26
US4470988A (en) 1984-09-11
EP0119161A3 (en) 1986-06-11
HU193671B (en) 1987-11-30
FI840463A (fi) 1984-08-11
NZ207090A (en) 1985-10-11
DD216717A5 (de) 1984-12-19
EP0119161A2 (de) 1984-09-19

Similar Documents

Publication Publication Date Title
ES8700240A1 (es) Procedimiento para preparar nuevos derivados de benzazocino-na y de benzaconinona
IE840302L (en) 3-(5-aminopentyl)amino-1-benzazepin-2-one-1-alkanoic acids.
ES8307263A1 (es) Un procedimiento para la preparacion de fosfonamidas sustituidas.
BG103417A (en) Condensed pyrimidine bicyclic derivatives
IL128205A0 (en) Potassium channel inhibitors and pharmaceutical compositions containing the same
NO930693L (no) Mometasonfuroatmonohydrat, fremgangsmaate for fremstillingav dette og farmasoeytiske preprater
IL135302A0 (en) Bicyclic kinase inhibitors
UA39166C2 (uk) Похідні n-гідроксисечовини, що є інгібіторами ліпоксигенази у ссавців, спосіб їх одержання і спосіб інгібування ліпоксигенази у ссавців
PH23645A (en) Pharmaceutically active pyrazolo 4,3-c) pyridines and method of use thereof
MY106202A (en) Saccharin derivatives useful as proteolytic enzyme inhibitors and preparation thereof.
YU211087A (en) Process for obtaining new n-substituted benzimidazolic derivatives
DK93685D0 (da) Benzisoselenazolthioner, fremgangsmaade til fremstilling af disse forbindelser og farmaceutiske praeparater indeholdende disse forbindelser
PT84823A (en) Process for the preparation of novel derivatives of 1-substituted imidazoles having dopamine beta-hydroxylase inhibiting pharmacological activity and of pharmaceutical compositions containing the same
MX9403088A (es) Composiciones farmaceuticas que contienen deriva- dos de indol y metodos de uso.
ES8400076A1 (es) Procedimiento para hidroformilar compuestos olefinicamente insaturados.
JO1406B1 (en) Chemical compounds
ES8305684A1 (es) Procedimiento para la obtencion de derivados aminopropanolicos de 2-hidroxi b-fenil-propiofenonas.
GR3032950T3 (en) Substituted fused and bridged bicyclic compounds as therapeutic agents
RU94046300A (ru) Химические соединения, способ их получения, фармкомпозиция, способ лечения, промежуточный продукт
ES8305783A1 (es) Procedimiento para la obtencion de derivados de aminociclitol saturados.
ES8802612A1 (es) Procedimiento para preparar derivados de benzisoselenazolilo
GR81247B (en) Antihypertensive 3-aryl-1,2-benzisoxazolsulfonyl and sulfrinylalkanoic acids, process for their preparation and their use as medicaments
HUP9903369A2 (hu) 8(9)-Dehidroösztradiol-származékok
RU94035756A (ru) Производные имидазола, являющиеся ингибиторами питокинов, способы их получения, фармацевтическая композиция

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970401