ES8604570A1 - Procedimiento para la obtencion de (pirrol-1-il)-fenil-dihi-dropiridazinona - Google Patents

Procedimiento para la obtencion de (pirrol-1-il)-fenil-dihi-dropiridazinona

Info

Publication number
ES8604570A1
ES8604570A1 ES545155A ES545155A ES8604570A1 ES 8604570 A1 ES8604570 A1 ES 8604570A1 ES 545155 A ES545155 A ES 545155A ES 545155 A ES545155 A ES 545155A ES 8604570 A1 ES8604570 A1 ES 8604570A1
Authority
ES
Spain
Prior art keywords
phenyl
dihydropyridazinones
pyrrol
preparation
ch2oh
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES545155A
Other languages
English (en)
Other versions
ES545155A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF SE
Original Assignee
BASF SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BASF SE filed Critical BASF SE
Publication of ES545155A0 publication Critical patent/ES545155A0/es
Publication of ES8604570A1 publication Critical patent/ES8604570A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Detergent Compositions (AREA)
  • Dental Preparations (AREA)
  • Photoreceptors In Electrophotography (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE (PIRROL-1-IL)-FENIL-DIHIDROPIRIDAZINONA.CONSISTE EN HACER REACCIONAR P-AMINOFENILDIHIDROPIRIDAZINONAS DE FORMULA (II) CON TETRAHIDROFURANOS DE FORMULA (III), PARA OBTENER (PIRROL-1-IL)-FENIL-DIHIDROPIRIDAZINONA DE FORMULA (I) EN LA QUE R1 ES UN ATOMO DE HIDROGENO, UN GRUPO METILO O UN GRUPO HIDROXIMETILO; R2 ES UN ATOMO DE HIDROGENO O UN GRUPO METILO; O R1 Y R2 JUNTOS SIGNIFICAN UN RESTO METILENO O ETILENO; A Y B SON ATOMOS DE HIDROGENO Y OTROS; R3 ES UN GRUPO FORMILO O HIDROXIMETILO O UN GRUPO CH2-NH4R5 DONDE R4 ES UN HRUPO ALQUILO CON C 1 A 6 O UN GRUPO FENILALQUILENO CON C 1 A 3 Y R5 ES UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO CON C 1 A 6 Y OTROS; Y R6 ES UN ATOMO DE NITROGENO O JUNTO CON R1 ES UN RESTO -(CH2)M-, DONDE M ES 0, 1, 2 O 3. SE EMPLEAN PARA AUMENTAR LA CONTRACTILIDAD MIOCARDIAL.
ES545155A 1984-07-12 1985-07-12 Procedimiento para la obtencion de (pirrol-1-il)-fenil-dihi-dropiridazinona Expired ES8604570A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843425632 DE3425632A1 (de) 1984-07-12 1984-07-12 (pyrrol-1-yl)-phenyl-dihydropyridazinone, ihre herstellung und verwendung

Publications (2)

Publication Number Publication Date
ES545155A0 ES545155A0 (es) 1986-02-01
ES8604570A1 true ES8604570A1 (es) 1986-02-01

Family

ID=6240427

Family Applications (1)

Application Number Title Priority Date Filing Date
ES545155A Expired ES8604570A1 (es) 1984-07-12 1985-07-12 Procedimiento para la obtencion de (pirrol-1-il)-fenil-dihi-dropiridazinona

Country Status (12)

Country Link
US (1) US4710496A (es)
EP (1) EP0167995B1 (es)
JP (1) JPS6169775A (es)
AT (1) ATE39694T1 (es)
AU (1) AU4482985A (es)
CA (1) CA1248947A (es)
DE (2) DE3425632A1 (es)
DK (1) DK317285A (es)
ES (1) ES8604570A1 (es)
FI (1) FI81347C (es)
NO (1) NO162557C (es)
ZA (1) ZA855224B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816454A (en) * 1984-09-21 1989-03-28 Cassella Aktiengesellschaft 4,5-dihydro-3(2H)-pyridazinones and their pharmacological use
IL79280A (en) * 1985-07-05 1990-07-12 Smith Kline French Lab 4-(6-oxo-dihydro or tetrahydropyridazin-3-yl)benzene derivatives,their preparation and pharmaceutical compositions containing them
DE3600275A1 (de) * 1986-01-08 1987-07-09 Basf Ag Substituierte pyrrol-1-ylphenyldihydropyridazinone, ihre herstellung und verwendung
DE3626865A1 (de) * 1986-08-08 1988-02-11 Boehringer Mannheim Gmbh Neue pyridazinon-derivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
US4888169A (en) * 1986-10-14 1989-12-19 Norden Laboratories, Inc. Bordetella Bronchiseptica vaccine
US4970210A (en) * 1987-07-17 1990-11-13 Abbott Laboratories Triazinone lipoxygenase compounds
US4806535A (en) * 1987-07-22 1989-02-21 Rorer Pharmaceutical Corporation Imidazolylphenyl and 1,2,4-triazolylphenyl benzopyridazinone and pyridopyridazinone compounds and their use for increasing cardiatonic contractility
DE3735207A1 (de) * 1987-10-17 1989-04-27 Basf Ag Mittel auf der basis von phenylpyridazinon-derivaten zur wachstumsfoerderung und fettreduktion bei tieren
DE3804490A1 (de) * 1988-02-12 1989-08-24 Heumann Pharma Gmbh & Co Substituierte 6-phenyldihydro-3(2h)-pyridazinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
JP3442815B2 (ja) * 1992-05-13 2003-09-02 第一製薬株式会社 ジアザビシクロアルケン誘導体
WO2020157199A1 (en) 2019-02-01 2020-08-06 Bayer Aktiengesellschaft Annulated dihydropyridazinone compounds as anti-cancer compounds

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU190412B (en) * 1981-09-17 1986-09-29 Warner-Lambert Co,Us Process for producing substituted 4,5-dihiydro-6-bracket-substituted-bracket closed-phenyl-3-bracket-2h-bracket closed-pyridazinones and 6-bracket-substituted-bracket closed-phenyl-3-bracket-2h-bracket closed-pyridazinones

Also Published As

Publication number Publication date
EP0167995A2 (de) 1986-01-15
FI81347C (fi) 1990-10-10
DE3567211D1 (en) 1989-02-09
FI852730A0 (fi) 1985-07-10
AU4482985A (en) 1986-01-16
NO852793L (no) 1986-01-13
US4710496A (en) 1987-12-01
FI852730L (fi) 1986-01-13
FI81347B (fi) 1990-06-29
CA1248947A (en) 1989-01-17
NO162557C (no) 1990-01-17
ES545155A0 (es) 1986-02-01
EP0167995A3 (en) 1986-12-10
ATE39694T1 (de) 1989-01-15
JPS6169775A (ja) 1986-04-10
ZA855224B (en) 1986-03-26
EP0167995B1 (de) 1989-01-04
DK317285A (da) 1986-01-13
NO162557B (no) 1989-10-09
DK317285D0 (da) 1985-07-11
DE3425632A1 (de) 1986-01-16

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Legal Events

Date Code Title Description
MM4A Patent lapsed

Effective date: 19960401