ES8603818A1 - Un metodo para preparar un derivado de acido benzoilpropio- nico - Google Patents
Un metodo para preparar un derivado de acido benzoilpropio- nicoInfo
- Publication number
- ES8603818A1 ES8603818A1 ES543884A ES543884A ES8603818A1 ES 8603818 A1 ES8603818 A1 ES 8603818A1 ES 543884 A ES543884 A ES 543884A ES 543884 A ES543884 A ES 543884A ES 8603818 A1 ES8603818 A1 ES 8603818A1
- Authority
- ES
- Spain
- Prior art keywords
- pharmaceutical compositions
- acid derivatives
- benzoylpropionic acid
- alkyl
- benzoylpropionic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- VNCQTTDYACAVDT-UHFFFAOYSA-N 2-methyl-3-oxo-3-phenylpropanoic acid Chemical class OC(=O)C(C)C(=O)C1=CC=CC=C1 VNCQTTDYACAVDT-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- AUQPEQFDSYFSTD-UHFFFAOYSA-N 2-(acetylsulfanylmethyl)-4-(4-bromophenyl)-4-oxobutanoic acid Chemical compound CC(=O)SCC(C(O)=O)CC(=O)C1=CC=C(Br)C=C1 AUQPEQFDSYFSTD-UHFFFAOYSA-N 0.000 abstract 1
- MAQSWCFADHGGOG-UHFFFAOYSA-N 2-(acetylsulfanylmethyl)-4-oxo-4-phenylbutanoic acid Chemical compound CC(=O)SCC(C(O)=O)CC(=O)C1=CC=CC=C1 MAQSWCFADHGGOG-UHFFFAOYSA-N 0.000 abstract 1
- KMQLIDDEQAJAGJ-UHFFFAOYSA-N 4-oxo-4-phenylbutyric acid Chemical compound OC(=O)CCC(=O)C1=CC=CC=C1 KMQLIDDEQAJAGJ-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/02—Monothiocarboxylic acids
- C07C327/04—Monothiocarboxylic acids having carbon atoms of thiocarboxyl groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
METODO PARA PREPARAR UN DERIVADO DE ACIDO BENZOILPROPIONICO. CONSISTE EN HACER REACCIONAR UN ACIDO CARBOXILICO DE FORMULA (II) CON UN ACIDO TIOCARBOXILICO DE FORMULA R2COSH PARA OBTENER UN DERIVADO DE ACIDO BENZOILPROPIONICO DE FORMULA (I), DONDE R1 REPRESENTA UN ATOMO DE H, UN GRUPO ALQUILO INFERIOR O UN GRUPO BENCILO; R2 REPRESENTA UN GRUPO ALQUILO INFERIOR O UN GRUPO FENILO; X REPRESENTA UN ATOMO DE H, UN ATOMO DE HALOGENO Y OTROS; E Y REPRESENTA UN ATOMO DE H O UN GRUPO ALQUILO INFERIOR. EN LA PRIMERA ETAPA DE LA REACCION SE EMPLEAN DE 1 A 2 EQUIVALENTES DEL ACIDO TIOCARBOXILICO Y DE 0,01 A 0,1 EQUIVALENTES DE CATALIZADOR BASICO POR CADA EQUIVALENTE DEL COMPUESTO DE FORMULA (II), EFECTUANDOSE A UNA TEMPERATURA DE C20 A C50JC Y DURANTE 0,5 A 24 HORAS. TIENEN UTILIDADES FARMACEUTICAS PARA EL TRATAMIENTO DE ENFERMEDADES CAUSADAS POR INMUNOFUNCION ANORMAL.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59114887A JPS60258160A (ja) | 1984-06-05 | 1984-06-05 | ベンゾイルプロピオン酸誘導体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8603818A1 true ES8603818A1 (es) | 1986-01-01 |
| ES543884A0 ES543884A0 (es) | 1986-01-01 |
Family
ID=14649144
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES543884A Granted ES543884A0 (es) | 1984-06-05 | 1985-06-04 | Un metodo para preparar un derivado de acido benzoilpropio- nico |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US4600540A (es) |
| EP (1) | EP0164101B1 (es) |
| JP (1) | JPS60258160A (es) |
| KR (1) | KR910006634B1 (es) |
| AT (1) | AT389508B (es) |
| CA (1) | CA1240696A (es) |
| DE (1) | DE3564806D1 (es) |
| ES (1) | ES543884A0 (es) |
| ZA (1) | ZA854126B (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102314436B1 (ko) | 2021-01-27 | 2021-10-19 | (주)국전약품 | 나파모스타트 메실산염 및 그의 중간체의 제조방법 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3598854A (en) * | 1968-10-31 | 1971-08-10 | Geigy Chem Corp | Alkylhydroxyphenylthioloalkanoates |
| US3821268A (en) * | 1970-05-05 | 1974-06-28 | Rorer Inc William H | Alpha-acylthio biphenylylacetic acids |
| JPS58150563A (ja) * | 1982-03-04 | 1983-09-07 | Taisho Pharmaceut Co Ltd | ３−ベンゾイル−２−メルカプトプロピオン酸誘導体 |
| JPS6054356A (ja) * | 1983-09-03 | 1985-03-28 | Taisho Pharmaceut Co Ltd | ３−ベンゾイル−２−メルカプトプロピオン酸誘導体 |
-
1984
- 1984-06-05 JP JP59114887A patent/JPS60258160A/ja active Granted
-
1985
- 1985-05-30 KR KR1019850003772A patent/KR910006634B1/ko not_active IP Right Cessation
- 1985-05-30 ZA ZA854126A patent/ZA854126B/xx unknown
- 1985-05-31 AT AT0166085A patent/AT389508B/de not_active IP Right Cessation
- 1985-06-04 EP EP85106893A patent/EP0164101B1/en not_active Expired
- 1985-06-04 US US06/741,127 patent/US4600540A/en not_active Expired - Lifetime
- 1985-06-04 DE DE8585106893T patent/DE3564806D1/de not_active Expired
- 1985-06-04 ES ES543884A patent/ES543884A0/es active Granted
- 1985-06-04 CA CA000483104A patent/CA1240696A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| KR910006634B1 (ko) | 1991-08-29 |
| EP0164101A3 (en) | 1986-04-09 |
| EP0164101A2 (en) | 1985-12-11 |
| ZA854126B (en) | 1986-01-29 |
| DE3564806D1 (en) | 1988-10-13 |
| JPS60258160A (ja) | 1985-12-20 |
| JPH0119383B2 (es) | 1989-04-11 |
| KR860000254A (ko) | 1986-01-27 |
| ES543884A0 (es) | 1986-01-01 |
| AT389508B (de) | 1989-12-27 |
| ATA166085A (de) | 1989-05-15 |
| CA1240696A (en) | 1988-08-16 |
| EP0164101B1 (en) | 1988-09-07 |
| US4600540A (en) | 1986-07-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU584701B2 (en) | 2-(4-Benzoyl-1-piperidyl)-1-phenylalkanol derivatives | |
| DK346085A (da) | Prostatriensyrederivater | |
| AU561450B2 (en) | 2-amino-3-acylamino-6-benzylamino pyridine derivatives | |
| FI860369A (fi) | Imidazolderivat, deras framstaellning och anvaendning samt dessa derivat innehaollande farmaceutiska kompositioner. | |
| ES2010284A6 (es) | Procedimiento para preparar derivados de tiourea. | |
| DE3861380D1 (de) | Fluessigkristallverbindung vom tolan-typ. | |
| AU558039B2 (en) | Pyridazinones | |
| ES8603818A1 (es) | Un metodo para preparar un derivado de acido benzoilpropio- nico | |
| JPS57131771A (en) | Novel pyrimidine derivative | |
| FI872997A0 (fi) | Amidderivat. | |
| DK10085D0 (da) | Aminoethylimidazoler, farmaceutisk komposition indeholdende disse forbindelser og fremgangsmaade til forbindelsernes fremstilling | |
| ES8505669A1 (es) | Procedimiento para la obtencion de derivados de triazolilmetil-piridiloximetil-carbinoles | |
| AU561149B2 (en) | Cardiotonic 4-semicarbazide quindyolines | |
| DE3660546D1 (en) | Phosphoroimidates |