ES8603758A1 - Procedimiento para la obtencion de un complejo lantanido pa-ramagnetico de efecto modificador del contraste de una ima- gen medica por rmn. - Google Patents

Procedimiento para la obtencion de un complejo lantanido pa-ramagnetico de efecto modificador del contraste de una ima- gen medica por rmn.

Info

Publication number
ES8603758A1
ES8603758A1 ES542928A ES542928A ES8603758A1 ES 8603758 A1 ES8603758 A1 ES 8603758A1 ES 542928 A ES542928 A ES 542928A ES 542928 A ES542928 A ES 542928A ES 8603758 A1 ES8603758 A1 ES 8603758A1
Authority
ES
Spain
Prior art keywords
modifying
contrast
pathologics
organs
magnetic resonance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES542928A
Other languages
English (en)
Other versions
ES542928A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Commissariat a lEnergie Atomique et aux Energies Alternatives CEA
Original Assignee
Commissariat a lEnergie Atomique CEA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Commissariat a lEnergie Atomique CEA filed Critical Commissariat a lEnergie Atomique CEA
Publication of ES542928A0 publication Critical patent/ES542928A0/es
Publication of ES8603758A1 publication Critical patent/ES8603758A1/es
Expired legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins
    • A61K49/16—Antibodies; Immunoglobulins; Fragments thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/003—Compounds containing elements of Groups 3 or 13 of the Periodic Table without C-Metal linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Signal Processing (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)

Abstract

METODO DE PRODUCCION DE COMPLEJOS DE LANTANIDO PARAMAGNETICOS DE EFECTO MODIFICADOR DEL CONTRASTE DE UNA IMAGEN MEDICA POR RESONANCIA MAGNETICA NUCLEAR. CONSISTE EN LA COPULACION DE UN ANTICUERPO MONOCLONAL CON UN LIGANDO CAPAZ DE FORMAR COMPLEJO CON UN LANTANIDO PARAMAGNETICO, POR MEZCLA DE UNA DISOLUCION DEL ANTICUERPO EN BICARBONATO SODICO CON UNA DISOLUCION DEL LIGANDO EN DIMETILSULFOXIDO; SEGUIDA DE LA REACCION DEL LIGANDO ASI COPULADO CON UNA SAL O UN OXIDO DE LANTANIDO PARAMAGNETICO; Y, FINALMENTE, SEPARACION DEL COMPLEJO DE LANTANIDO PARAMAGNETICO COPULADO CON DICHO ANTICUERPO MONOCLONAL ASI OBTENIDO. ESTOS COMPLEJOS TIENEN APLICACIONES PARA LA OBTENCION DE IMAGENES DE COMPARTIMENTOS ANATOMICOS, COMO CEREBRO, VIAS BILIARES, ARBOL URINARIO, ETC.
ES542928A 1983-08-12 1985-05-08 Procedimiento para la obtencion de un complejo lantanido pa-ramagnetico de efecto modificador del contraste de una ima- gen medica por rmn. Expired ES8603758A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8313281A FR2550449B1 (fr) 1983-08-12 1983-08-12 Agents de relaxation specifiques d'organes ou de pathologies, utilisables pour modifier les contrastes en imagerie medicale par resonance magnetique nucleaire

Publications (2)

Publication Number Publication Date
ES542928A0 ES542928A0 (es) 1986-01-01
ES8603758A1 true ES8603758A1 (es) 1986-01-01

Family

ID=9291604

Family Applications (3)

Application Number Title Priority Date Filing Date
ES535097A Expired ES8700058A1 (es) 1983-08-12 1984-08-10 Procedimiento para la obtencion de complejos plantanidos de efecto modificador del contraste de una imagen rmn
ES542927A Granted ES542927A0 (es) 1983-08-12 1985-05-08 Procedimiento para la obtencion de un complejo lantanido de efecto modificador del contraste de una imagen medica por rmn
ES542928A Expired ES8603758A1 (es) 1983-08-12 1985-05-08 Procedimiento para la obtencion de un complejo lantanido pa-ramagnetico de efecto modificador del contraste de una ima- gen medica por rmn.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES535097A Expired ES8700058A1 (es) 1983-08-12 1984-08-10 Procedimiento para la obtencion de complejos plantanidos de efecto modificador del contraste de una imagen rmn
ES542927A Granted ES542927A0 (es) 1983-08-12 1985-05-08 Procedimiento para la obtencion de un complejo lantanido de efecto modificador del contraste de una imagen medica por rmn

Country Status (5)

Country Link
US (1) US4804529A (es)
EP (1) EP0133603A1 (es)
JP (1) JPS60100526A (es)
ES (3) ES8700058A1 (es)
FR (1) FR2550449B1 (es)

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US5019370A (en) * 1989-07-10 1991-05-28 University Of Kentucky Research Foundation Biodegradable, low biological toxicity radiographic contrast medium and method of x-ray imaging
FR2654344B1 (fr) * 1989-11-16 1994-09-23 Cis Bio Int Complexe paramagnetique de gadolinium, son procede de preparation et son utilisation pour le diagnostic par irm.
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US5236695A (en) * 1989-11-27 1993-08-17 Concat, Ltd. MRI image enhancement of bone and related tissue using complexes of paramagnetic cations and polyphosphonate ligands
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US5154914A (en) * 1990-03-12 1992-10-13 Research Corporation Technologies, Inc. Methods of diagnostic image analysis using lipophilic contrast agents
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Also Published As

Publication number Publication date
ES8700058A1 (es) 1986-10-16
ES542928A0 (es) 1986-01-01
ES8603757A1 (es) 1986-01-01
EP0133603A1 (fr) 1985-02-27
ES542927A0 (es) 1986-01-01
FR2550449A1 (fr) 1985-02-15
ES535097A0 (es) 1986-10-16
US4804529A (en) 1989-02-14
JPS60100526A (ja) 1985-06-04
FR2550449B1 (fr) 1986-01-31

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970519