DK0513000T3 - Kvalitetsforbedring af IMR-billeder af knogler og lignende væv ved hjælp af paramagnetiske kationkomplekser og polyphosphonatligander - Google Patents
Kvalitetsforbedring af IMR-billeder af knogler og lignende væv ved hjælp af paramagnetiske kationkomplekser og polyphosphonatliganderInfo
- Publication number
- DK0513000T3 DK0513000T3 DK90917189.4T DK90917189T DK0513000T3 DK 0513000 T3 DK0513000 T3 DK 0513000T3 DK 90917189 T DK90917189 T DK 90917189T DK 0513000 T3 DK0513000 T3 DK 0513000T3
- Authority
- DK
- Denmark
- Prior art keywords
- imr
- bones
- images
- quality improvement
- polyphosphonate
- Prior art date
Links
- 210000000988 bone and bone Anatomy 0.000 title abstract 3
- 150000001768 cations Chemical class 0.000 title abstract 2
- 239000003446 ligand Substances 0.000 title abstract 2
- 230000005298 paramagnetic effect Effects 0.000 title abstract 2
- 210000001519 tissue Anatomy 0.000 title 1
- -1 dihydroxyphosphorylmethyl Chemical group 0.000 abstract 2
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical group OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
- G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
- G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Signal Processing (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- High Energy & Nuclear Physics (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- General Physics & Mathematics (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US44114489A | 1989-11-27 | 1989-11-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0513000T3 true DK0513000T3 (da) | 1996-12-30 |
Family
ID=23751720
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK90917189.4T DK0513000T3 (da) | 1989-11-27 | 1990-10-17 | Kvalitetsforbedring af IMR-billeder af knogler og lignende væv ved hjælp af paramagnetiske kationkomplekser og polyphosphonatligander |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0513000B1 (da) |
| JP (1) | JP2593963B2 (da) |
| AT (1) | ATE140869T1 (da) |
| AU (1) | AU649001B2 (da) |
| CA (1) | CA2069638C (da) |
| DE (1) | DE69028001T2 (da) |
| DK (1) | DK0513000T3 (da) |
| ES (1) | ES2091251T3 (da) |
| GR (1) | GR3020861T3 (da) |
| WO (1) | WO1991007911A1 (da) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5885549A (en) * | 1991-02-01 | 1999-03-23 | Imarx Pharmaceutical Corp. | Phosphorylated materials as contrast agents for use in magnetic resonance imaging of the gastrointestinal region |
| US5143716A (en) * | 1991-02-01 | 1992-09-01 | Unger Evan C | Phosphorylated sugar alcohols, Mono- and Di-Saccharides as contrast agents for use in magnetic resonance imaging of the gastrointestinal region |
| JPH07502044A (ja) * | 1991-12-10 | 1995-03-02 | ザ ダウ ケミカル カンパニー | 歯垢及び歯石の形成を抑制するための口内組成物 |
| US5555884A (en) * | 1992-12-16 | 1996-09-17 | Kabushiki Kaisha Egawa | Measuring method by using resonance of a resonance medium |
| US5714604A (en) * | 1993-05-06 | 1998-02-03 | The Dow Chemical Company | Process for the preparation of azamacrocyclic or acyclic aminophosphonate ester derivatives |
| US5409689A (en) * | 1993-08-13 | 1995-04-25 | Concat, Ltd. | MRI image enhancement using complexes of paramagnetic cations and amine ligands containing a mixture of phosphonate and non-phosphonate pendant arms |
| US5834456A (en) * | 1996-02-23 | 1998-11-10 | The Dow Chemical Company | Polyazamacrocyclofluoromonoalkylphosphonic acids, and their complexes, for use as contrast agents |
| US6093382A (en) | 1998-05-16 | 2000-07-25 | Bracco Research Usa Inc. | Metal complexes derivatized with folate for use in diagnostic and therapeutic applications |
| US6565828B2 (en) * | 2000-04-07 | 2003-05-20 | Bristol-Myers Squibb Company | Macrocyclic chelants for metallopharmaceuticals |
| EP1637524A1 (en) * | 2004-09-20 | 2006-03-22 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | 10-substituted 1-, 4, 7,-tris (carboxymethyl)-1,4,7,10-tetraazacyclo-dodecane derivative for use as contrast agents |
| US20120148492A1 (en) * | 2009-08-20 | 2012-06-14 | Fujifilm Ri Pharma Co., Ltd. | Bisphosphonic acid derivative and compound thereof labeled with radioactive metal nuclide |
| EP3880257A4 (en) * | 2018-11-16 | 2022-07-27 | The Research Foundation for the State University of New York | COMPOUNDS FOR USE AS FERRIC (III) CONTRAST AGENTS FOR MRI CONTAINING ANIONIC PENDANT GROUPS AND AUXILIARY GROUPS |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4515766A (en) * | 1980-06-23 | 1985-05-07 | The Massachusetts General Hospital | Labeled phosphonic acid compositions for investigations of in vivo deposits of calcium |
| US4647447A (en) * | 1981-07-24 | 1987-03-03 | Schering Aktiengesellschaft | Diagnostic media |
| DE3129906C3 (de) * | 1981-07-24 | 1996-12-19 | Schering Ag | Paramagnetische Komplexsalze, deren Herstellung und Mittel zur Verwendung bei der NMR-Diagnostik |
| DE3237573A1 (de) * | 1982-10-09 | 1984-04-12 | Hoechst Ag, 6230 Frankfurt | Technetium-99m-tri- und tetraphosphonate zur szintigraphischen dastellung res-haltiger organe und der lymphgefaesse und verfahren zu deren herstellung |
| FR2550449B1 (fr) * | 1983-08-12 | 1986-01-31 | Commissariat Energie Atomique | Agents de relaxation specifiques d'organes ou de pathologies, utilisables pour modifier les contrastes en imagerie medicale par resonance magnetique nucleaire |
| US4749560A (en) * | 1984-08-13 | 1988-06-07 | Research Corporation | Metal organo phosphorous compounds for NMR analysis |
| US4735210A (en) * | 1985-07-05 | 1988-04-05 | Immunomedics, Inc. | Lymphographic and organ imaging method and kit |
| GB8518300D0 (en) * | 1985-07-19 | 1985-08-29 | Amersham Int Plc | Contrast agent |
| AU608759B2 (en) * | 1986-08-04 | 1991-04-18 | Amersham Health Salutar Inc | NMR imaging with paramagnetic polyvalents metal salts of poly-(acid-alkylene-amido)-alkanes |
| GB8701054D0 (en) * | 1987-01-16 | 1987-02-18 | Amersham Int Plc | Contrast agent for nmr scanning |
| GB8903023D0 (en) * | 1989-02-10 | 1989-03-30 | Parker David | Chemical compounds |
| GB8914543D0 (en) * | 1989-06-23 | 1989-08-09 | Parker David | Chemical compounds |
| ZA914616B (en) * | 1990-06-18 | 1993-02-24 | Dow Chemical Co | The use of macrocyclic aminophosphonic acid complexes as imaging agents |
-
1990
- 1990-10-17 AT AT90917189T patent/ATE140869T1/de not_active IP Right Cessation
- 1990-10-17 WO PCT/US1990/005967 patent/WO1991007911A1/en active IP Right Grant
- 1990-10-17 DK DK90917189.4T patent/DK0513000T3/da active
- 1990-10-17 JP JP2515855A patent/JP2593963B2/ja not_active Expired - Fee Related
- 1990-10-17 CA CA002069638A patent/CA2069638C/en not_active Expired - Fee Related
- 1990-10-17 EP EP90917189A patent/EP0513000B1/en not_active Expired - Lifetime
- 1990-10-17 AU AU67322/90A patent/AU649001B2/en not_active Ceased
- 1990-10-17 DE DE69028001T patent/DE69028001T2/de not_active Expired - Fee Related
- 1990-10-17 ES ES90917189T patent/ES2091251T3/es not_active Expired - Lifetime
-
1996
- 1996-08-22 GR GR960402218T patent/GR3020861T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPH05504127A (ja) | 1993-07-01 |
| AU6732290A (en) | 1991-06-26 |
| EP0513000A4 (en) | 1992-09-01 |
| JP2593963B2 (ja) | 1997-03-26 |
| AU649001B2 (en) | 1994-05-12 |
| WO1991007911A1 (en) | 1991-06-13 |
| CA2069638A1 (en) | 1991-05-28 |
| ES2091251T3 (es) | 1996-11-01 |
| EP0513000A1 (en) | 1992-11-19 |
| ATE140869T1 (de) | 1996-08-15 |
| DE69028001T2 (de) | 1996-12-19 |
| EP0513000B1 (en) | 1996-07-31 |
| CA2069638C (en) | 1999-02-09 |
| GR3020861T3 (en) | 1996-11-30 |
| DE69028001D1 (de) | 1996-09-05 |
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