GB2177199A - Magnetic micro-particles as contrast agents in nuclear magnetic resonance imaging - Google Patents

Magnetic micro-particles as contrast agents in nuclear magnetic resonance imaging

Info

Publication number
GB2177199A
GB2177199A GB08607629A GB8607629A GB2177199A GB 2177199 A GB2177199 A GB 2177199A GB 08607629 A GB08607629 A GB 08607629A GB 8607629 A GB8607629 A GB 8607629A GB 2177199 A GB2177199 A GB 2177199A
Authority
GB
United Kingdom
Prior art keywords
particles
resonance imaging
contrast agents
micro
magnetic resonance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB08607629A
Other versions
GB8607629D0 (en
Inventor
Truman Brown
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fox Chase Cancer Center
Original Assignee
Fox Chase Cancer Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fox Chase Cancer Center filed Critical Fox Chase Cancer Center
Publication of GB8607629D0 publication Critical patent/GB8607629D0/en
Publication of GB2177199A publication Critical patent/GB2177199A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
    • A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nanotechnology (AREA)
  • Epidemiology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)

Abstract

NMR imaging of animal tissue is improved by a contrast-enhancing agent in the form of magnetic micro-particles comprising magnetic material coupled to a substance having binding affinity for the target tissue.
GB08607629A 1984-08-10 1985-08-06 Magnetic micro-particles as contrast agents in nuclear magnetic resonance imaging Withdrawn GB2177199A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64003784A 1984-08-10 1984-08-10
PCT/US1985/001495 WO1986001112A1 (en) 1984-08-10 1985-08-06 Magnetic micro-particles as contrast agents in nuclear magnetic resonance imaging

Publications (2)

Publication Number Publication Date
GB8607629D0 GB8607629D0 (en) 1986-04-30
GB2177199A true GB2177199A (en) 1987-01-14

Family

ID=24566571

Family Applications (1)

Application Number Title Priority Date Filing Date
GB08607629A Withdrawn GB2177199A (en) 1984-08-10 1985-08-06 Magnetic micro-particles as contrast agents in nuclear magnetic resonance imaging

Country Status (4)

Country Link
CA (1) CA1268208A (en)
DE (1) DE3590398T1 (en)
GB (1) GB2177199A (en)
WO (1) WO1986001112A1 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62181229A (en) * 1985-11-05 1987-08-08 ザ・ゼネラル・ホスピタル・コ−ポレ−シヨン Minus-charged specific affinity reagent
US5223242A (en) * 1985-11-05 1993-06-29 The General Hospital Corporation Negatively charged specific affinity reagents
US5314679A (en) * 1986-07-03 1994-05-24 Advanced Magnetics Inc. Vascular magnetic resonance imaging agent comprising nanoparticles
US5055288A (en) * 1987-06-26 1991-10-08 Advanced Magnetics, Inc. Vascular magnetic imaging method and agent comprising biodegradeable superparamagnetic metal oxides
FR2612400A1 (en) * 1987-03-16 1988-09-23 Centre Nat Rech Scient Microcapsules containing a radioactive and/or paramagnetic label in chelate form, and their use in the field of medical imaging
DE3709851A1 (en) * 1987-03-24 1988-10-06 Silica Gel Gmbh Adsorptions Te NMR DIAGNOSTIC LIQUID COMPOSITIONS
US5314681A (en) * 1988-12-23 1994-05-24 Nycomed Innovation Ab Composition of positive and negative contrast agents for electron spin resonance enhanced magnetic resonance imaging
US5164297A (en) * 1990-05-03 1992-11-17 Advanced Magnetics Inc. Solvent mediated relaxation assay system
US5948384A (en) * 1990-09-14 1999-09-07 Syngenix Limited Particulate agents
WO1992004916A2 (en) * 1990-09-14 1992-04-02 St. George's Enterprises Limited Particulate agents
GB9020075D0 (en) 1990-09-14 1990-10-24 Filler Aaron G Contrast agents for magnetic resonance imaging of axonal transport
US6919067B2 (en) 1991-09-13 2005-07-19 Syngenix Limited Compositions comprising a tissue glue and therapeutic agents
DE4309333A1 (en) * 1993-03-17 1994-09-22 Silica Gel Gmbh Superparamagnetic particles, process for their production and use thereof
DE69628731T3 (en) * 1995-11-01 2012-09-20 Bracco Suisse S.A. TARGETED MAGNETICALLY MARKED MOLECULAR MARKER SYSTEMS AS NMR IMAGING PRODUCTS
ATE291439T1 (en) 1996-01-10 2005-04-15 Amersham Health As CONTRAST AGENTS
GB9600427D0 (en) * 1996-01-10 1996-03-13 Nycomed Imaging As Contrast media
WO2006124726A2 (en) 2005-05-12 2006-11-23 The General Hospital Corporation Novel biotinylated compositions
CA2883130A1 (en) 2012-08-31 2014-03-06 The General Hospital Corporation Biotin complexes for treatment and diagnosis of alzheimer's disease

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU8633082A (en) * 1981-07-24 1983-01-27 Schering Aktiengesellschaft Paramagnetic complex salts and their use in nmr- diagnostics
US4452773A (en) * 1982-04-05 1984-06-05 Canadian Patents And Development Limited Magnetic iron-dextran microspheres
US4454106A (en) * 1982-06-07 1984-06-12 Gansow Otto A Use of metal chelate conjugated monoclonal antibodies

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU8633082A (en) * 1981-07-24 1983-01-27 Schering Aktiengesellschaft Paramagnetic complex salts and their use in nmr- diagnostics
EP0071564A1 (en) * 1981-07-24 1983-02-09 Schering Aktiengesellschaft Paramagnetic complex salts, their preparation and their use in NMR diagnostics
US4452773A (en) * 1982-04-05 1984-06-05 Canadian Patents And Development Limited Magnetic iron-dextran microspheres
US4454106A (en) * 1982-06-07 1984-06-12 Gansow Otto A Use of metal chelate conjugated monoclonal antibodies

Also Published As

Publication number Publication date
CA1268208A (en) 1990-04-24
DE3590398T1 (en) 1986-08-28
WO1986001112A1 (en) 1986-02-27
GB8607629D0 (en) 1986-04-30

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Legal Events

Date Code Title Description
WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)