DE69425572T2 - Iodierte paramagnetische chelaten, und deren verwendung als kontrastmittel - Google Patents

Iodierte paramagnetische chelaten, und deren verwendung als kontrastmittel

Info

Publication number
DE69425572T2
DE69425572T2 DE69425572T DE69425572T DE69425572T2 DE 69425572 T2 DE69425572 T2 DE 69425572T2 DE 69425572 T DE69425572 T DE 69425572T DE 69425572 T DE69425572 T DE 69425572T DE 69425572 T2 DE69425572 T2 DE 69425572T2
Authority
DE
Germany
Prior art keywords
pct
date
iodated
contrast agent
rays
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69425572T
Other languages
English (en)
Other versions
DE69425572D1 (de
Inventor
Fulvio Uggeri
Pier Lucio Anelli
Franco Fedeli
Marcella Murru
Haen Christoph De
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco SpA
Dibra SpA
Original Assignee
Bracco SpA
Dibra SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ITMI931155A external-priority patent/IT1270974B/it
Priority claimed from IT001274 external-priority patent/IT1264610B1/it
Application filed by Bracco SpA, Dibra SpA filed Critical Bracco SpA
Application granted granted Critical
Publication of DE69425572D1 publication Critical patent/DE69425572D1/de
Publication of DE69425572T2 publication Critical patent/DE69425572T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0438—Organic X-ray contrast-enhancing agent comprising an iodinated group or an iodine atom, e.g. iopamidol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Radiology & Medical Imaging (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
DE69425572T 1993-06-02 1994-05-25 Iodierte paramagnetische chelaten, und deren verwendung als kontrastmittel Expired - Lifetime DE69425572T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITMI931155A IT1270974B (it) 1993-06-02 1993-06-02 Chelati paramagnetici iodurati
IT001274 IT1264610B1 (it) 1993-06-15 1993-06-15 Chelati paramagnetici iodurati
PCT/EP1994/001677 WO1994027644A1 (en) 1993-06-02 1994-05-25 Iodinated paramagnetic chelates, and their use as contrast agents

Publications (2)

Publication Number Publication Date
DE69425572D1 DE69425572D1 (de) 2000-09-21
DE69425572T2 true DE69425572T2 (de) 2001-04-26

Family

ID=26330998

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69425572T Expired - Lifetime DE69425572T2 (de) 1993-06-02 1994-05-25 Iodierte paramagnetische chelaten, und deren verwendung als kontrastmittel

Country Status (9)

Country Link
US (1) US5660814A (de)
EP (1) EP0703790B1 (de)
JP (1) JPH08510458A (de)
AT (1) ATE195432T1 (de)
AU (1) AU6996594A (de)
DE (1) DE69425572T2 (de)
IL (1) IL109852A0 (de)
IS (1) IS4172A (de)
WO (1) WO1994027644A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4302287A1 (de) * 1993-01-25 1994-07-28 Schering Ag Derivatisierte DTPA-Komplexe, diese Verbindungen enthaltende pharmazeutische Mittel, ihre Verwendung und Verfahren zu deren Herstellung
US5672335A (en) * 1994-11-30 1997-09-30 Schering Aktiengesellschaft Use of metal complexes as liver and gallbladder X-ray diagnostic agents
TW319763B (de) * 1995-02-01 1997-11-11 Epix Medical Inc
FR2736051B3 (fr) * 1995-06-29 1997-09-26 Guerbet Sa Complexes metalliques de polyaminoacides, leur procede de preparation et leur utilisation en imagerie diagnostique
US5834456A (en) * 1996-02-23 1998-11-10 The Dow Chemical Company Polyazamacrocyclofluoromonoalkylphosphonic acids, and their complexes, for use as contrast agents
JP2002528521A (ja) * 1998-10-29 2002-09-03 ザ ゼネラル ホスピタル コーポレーション 放射線濃密性組成物
ES2581781T3 (es) * 2002-09-24 2016-09-07 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Método por imágenes para administración mejorada por convección de agentes terapéuticos
ITMI20022411A1 (it) * 2002-11-14 2004-05-15 Bracco Imaging Spa Agenti per la diagnosi e la terapia di tumori che espongono sulla superficie delle cellule proteine alterate.
DE10307759B3 (de) * 2003-02-19 2004-11-18 Schering Ag Trimere makrocyclisch substituierte Benzolderivate, deren Herstellung und Verwendung als Kontrastmittel sowie diese enthaltende pharmazeutische Mittel
US7208140B2 (en) * 2003-02-19 2007-04-24 Schering Aktiengesellschaft Trimeric macrocyclic substituted benzene derivatives
DE102004023093B3 (de) * 2004-05-05 2006-03-02 Schering Ag Trimere makrocyclisch substituierte Halogen-Benzolderivate
DE102004026103A1 (de) * 2004-05-25 2005-12-22 Schering Ag Trimere makrocyclisch substituierte Aminoisophthalsäure-Halogen-Benzolderivate
KR100695744B1 (ko) * 2005-05-03 2007-03-19 한국원자력연구소 디티피에이(ｄｔｐａ) 유도체 및 이들을 이용한 금속 착화물, 이들을 포함하는 방사선원 및 조영제
EP1762563A1 (de) * 2005-09-13 2007-03-14 BRACCO IMAGING S.p.A. Verfahren zur Herstellung von Kontrastmitteln
EP2073723A4 (de) * 2006-10-10 2011-03-30 Mayo Foundation Reduzierung kontrastmittelinduzierter toxizität
NO20073382L (no) * 2007-06-29 2008-12-30 Ge Healthcare As Contrast Agents
DE102007058220A1 (de) 2007-12-03 2009-06-04 Bayer Schering Pharma Aktiengesellschaft Dimere macrocyclisch substituierte Benzolderivate
GB0808086D0 (en) * 2008-05-02 2008-06-11 Iti Scotland Ltd Magnetic proteins for in vivo imaging
KR101638851B1 (ko) * 2014-06-13 2016-07-12 경북대학교 산학협력단 신규한 삼요오드화 화합물, 이의 제조방법 및 이를 포함하는 x-선 조영제
EP3101012A1 (de) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft Neue gadoliniumchelat-verbindung zur verwendung in der magnetresonanzbildgebung
CA3044877A1 (en) 2016-11-28 2018-05-31 Bayer Pharma Aktiengesellschaft High relaxivity gadolinium chelate compounds for use in magnetic resonance imaging
BR112021007707A2 (pt) 2018-11-23 2021-07-27 Bayer Aktiengesellschaft formulação de meios de contraste e processo de preparação da mesma
EP4015509A1 (de) 2020-12-18 2022-06-22 Justesa Imagen S.A.U Organometallische verbindungen und ihre verwendung als multimodale kontrastmedien zur bilddiagnose

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1213029B (it) * 1986-01-30 1989-12-07 Bracco Ind Chimica Spa Chelati di ioni metallici paramagnetici.
GB8916781D0 (en) * 1989-07-21 1989-09-06 Nycomed As Compositions
US5324503A (en) * 1992-02-06 1994-06-28 Mallinckrodt Medical, Inc. Iodo-phenylated chelates for x-ray contrast
US5525328A (en) * 1994-06-24 1996-06-11 Nanosystems L.L.C. Nanoparticulate diagnostic diatrizoxy ester X-ray contrast agents for blood pool and lymphatic system imaging

Also Published As

Publication number Publication date
US5660814A (en) 1997-08-26
IL109852A0 (en) 1994-10-07
EP0703790A1 (de) 1996-04-03
AU6996594A (en) 1994-12-20
WO1994027644A1 (en) 1994-12-08
ATE195432T1 (de) 2000-09-15
DE69425572D1 (de) 2000-09-21
EP0703790B1 (de) 2000-08-16
JPH08510458A (ja) 1996-11-05
IS4172A (is) 1994-12-03

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Legal Events

Date Code Title Description
8332 No legal effect for de
8370 Indication related to discontinuation of the patent is to be deleted