ES8602661A1 - Un procedimiento para preparar derivados de dihidropiridina - Google Patents

Un procedimiento para preparar derivados de dihidropiridina

Info

Publication number
ES8602661A1
ES8602661A1 ES541668A ES541668A ES8602661A1 ES 8602661 A1 ES8602661 A1 ES 8602661A1 ES 541668 A ES541668 A ES 541668A ES 541668 A ES541668 A ES 541668A ES 8602661 A1 ES8602661 A1 ES 8602661A1
Authority
ES
Spain
Prior art keywords
dihydropyridine derivatives
cycloalkyl
alkyl
production
pyridyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES541668A
Other languages
English (en)
Other versions
ES541668A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/JP1982/000159 external-priority patent/WO1983004023A1/ja
Priority claimed from PCT/JP1983/000008 external-priority patent/WO1984002702A1/ja
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of ES541668A0 publication Critical patent/ES541668A0/es
Publication of ES8602661A1 publication Critical patent/ES8602661A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR DERIVADOS DE HIDROPIRIDINA.CONSISTE EN HACER REACCIONAR ENTRE SI UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III) Y CON UN COMPUESTO DE FORMULA (IV), PARA OBTENER DERIVADOS DE HIDROPIRIDINA DE FORMULA (I), DONDE R1, R2 Y R3 SON IGUALES O DIFERENTES Y CADA UNO ES ALQUILO, CICLOALQUILO O ALCOXIALQUILO; R4 Y R5 SON IGUALES O DIFERENTES Y CADA UNO ES H, HALOGENO, NITRO Y OTROS; R6 ES H, ALQUILO, CICLOALQUILO, ARALQUILO ARILO O UN PIRIDILO; X ES 0, AZUFRE, VINILENO U OTROS; A ES ALQUILENO; AR ES ARILO O PIRIDILO; M ES UN ENTERO DE 1 A 3 Y N ES UN ENTERO DE 0 A 2. LA REACCION SE LLEVA A CABO EN UN DISOLVENTE COMO ALCANOLES, ETERES, BENCENO Y OTROS Y A UNA TEMPERATURA DE ENTRE 20 Y 160 C.TIENEN APLICACIONES FARMACEUTICAS POR PRESENTAR ACTIVIDADES DILATADORAS DE LA ARTERIA CORONARIA Y ANTIHIPERTENSAS.
ES541668A 1982-05-10 1985-03-28 Un procedimiento para preparar derivados de dihidropiridina Expired ES8602661A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/JP1982/000159 WO1983004023A1 (en) 1982-05-10 1982-05-10 Dihydropyridine derivatives
PCT/JP1983/000008 WO1984002702A1 (en) 1983-01-11 1983-01-11 Dihydropyridine derivatives

Publications (2)

Publication Number Publication Date
ES541668A0 ES541668A0 (es) 1985-12-01
ES8602661A1 true ES8602661A1 (es) 1985-12-01

Family

ID=26422991

Family Applications (3)

Application Number Title Priority Date Filing Date
ES522199A Expired ES8607966A1 (es) 1982-05-10 1983-05-09 Un procedimiento para preparar un derivado de dihidropiridina.
ES541668A Expired ES8602661A1 (es) 1982-05-10 1985-03-28 Un procedimiento para preparar derivados de dihidropiridina
ES547275A Expired ES8701171A1 (es) 1982-05-10 1985-09-25 Un procedimiento para preparar derivados de dihidropiridina

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES522199A Expired ES8607966A1 (es) 1982-05-10 1983-05-09 Un procedimiento para preparar un derivado de dihidropiridina.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES547275A Expired ES8701171A1 (es) 1982-05-10 1985-09-25 Un procedimiento para preparar derivados de dihidropiridina

Country Status (16)

Country Link
US (1) US4892875A (es)
EP (1) EP0094159B1 (es)
KR (1) KR880002357B1 (es)
AT (1) ATE50987T1 (es)
AU (1) AU556150B2 (es)
CA (1) CA1333487C (es)
DK (1) DK160984C (es)
ES (3) ES8607966A1 (es)
FI (1) FI79700C (es)
GR (1) GR78252B (es)
HK (1) HK3293A (es)
IE (1) IE56057B1 (es)
IL (1) IL68494A (es)
MY (1) MY102082A (es)
NO (1) NO159593C (es)
PT (1) PT76653B (es)

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Also Published As

Publication number Publication date
AU1415583A (en) 1983-11-17
AU556150B2 (en) 1986-10-23
EP0094159B1 (en) 1990-03-14
NO159593B (no) 1988-10-10
IE56057B1 (en) 1991-04-10
DK203083D0 (da) 1983-05-06
IL68494A (en) 1988-01-31
ES541668A0 (es) 1985-12-01
CA1333487C (en) 1994-12-13
ATE50987T1 (de) 1990-03-15
US4892875A (en) 1990-01-09
KR840004741A (ko) 1984-10-24
DK203083A (da) 1983-11-11
FI79700B (fi) 1989-10-31
ES8607966A1 (es) 1986-01-16
NO159593C (no) 1989-01-18
FI831604L (fi) 1983-11-11
PT76653B (en) 1986-01-27
PT76653A (en) 1983-06-01
GR78252B (es) 1984-09-26
ES522199A0 (es) 1986-01-16
KR880002357B1 (ko) 1988-10-29
EP0094159A1 (en) 1983-11-16
IE830897L (en) 1983-11-10
FI79700C (fi) 1990-02-12
HK3293A (en) 1993-01-21
DK160984C (da) 1991-11-11
MY102082A (en) 1992-03-31
IL68494A0 (en) 1983-07-31
ES547275A0 (es) 1986-11-16
NO831613L (no) 1983-11-11
FI831604A0 (fi) 1983-05-09
ES8701171A1 (es) 1986-11-16
DK160984B (da) 1991-05-13

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