DK203083A - Fremgangsmaade til fremstilling af dihydropyridinderivater - Google Patents

Fremgangsmaade til fremstilling af dihydropyridinderivater Download PDF

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Publication number
DK203083A
DK203083A DK203083A DK203083A DK203083A DK 203083 A DK203083 A DK 203083A DK 203083 A DK203083 A DK 203083A DK 203083 A DK203083 A DK 203083A DK 203083 A DK203083 A DK 203083A
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DK
Denmark
Prior art keywords
dihydropyridine derivatives
cycloalkyl
alkyl
procedure
preparation
Prior art date
Application number
DK203083A
Other languages
English (en)
Other versions
DK160984B (da
DK203083D0 (da
DK160984C (da
Inventor
Kanji Meguro
Akinobu Nagaoka
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/JP1982/000159 external-priority patent/WO1983004023A1/ja
Priority claimed from PCT/JP1983/000008 external-priority patent/WO1984002702A1/ja
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of DK203083D0 publication Critical patent/DK203083D0/da
Publication of DK203083A publication Critical patent/DK203083A/da
Publication of DK160984B publication Critical patent/DK160984B/da
Application granted granted Critical
Publication of DK160984C publication Critical patent/DK160984C/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK203083A 1982-05-10 1983-05-06 Analogifremgangsmaade til fremstilling af dihydropyridinderivater eller farmaceutisk acceptable syreadditionssalte deraf DK160984C (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP8200159 1982-05-10
PCT/JP1982/000159 WO1983004023A1 (en) 1982-05-10 1982-05-10 Dihydropyridine derivatives
PCT/JP1983/000008 WO1984002702A1 (en) 1983-01-11 1983-01-11 Dihydropyridine derivatives
JP8300008 1983-01-11

Publications (4)

Publication Number Publication Date
DK203083D0 DK203083D0 (da) 1983-05-06
DK203083A true DK203083A (da) 1983-11-11
DK160984B DK160984B (da) 1991-05-13
DK160984C DK160984C (da) 1991-11-11

Family

ID=26422991

Family Applications (1)

Application Number Title Priority Date Filing Date
DK203083A DK160984C (da) 1982-05-10 1983-05-06 Analogifremgangsmaade til fremstilling af dihydropyridinderivater eller farmaceutisk acceptable syreadditionssalte deraf

Country Status (16)

Country Link
US (1) US4892875A (da)
EP (1) EP0094159B1 (da)
KR (1) KR880002357B1 (da)
AT (1) ATE50987T1 (da)
AU (1) AU556150B2 (da)
CA (1) CA1333487C (da)
DK (1) DK160984C (da)
ES (3) ES8607966A1 (da)
FI (1) FI79700C (da)
GR (1) GR78252B (da)
HK (1) HK3293A (da)
IE (1) IE56057B1 (da)
IL (1) IL68494A (da)
MY (1) MY102082A (da)
NO (1) NO159593C (da)
PT (1) PT76653B (da)

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CH663616A5 (de) * 1983-06-21 1987-12-31 Sandoz Ag 1,4-dihydropyridin-derivate und sie enthaltende pharmazeutische zubereitungen.
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SE9904724D0 (sv) 1999-12-22 1999-12-22 Carlsson A Research Ab New modulators of dopamine neurotransmission I
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CN101090714A (zh) * 2004-07-26 2007-12-19 康泽里克斯公司 通过吸入伊洛前列素和微粒制剂治疗肺动脉高血压症
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CN101663262B (zh) 2006-12-01 2014-03-26 百时美施贵宝公司 用于治疗动脉粥样硬化和心血管疾病的作为cetp抑制剂的n-(3-苄基)-2,2-(二苯基)-丙-1胺衍生物
CN101215258A (zh) * 2008-01-21 2008-07-09 中国药科大学 二氢吡啶类钙拮抗剂化合物及其制备方法与医药用途
CN101575313B (zh) * 2009-01-20 2012-04-18 许昌恒生制药有限公司 无柱层析法分离合成盐酸马尼地平生产工艺
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WO2013152105A1 (en) 2012-04-04 2013-10-10 IVAX International GmbH Pharmaceutical compositions for combination therapy
CN102875451B (zh) * 2012-04-05 2014-12-03 常州制药厂有限公司 一种盐酸马尼地平合成工艺的改进方法
CN105143203A (zh) 2013-04-17 2015-12-09 辉瑞大药厂 用于治疗心血管疾病的n-哌啶-3-基苯甲酰胺衍生物
CN103351362A (zh) * 2013-06-17 2013-10-16 张家港威胜生物医药有限公司 一种马尼地平中间体2-(4-二苯甲基哌嗪)乙基乙酰乙酸酯的制备方法
CN103467364B (zh) * 2013-06-21 2015-07-15 四川海思科制药有限公司 一种盐酸马尼地平化合物
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CN106518806A (zh) * 2016-09-07 2017-03-22 张家港威胜生物医药有限公司 一种马尼地平中间体2‑(4‑二苯甲基哌嗪)乙基乙酰乙酸酯的制备方法
CN106380442A (zh) * 2016-09-07 2017-02-08 张家港威胜生物医药有限公司 一种钙离子通道拮抗剂马尼地平的制备方法
CN113574055B (zh) 2019-01-18 2024-07-23 阿斯利康(瑞典)有限公司 Pcsk9抑制剂及其使用方法

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Also Published As

Publication number Publication date
HK3293A (en) 1993-01-21
FI831604L (fi) 1983-11-11
US4892875A (en) 1990-01-09
DK160984B (da) 1991-05-13
ES8607966A1 (es) 1986-01-16
GR78252B (da) 1984-09-26
ES522199A0 (es) 1986-01-16
KR840004741A (ko) 1984-10-24
ES8602661A1 (es) 1985-12-01
KR880002357B1 (ko) 1988-10-29
AU556150B2 (en) 1986-10-23
DK203083D0 (da) 1983-05-06
ES541668A0 (es) 1985-12-01
EP0094159B1 (en) 1990-03-14
PT76653A (en) 1983-06-01
MY102082A (en) 1992-03-31
NO159593B (no) 1988-10-10
NO159593C (no) 1989-01-18
CA1333487C (en) 1994-12-13
PT76653B (en) 1986-01-27
EP0094159A1 (en) 1983-11-16
ES547275A0 (es) 1986-11-16
ES8701171A1 (es) 1986-11-16
AU1415583A (en) 1983-11-17
DK160984C (da) 1991-11-11
IL68494A0 (en) 1983-07-31
FI79700C (fi) 1990-02-12
IL68494A (en) 1988-01-31
IE830897L (en) 1983-11-10
FI79700B (fi) 1989-10-31
IE56057B1 (en) 1991-04-10
NO831613L (no) 1983-11-11
ATE50987T1 (de) 1990-03-15
FI831604A0 (fi) 1983-05-09

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