ES8602028A1 - Procedimiento para la obtencion de derivados del acido meti-lendifosfonico - Google Patents
Procedimiento para la obtencion de derivados del acido meti-lendifosfonicoInfo
- Publication number
- ES8602028A1 ES8602028A1 ES539833A ES539833A ES8602028A1 ES 8602028 A1 ES8602028 A1 ES 8602028A1 ES 539833 A ES539833 A ES 539833A ES 539833 A ES539833 A ES 539833A ES 8602028 A1 ES8602028 A1 ES 8602028A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- derivatives
- preparation
- pharmaceutical compositions
- compositions containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000003356 anti-rheumatic effect Effects 0.000 title abstract 2
- 239000003435 antirheumatic agent Substances 0.000 title 1
- MBKDYNNUVRNNRF-UHFFFAOYSA-N medronic acid Chemical class OP(O)(=O)CP(O)(O)=O MBKDYNNUVRNNRF-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- QOVOYVIEJROGHL-UHFFFAOYSA-N methanamine;phosphono dihydrogen phosphate Chemical compound NC.OP(O)(=O)OP(O)(O)=O QOVOYVIEJROGHL-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/44—Amides thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/58—Pyridine rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/59—Hydrogenated pyridine rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Pain & Pain Management (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Rheumatology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Medicinal Preparation (AREA)
- Dental Preparations (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
- Anti-Oxidant Or Stabilizer Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Detergent Compositions (AREA)
- Liquid Developers In Electrophotography (AREA)
- Steroid Compounds (AREA)
- External Artificial Organs (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Fireproofing Substances (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8401214A FR2558837B1 (fr) | 1984-01-26 | 1984-01-26 | Derives de l'acide methylenediphosphonique, procede d'obtention et medicaments antirhumatismaux les contenant |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8602028A1 true ES8602028A1 (es) | 1985-11-16 |
| ES539833A0 ES539833A0 (es) | 1985-11-16 |
Family
ID=9300506
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES539833A Granted ES539833A0 (es) | 1984-01-26 | 1985-01-25 | Procedimiento para la obtencion de derivados del acido meti-lendifosfonico |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US4876247A (en, 2012) |
| EP (1) | EP0151072B1 (en, 2012) |
| JP (1) | JPS60174792A (en, 2012) |
| KR (1) | KR850005449A (en, 2012) |
| AT (1) | ATE32900T1 (en, 2012) |
| AU (1) | AU570764B2 (en, 2012) |
| CA (1) | CA1263397A (en, 2012) |
| CS (2) | CS247199B2 (en, 2012) |
| DD (1) | DD233847A5 (en, 2012) |
| DE (1) | DE3561819D1 (en, 2012) |
| DK (1) | DK168573B1 (en, 2012) |
| EG (1) | EG16903A (en, 2012) |
| ES (1) | ES539833A0 (en, 2012) |
| FI (1) | FI77664C (en, 2012) |
| FR (1) | FR2558837B1 (en, 2012) |
| GR (1) | GR850160B (en, 2012) |
| HU (1) | HU192664B (en, 2012) |
| IE (1) | IE57971B1 (en, 2012) |
| IL (1) | IL74117A (en, 2012) |
| MA (1) | MA20331A1 (en, 2012) |
| NO (1) | NO161678C (en, 2012) |
| NZ (1) | NZ210945A (en, 2012) |
| OA (1) | OA07941A (en, 2012) |
| PH (1) | PH20913A (en, 2012) |
| PL (3) | PL142493B1 (en, 2012) |
| PT (1) | PT79859B (en, 2012) |
| SG (1) | SG43289G (en, 2012) |
| SU (3) | SU1382402A3 (en, 2012) |
| YU (2) | YU11785A (en, 2012) |
| ZA (1) | ZA85390B (en, 2012) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4902679A (en) * | 1985-12-13 | 1990-02-20 | Norwich Eaton Pharmaceuticals, Inc. | Methods of treating diseases with certain geminal diphosphonates |
| IL84731A0 (en) * | 1986-12-19 | 1988-05-31 | Norwich Eaton Pharma | Heterocycle-substituted diphosphonic acids and salts and esters and pharmaceutical compositions containing them |
| IE912115A1 (en) * | 1990-06-25 | 1992-01-01 | Takeda Chemical Industries Ltd | Bisphosphonic acid derivatives, their production and use |
| DE69116838T2 (de) * | 1990-12-19 | 1996-06-13 | Takeda Chemical Industries Ltd | Bisphosphonsäurederivate, ihre Produktion und ihre Verwendung |
| EP0594857B1 (en) * | 1991-09-05 | 1998-04-29 | Toray Industries, Inc. | Methanediphosphonic acid derivative, production thereof and medicinal use thereof |
| EP0541037A3 (en) * | 1991-11-06 | 1997-02-26 | Takeda Chemical Industries Ltd | Squalene synthetase inhibitory composition and use thereof |
| CZ297094A3 (en) * | 1992-05-29 | 1995-12-13 | Procter & Gamble Pharma | Phosphate compounds containing quaternary nitrogen, their use and pharmaceutical compositions containing thereof |
| US5391743A (en) * | 1992-05-29 | 1995-02-21 | Procter & Gamble Pharmaceuticals, Inc. | Quaternary nitrogen-containing phosphonate compounds, pharmaceutical compositions, and methods of treating abnormal calcium and phosphate metabolism and methods of treating and preventing dental calculus and plaque |
| CZ295994A3 (en) * | 1992-05-29 | 1995-10-18 | Procter & Gamble Pharma | Thiosubstituted heterocyclic phosphonate compounds containing nitrogen for treating abnormal metabolism of calcium and phosphate |
| US5763611A (en) * | 1992-05-29 | 1998-06-09 | The Procter & Gamble Company | Thio-substituted cyclic phosphonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism |
| US5753634A (en) * | 1992-05-29 | 1998-05-19 | The Procter & Gamble Company | Quaternary nitrogen containing phosphonate compounds, pharmaceutical compostions, and methods for treating abnormal calcium and phosphate metabolism |
| DE69329199D1 (de) * | 1992-05-29 | 2000-09-14 | Procter & Gamble Pharma | Schwefel-enthaltende phosphonat-verbindungen zur behandlung von abnormalem calzium- und phosphat- metabolismus |
| AU675796B2 (en) * | 1992-06-30 | 1997-02-20 | Procter & Gamble Pharmaceuticals, Inc. | Compositions for the treatment of arthritis containing phosphonates and NSAIDS |
| ES2155446T3 (es) * | 1992-07-10 | 2001-05-16 | Toray Industries | Derivado de metanodifosfonato, su produccion y su uso farmaceutico. |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1958123C3 (de) * | 1969-11-19 | 1978-09-28 | Henkel Kgaa, 4000 Duesseldorf | Verfahren zur Herstellung von 1 -Aminoalkan-1,1 -diphosphonsäuren oder deren Salzen |
| DE2115737C3 (de) * | 1971-03-31 | 1979-11-08 | Henkel Kgaa, 4000 Duesseldorf | Verfahren zur Herstellung von 1 - Aminoalkan-1,1 -diphosphonsäuren |
| DE2405254C2 (de) * | 1974-02-04 | 1982-05-27 | Henkel KGaA, 4000 Düsseldorf | Verwendung von 3-Amino-1-Hydroxypropan-1, 1-diphosphonsäure oder ihrer wasserlöslichen Salze bei der Beeinflußung von Calciumstoffwechselstörungen im menschlichen oder tierischen Körper |
| US4100167A (en) * | 1977-05-09 | 1978-07-11 | Nalco Chemical Company | Production of 1-aminoalkane-1, 1-diphosphonic acids using phosphorous acid and nitriles in a non-aqueous system |
| DE2754821C3 (de) * | 1977-12-09 | 1981-08-13 | Benckiser-Knapsack Gmbh, 6802 Ladenburg | Verfahren zur Herstellung von 1-Aminoalkan-1,1-diphosphonsäuren |
| GB2043072B (en) * | 1979-02-13 | 1983-11-23 | Symphar Sa | Diphosphonate compounds |
| DE3225469A1 (de) * | 1982-07-05 | 1984-01-05 | Schering AG, 1000 Berlin und 4709 Bergkamen | Diphosphonsaeure-derivate und diese enthaltende pharmazeutische praeparate |
| FR2531088B1 (fr) * | 1982-07-29 | 1987-08-28 | Sanofi Sa | Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation |
-
1984
- 1984-01-26 FR FR8401214A patent/FR2558837B1/fr not_active Expired
-
1985
- 1985-01-17 PH PH31729A patent/PH20913A/en unknown
- 1985-01-17 CA CA000472285A patent/CA1263397A/en not_active Expired
- 1985-01-17 ZA ZA85390A patent/ZA85390B/xx unknown
- 1985-01-21 GR GR850160A patent/GR850160B/el unknown
- 1985-01-21 AU AU37940/85A patent/AU570764B2/en not_active Ceased
- 1985-01-21 IL IL74117A patent/IL74117A/xx unknown
- 1985-01-22 DK DK029285A patent/DK168573B1/da not_active IP Right Cessation
- 1985-01-23 PT PT79859A patent/PT79859B/pt not_active IP Right Cessation
- 1985-01-23 IE IE140/85A patent/IE57971B1/en not_active IP Right Cessation
- 1985-01-24 DE DE8585400113T patent/DE3561819D1/de not_active Expired
- 1985-01-24 AT AT85400113T patent/ATE32900T1/de not_active IP Right Cessation
- 1985-01-24 FI FI850319A patent/FI77664C/fi not_active IP Right Cessation
- 1985-01-24 EP EP85400113A patent/EP0151072B1/fr not_active Expired
- 1985-01-25 ES ES539833A patent/ES539833A0/es active Granted
- 1985-01-25 NZ NZ210945A patent/NZ210945A/en unknown
- 1985-01-25 JP JP60012348A patent/JPS60174792A/ja active Granted
- 1985-01-25 SU SU853846603A patent/SU1382402A3/ru active
- 1985-01-25 KR KR1019850000466A patent/KR850005449A/ko not_active Withdrawn
- 1985-01-25 NO NO850315A patent/NO161678C/no unknown
- 1985-01-25 PL PL1985251700A patent/PL142493B1/pl unknown
- 1985-01-25 YU YU00117/85A patent/YU11785A/xx unknown
- 1985-01-25 MA MA20555A patent/MA20331A1/fr unknown
- 1985-01-25 OA OA58514A patent/OA07941A/xx unknown
- 1985-01-25 PL PL1985263722A patent/PL144353B1/pl unknown
- 1985-01-25 PL PL1985262371A patent/PL148892B1/pl unknown
- 1985-01-25 DD DD85272782A patent/DD233847A5/de unknown
- 1985-01-25 HU HU85302A patent/HU192664B/hu not_active IP Right Cessation
- 1985-01-26 EG EG49/85A patent/EG16903A/xx active
- 1985-01-28 CS CS855573A patent/CS247199B2/cs unknown
- 1985-01-28 CS CS85582A patent/CS247192B2/cs unknown
-
1986
- 1986-04-18 SU SU864027243A patent/SU1419520A3/ru active
- 1986-05-07 SU SU864027412A patent/SU1410865A3/ru active
-
1987
- 1987-06-17 YU YU01137/87A patent/YU113787A/xx unknown
- 1987-10-30 US US07/115,615 patent/US4876247A/en not_active Expired - Fee Related
-
1989
- 1989-07-17 SG SG43289A patent/SG43289G/en unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19971001 |