ES8601839A1 - Procedimiento para preparar un acido alfa-arilalcanoico. - Google Patents

Procedimiento para preparar un acido alfa-arilalcanoico.

Info

Publication number
ES8601839A1
ES8601839A1 ES524528A ES524528A ES8601839A1 ES 8601839 A1 ES8601839 A1 ES 8601839A1 ES 524528 A ES524528 A ES 524528A ES 524528 A ES524528 A ES 524528A ES 8601839 A1 ES8601839 A1 ES 8601839A1
Authority
ES
Spain
Prior art keywords
alpha
ester
arylalkanoic
substrate
ortho
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES524528A
Other languages
English (en)
Other versions
ES524528A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex Pharmaceuticals International Ltd
Original Assignee
Syntex Pharmaceuticals International Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex Pharmaceuticals International Ltd filed Critical Syntex Pharmaceuticals International Ltd
Publication of ES8601839A1 publication Critical patent/ES8601839A1/es
Publication of ES524528A0 publication Critical patent/ES524528A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/48—Preparation of compounds having groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
    • C07C45/292—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups with chromium derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cosmetics (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR UN ACIDO A-ARILALCANOICO. COMPRENDE: A) CATALIZAR UNA A-HALO-ALCOHIL-ARIL-CETONA DE FORMULA (II) CON UN ARILOXIDO O ALCOXIDO DE UN METAL ALCALINO PARA OBTENER EL COMPUESTO DE FORMULA (III); B) ESTEORIFICAR EL COMPUESTO DE FORMULA (III) CON UN MANANTIAL DE ION SULFONILO COMO UN HALOGENURO DE ALCOHISULFONILO O DE ARILSULFONILO, PARA FORMAR EL CORRESPONDIENTE ESTER SULFONATO; Y C) MANTENER EL ESTER SULFONATO EN CONTACTO CON UN DISOLVENTE PROTICO O DIPOLAR APROTICO PARA FORMAR EL ACIDO A-ARIL-ALCANOICO DE FORMULA (I) O UN ESTER ORTOESTER, O UNA AMINA DEL MISMO. SIENDO: AR, RESTO ARILICO; R1, ALCOHILO DE C 1A 8 O CICLOALQUILO DE C 3 A 7; R2 Y R3 RESIDUOS ARILICOS O ALCOHILICOS; Y X ES HAL. SE UTILIZA COMO PRODUCTO DE PARTIDA A PREPARADOS FARMACEUTICOS.
ES524528A 1981-04-30 1983-07-28 Procedimiento para preparar un acido alfa-arilalcanoico. Granted ES524528A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25911981A 1981-04-30 1981-04-30

Publications (2)

Publication Number Publication Date
ES8601839A1 true ES8601839A1 (es) 1985-12-01
ES524528A0 ES524528A0 (es) 1985-12-01

Family

ID=22983610

Family Applications (2)

Application Number Title Priority Date Filing Date
ES511816A Expired ES8401007A1 (es) 1981-04-30 1982-04-29 "procedimiento para preparar un acido x-arilalcanoico".
ES524528A Granted ES524528A0 (es) 1981-04-30 1983-07-28 Procedimiento para preparar un acido alfa-arilalcanoico.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES511816A Expired ES8401007A1 (es) 1981-04-30 1982-04-29 "procedimiento para preparar un acido x-arilalcanoico".

Country Status (21)

Country Link
EP (1) EP0064394A1 (es)
JP (1) JPS57192325A (es)
KR (1) KR890002772B1 (es)
AU (1) AU8313382A (es)
CA (1) CA1199646A (es)
CS (1) CS241104B2 (es)
DD (1) DD202688A5 (es)
DK (1) DK192982A (es)
ES (2) ES8401007A1 (es)
FI (1) FI821501A0 (es)
GR (1) GR75425B (es)
HU (1) HU189577B (es)
IL (1) IL65629A (es)
IN (1) IN155753B (es)
NO (3) NO821417L (es)
NZ (1) NZ200458A (es)
PH (1) PH24244A (es)
PL (1) PL139818B1 (es)
PT (1) PT74818B (es)
RO (1) RO83840B1 (es)
ZA (1) ZA822955B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ198271A (en) * 1980-09-11 1985-05-31 Syntex Pharma Int Preparation of alpha-aromatic-substituted alkanoic acids and intermediates
FI82680C (fi) * 1981-12-11 1991-04-10 Syntex Pharma Int Framstaellning av - arylalkansyror.
ATE23987T1 (de) * 1984-02-02 1986-12-15 Zambon Spa Verfahren zur herstellung von alpharylalkans|uren.
IT1173216B (it) * 1984-02-03 1987-06-18 Zambon Spa Processo per la preparazione di acidi alfa-idrossiaril-alcanoici
IT1196013B (it) * 1984-02-03 1988-11-10 Zambon Spa Procedimento per preparare acidi alfa-aril-alcanoici
EP0160241B1 (en) * 1984-04-14 1988-11-30 Kyowa Hakko Kogyo Co., Ltd. Process for producing an alpha-aromatic group substituted alkanoic acid derivative
US4608441A (en) * 1984-07-11 1986-08-26 Blaschim S.P.A. Process for the preparation of arylalkanoic acids by oxidative rearrangement of arylalkanones
IT1201443B (it) * 1985-07-31 1989-02-02 Zambon Spa Intermedi per la sintesi di acidi carbossilici
JPS62263153A (ja) * 1986-05-28 1987-11-16 エフ・ホフマン―ラ　ロシユ　アーゲー カルバゾ−ル誘導体
IT1197800B (it) * 1986-08-01 1988-12-06 Zambon Spa Processo per la sintesi di acidi carbossilici
US4761497A (en) * 1987-10-13 1988-08-02 Eastman Kodak Company Process for preparing 2-naphthanoic acids and esters thereof
IT1251958B (it) * 1991-10-18 1995-05-27 Zambon Spa Processo per la dealogenazione di derivati del naftalene
JP3744060B2 (ja) * 1996-06-20 2006-02-08 ダイソー株式会社 アシルオキシスルホン酸エステル誘導体の製造法
EP3395806B1 (en) 2017-04-24 2020-04-08 IGM Group B.V. Simple oxidative functionalization of alkyl aryl ketones
CN114644554A (zh) * 2020-12-21 2022-06-21 上海医药工业研究院 (s)-氟比洛芬的制备方法及其中间体

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE50898B1 (en) * 1980-02-26 1986-08-06 Blaschim Spa Process for preparing esters of 2-(6'-methoxy-2'-naphthyl)-propionic acid via rearrangement of new ketals of 2-halo-1-(6'-methoxy-2'-naphthyl)-propan-1-one
JPS5798232A (en) * 1980-11-10 1982-06-18 Sagami Chem Res Center 1-(6-methoxy-2-naphthyl)-2-oxy-1-alkanone acetal
NZ198271A (en) * 1980-09-11 1985-05-31 Syntex Pharma Int Preparation of alpha-aromatic-substituted alkanoic acids and intermediates
JPS57144234A (en) * 1981-03-03 1982-09-06 Sagami Chem Res Center 1-halophenyl-2-oxy-1-alkanone acetal

Also Published As

Publication number Publication date
CS310082A2 (en) 1985-07-16
NO824255L (no) 1982-11-01
HU189577B (en) 1986-07-28
FI821501A0 (fi) 1982-04-29
ES511816A0 (es) 1983-12-01
IL65629A (en) 1987-08-31
DD202688A5 (de) 1983-09-28
PT74818B (en) 1983-10-28
AU8313382A (en) 1982-11-04
NZ200458A (en) 1985-11-08
ES524528A0 (es) 1985-12-01
DK192982A (da) 1982-10-31
ZA822955B (en) 1983-12-28
JPS57192325A (en) 1982-11-26
EP0064394A1 (en) 1982-11-10
GR75425B (es) 1984-07-17
IN155753B (es) 1985-03-02
CS241104B2 (en) 1986-03-13
ES8401007A1 (es) 1983-12-01
IL65629A0 (en) 1982-07-30
PH24244A (en) 1990-05-04
PL139818B1 (en) 1987-02-28
NO831338L (no) 1982-11-01
RO83840B1 (ro) 1984-04-30
RO83840A2 (ro) 1984-04-02
NO821417L (no) 1982-11-01
CA1199646A (en) 1986-01-21
KR830010036A (ko) 1983-12-24
PL236221A1 (es) 1982-12-06
KR890002772B1 (ko) 1989-07-28
PT74818A (en) 1982-05-01

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970303