ES8601085A1 - Procedimiento de preparacion de nuevos derivados 4-hidroxi- -etil-benzoles - Google Patents

Procedimiento de preparacion de nuevos derivados 4-hidroxi- -etil-benzoles

Info

Publication number
ES8601085A1
ES8601085A1 ES528458A ES528458A ES8601085A1 ES 8601085 A1 ES8601085 A1 ES 8601085A1 ES 528458 A ES528458 A ES 528458A ES 528458 A ES528458 A ES 528458A ES 8601085 A1 ES8601085 A1 ES 8601085A1
Authority
ES
Spain
Prior art keywords
hydroxy
alpha
ethyl
pref
trifluoromethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES528458A
Other languages
English (en)
Other versions
ES528458A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Vegyeszeti Gyar Nyrt
Original Assignee
Richter Gedeon Vegyeszeti Gyar RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszeti Gyar RT filed Critical Richter Gedeon Vegyeszeti Gyar RT
Publication of ES8601085A1 publication Critical patent/ES8601085A1/es
Publication of ES528458A0 publication Critical patent/ES528458A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/01—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis
    • C07C37/055—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/11—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions increasing the number of carbon atoms
    • C07C37/20—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions increasing the number of carbon atoms using aldehydes or ketones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/24—Halogenated derivatives
    • C07C39/367—Halogenated derivatives polycyclic non-condensed, containing only six-membered aromatic rings as cyclic parts, e.g. halogenated poly-hydroxyphenylalkanes

Abstract

PROCEDIMIENTO DE PREPARACION DE NUEVOS DERIVADOS 4-HIDROXI-A-ETIL-BENZOLES. CONSISTE EN HACER REACCIONAR UNA 4-HIDROXI-PROPIOFENONA CON UN COMPUESTO ORGANOMETALICO DE FORMULA (II) EN RELACION MOLAR 1:2 EN UN DISOLVENTE ORGHANICO APROTICO COMO AMIDA HEXAMETILFOSFORICA SULFOXIDO DIMETILICO ETERES ALIFATICOS Y CICLOALIFATICOS Y OTROS EN ATMOSFERA INERTE DE N2 O AR Y ENTRE C40 Y 100JC Y PURIFICAN MEDIANTE CROMATOGRAFIA O RECRISTALIZACION PARA OBTENER DERIVADOS 4-HIDROXI-A-ETIL-BENZOLES DE FORMULA (I). SIENDO: M LI NA K O EL GRUPO MGX; X ES HALOGENO; R1 Y R2 INDEPENDIENTEMENTE H HAL TRIHALOMETILO ALQUILO DE C 1 A 4 SIEMPRE QUE R1 SEA H R2 NO SEA UN GRUPO 3-TRIFLUORO-METILO Y SIEMPRE QUE R SEA 2-METILO R2 NO SEA UN GRUPO 5-METILO. SE UTILIZA EN FARMACOLOGIA PARA EL TRATAMIENTO DE INTOXICACIONES ETANOLICAS AGUDAS.
ES528458A 1982-12-28 1983-12-27 Procedimiento de preparacion de nuevos derivados 4-hidroxi- -etil-benzoles Granted ES528458A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU824188A HU190054B (en) 1982-12-28 1982-12-28 Process for the production of new 4-hydroxi -benzhydrols, as well as of therapeutic preparations contaning them

Publications (2)

Publication Number Publication Date
ES8601085A1 true ES8601085A1 (es) 1985-11-01
ES528458A0 ES528458A0 (es) 1985-11-01

Family

ID=10967259

Family Applications (2)

Application Number Title Priority Date Filing Date
ES528458A Granted ES528458A0 (es) 1982-12-28 1983-12-27 Procedimiento de preparacion de nuevos derivados 4-hidroxi- -etil-benzoles
ES543798A Granted ES543798A0 (es) 1982-12-28 1985-06-01 Procedimiento de preparacion de nuevos derivados 4-hidroxi- -a-etil-benzoles

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES543798A Granted ES543798A0 (es) 1982-12-28 1985-06-01 Procedimiento de preparacion de nuevos derivados 4-hidroxi- -a-etil-benzoles

Country Status (14)

Country Link
US (1) US4508926A (es)
EP (1) EP0112588B1 (es)
JP (1) JPS59134740A (es)
AT (1) ATE30712T1 (es)
AU (1) AU558329B2 (es)
CA (1) CA1199939A (es)
DE (1) DE3374401D1 (es)
DK (1) DK159649C (es)
ES (2) ES528458A0 (es)
FI (1) FI78898C (es)
GR (1) GR79150B (es)
HU (1) HU190054B (es)
IL (1) IL70555A (es)
ZA (1) ZA839614B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU190434B (en) * 1982-12-28 1986-09-29 Richter Gedeon Vegyeszeti Gyar,Rt,Hu Process for the production of 3-trifluor-methyl- and 2,5-dimethyl-4'-hydroxy-alpha-ethyl-benzhydrol,as well as of therapeutci preparations containing them
US7858825B2 (en) * 2007-02-15 2010-12-28 Colorado State University Research Foundation Acid and base stable diphenylmethanol derivatives and methods of use
SG174923A1 (en) 2009-03-27 2011-11-28 Mitsui Chemicals Inc Method for producing optically active alcohol

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2247404A (en) * 1939-03-24 1941-07-01 Dow Chemical Co Aralkyl polyhydric phenol
US2719866A (en) * 1951-08-04 1955-10-04 Lilly Co Eli Substituted resorcinols
FR2121446B1 (es) * 1971-01-14 1974-03-22 Pechiney Ugine Kuhlmann
DE2260138A1 (de) * 1972-12-08 1974-06-12 Hoechst Ag Stoffwechselwirksame bisphenolalkanderivate
US4094908A (en) * 1973-08-15 1978-06-13 Richter Gedeon Vegyeszeti Gyar Rt. Alpha-substituted benzhydrol derivatives

Also Published As

Publication number Publication date
IL70555A (en) 1986-10-31
DK159649C (da) 1991-04-08
JPH0240052B2 (es) 1990-09-10
ZA839614B (en) 1984-08-29
ATE30712T1 (de) 1987-11-15
EP0112588A3 (en) 1986-03-12
ES528458A0 (es) 1985-11-01
EP0112588A2 (de) 1984-07-04
JPS59134740A (ja) 1984-08-02
DK159649B (da) 1990-11-12
ES8603800A1 (es) 1986-01-01
ES543798A0 (es) 1986-01-01
US4508926A (en) 1985-04-02
DE3374401D1 (en) 1987-12-17
EP0112588B1 (de) 1987-11-11
AU558329B2 (en) 1987-01-29
GR79150B (es) 1984-10-02
DK602083D0 (da) 1983-12-27
FI834796A0 (fi) 1983-12-27
CA1199939A (en) 1986-01-28
HUT34942A (en) 1985-05-28
HU190054B (en) 1986-08-28
FI78898C (fi) 1989-10-10
AU2291183A (en) 1984-07-05
DK602083A (da) 1984-06-29
FI834796A (fi) 1984-06-29
FI78898B (fi) 1989-06-30
IL70555A0 (en) 1984-03-30

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970303