ES8504107A1 - "metodo de preparar compuestos glicinicos utiles como farmacos" - Google Patents

"metodo de preparar compuestos glicinicos utiles como farmacos"

Info

Publication number
ES8504107A1
ES8504107A1 ES524324A ES524324A ES8504107A1 ES 8504107 A1 ES8504107 A1 ES 8504107A1 ES 524324 A ES524324 A ES 524324A ES 524324 A ES524324 A ES 524324A ES 8504107 A1 ES8504107 A1 ES 8504107A1
Authority
ES
Spain
Prior art keywords
alkyl
cycloalkyl
heteroaryl
integer
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES524324A
Other languages
English (en)
Other versions
ES524324A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
USV Pharmaceutical Corp
Original Assignee
USV Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by USV Pharmaceutical Corp filed Critical USV Pharmaceutical Corp
Publication of ES8504107A1 publication Critical patent/ES8504107A1/es
Publication of ES524324A0 publication Critical patent/ES524324A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/30—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds
    • C07C209/32—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds by reduction of nitro groups
    • C07C209/34—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds by reduction of nitro groups by reduction of nitro groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings in presence of hydrogen-containing gases and a catalyst

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Furan Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

METODO DE PREPARAR COMPUESTOS GLICINICOS UTILES COMO FARMACOS.CONSISTE EN HACER REACSIONAR BAJO CONDICIONES DE ACILACION UN DERIVADO ACILANTE DE UN ACIDO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III) PARA OBTENER COMPUESTOS GLICINICOS DE FORMULA (I), DONDE X ES UN COMPUESTO DE FORMULA (IV); R1, R2, R3, R4, R5 Y R6 SON H, ALQUILO, ALQUENILO, ALQUINILO, FENILALQUILO Y CICLOALQUILO; N ES 0 A 4; M ES ALQUENILO Y OTROS; Y ES HIDROXI, ALCOXI Y OTROS; Z1 Y Z2 SON UN ENLACE QUIMICO; A Y B SON R1 O HALOGENO; C ES H, ALQUILO Y OTROS; X1 Y X2 SON S, SO2 Y OTROS; Y R7 Y R8 SON H, HALO, CIANO Y OTROS.PRESENTAN ACTIVIDAD INHIBIDORA DE LA ENZIMA DE CONVERSION DE LA ANGIOTENSINA Y ACTIVIDAD DIURETICA.
ES524324A 1982-07-21 1983-07-21 "metodo de preparar compuestos glicinicos utiles como farmacos" Granted ES524324A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US40055582A 1982-07-21 1982-07-21

Publications (2)

Publication Number Publication Date
ES8504107A1 true ES8504107A1 (es) 1985-05-01
ES524324A0 ES524324A0 (es) 1985-05-01

Family

ID=23584069

Family Applications (1)

Application Number Title Priority Date Filing Date
ES524324A Granted ES524324A0 (es) 1982-07-21 1983-07-21 "metodo de preparar compuestos glicinicos utiles como farmacos"

Country Status (13)

Country Link
EP (1) EP0100053B1 (es)
JP (1) JPS5933251A (es)
KR (1) KR840005711A (es)
AT (1) ATE30320T1 (es)
AU (1) AU561145B2 (es)
DE (1) DE3374122D1 (es)
DK (1) DK333983A (es)
ES (1) ES524324A0 (es)
FI (1) FI832646A (es)
IL (1) IL69228A0 (es)
NO (1) NO832654L (es)
NZ (1) NZ204961A (es)
ZA (1) ZA835331B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54115075A (en) * 1978-02-28 1979-09-07 Cho Lsi Gijutsu Kenkyu Kumiai Plasma etching method
EP0127090A3 (en) * 1983-05-20 1985-08-28 Usv Pharmaceutical Corporation Angiotensin-converting enzyme inhibitors
US4576941A (en) * 1984-02-29 1986-03-18 Usv Pharmaceutical Corp. Compounds for treating hypertension
EP0284510A3 (en) * 1987-03-24 1990-08-22 Asahi Breweries, Ltd. N-[N alpha-(1(S)-carboxy-3-cyclohexyl-propyl)-1-lysyl] N-cyclopentylglycine as antihypertensives

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4105776A (en) * 1976-06-21 1978-08-08 E. R. Squibb & Sons, Inc. Proline derivatives and related compounds
US4053651A (en) * 1976-05-10 1977-10-11 E. R. Squibb & Sons, Inc. Compounds and method for alleviating angiotensin related hypertension
US4256761A (en) * 1979-07-13 1981-03-17 Usv Pharmaceutical Corporation Antihypertensive amides
DE3044236A1 (de) * 1980-11-25 1982-06-16 Hoechst Ag, 6000 Frankfurt Aminosaeurederivate und verfahren zu ihrer herstellung
ZA811340B (en) * 1980-06-09 1982-03-31 Morton Norwich Products Inc N-(cycloalkyl)amino acid compounds

Also Published As

Publication number Publication date
DK333983D0 (da) 1983-07-20
NO832654L (no) 1984-01-23
FI832646A (fi) 1984-01-22
DK333983A (da) 1984-01-22
FI832646A0 (fi) 1983-07-20
IL69228A0 (en) 1983-11-30
ATE30320T1 (de) 1987-11-15
ZA835331B (en) 1984-04-25
EP0100053B1 (en) 1987-10-21
EP0100053A1 (en) 1984-02-08
JPS5933251A (ja) 1984-02-23
NZ204961A (en) 1986-02-21
AU561145B2 (en) 1987-04-30
DE3374122D1 (en) 1987-11-26
KR840005711A (ko) 1984-11-16
ES524324A0 (es) 1985-05-01
AU1698283A (en) 1984-01-26

Similar Documents

Publication Publication Date Title
GB1527297A (en) Pyrazine carboxamides
EP0585913A3 (en) Condensed heterocyclic compounds, their production and use
UA48937C2 (uk) Імідазолідини, заміщені гетероциклом, спосіб їх одержання і фармацевтична композиція, що їх містить
ES2073258T3 (es) Nuevos derivados de la urea, su preparacion y su aplicacion en terapeutica.
DE3374122D1 (en) Compounds having angiotensin converting enzyme inhibitory activity and diuretic activity
IE40742L (en) Dimethyl diketo isoquinoline derivatives
GB1460980A (en) 3-substituted diphenylhydantoins
CA1273641C (en) ALCENIC DERIVATIVES OF L-AMINOCARBOXYLIC ACIDS
ES422906A1 (es) Un procedimiento para preparar nuevos derivados de 2-amino-indano.
ES8604960A1 (es) Procedimiento para preparar derivados de 1,6-naftiridina
GB1490507A (en) Piperazine derivatives
ES8203358A1 (es) Metodo de producir lactamas antihipertensoras
GB8515212D0 (en) Thiazolidine derivatives
ES481214A1 (es) Un procedimiento para preparar benzoxepinas
CA1270259C (en) L-AMINOCARBOXYLIC ACID DIAMINES
ES8200668A1 (es) Un procedimiento para la preparacion de nuevos derivados de oxazolina y tiazolina
ES445339A1 (es) Un procedimiento para la preparacion de derivados pirrolidi-nicos.
GB1433459A (en) 5-hydroxy-6-amino-methlybenzofuran derivatives and preparation thereof
ES483275A1 (es) Un procedimiento para la preparacion de derivados de benzo- diacepina
ES485517A1 (es) Un procedimiento para la obtencion de nuevos derivados hete-rociclicos de nitrogeno
ES446131A1 (es) Un procedimiento para la preparacion de nuevos derivados de acido 2-alquil (inferior)-2 o 3-cefem-4-carboxilico.