ES8502978A1 - Un procedimiento para preparar derivados de 5-halovinil-2'-desoxiuridina - Google Patents

Un procedimiento para preparar derivados de 5-halovinil-2'-desoxiuridina

Info

Publication number
ES8502978A1
ES8502978A1 ES525670A ES525670A ES8502978A1 ES 8502978 A1 ES8502978 A1 ES 8502978A1 ES 525670 A ES525670 A ES 525670A ES 525670 A ES525670 A ES 525670A ES 8502978 A1 ES8502978 A1 ES 8502978A1
Authority
ES
Spain
Prior art keywords
halovinyl
deoxyuridine derivatives
deoxyuridine
derivatives
bromine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES525670A
Other languages
English (en)
Other versions
ES525670A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of ES525670A0 publication Critical patent/ES525670A0/es
Publication of ES8502978A1 publication Critical patent/ES8502978A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/04—Saturated ethers
    • C07C43/13—Saturated ethers containing hydroxy or O-metal groups
    • C07C43/135—Saturated ethers containing hydroxy or O-metal groups having more than one ether bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/08—Saturated compounds containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/70—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with ring systems containing two or more relevant rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Oncology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pyridine Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR DERIVADOS DE 5-HALOVINIL-2K-DESOXIURIDINA.CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) O UNA DE SUS SALES CON UN AGENTE DE HALOGENACION, SEGUIDO DE LA ELIMINACION DE CUALQUIER GRUPO PROTECTOR PARA OBTENER DERIVADOS DE 5-HALOVINIL-2K-DESOXIURIDINA DE FORMULA (I), DONDE R ES CLORO, BROMO O YODO, Y R, R Y R SON IGUALES O DIFERENTES Y PUEDEN SER HIDROGENO O GRUPOS PROTECTORES. LA REACCION SE REALIZA EN UN MEDIO TAL COMO AGUA, UN ALCOHOL COMO METANOL, UN HIDROCARBURO HALOGENADO COMO CLOROFORMO, O UNA AMIDA SUSTITUIDA COMO N,N-DIMETILFORMAMIDA, A TEMPERATURA ENTRE 7JC Y 100JC.TIENEN APLICACION POR SU ACTIVIDAD ANTIVIRICA SELECTIVA CONTRA VIRUS DE HERPES SIMPLEX.
ES525670A 1982-09-17 1983-09-16 Un procedimiento para preparar derivados de 5-halovinil-2'-desoxiuridina Expired ES8502978A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8226515 1982-09-17

Publications (2)

Publication Number Publication Date
ES525670A0 ES525670A0 (es) 1985-02-01
ES8502978A1 true ES8502978A1 (es) 1985-02-01

Family

ID=10532974

Family Applications (2)

Application Number Title Priority Date Filing Date
ES525670A Expired ES8502978A1 (es) 1982-09-17 1983-09-16 Un procedimiento para preparar derivados de 5-halovinil-2'-desoxiuridina
ES532056A Granted ES532056A0 (es) 1982-09-17 1984-04-30 Un procedimiento para preparar derivados de 5-halovinil-2'-desoxiuridina.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES532056A Granted ES532056A0 (es) 1982-09-17 1984-04-30 Un procedimiento para preparar derivados de 5-halovinil-2'-desoxiuridina.

Country Status (17)

Country Link
US (1) US4564618A (es)
EP (1) EP0104066B1 (es)
JP (1) JPS5980620A (es)
AT (1) ATE36325T1 (es)
AU (2) AU575022B2 (es)
CA (1) CA1257595A (es)
CZ (1) CZ402691A3 (es)
DE (1) DE3377647D1 (es)
DK (1) DK160271C (es)
ES (2) ES8502978A1 (es)
GB (1) GB2129425B (es)
HK (1) HK84190A (es)
IE (1) IE55921B1 (es)
MX (1) MX9203234A (es)
NZ (1) NZ205619A (es)
SG (1) SG68890G (es)
ZA (1) ZA836902B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4719214A (en) * 1985-07-25 1988-01-12 Southern Research Institute Carbocyclic analogues of thymine nucleosides
ES2001094A6 (es) * 1985-08-16 1988-04-16 Glaxo Group Ltd Un procedimiento para la preparacion de un derivado de guanina
EP0516186A3 (en) * 1987-04-16 1993-01-13 Medivir Aktiebolag Nucleosides and nucleoside analogues, pharmaceutical composition and processes for the preparation of the compounds
US5215970A (en) * 1987-04-16 1993-06-01 Medivir Ab Nucleosides and nucleotide analogues, pharmaceutical composition and processes for the preparation of the compounds
US4863927A (en) * 1987-05-11 1989-09-05 Merck & Co., Inc. 1-(2-hydroxymethyl)cycloalkylmethyl)-5-substituted uracils
GB8920457D0 (en) * 1989-09-11 1989-10-25 Glaxo Group Ltd Chemical compounds
USH1142H (en) 1990-11-05 1993-02-02 Optically active cyclobutyl pyrimidine

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS606943B2 (ja) * 1975-04-01 1985-02-21 三井製薬工業株式会社 １−（α−アルコキシアルキル）−ウラシル類の製造法
US4177348A (en) * 1977-12-13 1979-12-04 United States Government Carbocyclic analogs of cytosine nucleosides
US4232154A (en) * 1977-12-13 1980-11-04 United States Of America Carbocyclic analogs of cytosine nucleosides exhibiting antiviral and antineoplasticactivity
GB1601020A (en) * 1978-04-24 1981-10-21 Stichting Grega Vzw 2'-deoxy-5 (2-halogenovinyl)-uridines
GB2060604B (en) * 1979-10-03 1983-11-23 Univ Birmingham And Stichting E15-(2-halogenovinyl)-2'-deoxycytidines
JPS5738774A (en) * 1980-08-19 1982-03-03 Chugai Pharmaceut Co Ltd Uracil derivative and its preparation
US4347360A (en) * 1980-09-16 1982-08-31 Ens Bio Logicals Inc. Ring open nucleoside analogues
NZ199764A (en) * 1981-03-20 1984-08-24 Beecham Group Plc 5-(2-halogenovinyl)-2'-deoxyuridine derivatives and pharmaceutical compositions
EP0072137A1 (en) * 1981-08-01 1983-02-16 Beecham Group Plc Antiviral deoxyuridine compounds
US4396623A (en) * 1981-08-26 1983-08-02 Southern Research Institute Carbocyclic analogs of uracil nucleosides as antiviral agents
HU183567B (en) * 1981-09-07 1984-05-28 Mta Koezponti Kemiai Kutato In Process for preparing /e/-5-/2-bromo-vinyl/-uridine and derivatives thereof
JPS5843993A (ja) * 1981-09-09 1983-03-14 Yamasa Shoyu Co Ltd １−β−Ｄ−アラビノフラノシル−（Ｅ）−５−（２−ハロゲノビニル）ウラシル−５′−りん酸およびその製造法
EP0080305A1 (en) * 1981-11-19 1983-06-01 Beecham Group Plc Antiviral 2'-deoxyuridines, their preparation and use
EP0082668A1 (en) * 1981-12-18 1983-06-29 Beecham Group Plc 5-(2-Halogenovinyl)-2'-deoxyuridine derivatives, processes for their preparation, pharmaceutical compositions containing them and their use in treating viral infections
DE3620646A1 (de) * 1986-06-20 1987-12-23 Bayer Ag Verfahren zur herstellung von (1r, 4s)-4-hydroxy-2-cyclopentenylestern

Also Published As

Publication number Publication date
DK160271C (da) 1991-07-22
ZA836902B (en) 1985-05-29
HK84190A (en) 1990-10-25
IE832175L (en) 1984-03-17
GB2129425A (en) 1984-05-16
DK160271B (da) 1991-02-18
EP0104066A2 (en) 1984-03-28
EP0104066B1 (en) 1988-08-10
ES8506751A1 (es) 1985-08-01
SG68890G (en) 1990-10-26
CA1257595A (en) 1989-07-18
ES532056A0 (es) 1985-08-01
GB2129425B (en) 1987-02-11
JPS5980620A (ja) 1984-05-10
DK422183A (da) 1984-03-18
DK422183D0 (da) 1983-09-16
AU601583B2 (en) 1990-09-13
AU1918583A (en) 1984-03-22
ATE36325T1 (de) 1988-08-15
AU575022B2 (en) 1988-07-21
IE55921B1 (en) 1991-02-27
DE3377647D1 (de) 1988-09-15
GB8324813D0 (en) 1983-10-19
US4564618A (en) 1986-01-14
ES525670A0 (es) 1985-02-01
CZ402691A3 (en) 1993-07-14
AU1646588A (en) 1988-08-11
CA1271199C (es) 1990-07-03
NZ205619A (en) 1987-09-30
EP0104066A3 (en) 1984-06-06
MX9203234A (es) 1992-07-01

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970612