ES8502977A1 - Un metodo de preparar profarmacos de pilocarpina - Google Patents

Un metodo de preparar profarmacos de pilocarpina

Info

Publication number
ES8502977A1
ES8502977A1 ES525656A ES525656A ES8502977A1 ES 8502977 A1 ES8502977 A1 ES 8502977A1 ES 525656 A ES525656 A ES 525656A ES 525656 A ES525656 A ES 525656A ES 8502977 A1 ES8502977 A1 ES 8502977A1
Authority
ES
Spain
Prior art keywords
group
formula
defined above
image
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES525656A
Other languages
English (en)
Other versions
ES525656A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
FALCH ERIK
Original Assignee
FALCH ERIK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by FALCH ERIK filed Critical FALCH ERIK
Publication of ES8502977A1 publication Critical patent/ES8502977A1/es
Publication of ES525656A0 publication Critical patent/ES525656A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics

Abstract

METODO DE PREPARAR PROFARMACOS DE PILOCARPINA.CONSISTE EN HACER REACCIONAR UNA SAL DE ACIDO POLICARPICO, TAL COMO UNA SAL METALICA O UN COMPUESTO DE FORMULA (II) O UNA DE SUS SALES, CON UN COMPUESTO DE FORMULA (III), CON LA CONDICION DE QUE EN LA FORMULA (III) RA SEA DIFERENTE DE RK1 DE LA FORMULA (II), PARA OBTENER PROFARMACOS DE PILOCARPINA DE FORMULA (I), DONDE R1 ES UN GRUPO DE FORMULA (IV), (V) Y OTRAS; R3 ES ALQUILO, FENILO Y OTROS; R4 ES R3 Y OTROS; R5 Y R6 SON HIDROGENO O SIGNIFICAN IGUAL QUE R3; R2 ES H O R4; RA ES IGUAL QUE R3 Y OTRAS; ZA ES HIDROXI; H O UN GRUPO ELIMINABLE; RK1 ES OH O UN GRUPO R1; Y RK2 ES OH O UN GRUPO R2.TIENEN APLICACION PARA EL TRATAMIENTO DE GLAUCOMA.
ES525656A 1982-09-17 1983-09-16 Un metodo de preparar profarmacos de pilocarpina Granted ES525656A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK417082 1982-09-17

Publications (2)

Publication Number Publication Date
ES8502977A1 true ES8502977A1 (es) 1985-02-01
ES525656A0 ES525656A0 (es) 1985-02-01

Family

ID=8130941

Family Applications (1)

Application Number Title Priority Date Filing Date
ES525656A Granted ES525656A0 (es) 1982-09-17 1983-09-16 Un metodo de preparar profarmacos de pilocarpina

Country Status (10)

Country Link
US (1) US4742073A (es)
EP (1) EP0106541A3 (es)
JP (1) JPS59130275A (es)
KR (1) KR840006213A (es)
AU (1) AU557083B2 (es)
CA (1) CA1235416A (es)
ES (1) ES525656A0 (es)
IL (1) IL69593A (es)
NZ (1) NZ205617A (es)
PT (1) PT77347B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL69593A (en) * 1982-09-17 1988-09-30 Bundegaard Hans Pilocarpine prodrugs,their preparation and pharmaceutical compositions containing them
DK406686D0 (da) * 1986-08-26 1986-08-26 Hans Bundgaard Carboxylsyrederivater
US5066663A (en) * 1990-05-21 1991-11-19 Warner-Lambert Company Substituted-hetero-cyclopentanones and cyclopentenones and derivatives thereof acting at muscarinic receptors
US5066665A (en) * 1990-05-21 1991-11-19 Warner-Lambert Co. Substituted isoxazolidin-3-ones and derivatives thereof acting at muscarinic receptors
FI98815C (fi) 1990-11-30 1997-08-25 Santen Oy Menetelmä uusien, farmakologisesti käyttökelpoisten bispilokarpiinihapon esterijohdannaisten valmistamiseksi
FI98910C (fi) 1992-05-29 1997-09-10 Santen Oy Menetelmä farmaseuttisesti käyttökelpoisten pilokarpiinijohdannaisten valmistamiseksi
US5436350A (en) * 1990-11-30 1995-07-25 Jaervinen; Tomi Bispilocarpic acid ester derivatives and process for their preparation
WO1993024466A1 (en) * 1992-05-29 1993-12-09 Leiras Oy Novel pilocarpine derivatives and process for their preparation
US5521210A (en) * 1993-04-13 1996-05-28 Allergan, Inc. Ophthalmic use of muscarinic agonists having increased duration of activity

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3470197A (en) * 1967-08-30 1969-09-30 Miles Lab 1-substituted derivatives of 3-ethyl-4 - (1-methylimidazolyl-(5)-methyl)-2-pyrrolidinone
US3631059A (en) * 1967-09-11 1971-12-28 John T Goorley Process for the extraction and purification of pilocarpine
US4045558A (en) * 1975-10-08 1977-08-30 Merck & Co., Inc. Pilocarpine salts
US4061722A (en) * 1976-04-26 1977-12-06 Interx Research Corporation Selected quaternary ammonium salts of pilocarpine useful in reducing intraocular pressure in warm-blooded animals
IL69593A (en) * 1982-09-17 1988-09-30 Bundegaard Hans Pilocarpine prodrugs,their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
AU557083B2 (en) 1986-12-04
AU1849483A (en) 1984-03-22
IL69593A (en) 1988-09-30
JPS59130275A (ja) 1984-07-26
CA1235416A (en) 1988-04-19
ES525656A0 (es) 1985-02-01
KR840006213A (ko) 1984-11-22
EP0106541A2 (en) 1984-04-25
US4742073A (en) 1988-05-03
NZ205617A (en) 1986-06-11
PT77347A (en) 1983-10-01
PT77347B (en) 1986-03-11
EP0106541A3 (en) 1985-12-18

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