ES8501412A1 - "un metodo para la preparacion de un derivado de aminoacido" - Google Patents
"un metodo para la preparacion de un derivado de aminoacido"Info
- Publication number
- ES8501412A1 ES8501412A1 ES524285A ES524285A ES8501412A1 ES 8501412 A1 ES8501412 A1 ES 8501412A1 ES 524285 A ES524285 A ES 524285A ES 524285 A ES524285 A ES 524285A ES 8501412 A1 ES8501412 A1 ES 8501412A1
- Authority
- ES
- Spain
- Prior art keywords
- amino acid
- acid derivatives
- drugs containing
- antihypertensive drugs
- tripeptides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/80—Antihypertensive peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
METODO PARA LA PREPARACION DE UN DERIVADO DE AMINOACIDO.CONSISTE EN SOMETER UN COMPUESTO DE FORMULA (II) O UN DERIVADO REACTIVO DEL MISMO, CON UN COMPUESTO DE FORMULA (III) O UNA DE SUS SALES, A UNA REACCION DE CONDENSACION EN UN DISOLVENTE INERTE TAL COMO DIMETILFORMAMIDA EN PRESENCIA DE UN AGENTE DE CONDENSACION, PARA OBTENER UN DERIVADO DE FOSFORO DE UN TRIPEPTIDO DE FORMULA (I). DONDE R1 Y R2 SON HIDROXILO, ALCOHILOXI, ARILOXI, ARALCOHILOXI, ALCOHILO, ARILO O ARALCOHILO; R3, R5, R8 Y R11 SON HIDROGENO O ALCOHILO; R4, R7 Y R10 SON HIDROGENO, ALCOHILO, ALILO O ARALCOHILO; R6 Y R9 SON HIDROGENO, ALCOHILO, ARILO O ARALCOHILO Y R12 ES HIDROXILO, ALCOHILOXI, ARILOXI, ARALCOHILOXI, AMINO, MONO - O DI - ALCOHIL, ARIL O ARALCOHILAMINO.ESTE PRODUCTO ES UTIL COMO FARMACO ANTIHIPERTENSIVO Y COMO UN COMPUESTO INTERMEDIO PARA SU PRODUCCION.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP57009341A JPS58126896A (ja) | 1982-01-23 | 1982-01-23 | アラニルプロリン誘導体およびこれを含有する降圧剤 |
JP57141831A JPS5931788A (ja) | 1982-08-16 | 1982-08-16 | アミノ酸誘導体およびこれを含有する降圧剤 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES524285A0 ES524285A0 (es) | 1984-11-16 |
ES8501412A1 true ES8501412A1 (es) | 1984-11-16 |
Family
ID=26344046
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES519168A Expired ES8403138A1 (es) | 1982-01-23 | 1983-01-21 | Un metodo para la preparacion de un derivado de aminoacido. |
ES524285A Expired ES8501412A1 (es) | 1982-01-23 | 1983-07-20 | "un metodo para la preparacion de un derivado de aminoacido" |
ES524284A Granted ES524284A0 (es) | 1982-01-23 | 1983-07-20 | Un metodo para la preparacion de un derivado de aminoacido. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES519168A Expired ES8403138A1 (es) | 1982-01-23 | 1983-01-21 | Un metodo para la preparacion de un derivado de aminoacido. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES524284A Granted ES524284A0 (es) | 1982-01-23 | 1983-07-20 | Un metodo para la preparacion de un derivado de aminoacido. |
Country Status (4)
Country | Link |
---|---|
US (3) | US4472381A (es) |
EP (1) | EP0085488B1 (es) |
DE (1) | DE3381378D1 (es) |
ES (3) | ES8403138A1 (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4595675A (en) * | 1979-09-19 | 1986-06-17 | Hoechst Aktiengesellschaft | Bicyclic α-iminocarboxylic acid compounds having hypotensive activity |
DE3381378D1 (de) * | 1982-01-23 | 1990-05-03 | Ajinomoto Kk | Derivate von aminosaeuren und antihypertensive arzneimittel diese enthaltend. |
JPS60193994A (ja) * | 1984-03-13 | 1985-10-02 | Ajinomoto Co Inc | Ν−ホスフイノイル化方法 |
JPH0655758B2 (ja) * | 1984-08-24 | 1994-07-27 | 味の素株式会社 | アミノ酸誘導体 |
AU595309B2 (en) * | 1986-05-09 | 1990-03-29 | Dainippon Pharmaceutical Co. Ltd. | Tripeptide derivatives |
EP0376040A3 (en) * | 1988-12-27 | 1990-09-12 | American Cyanamid Company | N-phosphinyl di-and tripeptides as renin inhibitors |
FR2654430B1 (fr) * | 1989-11-15 | 1995-01-06 | Commissariat Energie Atomique | Nouveaux derives de peptides, utilisables comme inhibiteurs des collagenases bacteriennes. |
US6075121A (en) * | 1990-05-15 | 2000-06-13 | Chiron Corporation | Modified peptide and peptide libraries with protease resistance, derivatives thereof and methods of producing and screening such |
IE66205B1 (en) * | 1990-06-14 | 1995-12-13 | Paul A Bartlett | Polypeptide analogs |
US5189023A (en) * | 1990-09-04 | 1993-02-23 | American Cyanamid Company | Renin inhibitors |
FR2689764B1 (fr) * | 1992-04-10 | 1995-05-12 | Commissariat Energie Atomique | Utilisation de dérivés de peptides pour la fabrication de médicaments inhibiteurs des endopeptidases 24.15 et 24.16. |
WO2009037416A1 (en) * | 2007-09-20 | 2009-03-26 | Npil Pharmaceuticals (Uk) Limited | Process for preparing sulphonamides |
US9040046B2 (en) | 2011-01-31 | 2015-05-26 | Kai Xu | Sodium pump antibody agonists and methods of treating heart disease using the same |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4316896A (en) * | 1978-09-07 | 1982-02-23 | Merck & Co., Inc. | Aminoacid derivatives as antihypertensives |
EP0026867A1 (de) * | 1979-09-28 | 1981-04-15 | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft | Peptidylphosphonsäuren, deren Herstellung und Verwendung und sie enthaltende pharmazeutische Präparate |
US4379146A (en) * | 1981-02-17 | 1983-04-05 | Merck & Co., Inc. | Substituted phosphonamides as antihypertensives |
US4466913A (en) * | 1981-06-30 | 1984-08-21 | Maiji Seika Kaisha Ltd. | Phosphorus-containing compounds and process for producing the same |
US4432972A (en) * | 1981-08-03 | 1984-02-21 | E. R. Squibb & Sons, Inc. | Phosphonamidate compounds |
US4432971A (en) * | 1981-08-03 | 1984-02-21 | E. R. Squibb & Sons, Inc. | Phosphonamidate compounds |
DE3381378D1 (de) * | 1982-01-23 | 1990-05-03 | Ajinomoto Kk | Derivate von aminosaeuren und antihypertensive arzneimittel diese enthaltend. |
-
1983
- 1983-01-12 DE DE8383300146T patent/DE3381378D1/de not_active Expired - Lifetime
- 1983-01-12 EP EP83300146A patent/EP0085488B1/en not_active Expired
- 1983-01-18 US US06/458,844 patent/US4472381A/en not_active Expired - Fee Related
- 1983-01-21 ES ES519168A patent/ES8403138A1/es not_active Expired
- 1983-07-14 US US06/513,738 patent/US4536395A/en not_active Expired - Fee Related
- 1983-07-20 ES ES524285A patent/ES8501412A1/es not_active Expired
- 1983-07-20 ES ES524284A patent/ES524284A0/es active Granted
-
1984
- 1984-03-16 US US06/590,428 patent/US4590178A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US4536395A (en) | 1985-08-20 |
EP0085488B1 (en) | 1990-03-28 |
ES519168A0 (es) | 1984-03-01 |
US4590178A (en) | 1986-05-20 |
ES524285A0 (es) | 1984-11-16 |
ES8501411A1 (es) | 1984-11-16 |
EP0085488A2 (en) | 1983-08-10 |
EP0085488A3 (en) | 1985-12-27 |
US4472381A (en) | 1984-09-18 |
ES8403138A1 (es) | 1984-03-01 |
ES524284A0 (es) | 1984-11-16 |
DE3381378D1 (de) | 1990-05-03 |
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