ES8406437A1 - Procedimiento para preparar derivados del acido cis endo 2-azabiciclo 5.3.0)decan 3 carboxilico - Google Patents

Procedimiento para preparar derivados del acido cis endo 2-azabiciclo 5.3.0)decan 3 carboxilico

Info

Publication number
ES8406437A1
ES8406437A1 ES528031A ES528031A ES8406437A1 ES 8406437 A1 ES8406437 A1 ES 8406437A1 ES 528031 A ES528031 A ES 528031A ES 528031 A ES528031 A ES 528031A ES 8406437 A1 ES8406437 A1 ES 8406437A1
Authority
ES
Spain
Prior art keywords
alkyl
denotes hydrogen
denotes
azabicyclo
endo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES528031A
Other languages
English (en)
Other versions
ES528031A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES528031A0 publication Critical patent/ES528031A0/es
Publication of ES8406437A1 publication Critical patent/ES8406437A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DEL ACIDO CIS, ENDO-2-AZABICICLO5.3.0-DECAN-3-CARBOXILICO Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE X, Y, Z, R, R Y R PUEDEN SER VARIOS RADICALES.CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULAS (III) O (IV) O CON EL RACEMATO, EN LAS QUE W ES UN GRUPO DE ESTERIFICACION Y LOS DEMAS SIMBOLOS SON LOS MISMOS QUE EN LA FORMULA (I); SEGUIDA DE LA HIDROGENACION O TRATAMIENTO CON UN ACIDO O UNA BASE.ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA COMBATIR LA HIPERTENSION.
ES528031A 1982-12-16 1983-12-14 Procedimiento para preparar derivados del acido cis endo 2-azabiciclo 5.3.0)decan 3 carboxilico Expired ES8406437A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19823246503 DE3246503A1 (de) 1982-12-16 1982-12-16 Derivate der cis, endo-2-azabicyclo-(5.3.0)-decan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung

Publications (2)

Publication Number Publication Date
ES528031A0 ES528031A0 (es) 1984-08-01
ES8406437A1 true ES8406437A1 (es) 1984-08-01

Family

ID=6180782

Family Applications (2)

Application Number Title Priority Date Filing Date
ES528031A Expired ES8406437A1 (es) 1982-12-16 1983-12-14 Procedimiento para preparar derivados del acido cis endo 2-azabiciclo 5.3.0)decan 3 carboxilico
ES528820A Expired ES8407474A1 (es) 1982-12-16 1984-01-12 Procedimiento para preparar esteres de acido cis, endo-2-azabiciclo(5.3.0)-decan-3-carboxilico

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES528820A Expired ES8407474A1 (es) 1982-12-16 1984-01-12 Procedimiento para preparar esteres de acido cis, endo-2-azabiciclo(5.3.0)-decan-3-carboxilico

Country Status (22)

Country Link
US (1) US4714708A (es)
EP (1) EP0111873B1 (es)
JP (1) JPS59118766A (es)
KR (1) KR910000234B1 (es)
AT (1) ATE30151T1 (es)
AU (1) AU565913B2 (es)
CA (1) CA1210768A (es)
DE (2) DE3246503A1 (es)
DK (1) DK164557C (es)
ES (2) ES8406437A1 (es)
FI (1) FI78684C (es)
GR (1) GR79476B (es)
HU (1) HU197756B (es)
IE (1) IE56455B1 (es)
IL (1) IL70446A (es)
MA (1) MA19976A1 (es)
MX (1) MX7012A (es)
NO (1) NO164536C (es)
NZ (1) NZ206574A (es)
PH (1) PH19453A (es)
PT (1) PT77818B (es)
ZA (1) ZA839344B (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3226768A1 (de) * 1981-11-05 1983-05-26 Hoechst Ag, 6230 Frankfurt Derivate der cis, endo-2-azabicyclo-(3.3.0)-octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung
IE55867B1 (en) * 1981-12-29 1991-02-14 Hoechst Ag New derivatives of bicyclic aminoacids,processes for their preparation,agents containing these compounds and their use,and new bicyclic aminoacids as intermediates and processes for their preparation
US5175306A (en) * 1983-01-31 1992-12-29 Hoechst Aktiengesellschaft Process for the resolution of racemates of optically active bicyclic imino-α-carboxylic esters
DE3303344A1 (de) 1983-02-02 1984-08-02 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von n-alkylierten aminosaeuren und deren estern
DE3333455A1 (de) * 1983-09-16 1985-04-11 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung n-alkylierter dipeptide und deren estern
DE3413710A1 (de) * 1984-04-12 1985-10-24 Hoechst Ag, 6230 Frankfurt Verfahren zur behandlung der herzinsuffizienz
US5684016A (en) * 1984-04-12 1997-11-04 Hoechst Aktiengesellschaft Method of treating cardiac insufficiency
DE3431541A1 (de) * 1984-08-28 1986-03-06 Hoechst Ag, 6230 Frankfurt Cis,endo-2-azabicycloalkan-3-carbonsaeure-derivate, verfahren zu deren herstellung, deren verwendung sowie zwischenprodukte bei deren herstellung
US5231080A (en) * 1985-10-15 1993-07-27 Hoechst Aktiengesellschaft Method for the treatment of atherosclerosis, thrombosis, and peripheral vessel disease
US5231084A (en) * 1986-03-27 1993-07-27 Hoechst Aktiengesellschaft Compounds having a cognition adjuvant action, agents containing them, and the use thereof for the treatment and prophylaxis of cognitive dysfuncitons
JPH01104034A (ja) * 1986-03-27 1989-04-21 Kanegafuchi Chem Ind Co Ltd Ｎ↑２−（１−カルボキシ−３−フエニルプロピル）−ｌ−リジン誘導体の製造法
DE3633496A1 (de) * 1986-10-02 1988-04-14 Hoechst Ag Kombination von angiotensin-converting-enzyme-hemmern mit calciumantagonisten sowie deren verwendung in arzneimitteln
DE3639879A1 (de) * 1986-11-21 1988-06-01 Hoechst Ag Verfahren zur herstellung von mono-, bi- und tricyclischen aminosaeuren, zwischenprodukte dieses verfahrens sowie ein verfahren zu deren herstellung
DE3641451A1 (de) * 1986-12-04 1988-06-16 Hoechst Ag Derivate bicyclischer aminocarbonsaeuren, verfahren und zwischenprodukte zu deren herstellung sowie deren verwendung
DE3722007A1 (de) * 1987-07-03 1989-01-12 Hoechst Ag Verfahren zur herstellung bicyclischer aminocarbonsaeuren, zwischenprodukte dieses verfahrens und deren verwendung
HU904967D0 (en) * 1988-04-22 1991-01-28 Hoechst Ag Process for producing new azabicyclo(3.3.o)octane-3-carboxylic acid-octylesther derivatives
LT3872B (en) 1993-12-06 1996-04-25 Hoechst Ag Novel peptides and pharmaceutical compositions containing them
EP0796855B1 (de) 1996-03-20 2002-02-06 Hoechst Aktiengesellschaft Inhibitoren der Knochenresorption und Vitronectinrezeptor-Antagonisten
FR2746394B1 (fr) 1996-03-20 1998-05-29 Roussel Uclaf Nouveaux composes tricycliques, leur procede de preparation, et les intermediaires de ce procede, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant
JP3792777B2 (ja) * 1996-05-10 2006-07-05 株式会社カネカ １−アルコキシカルボニル−３−フェニルプロピル誘導体の製造方法
DE19653647A1 (de) 1996-12-20 1998-06-25 Hoechst Ag Vitronectin - Rezeptorantagonisten, deren Herstellung sowie deren Verwendung
JP3847934B2 (ja) * 1997-02-14 2006-11-22 株式会社カネカ γ−オキソ−ホモフェニルアラニン誘導体及びそれを還元してなるホモフェニルアラニン誘導体の製造方法
DE19741235A1 (de) 1997-09-18 1999-03-25 Hoechst Marion Roussel De Gmbh Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19741873A1 (de) * 1997-09-23 1999-03-25 Hoechst Marion Roussel De Gmbh Neue 5-Ring-Heterocyclen, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19751251A1 (de) 1997-11-19 1999-05-20 Hoechst Marion Roussel De Gmbh Substituierte Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmezeutische Präparate
DE19821483A1 (de) 1998-05-14 1999-11-18 Hoechst Marion Roussel De Gmbh Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
EP1615885A1 (en) * 2003-04-15 2006-01-18 Warner-Lambert Company LLC B -fused bicyclic proline derivatives and their use for treating arthritic conditions
BRPI0409428A (pt) * 2003-04-15 2006-04-18 Warner Lambert Co derivados de prolina bicìclicos [c]-fundidos e a sua utilização para tratar estados artrìticos

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3113950A (en) * 1960-05-06 1963-12-10 Sankyo Co Process for the preparation of cyclohepta [b] pyrrol-8(1h)-one derivatives
IE52663B1 (en) * 1980-04-02 1988-01-20 Warner Lambert Co Substituted acyl derivatives of octahydro-1h-indole-2-carboxylic acids
ZA817261B (en) * 1980-10-23 1982-09-29 Schering Corp Carboxyalkyl dipeptides,processes for their production and pharmaceutical compositions containing them
EP0050800B2 (en) * 1980-10-23 1995-06-07 Schering Corporation Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them
DE3226768A1 (de) * 1981-11-05 1983-05-26 Hoechst Ag, 6230 Frankfurt Derivate der cis, endo-2-azabicyclo-(3.3.0)-octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung
EP0079522B1 (en) * 1981-11-09 1986-05-07 Merck & Co. Inc. N-carboxymethyl(amidino)lysyl-proline antihypertensive agents
EP0081094A1 (en) * 1981-11-12 1983-06-15 Merck & Co. Inc. Substituted omega-amino-carboxymethyldipeptide antihypertensive agents
IE55867B1 (en) * 1981-12-29 1991-02-14 Hoechst Ag New derivatives of bicyclic aminoacids,processes for their preparation,agents containing these compounds and their use,and new bicyclic aminoacids as intermediates and processes for their preparation
DE3211676A1 (de) * 1982-03-30 1983-10-06 Hoechst Ag Neue derivate von cycloalka (c) pyrrol-carbonsaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue cycloalka (c) pyrrol-carbonsaeuren als zwischenstufen und verfahren zu deren herstellung

Also Published As

Publication number Publication date
NZ206574A (en) 1987-03-06
DK164557B (da) 1992-07-13
DE3374004D1 (en) 1987-11-12
ES528031A0 (es) 1984-08-01
PH19453A (en) 1986-04-18
MX7012A (es) 1994-03-31
AU2246083A (en) 1984-06-21
ATE30151T1 (de) 1987-10-15
GR79476B (es) 1984-10-30
IL70446A0 (en) 1984-03-30
DK580583A (da) 1984-06-17
NO834626L (no) 1984-06-18
MA19976A1 (fr) 1984-07-01
PT77818A (de) 1984-01-01
DK164557C (da) 1992-11-30
FI78684C (fi) 1989-09-11
NO164536B (no) 1990-07-09
NO164536C (no) 1990-10-17
EP0111873A1 (de) 1984-06-27
FI834593A0 (fi) 1983-12-14
AU565913B2 (en) 1987-10-01
IE832963L (en) 1984-06-16
IL70446A (en) 1990-11-29
JPH0572398B2 (es) 1993-10-12
KR840006965A (ko) 1984-12-04
IE56455B1 (en) 1991-08-14
DE3246503A1 (de) 1984-06-20
JPS59118766A (ja) 1984-07-09
US4714708A (en) 1987-12-22
HU197756B (en) 1989-05-29
FI78684B (fi) 1989-05-31
FI834593A (fi) 1984-06-17
ZA839344B (en) 1984-08-29
ES528820A0 (es) 1984-09-16
EP0111873B1 (de) 1987-10-07
ES8407474A1 (es) 1984-09-16
PT77818B (de) 1986-04-21
CA1210768A (en) 1986-09-02
DK580583D0 (da) 1983-12-15
KR910000234B1 (ko) 1991-01-23

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20041102