DK580583A - Derivater af cis,endo-2-azabicyclo-(5.3.0)-decan-3-carboxylsyre, fremgangsmaade til deres fremstilling samt midler indeholdende disse og deres anvendelse - Google Patents

Derivater af cis,endo-2-azabicyclo-(5.3.0)-decan-3-carboxylsyre, fremgangsmaade til deres fremstilling samt midler indeholdende disse og deres anvendelse Download PDF

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Publication number
DK580583A
DK580583A DK580583A DK580583A DK580583A DK 580583 A DK580583 A DK 580583A DK 580583 A DK580583 A DK 580583A DK 580583 A DK580583 A DK 580583A DK 580583 A DK580583 A DK 580583A
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DK
Denmark
Prior art keywords
alkyl
denotes hydrogen
denotes
azabicyclo
endo
Prior art date
Application number
DK580583A
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English (en)
Other versions
DK580583D0 (da
DK164557B (da
DK164557C (da
Inventor
Hansjoerg Urbach
Rainer Henning
Volker Teetz
Reinhard Becker
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of DK580583D0 publication Critical patent/DK580583D0/da
Publication of DK580583A publication Critical patent/DK580583A/da
Publication of DK164557B publication Critical patent/DK164557B/da
Application granted granted Critical
Publication of DK164557C publication Critical patent/DK164557C/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Plant Substances (AREA)
DK580583A 1982-12-16 1983-12-15 Derivater af cis,endo-2-azabicyclo-oe5.3.0aa-decan-3-carboxylsyre samt laegemiddel indeholdende dem DK164557C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19823246503 DE3246503A1 (de) 1982-12-16 1982-12-16 Derivate der cis, endo-2-azabicyclo-(5.3.0)-decan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung
DE3246503 1982-12-16

Publications (4)

Publication Number Publication Date
DK580583D0 DK580583D0 (da) 1983-12-15
DK580583A true DK580583A (da) 1984-06-17
DK164557B DK164557B (da) 1992-07-13
DK164557C DK164557C (da) 1992-11-30

Family

ID=6180782

Family Applications (1)

Application Number Title Priority Date Filing Date
DK580583A DK164557C (da) 1982-12-16 1983-12-15 Derivater af cis,endo-2-azabicyclo-oe5.3.0aa-decan-3-carboxylsyre samt laegemiddel indeholdende dem

Country Status (22)

Country Link
US (1) US4714708A (da)
EP (1) EP0111873B1 (da)
JP (1) JPS59118766A (da)
KR (1) KR910000234B1 (da)
AT (1) ATE30151T1 (da)
AU (1) AU565913B2 (da)
CA (1) CA1210768A (da)
DE (2) DE3246503A1 (da)
DK (1) DK164557C (da)
ES (2) ES528031A0 (da)
FI (1) FI78684C (da)
GR (1) GR79476B (da)
HU (1) HU197756B (da)
IE (1) IE56455B1 (da)
IL (1) IL70446A (da)
MA (1) MA19976A1 (da)
MX (1) MX7012A (da)
NO (1) NO164536C (da)
NZ (1) NZ206574A (da)
PH (1) PH19453A (da)
PT (1) PT77818B (da)
ZA (1) ZA839344B (da)

Families Citing this family (28)

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DE3226768A1 (de) * 1981-11-05 1983-05-26 Hoechst Ag, 6230 Frankfurt Derivate der cis, endo-2-azabicyclo-(3.3.0)-octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung
GR78413B (da) * 1981-12-29 1984-09-27 Hoechst Ag
US5175306A (en) * 1983-01-31 1992-12-29 Hoechst Aktiengesellschaft Process for the resolution of racemates of optically active bicyclic imino-α-carboxylic esters
DE3303344A1 (de) 1983-02-02 1984-08-02 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von n-alkylierten aminosaeuren und deren estern
DE3333455A1 (de) * 1983-09-16 1985-04-11 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung n-alkylierter dipeptide und deren estern
DE3413710A1 (de) * 1984-04-12 1985-10-24 Hoechst Ag, 6230 Frankfurt Verfahren zur behandlung der herzinsuffizienz
US5684016A (en) * 1984-04-12 1997-11-04 Hoechst Aktiengesellschaft Method of treating cardiac insufficiency
DE3431541A1 (de) * 1984-08-28 1986-03-06 Hoechst Ag, 6230 Frankfurt Cis,endo-2-azabicycloalkan-3-carbonsaeure-derivate, verfahren zu deren herstellung, deren verwendung sowie zwischenprodukte bei deren herstellung
US5231080A (en) * 1985-10-15 1993-07-27 Hoechst Aktiengesellschaft Method for the treatment of atherosclerosis, thrombosis, and peripheral vessel disease
JPH01104034A (ja) * 1986-03-27 1989-04-21 Kanegafuchi Chem Ind Co Ltd Ｎ↑２−（１−カルボキシ−３−フエニルプロピル）−ｌ−リジン誘導体の製造法
US5231084A (en) * 1986-03-27 1993-07-27 Hoechst Aktiengesellschaft Compounds having a cognition adjuvant action, agents containing them, and the use thereof for the treatment and prophylaxis of cognitive dysfuncitons
DE3633496A1 (de) * 1986-10-02 1988-04-14 Hoechst Ag Kombination von angiotensin-converting-enzyme-hemmern mit calciumantagonisten sowie deren verwendung in arzneimitteln
DE3639879A1 (de) * 1986-11-21 1988-06-01 Hoechst Ag Verfahren zur herstellung von mono-, bi- und tricyclischen aminosaeuren, zwischenprodukte dieses verfahrens sowie ein verfahren zu deren herstellung
DE3641451A1 (de) * 1986-12-04 1988-06-16 Hoechst Ag Derivate bicyclischer aminocarbonsaeuren, verfahren und zwischenprodukte zu deren herstellung sowie deren verwendung
DE3722007A1 (de) * 1987-07-03 1989-01-12 Hoechst Ag Verfahren zur herstellung bicyclischer aminocarbonsaeuren, zwischenprodukte dieses verfahrens und deren verwendung
HU904967D0 (en) * 1988-04-22 1991-01-28 Hoechst Ag Process for producing new azabicyclo(3.3.o)octane-3-carboxylic acid-octylesther derivatives
LT3872B (en) 1993-12-06 1996-04-25 Hoechst Ag Novel peptides and pharmaceutical compositions containing them
FR2746394B1 (fr) 1996-03-20 1998-05-29 Roussel Uclaf Nouveaux composes tricycliques, leur procede de preparation, et les intermediaires de ce procede, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant
PT796855E (pt) 1996-03-20 2002-07-31 Hoechst Ag Inibicao da reabsorcao nos ossos e antagonistas de vitronectina
JP3792777B2 (ja) * 1996-05-10 2006-07-05 株式会社カネカ １−アルコキシカルボニル−３−フェニルプロピル誘導体の製造方法
DE19653647A1 (de) 1996-12-20 1998-06-25 Hoechst Ag Vitronectin - Rezeptorantagonisten, deren Herstellung sowie deren Verwendung
JP3847934B2 (ja) * 1997-02-14 2006-11-22 株式会社カネカ γ−オキソ−ホモフェニルアラニン誘導体及びそれを還元してなるホモフェニルアラニン誘導体の製造方法
DE19741235A1 (de) 1997-09-18 1999-03-25 Hoechst Marion Roussel De Gmbh Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19741873A1 (de) * 1997-09-23 1999-03-25 Hoechst Marion Roussel De Gmbh Neue 5-Ring-Heterocyclen, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19751251A1 (de) 1997-11-19 1999-05-20 Hoechst Marion Roussel De Gmbh Substituierte Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmezeutische Präparate
DE19821483A1 (de) 1998-05-14 1999-11-18 Hoechst Marion Roussel De Gmbh Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
BRPI0409428A (pt) * 2003-04-15 2006-04-18 Warner Lambert Co derivados de prolina bicìclicos [c]-fundidos e a sua utilização para tratar estados artrìticos
MXPA05011168A (es) * 2003-04-15 2005-12-14 Warner Lambert Co Derivados de prolina biciclicos [b]-condensados y sus usos para tratar afecciones artriticas.

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3113950A (en) * 1960-05-06 1963-12-10 Sankyo Co Process for the preparation of cyclohepta [b] pyrrol-8(1h)-one derivatives
IE52663B1 (en) * 1980-04-02 1988-01-20 Warner Lambert Co Substituted acyl derivatives of octahydro-1h-indole-2-carboxylic acids
ZA817261B (en) * 1980-10-23 1982-09-29 Schering Corp Carboxyalkyl dipeptides,processes for their production and pharmaceutical compositions containing them
DE19575012I2 (de) * 1980-10-23 2002-01-24 Schering Corp Carboxyalkyl-Dipeptide Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
DE3226768A1 (de) * 1981-11-05 1983-05-26 Hoechst Ag, 6230 Frankfurt Derivate der cis, endo-2-azabicyclo-(3.3.0)-octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung
EP0079522B1 (en) * 1981-11-09 1986-05-07 Merck & Co. Inc. N-carboxymethyl(amidino)lysyl-proline antihypertensive agents
EP0081094A1 (en) * 1981-11-12 1983-06-15 Merck & Co. Inc. Substituted omega-amino-carboxymethyldipeptide antihypertensive agents
GR78413B (da) * 1981-12-29 1984-09-27 Hoechst Ag
DE3211676A1 (de) * 1982-03-30 1983-10-06 Hoechst Ag Neue derivate von cycloalka (c) pyrrol-carbonsaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue cycloalka (c) pyrrol-carbonsaeuren als zwischenstufen und verfahren zu deren herstellung

Also Published As

Publication number Publication date
FI78684C (fi) 1989-09-11
PH19453A (en) 1986-04-18
DK580583D0 (da) 1983-12-15
IE832963L (en) 1984-06-16
ZA839344B (en) 1984-08-29
DK164557B (da) 1992-07-13
NO164536C (no) 1990-10-17
KR840006965A (ko) 1984-12-04
NO164536B (no) 1990-07-09
DK164557C (da) 1992-11-30
JPS59118766A (ja) 1984-07-09
CA1210768A (en) 1986-09-02
ES8406437A1 (es) 1984-08-01
JPH0572398B2 (da) 1993-10-12
EP0111873B1 (de) 1987-10-07
DE3246503A1 (de) 1984-06-20
NO834626L (no) 1984-06-18
IE56455B1 (en) 1991-08-14
EP0111873A1 (de) 1984-06-27
NZ206574A (en) 1987-03-06
AU2246083A (en) 1984-06-21
HU197756B (en) 1989-05-29
FI834593A0 (fi) 1983-12-14
ATE30151T1 (de) 1987-10-15
IL70446A (en) 1990-11-29
ES8407474A1 (es) 1984-09-16
KR910000234B1 (ko) 1991-01-23
FI834593A (fi) 1984-06-17
ES528031A0 (es) 1984-08-01
US4714708A (en) 1987-12-22
DE3374004D1 (en) 1987-11-12
PT77818A (de) 1984-01-01
MX7012A (es) 1994-03-31
IL70446A0 (en) 1984-03-30
FI78684B (fi) 1989-05-31
ES528820A0 (es) 1984-09-16
MA19976A1 (fr) 1984-07-01
GR79476B (da) 1984-10-30
AU565913B2 (en) 1987-10-01
PT77818B (de) 1986-04-21

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