ES8404328A1 - Procedimiento de preparacion de nuevas iminas ciclicas y de sus sales de adicion acidas y sales cuaternarias. - Google Patents
Procedimiento de preparacion de nuevas iminas ciclicas y de sus sales de adicion acidas y sales cuaternarias.Info
- Publication number
- ES8404328A1 ES8404328A1 ES517049A ES517049A ES8404328A1 ES 8404328 A1 ES8404328 A1 ES 8404328A1 ES 517049 A ES517049 A ES 517049A ES 517049 A ES517049 A ES 517049A ES 8404328 A1 ES8404328 A1 ES 8404328A1
- Authority
- ES
- Spain
- Prior art keywords
- propanol
- compounds
- preparation
- lower alkyl
- pharmaceutical compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE IMINAS CICLICAS, DE FORMULA GENERAL (I), EN LA QUE B ES OXOGENO O IMINO; X1 Y X2 REPRESENTAN HIDROGENO, HALOGENO, ALQUILO O ALCOXILO INFERIOR; Y N ES 6 O 7, Y SUS SALES DE ADICION ACIDAS Y SUS SALES CUATERNARIAS, FARMACEUTICAMENTE ACEPTABLES.CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II), EN LA QUE X1, X2 Y B TIENEN LOS SIGNIFICADOS YA MENCIONADOS; R1 ES HIDROGENO; Y R2 ES HALOGENO, CON UN COMPUESTO DE FORMULA (III), EN LA QUE N TIENE EL SIGNIFICADO YA INDICADO. EL COMPUESTO ASI OBTENIDO SE PUEDE CONVERTIR EN UNA SAL DE ADICIONBASICA, FARMACOLOGICAMENTE ACEPTABLE O EN UNA SAL CUATERNARIA.DE APLICACION EN LA PREPARACION DE COMPOSICIONES FARMACEUTICAS UTILIZADAS EN EL TRATAMIENTO DE ENFERMEDADES CARDIOVASCULARES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU813308A HU183721B (en) | 1981-11-06 | 1981-11-06 | Process for producing new cyclic imine derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8404328A1 true ES8404328A1 (es) | 1984-05-01 |
ES517049A0 ES517049A0 (es) | 1984-05-01 |
Family
ID=10963511
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES517049A Granted ES517049A0 (es) | 1981-11-06 | 1982-11-02 | Procedimiento de preparacion de nuevas iminas ciclicas y de sus sales de adicion acidas y sales cuaternarias. |
Country Status (18)
Country | Link |
---|---|
US (1) | US4530923A (es) |
JP (1) | JPS5885879A (es) |
AT (1) | AT382371B (es) |
BE (1) | BE894889A (es) |
CA (1) | CA1197241A (es) |
CH (1) | CH652399A5 (es) |
DD (1) | DD206992A5 (es) |
DE (1) | DE3240908A1 (es) |
DK (1) | DK494282A (es) |
ES (1) | ES517049A0 (es) |
FI (1) | FI77241C (es) |
FR (1) | FR2516080B1 (es) |
GB (1) | GB2111485B (es) |
HU (1) | HU183721B (es) |
IT (1) | IT1218328B (es) |
NL (1) | NL8204275A (es) |
SE (1) | SE8206230L (es) |
SU (1) | SU1272986A3 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES513980A0 (es) * | 1982-07-14 | 1983-04-16 | Medichem Sa | Un procedimiento para la obtencion de la 2-(hexahidroazepin)-n-(2,6-dimetilfenil)acetamida. |
WO2003018549A2 (en) * | 2001-08-30 | 2003-03-06 | Chemocentryx, Inc. | Bicyclic compounds as inhibitors of chemokine binding to us28 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1552758A (es) * | 1963-07-01 | 1969-01-10 | ||
FR6571M (es) * | 1967-08-03 | 1968-12-23 | ||
CA956632A (en) * | 1969-05-16 | 1974-10-22 | Yoshitomi Pharmaceutical Industries | Phenoxy-aminopropanol derivatives |
BE790133A (fr) * | 1971-10-16 | 1973-04-16 | Basf Ag | Nouveaux derives de la trimethylhydroquinone, leur preparation et leursutilisations therapeutiques |
DE2300543A1 (de) * | 1973-01-08 | 1974-07-11 | Basf Ag 6700 Ludwigshafen | Neue derivate des trimethylphenols und verfahren zu ihrer herstellung |
JPS50106947A (es) * | 1974-02-06 | 1975-08-22 | ||
CS195321B2 (en) * | 1975-12-23 | 1980-01-31 | Ciba Geigy Ag | Plant growth suppressing agents |
US4191765A (en) * | 1976-05-25 | 1980-03-04 | Hoechst Aktiengesellschaft | 1-Aryloxy-2-hydroxy-3-aminopropanes |
DE2915250A1 (de) * | 1979-04-14 | 1980-10-30 | Basf Ag | Salze von alpha -aminoacetaniliden |
DE3004360A1 (de) * | 1980-02-06 | 1981-09-24 | Chem. pharmaz. Fabrik Dr. Hermann Thiemann GmbH, 4670 Lünen | 1,3-dicarbonyl-2-hydroxy- und -alkoxy-5-(amino-acetamido)-benzolverbindungen, verfahren zu ihrer herstellung und ihre verwendung |
-
1981
- 1981-11-06 HU HU813308A patent/HU183721B/hu not_active IP Right Cessation
-
1982
- 1982-10-12 FI FI823470A patent/FI77241C/fi not_active IP Right Cessation
- 1982-10-20 US US06/435,493 patent/US4530923A/en not_active Expired - Fee Related
- 1982-11-02 ES ES517049A patent/ES517049A0/es active Granted
- 1982-11-02 SE SE8206230A patent/SE8206230L/xx not_active Application Discontinuation
- 1982-11-03 BE BE1/10630A patent/BE894889A/fr not_active IP Right Cessation
- 1982-11-04 NL NL8204275A patent/NL8204275A/nl not_active Application Discontinuation
- 1982-11-04 FR FR8218475A patent/FR2516080B1/fr not_active Expired
- 1982-11-05 DK DK494282A patent/DK494282A/da not_active Application Discontinuation
- 1982-11-05 IT IT8224085A patent/IT1218328B/it active
- 1982-11-05 CA CA000415034A patent/CA1197241A/en not_active Expired
- 1982-11-05 AT AT0403982A patent/AT382371B/de not_active IP Right Cessation
- 1982-11-05 DD DD82244611A patent/DD206992A5/de unknown
- 1982-11-05 DE DE19823240908 patent/DE3240908A1/de not_active Withdrawn
- 1982-11-05 GB GB08231604A patent/GB2111485B/en not_active Expired
- 1982-11-05 CH CH6448/82A patent/CH652399A5/de not_active IP Right Cessation
- 1982-11-06 JP JP57193985A patent/JPS5885879A/ja active Pending
-
1983
- 1983-10-13 SU SU833651388A patent/SU1272986A3/ru active
Also Published As
Publication number | Publication date |
---|---|
IT1218328B (it) | 1990-04-12 |
FI823470L (fi) | 1983-05-07 |
AT382371B (de) | 1987-02-25 |
US4530923A (en) | 1985-07-23 |
FR2516080B1 (fr) | 1985-11-22 |
GB2111485B (en) | 1985-07-17 |
DD206992A5 (de) | 1984-02-15 |
BE894889A (fr) | 1983-05-03 |
FI77241C (fi) | 1989-02-10 |
CH652399A5 (de) | 1985-11-15 |
FR2516080A1 (fr) | 1983-05-13 |
HU183721B (en) | 1984-05-28 |
SE8206230L (sv) | 1983-05-07 |
SE8206230D0 (sv) | 1982-11-02 |
CA1197241A (en) | 1985-11-26 |
GB2111485A (en) | 1983-07-06 |
DE3240908A1 (de) | 1983-05-19 |
FI77241B (fi) | 1988-10-31 |
ES517049A0 (es) | 1984-05-01 |
JPS5885879A (ja) | 1983-05-23 |
DK494282A (da) | 1983-05-07 |
IT8224085A0 (it) | 1982-11-05 |
FI823470A0 (fi) | 1982-10-12 |
SU1272986A3 (ru) | 1986-11-23 |
ATA403982A (de) | 1986-07-15 |
NL8204275A (nl) | 1983-06-01 |
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