ES8404328A1 - Procedimiento de preparacion de nuevas iminas ciclicas y de sus sales de adicion acidas y sales cuaternarias. - Google Patents

Procedimiento de preparacion de nuevas iminas ciclicas y de sus sales de adicion acidas y sales cuaternarias.

Info

Publication number
ES8404328A1
ES8404328A1 ES517049A ES517049A ES8404328A1 ES 8404328 A1 ES8404328 A1 ES 8404328A1 ES 517049 A ES517049 A ES 517049A ES 517049 A ES517049 A ES 517049A ES 8404328 A1 ES8404328 A1 ES 8404328A1
Authority
ES
Spain
Prior art keywords
propanol
compounds
preparation
lower alkyl
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES517049A
Other languages
English (en)
Other versions
ES517049A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Egyt Gyogyszervegyeszeti Gyar
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egyt Gyogyszervegyeszeti Gyar filed Critical Egyt Gyogyszervegyeszeti Gyar
Publication of ES8404328A1 publication Critical patent/ES8404328A1/es
Publication of ES517049A0 publication Critical patent/ES517049A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE IMINAS CICLICAS, DE FORMULA GENERAL (I), EN LA QUE B ES OXOGENO O IMINO; X1 Y X2 REPRESENTAN HIDROGENO, HALOGENO, ALQUILO O ALCOXILO INFERIOR; Y N ES 6 O 7, Y SUS SALES DE ADICION ACIDAS Y SUS SALES CUATERNARIAS, FARMACEUTICAMENTE ACEPTABLES.CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II), EN LA QUE X1, X2 Y B TIENEN LOS SIGNIFICADOS YA MENCIONADOS; R1 ES HIDROGENO; Y R2 ES HALOGENO, CON UN COMPUESTO DE FORMULA (III), EN LA QUE N TIENE EL SIGNIFICADO YA INDICADO. EL COMPUESTO ASI OBTENIDO SE PUEDE CONVERTIR EN UNA SAL DE ADICIONBASICA, FARMACOLOGICAMENTE ACEPTABLE O EN UNA SAL CUATERNARIA.DE APLICACION EN LA PREPARACION DE COMPOSICIONES FARMACEUTICAS UTILIZADAS EN EL TRATAMIENTO DE ENFERMEDADES CARDIOVASCULARES.
ES517049A 1981-11-06 1982-11-02 Procedimiento de preparacion de nuevas iminas ciclicas y de sus sales de adicion acidas y sales cuaternarias. Granted ES517049A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU813308A HU183721B (en) 1981-11-06 1981-11-06 Process for producing new cyclic imine derivatives

Publications (2)

Publication Number Publication Date
ES8404328A1 true ES8404328A1 (es) 1984-05-01
ES517049A0 ES517049A0 (es) 1984-05-01

Family

ID=10963511

Family Applications (1)

Application Number Title Priority Date Filing Date
ES517049A Granted ES517049A0 (es) 1981-11-06 1982-11-02 Procedimiento de preparacion de nuevas iminas ciclicas y de sus sales de adicion acidas y sales cuaternarias.

Country Status (18)

Country Link
US (1) US4530923A (es)
JP (1) JPS5885879A (es)
AT (1) AT382371B (es)
BE (1) BE894889A (es)
CA (1) CA1197241A (es)
CH (1) CH652399A5 (es)
DD (1) DD206992A5 (es)
DE (1) DE3240908A1 (es)
DK (1) DK494282A (es)
ES (1) ES517049A0 (es)
FI (1) FI77241C (es)
FR (1) FR2516080B1 (es)
GB (1) GB2111485B (es)
HU (1) HU183721B (es)
IT (1) IT1218328B (es)
NL (1) NL8204275A (es)
SE (1) SE8206230L (es)
SU (1) SU1272986A3 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES513980A0 (es) * 1982-07-14 1983-04-16 Medichem Sa Un procedimiento para la obtencion de la 2-(hexahidroazepin)-n-(2,6-dimetilfenil)acetamida.
DE60233336D1 (de) * 2001-08-30 2009-09-24 Chemocentryx Inc Bicyclische verbindungen als hemmer der chemokin-bindung an us28

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1552758A (es) * 1963-07-01 1969-01-10
FR6571M (es) * 1967-08-03 1968-12-23
CA956632A (en) * 1969-05-16 1974-10-22 Yoshitomi Pharmaceutical Industries Phenoxy-aminopropanol derivatives
BE790133A (fr) * 1971-10-16 1973-04-16 Basf Ag Nouveaux derives de la trimethylhydroquinone, leur preparation et leursutilisations therapeutiques
DE2300543A1 (de) * 1973-01-08 1974-07-11 Basf Ag 6700 Ludwigshafen Neue derivate des trimethylphenols und verfahren zu ihrer herstellung
JPS50106947A (es) * 1974-02-06 1975-08-22
CS195321B2 (en) * 1975-12-23 1980-01-31 Ciba Geigy Ag Plant growth suppressing agents
US4191765A (en) * 1976-05-25 1980-03-04 Hoechst Aktiengesellschaft 1-Aryloxy-2-hydroxy-3-aminopropanes
DE2915250A1 (de) * 1979-04-14 1980-10-30 Basf Ag Salze von alpha -aminoacetaniliden
DE3004360A1 (de) * 1980-02-06 1981-09-24 Chem. pharmaz. Fabrik Dr. Hermann Thiemann GmbH, 4670 Lünen 1,3-dicarbonyl-2-hydroxy- und -alkoxy-5-(amino-acetamido)-benzolverbindungen, verfahren zu ihrer herstellung und ihre verwendung

Also Published As

Publication number Publication date
BE894889A (fr) 1983-05-03
AT382371B (de) 1987-02-25
CH652399A5 (de) 1985-11-15
NL8204275A (nl) 1983-06-01
FI823470A0 (fi) 1982-10-12
FI823470L (fi) 1983-05-07
IT8224085A0 (it) 1982-11-05
IT1218328B (it) 1990-04-12
ATA403982A (de) 1986-07-15
FI77241B (fi) 1988-10-31
GB2111485A (en) 1983-07-06
SE8206230D0 (sv) 1982-11-02
HU183721B (en) 1984-05-28
JPS5885879A (ja) 1983-05-23
CA1197241A (en) 1985-11-26
GB2111485B (en) 1985-07-17
FR2516080B1 (fr) 1985-11-22
FI77241C (fi) 1989-02-10
DK494282A (da) 1983-05-07
DE3240908A1 (de) 1983-05-19
FR2516080A1 (fr) 1983-05-13
US4530923A (en) 1985-07-23
DD206992A5 (de) 1984-02-15
ES517049A0 (es) 1984-05-01
SU1272986A3 (ru) 1986-11-23
SE8206230L (sv) 1983-05-07

Similar Documents

Publication Publication Date Title
GR3032395T3 (en) New aminoacid derivates, process for producing the same and pharmaceutical compositions containing these compounds.
ES8203883A1 (es) Un procedimiento para la preparacion de derivados de imida- zol
ATE19878T1 (de) Benzimidazol-derivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen.
ES481714A1 (es) Procedimiento para la obtencion de derivados de tetrahidro- piridina y piperidina.
ES8503666A1 (es) Procedimiento para la preparacion de 1-ariloxi-2,3,4,5-tetrahidro-3-benzazepinas
ATE2265T1 (de) Sekundaere amine, ihre herstellung und verwendung in pharmazeutischen zusammensetzungen.
ES479820A1 (es) Procedimiento para la preparacion de isoquinoleinas.
ES8205791A1 (es) Procedimiento para la preparacion de derivados de imidazol del sistema de 1,4-benzodioxan-2-ilo
NO913391L (no) Fremgangsmaate for fremstilling av nye hetrazepinoide syreamider.
GB1489711A (en) 1-phenoxyphenyl-piperazine derivatives process for their preparation and pharmaceutical compositions containing the
HUP9601680A2 (hu) Benzizotiazolil-szubsztituált amino-metil-krománok, az ezeket tartalmazó gyógyszerkészítmények, eljárás előállításukra és a vegyületek alkalmazása
ES8604103A1 (es) Procedimiento de preparacion de nuevos derivados a-etilben- zol con un grupo dialquilaminoalcoxi sustituido y de sus sa-les de adicion acidas y amonicas cuaternarias
ES8404328A1 (es) Procedimiento de preparacion de nuevas iminas ciclicas y de sus sales de adicion acidas y sales cuaternarias.
ES8606880A1 (es) Un procedimiento para la preparacion de nuevos peptidos.
GB1168080A (en) New N-Propynyl Methylamines and their Salts, and process for preparation thereof
ES2005042A6 (es) Procedimiento de preparar derivados de aminoacidos que tienen actividad sobre el sistema nervioso central.
UA34451C2 (uk) 2,3,4,5-тетрагідро-1н-3-бензазепіни, що використовуються для лікування захворювань центральної нервової системи, спосіб їх одержання, фармацевтична композиція та спосіб лікування захворювань центральної нервової системи
IE810901L (en) Naphthotriazoles.
IE31997B1 (en) New substituted 2-arylalkyloxy-benzamides and the preparation thereof
ES2027492A6 (es) Procedimiento de preparacion de nuevos derivados dihidropirimidotiazinos y de sus sales de adicion acidas farmaceuticamente aceptables.
GB1193534A (en) Novel Benzazocine Derivatives, the Preparation thereof and Compositions Containing the same
ES8603845A1 (es) Procedimiento de preparacion de nuevos derivados a-etilami- noetoxibencilalcoholicos con un grupo fenil sustituido en situacion a y de sus sales de adicion acida y amobica cua- ternaria
ES8502424A1 (es) Procedimiento para la preparacion de derivados de benzazepina
ATE56438T1 (de) 1-(cyclohexyl>-3,4-di-(hydro>isochinolinderivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel.
ES464773A1 (es) Procedimiento para la preparacion de 2,9-dioxatriciclo (4,3,1,03,7)decanos.