ES8402837A1 - Un metodo de preparacion de quaninas antiviricas. - Google Patents

Un metodo de preparacion de quaninas antiviricas.

Info

Publication number
ES8402837A1
ES8402837A1 ES515193A ES515193A ES8402837A1 ES 8402837 A1 ES8402837 A1 ES 8402837A1 ES 515193 A ES515193 A ES 515193A ES 515193 A ES515193 A ES 515193A ES 8402837 A1 ES8402837 A1 ES 8402837A1
Authority
ES
Spain
Prior art keywords
compounds
viral
guanine
propoxymethyl
dihydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES515193A
Other languages
English (en)
Spanish (es)
Other versions
ES515193A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES515193A0 publication Critical patent/ES515193A0/es
Publication of ES8402837A1 publication Critical patent/ES8402837A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
ES515193A 1981-08-26 1982-08-23 Un metodo de preparacion de quaninas antiviricas. Expired ES8402837A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US29660481A 1981-08-26 1981-08-26

Publications (2)

Publication Number Publication Date
ES515193A0 ES515193A0 (es) 1984-03-01
ES8402837A1 true ES8402837A1 (es) 1984-03-01

Family

ID=23142740

Family Applications (2)

Application Number Title Priority Date Filing Date
ES515193A Expired ES8402837A1 (es) 1981-08-26 1982-08-23 Un metodo de preparacion de quaninas antiviricas.
ES522456A Granted ES522456A0 (es) 1981-08-26 1983-05-16 Un metodo de preparacion de un derivado de monofosfato de guaminas antiviricas.(como divisional de la patente numero 515.193)

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES522456A Granted ES522456A0 (es) 1981-08-26 1983-05-16 Un metodo de preparacion de un derivado de monofosfato de guaminas antiviricas.(como divisional de la patente numero 515.193)

Country Status (14)

Country Link
EP (1) EP0074306B1 (forum.php)
JP (3) JPS5877881A (forum.php)
KR (1) KR840001168A (forum.php)
AT (1) ATE34750T1 (forum.php)
AU (1) AU8755282A (forum.php)
CA (1) CA1300622C (forum.php)
DE (1) DE3278561D1 (forum.php)
DK (1) DK379782A (forum.php)
ES (2) ES8402837A1 (forum.php)
GR (1) GR76861B (forum.php)
IL (1) IL66640A0 (forum.php)
NZ (1) NZ201662A (forum.php)
PT (1) PT75463B (forum.php)
ZA (1) ZA826196B (forum.php)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5157120A (en) * 1980-09-16 1992-10-20 Syntex (U.S.A.) Inc. Guanine derivatives
US4347360A (en) * 1980-09-16 1982-08-31 Ens Bio Logicals Inc. Ring open nucleoside analogues
FI76086C (fi) * 1981-08-11 1988-09-09 Wellcome Found Foerfarande foer framstaellning av antivirala purinderivat.
US4816447A (en) * 1981-08-26 1989-03-28 Merck & Co., Inc. Anti-viral guanine compounds
ZA83626B (en) * 1982-02-01 1983-12-28 Syntex Inc Substituted 9-(1 or 3-monoacyloxy or 1, 3-diacyloxy-2-propoxy-methyl purines as antiviral agent
US5250535A (en) * 1982-02-01 1993-10-05 Syntex Inc. Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl) purines as antiviral agent
US4556659A (en) * 1982-08-09 1985-12-03 Syntex (U.S.A.) Inc. Substituted 9-(1-0- or 3-0-monosubstituted or 1,3-Di-0-substituted propoxymethyl)-purines as antiviral agents
ES8507550A1 (es) * 1982-09-30 1985-09-16 Syntex Inc Procedimiento para la preparacion de 1-esteres monofosfato, 1,3-bis-esteres fosfato y esteres fosfato ciclico de 9-(1,3-dihidroxi-2-propoximetil)-guanina
US4544634A (en) * 1982-10-14 1985-10-01 Burroughs Wellcome Co. Method of producing acyclovir
US4609662A (en) * 1982-10-14 1986-09-02 Burroughs Wellcome Co. Method for using purine derivatives
US4462986A (en) * 1982-11-04 1984-07-31 Ens Bio Logicals, Inc. Synergistic anti-herpes compositions
DE3490262T1 (de) * 1983-05-24 1985-11-28 Sri International, Menlo Park, Calif. Antivirus-Mittel
US5047533A (en) * 1983-05-24 1991-09-10 Sri International Acyclic purine phosphonate nucleotide analogs
US4880820A (en) * 1983-06-24 1989-11-14 Merck & Co., Inc. Guanine derivatives
PT78769A (en) * 1983-06-24 1984-07-01 Merck & Co Inc Process for preparing (s)-9-(2,3-dihydroxy-1-propoxymethyl)guanine and derivatives thereof useful as antiviral agents
ZA844744B (en) * 1983-06-24 1986-02-26 Merck & Co Inc Antiviral agents
US4670424A (en) * 1983-09-19 1987-06-02 Merck & Co., Inc. Cyclic pyrophosphates of purine and pyrimidine acyclonucleosides
EP0138683A3 (en) * 1983-09-30 1988-01-20 Merck & Co. Inc. Purine derivatives, their application in anti-viral compositions
US4897479A (en) * 1983-09-30 1990-01-30 Merck & Co., Inc. Arylsulfonyloxy purine intermediates
IL73682A (en) * 1983-12-20 1991-08-16 Medivir Ab Antiviral pharmaceutical compositions containing 9-hydroxy aliphatic derivatives of guanine,some new such derivatives and process for their preparation
EP0152316B1 (en) * 1984-01-26 1989-07-26 Merck & Co. Inc. Substituted butyl guanines and their utilization in antiviral compositions
US4579849A (en) * 1984-04-06 1986-04-01 Merck & Co., Inc. N-alkylguanine acyclonucleosides as antiviral agents
EP0184473A1 (en) * 1984-10-26 1986-06-11 Merck & Co. Inc. Regioselective synthesis of 9-substituted purine acyclonucleoside derivatives
IL77298A (en) * 1984-12-12 1999-11-30 Syntex Inc Process for preparing 2-(alkanoyloxymethoxy)-1, 3-propanediols esters and ehers thereof their use in the preparation of (9H-guaninemethoxy)-1, 3-propanediol-derivatives and some new esters and ethers of 2-(alkanoyloxymethoxy)-1, 3-propanediols
SE8406538D0 (sv) 1984-12-21 1984-12-21 Astra Laekemedel Ab Novel derivatives of purine
CA1330794C (en) * 1987-03-27 1994-07-19 Phillip Frost Anti-viral compounds, dosage forms and methods
US4966895A (en) * 1989-02-02 1990-10-30 Merck & Co. Inc. Cyclic monophosphates of purine and pyrimidine acyclonucleosides as anti-retroviral agents
US5068119A (en) * 1990-09-28 1991-11-26 Nabisco Brands, Inc. Acid-hydrolyzable ester derivatives as low calorie fat mimetics
GB2260319B (en) 1991-10-07 1995-12-06 Norsk Hydro As Acyl derivatives of nucleosides and nucleoside analogues having anti-viral activity
US6964890B1 (en) 1992-03-17 2005-11-15 Semiconductor Energy Laboratory Co., Ltd. Semiconductor device and method for forming the same
US5532225A (en) * 1992-07-31 1996-07-02 Sri International Acyclic purine phosphonate nucleotide analogs as antiviral agents, and related synthetic methods
JPH07109573A (ja) 1993-10-12 1995-04-25 Semiconductor Energy Lab Co Ltd ガラス基板および加熱処理方法
US5565565A (en) * 1994-08-04 1996-10-15 Syntex (U.S.A.) Inc. Preparation of N-9 substituted guanine compounds
US5840890A (en) * 1996-01-26 1998-11-24 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
CN1091445C (zh) * 1999-12-29 2002-09-25 湖北省医药工业研究院 抗病毒药物中间体、它们的制备及应用
US20060142574A1 (en) * 2002-10-31 2006-06-29 Babu Jayachandra S Process for the preparation of ganciclovir
CN113024559B (zh) * 2019-12-25 2022-03-29 上药康丽（常州）药业有限公司 一种异更昔洛韦的制备方法
KR20240077879A (ko) * 2022-11-25 2024-06-03 롯데케미칼 주식회사 올레핀 올리고머화의 부산물 저감 방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4146715A (en) * 1975-08-27 1979-03-27 Burroughs Wellcome Co. 2-amido-9-(2-acyloxyethoxymethyl)hypoxanthines
US4347360A (en) * 1980-09-16 1982-08-31 Ens Bio Logicals Inc. Ring open nucleoside analogues
US4355032B2 (en) * 1981-05-21 1990-10-30 9-(1,3-dihydroxy-2-propoxymethyl)guanine as antiviral agent
FI76086C (fi) * 1981-08-11 1988-09-09 Wellcome Found Foerfarande foer framstaellning av antivirala purinderivat.
ZA83626B (en) * 1982-02-01 1983-12-28 Syntex Inc Substituted 9-(1 or 3-monoacyloxy or 1, 3-diacyloxy-2-propoxy-methyl purines as antiviral agent

Also Published As

Publication number Publication date
JPH04217940A (ja) 1992-08-07
ES515193A0 (es) 1984-03-01
IL66640A0 (en) 1982-12-31
JPH05286974A (ja) 1993-11-02
GR76861B (forum.php) 1984-09-04
ZA826196B (en) 1984-04-25
DK379782A (da) 1983-02-27
ES8406547A1 (es) 1984-08-01
JPH0729979B2 (ja) 1995-04-05
ATE34750T1 (de) 1988-06-15
PT75463B (en) 1986-08-28
CA1300622C (en) 1992-05-12
NZ201662A (en) 1986-07-11
PT75463A (en) 1982-09-01
EP0074306B1 (en) 1988-06-01
KR840001168A (ko) 1984-03-28
JPH0480914B2 (forum.php) 1992-12-21
EP0074306A3 (en) 1983-05-25
EP0074306A2 (en) 1983-03-16
AU8755282A (en) 1983-03-03
JPH0714938B2 (ja) 1995-02-22
JPS5877881A (ja) 1983-05-11
ES522456A0 (es) 1984-08-01
DE3278561D1 (en) 1988-07-07

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