ES8307002A1 - "procedimiento para preparar nuevos compuestos de aroilimidazol-2-onas". - Google Patents

"procedimiento para preparar nuevos compuestos de aroilimidazol-2-onas".

Info

Publication number
ES8307002A1
ES8307002A1 ES509636A ES509636A ES8307002A1 ES 8307002 A1 ES8307002 A1 ES 8307002A1 ES 509636 A ES509636 A ES 509636A ES 509636 A ES509636 A ES 509636A ES 8307002 A1 ES8307002 A1 ES 8307002A1
Authority
ES
Spain
Prior art keywords
alkyl
aroylimidazol
ones
novel
piperazino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES509636A
Other languages
English (en)
Other versions
ES509636A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Publication of ES509636A0 publication Critical patent/ES509636A0/es
Publication of ES8307002A1 publication Critical patent/ES8307002A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/70—One oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Polyurethanes Or Polyureas (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Luminescent Compositions (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR NUEVOS COMPUESTOS DE AROILIMIDAZOL-2-ONAS. CONSISTE EN ACILAR SEGUN FRIDEL-CRAFTS UN COMPUESTOS (II) CON 1 A 10 EQUIVALENTES MOLARES DE HALURO DE BENZOILO MONOSUSTITUIDO EN LA POSICION ORTO, META O PARA, EN PRESENCIA DE UN CATALIZADOR DE ACIDO DE LEWIS EN UN DISOLVENTE A TEMPERATURAS COMPRENDIDAS ENTRE 0 C Y 100 C DURANTE UN TIEMPO DE 1 A 10 HORAS. SE OBTIENE EL COMPUESTO (I) EN QUE AR ES FENILO MONOSUSTITUIDO EN ORTO, META O PARA CON X ; X ES UN ALQUILSULFOXIDO DE CADENA RECTA O RAMIFICADA O UNA ALQUILSULFONA INFERIOR; R ES HIDROGENO, UN ALQUILO INFERIOR, UN ALQUILCARBONILO INFERIOR O UN BENZOILO; R ES HIDROGENO O UN ALQUILO INFERIOR DE CADENA RECTA O RAMIFICADA.
ES509636A 1981-02-18 1982-02-16 "procedimiento para preparar nuevos compuestos de aroilimidazol-2-onas". Expired ES8307002A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US23545381A 1981-02-18 1981-02-18

Publications (2)

Publication Number Publication Date
ES509636A0 ES509636A0 (es) 1983-07-01
ES8307002A1 true ES8307002A1 (es) 1983-07-01

Family

ID=22885573

Family Applications (1)

Application Number Title Priority Date Filing Date
ES509636A Expired ES8307002A1 (es) 1981-02-18 1982-02-16 "procedimiento para preparar nuevos compuestos de aroilimidazol-2-onas".

Country Status (18)

Country Link
EP (1) EP0058435B1 (es)
JP (1) JPS57150668A (es)
KR (1) KR860001338B1 (es)
AT (1) ATE24496T1 (es)
AU (1) AU558789B2 (es)
CA (1) CA1173047A (es)
DE (1) DE3274855D1 (es)
DK (1) DK161250C (es)
ES (1) ES8307002A1 (es)
GB (1) GB2093031B (es)
GR (1) GR76025B (es)
HK (1) HK61586A (es)
IE (1) IE52422B1 (es)
IL (1) IL65010A0 (es)
MY (1) MY8600710A (es)
NZ (1) NZ199733A (es)
PH (1) PH18106A (es)
ZA (1) ZA82969B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4405628A (en) * 1981-03-05 1983-09-20 Merrell Dow Pharmaceuticals Inc. 4-Pyridylimidazolones and method of use
US4367236A (en) * 1981-11-04 1983-01-04 Merrell Dow Pharmaceuticals Inc. Method for the treatment of cardiac failure with alkanoylimidazol-2-one derivatives
US4410540A (en) * 1981-11-04 1983-10-18 Merrell Dow Pharmaceuticals Inc. Cardiotonic 4-aroylimidazolidin-2-ones
ZA826501B (en) * 1982-09-06 1984-04-25 Du Pont Anti-hypertensive imidazole derivative
US4552880A (en) * 1983-02-15 1985-11-12 Merrell Dow Pharmaceuticals Inc. Aroylimidazolones
US4556665A (en) * 1984-07-09 1985-12-03 Schering A.G. Cardiotonic 1,3-dihydro-4-[[(imidazol-1-yl)aryl]carbonyl]imidazol-2-ones
JP2007530566A (ja) * 2004-03-22 2007-11-01 ミオゲン インコーポレイティッド （ｒ）−エノキシモンスルホキシドおよびｐｄｅ−ｉｉｉ媒介疾患の治療におけるその使用
EP1737448A1 (en) * 2004-03-22 2007-01-03 Myogen, Inc. (s) - enoximone sulfoxide and its use in the treatment of pde-iii mediated diseases

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA803332B (en) * 1979-06-18 1981-01-28 Richardson Merrell Inc Novel 4-aroylimidazol-2-ones
NZ193935A (en) * 1979-06-18 1985-05-31 Richardson Merrell Inc 4-aroyl-imidazol-2-one derivatives;pharmaceutical compositions

Also Published As

Publication number Publication date
ES509636A0 (es) 1983-07-01
EP0058435B1 (en) 1986-12-30
GR76025B (es) 1984-08-03
GB2093031B (en) 1984-10-24
PH18106A (en) 1985-03-21
HK61586A (en) 1986-08-29
IE820333L (en) 1982-08-18
DK67582A (da) 1982-08-19
JPS57150668A (en) 1982-09-17
JPH048421B2 (es) 1992-02-17
AU8048682A (en) 1982-08-26
DK161250B (da) 1991-06-17
DE3274855D1 (de) 1987-02-05
AU558789B2 (en) 1987-02-12
ATE24496T1 (de) 1987-01-15
EP0058435A3 (en) 1984-03-21
CA1173047A (en) 1984-08-21
ZA82969B (en) 1983-09-28
KR860001338B1 (ko) 1986-09-15
KR830009045A (ko) 1983-12-17
NZ199733A (en) 1985-05-31
IE52422B1 (en) 1987-10-28
DK161250C (da) 1991-12-09
IL65010A0 (en) 1982-04-30
EP0058435A2 (en) 1982-08-25
GB2093031A (en) 1982-08-25
MY8600710A (en) 1986-12-31

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