ES8301955A1 - Un procedimiento para la preparacion de ranitidina. - Google Patents
Un procedimiento para la preparacion de ranitidina.Info
- Publication number
- ES8301955A1 ES8301955A1 ES508474A ES508474A ES8301955A1 ES 8301955 A1 ES8301955 A1 ES 8301955A1 ES 508474 A ES508474 A ES 508474A ES 508474 A ES508474 A ES 508474A ES 8301955 A1 ES8301955 A1 ES 8301955A1
- Authority
- ES
- Spain
- Prior art keywords
- aldehyde
- iii
- formula
- image
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/40—Radicals substituted by oxygen atoms
- C07D307/46—Doubly bound oxygen atoms, or two oxygen atoms singly bound to the same carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Furan Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Catalysts (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE RANITIDINA DE FORMULA (I). CONSISTE EN LA REACCION DE UN ALDEHIDO DE FORMULA (II) CON DIMETILAMINA Y UN AGENTE REDUCTOR CAPAZ DE EFECTUAR LA ALQUILACION REDUCTIVA PARA INTRODUCIR EL GRUPO DIMETILAMINOMETILO, PERO QUE NO REDUZCA EL GRUPO NITROETANO, TAL COMO DIBORANO, HIDRURO DE ALUMINIO O BOROHIDRURO O CIANOBOROHIDRURO SODICOS. LA REACCION SE LLEVA A CABO EN UN DISOLVENTE ACUORGANICO, A UNA TEMPERATURA ENTRE 10<025> Y 100<025>C. ESTE COMPUESTO TIENE APLICACIONES FARMACOLOGICAS COMO ANTAGONISTA-H .
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8041493 | 1980-12-30 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES508474A0 ES508474A0 (es) | 1983-01-01 |
ES8301955A1 true ES8301955A1 (es) | 1983-01-01 |
Family
ID=10518248
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES508474A Expired ES8301955A1 (es) | 1980-12-30 | 1981-12-30 | Un procedimiento para la preparacion de ranitidina. |
Country Status (11)
Country | Link |
---|---|
US (1) | US4399294A (es) |
EP (1) | EP0055625B1 (es) |
JP (1) | JPS57134475A (es) |
KR (1) | KR850001935B1 (es) |
AR (2) | AR230442A1 (es) |
AT (1) | ATE13057T1 (es) |
DE (1) | DE3170346D1 (es) |
DK (1) | DK153841C (es) |
ES (1) | ES8301955A1 (es) |
FI (1) | FI82241C (es) |
PT (1) | PT74235B (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5988458A (ja) * | 1982-11-12 | 1984-05-22 | Toyama Chem Co Ltd | アミン誘導体およびその塩 |
YU45634B (sh) * | 1983-07-15 | 1992-07-20 | Richter Gedeon Vegyeszeti Gyar R.T. | Postupak za dobijanje hidrohlorida 1-/2-/5-dimetilaminometil-2-(furilmetiltio)-etil /-amino-1-metilamino-2-nitroetilena |
DK153758B (da) * | 1985-09-27 | 1988-08-29 | Gea Farmaceutisk Fabrik As | Fremgangsmaade til fremstilling af ranitidin eller syreadditionssalte deraf samt derivat af 5-((2-aminoethyl)thiomethyl)-2-furanmethanol til brug som udgangsmateriale for fremgangsmaaden |
AU7235287A (en) * | 1986-03-28 | 1987-10-20 | Janus Farmaceutici S.R.L | Synthesis of antiulcer compounds |
YU52598A (sh) * | 1998-11-19 | 2001-05-28 | D.D. Zdravlje- sektor za istraživanje i razvoj | POSTUPAK ZA sintezu N-[2[[[5=[(DIALKILAMINO)METIL]-2= FURANIL]METIL]TIO]ETIL]-N'-ALKIL-2-NITRO 1,1 ALKENDIAMINA I NJIHOVIH HIDROHLORIDA |
CN108864001A (zh) * | 2018-06-30 | 2018-11-23 | 郑州明泽医药科技有限公司 | 一种合成雷尼替丁的新方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1565966A (en) * | 1976-08-04 | 1980-04-23 | Allen & Hanburys Ltd | Aminoalkyl furan derivatives |
AR228941A1 (es) * | 1978-04-26 | 1983-05-13 | Glaxo Group Ltd | Procedimiento para preparar nuevos derivados de 3,5-diamino-1,2,4-triazol que son activos contra receptores histaminicos |
GB2067991B (en) * | 1980-01-08 | 1983-10-19 | Glaxo Group Ltd | Process for the preparation of a furan derivative |
-
1981
- 1981-12-30 EP EP81306164A patent/EP0055625B1/en not_active Expired
- 1981-12-30 FI FI814215A patent/FI82241C/fi not_active IP Right Cessation
- 1981-12-30 US US06/335,686 patent/US4399294A/en not_active Expired - Lifetime
- 1981-12-30 AT AT81306164T patent/ATE13057T1/de not_active IP Right Cessation
- 1981-12-30 PT PT74235A patent/PT74235B/pt unknown
- 1981-12-30 DE DE8181306164T patent/DE3170346D1/de not_active Expired
- 1981-12-30 AR AR288011A patent/AR230442A1/es active
- 1981-12-30 JP JP56216182A patent/JPS57134475A/ja active Granted
- 1981-12-30 AR AR288012A patent/AR230275A1/es active
- 1981-12-30 KR KR1019810005251A patent/KR850001935B1/ko active
- 1981-12-30 ES ES508474A patent/ES8301955A1/es not_active Expired
- 1981-12-30 DK DK582081A patent/DK153841C/da not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
KR850001935B1 (ko) | 1985-12-31 |
PT74235A (en) | 1982-01-02 |
ATE13057T1 (de) | 1985-05-15 |
DK153841B (da) | 1988-09-12 |
US4399294A (en) | 1983-08-16 |
PT74235B (en) | 1984-01-04 |
FI82241C (fi) | 1991-02-11 |
DE3170346D1 (en) | 1985-06-05 |
EP0055625A1 (en) | 1982-07-07 |
KR830007614A (ko) | 1983-11-04 |
DK153841C (da) | 1989-02-20 |
JPS57134475A (en) | 1982-08-19 |
ES508474A0 (es) | 1983-01-01 |
AR230442A1 (es) | 1984-04-30 |
FI814215L (fi) | 1982-07-01 |
JPH038349B2 (es) | 1991-02-05 |
DK582081A (da) | 1982-07-01 |
EP0055625B1 (en) | 1985-05-02 |
FI82241B (fi) | 1990-10-31 |
AR230275A1 (es) | 1984-03-01 |
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