ES8301955A1 - Un procedimiento para la preparacion de ranitidina. - Google Patents

Un procedimiento para la preparacion de ranitidina.

Info

Publication number
ES8301955A1
ES8301955A1 ES508474A ES508474A ES8301955A1 ES 8301955 A1 ES8301955 A1 ES 8301955A1 ES 508474 A ES508474 A ES 508474A ES 508474 A ES508474 A ES 508474A ES 8301955 A1 ES8301955 A1 ES 8301955A1
Authority
ES
Spain
Prior art keywords
aldehyde
iii
formula
image
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES508474A
Other languages
English (en)
Other versions
ES508474A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of ES8301955A1 publication Critical patent/ES8301955A1/es
Publication of ES508474A0 publication Critical patent/ES508474A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/40—Radicals substituted by oxygen atoms
    • C07D307/46—Doubly bound oxygen atoms, or two oxygen atoms singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE RANITIDINA DE FORMULA (I). CONSISTE EN LA REACCION DE UN ALDEHIDO DE FORMULA (II) CON DIMETILAMINA Y UN AGENTE REDUCTOR CAPAZ DE EFECTUAR LA ALQUILACION REDUCTIVA PARA INTRODUCIR EL GRUPO DIMETILAMINOMETILO, PERO QUE NO REDUZCA EL GRUPO NITROETANO, TAL COMO DIBORANO, HIDRURO DE ALUMINIO O BOROHIDRURO O CIANOBOROHIDRURO SODICOS. LA REACCION SE LLEVA A CABO EN UN DISOLVENTE ACUORGANICO, A UNA TEMPERATURA ENTRE 10<025> Y 100<025>C. ESTE COMPUESTO TIENE APLICACIONES FARMACOLOGICAS COMO ANTAGONISTA-H .
ES508474A 1980-12-30 1981-12-30 Un procedimiento para la preparacion de ranitidina. Granted ES508474A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8041493 1980-12-30

Publications (2)

Publication Number Publication Date
ES8301955A1 true ES8301955A1 (es) 1983-01-01
ES508474A0 ES508474A0 (es) 1983-01-01

Family

ID=10518248

Family Applications (1)

Application Number Title Priority Date Filing Date
ES508474A Granted ES508474A0 (es) 1980-12-30 1981-12-30 Un procedimiento para la preparacion de ranitidina.

Country Status (11)

Country Link
US (1) US4399294A (es)
EP (1) EP0055625B1 (es)
JP (1) JPS57134475A (es)
KR (1) KR850001935B1 (es)
AR (2) AR230275A1 (es)
AT (1) ATE13057T1 (es)
DE (1) DE3170346D1 (es)
DK (1) DK153841C (es)
ES (1) ES508474A0 (es)
FI (1) FI82241C (es)
PT (1) PT74235B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5988458A (ja) * 1982-11-12 1984-05-22 Toyama Chem Co Ltd アミン誘導体およびその塩
SU1384197A3 (ru) * 1983-07-15 1988-03-23 Рихтер Гедеон Ведьесети Дьяр Рт (Инопредприятие) Способ получени 1- @ 2-(5-(ди-метиламинометил)-2-(фурилметилтио)-этил) @ амино-1-(метиламино)-2-нитроэтилена или его гидрохлорида и способ получени дигидрохлорида 2-(2-аминоэтил)-тиометил-5-(диметиламинометил)-фурана или его моногидрохлорида
DK153758C (da) * 1985-09-27 1995-10-02 Gea Farmaceutisk Fabrik As Fremgangsmåde til fremstilling af ranitidin eller syreadditionssalte deraf samt derivat af 5-((2-aminoethyl)thiomethyl)-2-furanmethanol til brug som udgangsmateriale for fremgangsmåden
AR245716A1 (es) * 1986-03-28 1994-02-28 Janus Farma Srl Procedimiento para la sintesis de niperotidina que tiene actividad terapeutica anti-ulcera.
YU52598A (sh) * 1998-11-19 2001-05-28 D.D. Zdravlje- sektor za istraživanje i razvoj POSTUPAK ZA sintezu N-[2[[[5=[(DIALKILAMINO)METIL]-2= FURANIL]METIL]TIO]ETIL]-N'-ALKIL-2-NITRO 1,1 ALKENDIAMINA I NJIHOVIH HIDROHLORIDA
CN108864001A (zh) * 2018-06-30 2018-11-23 郑州明泽医药科技有限公司 一种合成雷尼替丁的新方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1565966A (en) * 1976-08-04 1980-04-23 Allen & Hanburys Ltd Aminoalkyl furan derivatives
AR228941A1 (es) * 1978-04-26 1983-05-13 Glaxo Group Ltd Procedimiento para preparar nuevos derivados de 3,5-diamino-1,2,4-triazol que son activos contra receptores histaminicos
CH654830A5 (en) * 1980-01-08 1986-03-14 Glaxo Group Ltd Aziridine derivative

Also Published As

Publication number Publication date
JPS57134475A (en) 1982-08-19
PT74235B (en) 1984-01-04
AR230442A1 (es) 1984-04-30
EP0055625A1 (en) 1982-07-07
FI82241C (fi) 1991-02-11
JPH038349B2 (es) 1991-02-05
ES508474A0 (es) 1983-01-01
KR830007614A (ko) 1983-11-04
US4399294A (en) 1983-08-16
DK153841C (da) 1989-02-20
DK582081A (da) 1982-07-01
DK153841B (da) 1988-09-12
EP0055625B1 (en) 1985-05-02
DE3170346D1 (en) 1985-06-05
AR230275A1 (es) 1984-03-01
PT74235A (en) 1982-01-02
FI82241B (fi) 1990-10-31
FI814215L (fi) 1982-07-01
ATE13057T1 (de) 1985-05-15
KR850001935B1 (ko) 1985-12-31

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