JPS5750965A - Preparation of n-methyl-4-benzazonine derivative - Google Patents
Preparation of n-methyl-4-benzazonine derivativeInfo
- Publication number
- JPS5750965A JPS5750965A JP12628080A JP12628080A JPS5750965A JP S5750965 A JPS5750965 A JP S5750965A JP 12628080 A JP12628080 A JP 12628080A JP 12628080 A JP12628080 A JP 12628080A JP S5750965 A JPS5750965 A JP S5750965A
- Authority
- JP
- Japan
- Prior art keywords
- benzazonine
- formula
- derivative
- compound
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
PURPOSE: To prepare the titled compound useful for the medical use, economically, in an industrial scale, in high yield, with simplified process, by the reduction and N-methylation of a 4-benzazonine derivative having no substituent group at the N-position.
CONSTITUTION: A 4-benzazonine derivative of formula I ( R and R' are H or lower alkyl ), e.g. 10-hydroxy-1-methyl-2,3,4,5,6,7-hexahydro-1,6-methano-1H-4-benzazonine, is made to react with the compound of formula XCOOY (X is halogen; Y is lower alkyl, alkenyl, or aralkyl) or with formic acid in a solvent, and the product is reduced with a complex metal hydride such as lithium aluminum hydride to obtain the objective compound of formula II. As an alternative method, the compound of formula II can be prepared by the reductive reaction of the 4-benzazonine derivative of formula I with formaldehyde in the presence of formic acid, a complex metal hydride, or hydrogen activated by a catalyst such as Raney-nickel.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12628080A JPS5750965A (en) | 1980-09-11 | 1980-09-11 | Preparation of n-methyl-4-benzazonine derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12628080A JPS5750965A (en) | 1980-09-11 | 1980-09-11 | Preparation of n-methyl-4-benzazonine derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5750965A true JPS5750965A (en) | 1982-03-25 |
Family
ID=14931298
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP12628080A Pending JPS5750965A (en) | 1980-09-11 | 1980-09-11 | Preparation of n-methyl-4-benzazonine derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5750965A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110563605A (en) * | 2018-06-05 | 2019-12-13 | 上海医药工业研究院 | Intermediate for preparing eptazocine hydrobromide and preparation method thereof |
-
1980
- 1980-09-11 JP JP12628080A patent/JPS5750965A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110563605A (en) * | 2018-06-05 | 2019-12-13 | 上海医药工业研究院 | Intermediate for preparing eptazocine hydrobromide and preparation method thereof |
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