JPS5626821A - Preparation of alpha-aminoacrylic acid derivative - Google Patents

Preparation of alpha-aminoacrylic acid derivative

Info

Publication number
JPS5626821A
JPS5626821A JP10206679A JP10206679A JPS5626821A JP S5626821 A JPS5626821 A JP S5626821A JP 10206679 A JP10206679 A JP 10206679A JP 10206679 A JP10206679 A JP 10206679A JP S5626821 A JPS5626821 A JP S5626821A
Authority
JP
Japan
Prior art keywords
acid derivative
treating
formula
base
halogenating agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP10206679A
Other languages
Japanese (ja)
Inventor
Soji Miyoshi
Kazuo Matsumoto
Tamon Moriya
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Seiyaku Co Ltd
Original Assignee
Tanabe Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co Ltd filed Critical Tanabe Seiyaku Co Ltd
Priority to JP10206679A priority Critical patent/JPS5626821A/en
Publication of JPS5626821A publication Critical patent/JPS5626821A/en
Pending legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

PURPOSE: To prepare the titled compound useful as an intermediate of an amino acid, etc., economically in an industrial scale, using single reactor without separating intermediate products, by treating an aspartic acid derivative with a halogenating agent and a base, and if necessary, further with an acid.
CONSTITUTION: An α-aminoacrylic acid derivative of formula I (R1 is H or ester residue; R2 is amino-protecting group) is prepared by treating an aspartic acid derivative of formula II with a halogenating agent (e.g. alkali hypochlorite, chlorine, etc.) and a base (e.g. NaOH, sodium carbonate, etc.) in an inert solvent such as water, ethanol, etc., and when the liquid is neutral or alkaline after the reaction, treating the liquid with an acid. When an alkali hypochlorite is used as the halogenating agent and the base, the compound of formula I can be obtained in one step and in high yield.
USE: An intermediate of α-mercapto-α-amino acid having antiviral activity.
COPYRIGHT: (C)1981,JPO&Japio
JP10206679A 1979-08-09 1979-08-09 Preparation of alpha-aminoacrylic acid derivative Pending JPS5626821A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP10206679A JPS5626821A (en) 1979-08-09 1979-08-09 Preparation of alpha-aminoacrylic acid derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10206679A JPS5626821A (en) 1979-08-09 1979-08-09 Preparation of alpha-aminoacrylic acid derivative

Publications (1)

Publication Number Publication Date
JPS5626821A true JPS5626821A (en) 1981-03-16

Family

ID=14317384

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10206679A Pending JPS5626821A (en) 1979-08-09 1979-08-09 Preparation of alpha-aminoacrylic acid derivative

Country Status (1)

Country Link
JP (1) JPS5626821A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4456766A (en) * 1981-10-09 1984-06-26 Degussa Aktiengesellschaft Process for the production of N-acetyl-2,3-dehydro-aminocarboxylic acid esters

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4456766A (en) * 1981-10-09 1984-06-26 Degussa Aktiengesellschaft Process for the production of N-acetyl-2,3-dehydro-aminocarboxylic acid esters

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